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Browse Mutations rpoCD245Y

GenerpoC

Protein ChangeD245Y

Validation StatusEstablished

Databases

Reference Gene Catalog

Overview

Mechanism: DNA-directed RNA polymerase subunit beta RpoC
Resistance To: vancomycin
Organisms: Clostridioides difficile
Papers: 1

Paper Information1

1

In vitro selection, via serial passage, of Clostridium difficile mutants with reduced susceptibility to fidaxomicin or vancomycin.

PMID 23887866 · 2014

rpoC

Mutation Information

Protein Change: D245Y
Organisms: Clostridioides difficile
Confers Resistance To: vancomycin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoC
Source Database: Reference Gene Catalog

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research