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Browse Mutations sigEV166L

GenesigE

Protein ChangeV166L

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: The V166L substitution falls within the SigE σ 2 /σ 4 linker, influencing transcription initiation.
Resistance To: pyrazinamide
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

1

Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis.

PMID 35100871 · 2021

The V166L substitution falls within the SigE σ 2 /σ 4 linker, influencing transcription initiation.

Mutation Information

Protein Change: V166L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: The V166L substitution falls within the SigE σ 2 /σ 4 linker, influencing transcription initiation.
Validation Method: Observation of nonsynonymous sigE mutation in PZA-monoresistant isolate
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research