Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ileS	G593V	-	isoleucine--tRNA ligase IleS	Staphylococcus aureus	mupirocin	Reference Gene Catalog	Established
ileS	H67Q	-	isoleucine--tRNA ligase IleS	Staphylococcus aureus	mupirocin	Reference Gene Catalog	Established
ileS isoleucyl-tRNA synthetase	I637V	-	-	Staphylococcus aureus	mupirocin	Reslit	Candidate
ileS isoleucyl-tRNA synthetase	K226T	-	K226T are on the outer surface adjacent to the tRNA molecule about 20 Å from the editing active site	Staphylococcus aureus	mupirocin	Reslit	Candidate
ileS isoleucyl tRNA synthetase	N213D	-	-	Staphylococcus aureus	mupirocin	Reslit	Candidate
ileS isoleucyl-tRNA synthetase	P187F	-	mutation of this residue causes steric repulsion to mupirocin	Staphylococcus aureus	mupirocin	Reslit	Candidate
ileS isoleucyl-tRNA synthetase	Q612H	-	Q612H has potential to interact with mupirocin. Q612 sits close to the core of IleS Rossman fold motif, where it forms a water-bridged hydrogen bond with the side chain of D635	Staphylococcus aureus	mupirocin	Reslit	Candidate
ileS	R816C	-	isoleucine--tRNA ligase IleS	Staphylococcus aureus	mupirocin	Reference Gene Catalog	Established
ileS isoleucyl-tRNA synthetase	V588F	G1762T	V588 is located in a hydrophobic pocket that interacts directly with the fatty acid side chain of mupirocin, mutation of this residue causes steric repulsion to mupirocin, Target modification, single resistance variant, isoleucine--tRNA ligase IleS	Staphylococcus aureus	mupirocin	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
ileS isoleucyl-tRNA synthetase	V631F	-	Target modification, single resistance variant, isoleucine--tRNA ligase IleS	Staphylococcus aureus	mupirocin	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed