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Browse Mutations cfrN2K

Genecfr

rRNA methyltransferase

Protein ChangeN2K

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: hygromycin|tiamulin
Organisms: E. coli
Papers: 1

Paper Information1

1

Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance.

PMID 35015630 · 2022

Promoter alterations and mutations in the cfr open reading frame enhance resistance

Mutation Information

Protein Change: N2K
Organisms: E. coli
Confers Resistance To: hygromycin|tiamulin
Validation Method: expression in E. coli, polysome profiling, protein degradation kinetics
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research