ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneblaPDC

beta-lactamase

Protein ChangeL293P

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: enhanced cefiderocol hydrolysis
Resistance To: cefiderocol
Organisms: Pseudomonas aeruginosa
Papers: 1

Paper Information1

Functional and structural analyses of amino acid sequence variation in PDC β-lactamase reveal different mechanistic pathways toward cefiderocol resistance in Pseudomonas aeruginosa.

PMID 40422084 · 2025

Both mutations are located in the PDC β-lactamase and contribute to cefiderocol resistance.

Mutation Information

blaPDC: p.L293P

Protein Change: L293P
Organisms: Pseudomonas aeruginosa
Confers Resistance To: cefiderocol
Effect on Function: enhanced cefiderocol hydrolysis
Validation Method: kinetic studies and molecular dynamics simulations
Source Database: Reslit

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