ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeI444F

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogResFinder DatabaseReslit

Overview

Mechanism: Target modification, DNA topoisomerase IV subunit B ParE
Resistance To: norfloxacin|ciprofloxacin, nalidixic acid|ciprofloxacin, quinolones
Organisms: Escherichia coli
Papers: 1

Paper Information1

Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.

Unknown phenotype if I444F occurs alone. Nalidixic acid and ciprofloxacin resistance when associated with gyrA mutations

parE

Protein Change: I444F
Nucleotide Change: ATA -> TTC
Organisms: Escherichia coli
Confers Resistance To: norfloxacin|ciprofloxacinnalidixic acid|ciprofloxacinquinolones
Effect on Function: Target modification; DNA topoisomerase IV subunit B ParE
Validation Method: DNA sequencing
Source Database: ReslitResFinder DatabaseReference Gene Catalog

Comments (0)

No comments yet. Be the first to comment!

Browse AMR Mutations