ResLit - Antimicrobial Resistance Gene & Mutation Database

GenegrlA

Protein ChangeA48T

Validation StatusConfirmed2+ DBs

Databases

ResFinder DatabaseReslit

Overview

Mechanism: mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones, Target modification
Resistance To: ciprofloxacin|levofloxacin|moxifloxacin, ciprofloxacin
Organisms: Staphylococcus aureus
Papers: 2

Paper Information2

Molecular Mechanisms of Drug Resistance in Staphylococcus aureus.

PMID 35897667 · 2022

Mutation Information

grlA: p.A48T

Protein Change: A48T
Organisms: Staphylococcus aureus
Confers Resistance To: ciprofloxacin|levofloxacin|moxifloxacin
Effect on Function: mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones
Validation Method: mutations in grlA gene have been most frequently described
Source Database: Reslit

Characterization of grlA, grlB, gyrA, and gyrB mutations in 116 unrelated isolates of Staphylococcus aureus and effects of mutations on ciprofloxacin MIC.

PMID 9593159 · 1998

Mutation Information

grlA: p.A48T

Protein Change: A48T
Organisms: Staphylococcus aureus
Confers Resistance To: ciprofloxacin
Effect on Function: Target modification
Source Database: ResFinder Database

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