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Browse Mutations pbp4E218K

Genepbp4

Protein ChangeE218K

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: increased survival in the presence of the β-lactams nafcillin and cefoxitin, D-alanyl-D-alanine carboxypeptidase PBP4
Resistance To: nafcillin|cefoxitin, cephalosporins
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

1

PBP4-mediated β-lactam resistance among clinical strains of Staphylococcus aureus.

PMID 34151961 · 2021

mutations in pbp4 promoter and gene mediate β-lactam resistance

pbp4

Mutation Information

Protein Change: E218K
Organisms: Staphylococcus aureus
Confers Resistance To: nafcillin|cefoxitincephalosporins
Effect on Function: increased survival in the presence of the β-lactams nafcillin and cefoxitin; D-alanyl-D-alanine carboxypeptidase PBP4
Validation Method: growth assays
Source Database: ReslitReference Gene Catalog

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research