ResLit - Antimicrobial Resistance Gene & Mutation Database

Generrs

ribosomal RNA small subunit

Nucleotide ChangeC1066T

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogResFinder Database

Overview

Mechanism: Target modification, 16S ribosomal RNA
Resistance To: spectinomycin
Organisms: Escherichia coli
Papers: 2

Paper Information2

A new mutation in 16S rRNA of Escherichia coli conferring spectinomycin resistance.

PMID 7885842 · 1995

Mutation Information

rrs: c.C1066T

Nucleotide Change: C1066T
Organisms: Escherichia coli
Confers Resistance To: spectinomycin
Effect on Function: Target modification
Source Database: ResFinder Database

Spectinomycin interacts specifically with the residues G1064 and C1192 in 16S rRNA, thereby potentially freezing this molecule into an inactive conformation.

PMID 8127669 · 1994

16S

Mutation Information

rrs: c.C1066T

Nucleotide Change: C1066T
Organisms: Escherichia coli
Confers Resistance To: spectinomycin
Effect on Function: 16S ribosomal RNA
Source Database: Reference Gene Catalog

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