ResLit - Antimicrobial Resistance Gene & Mutation Database

GenenalC

DNA gyrase inhibitor

Protein ChangeG125D

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: mutations in nalC lead to the overexpression of mexAB-oprM, efflux system transcriptional repressor NalC
Resistance To: meropenem, aztreonam
Organisms: Pseudomonas aeruginosa
Papers: 2

Paper Information2

A Large-Scale Whole-Genome Comparison Shows that Experimental Evolution in Response to Antibiotics Predicts Changes in Naturally Evolved Clinical Pseudomonas aeruginosa.

PMID 31570397 · 2019

Mutation Information

nalC: p.G125D

Protein Change: G125D
Organisms: Pseudomonas aeruginosa
Confers Resistance To: meropenem
Effect on Function: mutations in nalC lead to the overexpression of mexAB-oprM
Validation Method: whole-genome sequencing and experimental evolution
Source Database: Reslit

Mutant prevention concentrations and phenotypic and genomic profiling of first-step resistance mechanisms to classical and novel β-lactams in Pseudomonas aeruginosa.

PMID 40067045 · 2025

nalC

Mutation Information

nalC: p.G125D

Protein Change: G125D
Organisms: Pseudomonas aeruginosa
Confers Resistance To: aztreonam
Effect on Function: efflux system transcriptional repressor NalC
Source Database: Reference Gene Catalog

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