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Explore antimicrobial resistance mutations from the literature

ResLit

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Browse Mutations rpoAD451N

GenerpoA

Protein ChangeD451N

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: rifampicin
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

1

Genomic epidemiology analysis of extremely drug-resistant tuberculosis in Shanghai, China.

PMID 40548454 · 2025

Mutations in rpoA were observed in EDR-TB strains and linked to transmission clustering.

Mutation Information

Protein Change: D451N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research