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Browse Mutations mdtFV610F

GenemdtF

multidrug inner membrane transporter for the mdtEF-TolC efflux complex

Protein ChangeV610F

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: linezolid|tetracycline, fluoroquinolones|macrolides|oxazolidinones
Organisms: Escherichia coli
Papers: 1

Paper Information1

1

Molecular basis for multidrug efflux by an anaerobic-associated RND transporter.

PMID 41339309 · 2025

Mutation in the distal binding pocket of MdtF

Mutation Information

Protein Change: V610F
Organisms: Escherichia coli
Confers Resistance To: linezolid|tetracyclinefluoroquinolones|macrolides|oxazolidinones
Validation Method: MIC assay and cryo-EM; structural analysis and molecular dynamics simulations
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research