Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpsL 30S ribosomal protein S12	K338R	-	-	Mycoplasma mycoides	streptomycin	Reslit	Candidate
rpsL ribosomal protein S12	K42A	-	-	Escherichia coli	streptomycin	Reslit	Candidate
rpsL ribosomal protein S12	K42N	-	impairs ribosome performance, reduces susceptibility	Salmonella enterica, Escherichia coli, Mycobacterium tuberculosis	streptomycin	Reslit	Supported
rpsL ribosomal protein S12	K42R	-	retains wild-type translation rate	Escherichia coli, Salmonella enterica, Mycobacterium tuberculosis, Mycobacterium smegmatis	streptomycin	Reslit	Supported
rpsL ribosomal protein S12	K43M	-	-	Mycobacterium smegmatis, Mycobacterium tuberculosis	streptomycin	Reslit	Candidate
rpsL ribosomal protein S12	K43N	A128T A131C	-	Escherichia coli, Mycobacterium smegmatis, Mycobacterium tuberculosis	streptomycinstreptomycin\|amikacin\|gentamicin\|kanamycin\|tobramycin	Reslit	Supported
rpsL ribosomal protein S12	K43R	A129G A128G A127G AAG->CGG C129T C127T	resistance, changed the tertiary structure of the 16S rRNA leading to decreased affinity to SM and high-level resistance, confers resistance to streptomycin, Target modification, single resistance variant, 30S ribosomal protein S12	Mycobacterium tuberculosis, Campylobacter jejuni, Mycobacterium bovis, Mycobacterium smegmatis, Francisella novicida, Francisella tularensis, Erwinia amylovora, E. amylovora, Neisseria meningitidis, Yersinia pestis, Campylobacter coli, Campylobacter spp., Agrobacterium fabrum, Haemophilus parasuis, Bifidobacterium bifidum, Escherichia coli	streptomycinaminoglycosideskanamycin	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
rpsL protein S12 of the 30S ribosomal subunit	K43T	-	30S ribosomal protein S12	Mycobacterium tuberculosis, Escherichia coli, Mycobacterium smegmatis	streptomycinstreptomycin\|amikacin\|gentamicin\|kanamycin\|tobramycinaminoglycosides	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
rpsL ribosomal protein S12	K47R	-	-	-	streptomycin	Reslit	Candidate
rpsL	K51N	-	-	Mycobacterium tuberculosis	streptomycin	ResFinder Database	Established