ResLit - Antimicrobial Resistance Gene & Mutation Database

Genepbp5

Protein ChangeV586L

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogResFinder Database

Overview

Mechanism: Target modification, penicillin-binding protein 5
Resistance To: ampicillin, beta lactams
Organisms: Enterococcus faecium
Papers: 3

Paper Information3

Enterococcus faecium PBP5-S/R, the missing link between PBP5-S and PBP5-R.

PMID 25182648 · 2014

Not essential for resistance phenotype

Mutation Information

pbp5: p.V586L

Protein Change: V586L
Organisms: Enterococcus faecium
Confers Resistance To: ampicillin
Effect on Function: Target modification
Source Database: ResFinder Database

Modification of penicillin-binding protein 5 associated with high-level ampicillin resistance in Enterococcus faecium.

PMID 8834879 · 1996

pbp5

Mutation Information

pbp5: p.V586L

Protein Change: V586L
Organisms: Enterococcus faecium
Confers Resistance To: beta lactams
Effect on Function: penicillin-binding protein 5
Source Database: Reference Gene Catalog

Antibiotic resistance determination using Enterococcus faecium whole-genome sequences: a diagnostic accuracy study using genotypic and phenotypic data.

PMID 38219758 · 2024

pbp5

Mutation Information

pbp5: p.V586L

Protein Change: V586L
Organisms: Enterococcus faecium
Confers Resistance To: beta lactams
Effect on Function: penicillin-binding protein 5
Source Database: Reference Gene Catalog

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