Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis.
Mutations in the cofactor binding site of InhA reduce NADH affinity but have minimal effect on INH-NAD adduct affinity.
Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis.
Molecular Dynamics Assisted Mechanistic Study of Isoniazid-Resistance against Mycobacterium tuberculosis InhA.
Mutations in InhA reduce NADH binding affinity, leading to isoniazid resistance.
The genetics and biochemistry of isoniazid resistance in mycobacterium tuberculosis.
Tuberculosis drug resistance mutation database.
Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates.
Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid; CARD accession: CARD:3003393
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