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Browse Mutations fabIY147H

GenefabI

Protein ChangeY147H

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: FabI(Y147H) was catalytically defective but retained its sensitivity to AFN-1252
Resistance To: triclosan
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

1

Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI).

PMID 24189061 · 2013

Mutations in fabI were identified as the cause of resistance to AFN-1252 and triclosan.

Mutation Information

Protein Change: Y147H
Organisms: Staphylococcus aureus
Confers Resistance To: triclosan
Effect on Function: FabI(Y147H) was catalytically defective but retained its sensitivity to AFN-1252
Validation Method: cloning in E. coli + MIC testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research