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Browse Mutations phoPC1234T

GenephoP

Nucleotide ChangeC1234T

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: polymyxin b
Organisms: Klebsiella pneumoniae
Papers: 1

Paper Information1

1

Lipid A in outer membrane vesicles shields bacteria from polymyxins.

PMID 38766978 · 2024

Mutation in the promoter region of phoP leads to increased expression and contributes to polymyxin B resistance.

Mutation Information

Nucleotide Change: C1234T
Organisms: Klebsiella pneumoniae
Confers Resistance To: polymyxin b
Validation Method: RNA-seq and qPCR
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research