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Browse Mutations pbp5D434A

Genepbp5

Protein ChangeD434A

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: penicillin-binding protein 5
Resistance To: ampicillin, beta lactams
Organisms: Enterococcus faecium
Papers: 1

Paper Information1

1

Diversification and Evolution of Vancomycin-Resistant Enterococcus faecium during Intestinal Domination.

PMID 31010813 · 2019

A nonsynonymous mutation in the gene for penicillin-binding protein 5 (pbp5) became fixed in the population by day 49.

pbp5

Mutation Information

Protein Change: D434A
Organisms: Enterococcus faecium
Confers Resistance To: ampicillinbeta lactams
Effect on Function: penicillin-binding protein 5
Validation Method: shotgun sequencing and experimental evolution in a mouse model
Source Database: ReslitReference Gene Catalog

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research