ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeD84N

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: DNA topoisomerase GrlA
Resistance To: enrofloxacin, ciprofloxacin, fluoroquinolones, quinolones
Organisms: Staphylococcus pseudintermedius, Staphylococcus intermedius
Papers: 3

Paper Information3

Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.

PMID 18305127 · 2008

grlA

Mutation Information

grlA: p.D84N

Protein Change: D84N
Organisms: Staphylococcus pseudintermedius, Staphylococcus intermedius
Confers Resistance To: enrofloxacinquinolones
Effect on Function: DNA topoisomerase GrlA
Validation Method: sequencing
Source Database: ReslitReference Gene Catalog

Novel pseudo-staphylococcal cassette chromosome mec element (ψSCCmec57395) in methicillin-resistant Staphylococcus pseudintermedius CC45.

PMID 23979735 · 2013

Mutation Information

grlA: p.D84N

Protein Change: D84N
Confers Resistance To: ciprofloxacin
Source Database: Reslit

Investigation of In Vitro Susceptibility and Resistance Mechanisms in Skin Pathogens: Perspectives for Fluoroquinolone Therapy in Canine Pyoderma.

PMID 36139982 · 2022

Mutation Information

grlA: p.D84N

Protein Change: D84N
Organisms: Staphylococcus pseudintermedius
Confers Resistance To: fluoroquinolones
Validation Method: sequencing
Source Database: Reslit

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