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Browse Mutations blaNDM-5G5561A

Nucleotide ChangeG5561A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reduces blaNDM-5 expression, leading to decreased carbapenem resistance
Resistance To: carbapenems
Organisms: Escherichia coli
Papers: 1

Paper Information1

1

A Natural Novel Mutation in the bla(NDM-5) Promoter Reducing Carbapenems Resistance in a Clinical Escherichia coli Strain.

PMID 35138141 · 2022

The mutation reduces blaNDM-5 expression, leading to decreased carbapenem resistance.

Mutation Information

blaNDM-5: c.G5561A

Nucleotide Change: G5561A
Organisms: Escherichia coli
Confers Resistance To: carbapenems
Effect on Function: reduces blaNDM-5 expression, leading to decreased carbapenem resistance
Validation Method: expression in E. coli DH5α and measurement of meropenem MIC
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research