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Browse Mutations bla TEM-1G175A

Nucleotide ChangeG175A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: increases expression
Resistance To: amoxicillin clavulanic acid
Organisms: Escherichia coli
Papers: 1

Paper Information1

1

Escherichia coli phylogeny drives co-amoxiclav resistance through variable expression of TEM-1 beta-lactamase.

PMID 41028731 · 2025

Promoter mutations C32T and G175A increase bla TEM-1 expression and co-amoxiclav resistance.

Mutation Information

bla TEM-1: c.G175A

Nucleotide Change: G175A
Organisms: Escherichia coli
Confers Resistance To: amoxicillin clavulanic acid
Effect on Function: increases expression
Validation Method: qPCR expression analysis and MIC testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research