ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeV96A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: resistance to quinolones and quinazolinediones without disrupting the water-metal ion bridge
Resistance To: ciprofloxacin
Organisms: Bacillus anthracis
Papers: 1

Paper Information1

Bacillus anthracis GrlAV96A topoisomerase IV, a quinolone resistance mutation that does not affect the water-metal ion bridge.

PMID 25246407 · 2014

The V96A mutation in GrlA of Bacillus anthracis topoisomerase IV confers resistance to quinolones and quinazolinediones without disrupting the water-metal ion bridge.

Mutation Information

grlA: p.V96A

Protein Change: V96A
Organisms: Bacillus anthracis
Confers Resistance To: ciprofloxacin
Effect on Function: resistance to quinolones and quinazolinediones without disrupting the water-metal ion bridge
Validation Method: enzymatic assays and DNA cleavage experiments
Source Database: Reslit

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