Home Browse Genes Browse Mutations Download Collaborators About Help

Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research

Home Browse Genes Browse Mutations Download Collaborators About Help

Browse Mutations grlAE85K

GenegrlA

Protein ChangeE85K

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: disrupts the water-metal ion bridge
Resistance To: ciprofloxacin
Organisms: Bacillus anthracis
Papers: 1

Paper Information1

1

Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance.

PMID 23460203 · 2013

Mutation E85K reduces ciprofloxacin potency by disrupting the water-metal ion bridge.

Mutation Information

Protein Change: E85K
Organisms: Bacillus anthracis
Confers Resistance To: ciprofloxacin
Effect on Function: disrupts the water-metal ion bridge
Validation Method: DNA cleavage and religation assays
Source Database: Reslit

Comments (0)

No comments yet. Be the first to comment!

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research