ResLit - Antimicrobial Resistance Gene & Mutation Database

GenegrlA

Protein ChangeS81F

Validation StatusSupported

Databases

Reslit

Overview

Mechanism: enhances single-stranded DNA cleavage and suppresses double-stranded DNA breaks
Resistance To: fluoroquinolones, ciprofloxacin
Organisms: Bacillus anthracis, Escherichia coli
Papers: 3

Paper Information3

Bimodal Actions of a Naphthyridone/Aminopiperidine-Based Antibacterial That Targets Gyrase and Topoisomerase IV.

PMID 31617352 · 2019

Mutation in GrlA (S81F) confers resistance to fluoroquinolones.

Mutation Information

grlA: p.S81F

Protein Change: S81F
Organisms: Bacillus anthracis, Escherichia coli
Confers Resistance To: fluoroquinolones
Effect on Function: enhances single-stranded DNA cleavage and suppresses double-stranded DNA breaks
Validation Method: enzymatic assay
Source Database: Reslit

Antimicrobial resistance, virulence genes profiling and molecular relatedness of methicillin-resistant Staphylococcus aureus strains isolated from hospitalized patients in Guangdong Province, China.

PMID 30881052 · 2019

Mutation Information

grlA: p.S81F

Protein Change: S81F
Confers Resistance To: ciprofloxacin
Validation Method: sequencing
Source Database: Reslit

Recombination-mediated dissemination of Methicillin-resistant S. aureus clonal complex 1 in the Egyptian health care settings.

PMID 38098126 · 2023

associated with CC8 and CC361 isolates

Mutation Information

grlA: p.S81F

Protein Change: S81F
Confers Resistance To: fluoroquinolones
Validation Method: genotypic analysis
Source Database: Reslit

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