Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
triC inner membrane RND transporter	Q181A	-	more than 8-fold decrease in the MIC (minimal inhibitory concentration) of triclosan, a decrease in the ability to expel Nile Red, and a concurrent the loss of protection against SDS	Pseudomonas aeruginosa	triclosan	Reslit	Candidate
triC inner membrane RND transporter	R603A	-	partial loss in the ability to confer triclosan resistance (2 to 4 fold MIC decrease in comparison to WT) and was matched by a partial loss of Nile Red efflux	Pseudomonas aeruginosa	triclosan	Reslit	Candidate
triC inner membrane RND transporter	S276A	-	active in efflux of Nile Red and displayed resistance to triclosan but could only partially complement the SDS susceptibility of efflux-deficient Δ9 cells	Pseudomonas aeruginosa	triclosan	Reslit	Candidate
triC inner membrane RND transporter	V698R	-	inactive in MIC measurements and Nile Red uptake assays	Pseudomonas aeruginosa	triclosan	Reslit	Candidate
trkA potassium transporter	Q26*	-	-	Clostridioides difficile	vancomycin	Reslit	Candidate
trkH Potassium ion uptake system	G25R	-	-	Escherichia coli	gentamicin	Reslit	Candidate
trkH Potassium ion uptake system	I15L	-	-	Escherichia coli	gentamicin	Reslit	Candidate
trkH Potassium ion uptake system	L185Q	-	-	Escherichia coli	gentamicin	Reslit	Candidate
trkH Potassium ion uptake system	P151S	-	-	Escherichia coli	gentamicin	Reslit	Candidate
trkH potassium ion transporter	T350K	-	decreases the uptake of aminoglycoside antibiotics	Escherichia coli, Salmonella enterica	kanamycin\|tobramycin\|streptomycin	Reslit	Candidate