ResLit - Antimicrobial Resistance Gene & Mutation Database

GenephoQ

Protein ChangeV24G

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogReslit

Overview

Mechanism: deleterious, single resistance variant, two-component system sensor histidine kinase PhoQ
Resistance To: colistin
Organisms: Klebsiella pneumoniae
Papers: 2

Paper Information2

Heteroresistance to colistin in wild-type Klebsiella pneumoniae isolates from clinical origin.

PMID 37962370 · 2023

Mutations in phoQ were associated with colistin resistance.

Mutation Information

phoQ: p.V24G

Protein Change: V24G
Organisms: Klebsiella pneumoniae
Confers Resistance To: colistin
Effect on Function: deleterious
Validation Method: whole-genome sequencing and PCR
Source Database: Reslit

Identification of a novel mutation involved in colistin resistance in Klebsiella pneumoniae through Next-Generation Sequencing (NGS) based approaches.

PMID 35920875 · 2022

Klebsiella pneumoniae mutant PhoQ conferring resistance to colistin; CARD accession: CARD:3007203

phoQ

Mutation Information

phoQ: p.V24G

Protein Change: V24G
Organisms: Klebsiella pneumoniae
Confers Resistance To: colistin
Effect on Function: single resistance variant; two-component system sensor histidine kinase PhoQ
Source Database: Card DatabaseReference Gene Catalog

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