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Browse Mutations phoQD434N

GenephoQ

Protein ChangeD434N

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: mutation in the cytoplasmic GHKL domain (ATP-lid loop)
Resistance To: colistin
Organisms: Klebsiella pneumoniae
Papers: 1

Paper Information1

1

Genomic and transcriptomic analyses of colistin-resistant clinical isolates of Klebsiella pneumoniae reveal multiple pathways of resistance.

PMID 25385117 · 2015

Mutation Information

Protein Change: D434N
Organisms: Klebsiella pneumoniae
Confers Resistance To: colistin
Effect on Function: mutation in the cytoplasmic GHKL domain (ATP-lid loop)
Validation Method: experimental validation
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research