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Home Browse Genes Browse Mutations Download Collaborators About

Browse Mutations mprFL425F

GenemprF

a gene which contributes to membrane charge through lysinylation of PG

Protein ChangeL425F

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: daptomycin
Organisms: methicillin-resistant Staphylococcus
Papers: 1

Paper Information1

1

Novel Daptomycin Tolerance and Resistance Mutations in Methicillin-Resistant Staphylococcus aureus from Adaptive Laboratory Evolution.

PMID 34585959 · 2021

Mutations in mprF lead to daptomycin resistance in MRSA.

Mutation Information

Protein Change: L425F
Organisms: methicillin-resistant Staphylococcus
Confers Resistance To: daptomycin
Validation Method: whole-genome sequencing and MIC testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research