Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| W20Ter | - | nonsense mutation | Mycobacterium tuberculosis | multiple antibiotics | Card Database | Established | |
ddn nitroimidazole reductase | W88* | loss-of-function | Mycobacterium tuberculosis | delamanid|pretomaniddelamanid | Reslit | Candidate | |
ddn deazaflavin-dependent nitroreductase | W88R | - | - | - | pretomanid | Reslit | Candidate |
| W88Ter | - | nonsense mutation | Mycobacterium tuberculosis | multiple antibiotics | Card Database | Established | |
ddn deazaflavin-dependent nitroreductase | Y133C | - | - | - | pretomanid | Reslit | Candidate |
ddn deazaflavin-dependent nitroreductase | Y133F | - | - | Mycobacterium smegmatis | pa 824 | Reslit | Candidate |
ddn deazaflavin-dependent nitroreductase | Y65L | - | - | Mycobacterium smegmatis | pa 824 | Reslit | Candidate |
ddn F420-dependent mycobacterial nitroreductase | Y89S | - | - | Mycobacterium tuberculosis | delamanid | Reslit | Candidate |
deoD2 purine nucleoside phosphorylase | G278* | - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
dfrA1 dihydrofolate reductase | D27E | - | increased ligand dissociation rates while maintaining the enzyme’s ability to turnover substrate | Escherichia coli, Salmonella enterica | trimethoprim | Reslit | Candidate |
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