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ResLit

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Browse Mutations folAY151D

GenefolA

Protein ChangeY151D

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: trimethoprim
Organisms: Escherichia coli
Papers: 1

Paper Information1

1

Proteostasis modulates gene dosage evolution in antibiotic-resistant bacteria.

PMID 40073078 · 2025

Mutations in folA were found to confer resistance to trimethoprim.

Mutation Information

Protein Change: Y151D
Organisms: Escherichia coli
Confers Resistance To: trimethoprim
Validation Method: genomic sequencing and IC50 measurement
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research