ResLit - Antimicrobial Resistance Gene & Mutation Database

GenedfrA1

dihydrofolate reductase

Protein ChangeD27E

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: increased ligand dissociation rates while maintaining the enzyme’s ability to turnover substrate
Resistance To: trimethoprim
Organisms: Escherichia coli, Salmonella enterica
Papers: 1

Paper Information1

Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.

PMID 35562546 · 2022

Mutation Information

dfrA1: p.D27E

Protein Change: D27E
Organisms: Escherichia coli, Salmonella enterica
Confers Resistance To: trimethoprim
Effect on Function: increased ligand dissociation rates while maintaining the enzyme’s ability to turnover substrate
Validation Method: kinetic analysis and structural studies
Source Database: Reslit

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