Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
mexZ local repressor of the operon mexXY	A38V	-	disturb the 3D structure of MexZ	Pseudomonas aeruginosa	aminoglycosides	Reslit	Candidate
mexZ local repressor of the operon mexXY	C59Y	-	rigidify the helix locally and abrogate this transmission	Pseudomonas aeruginosa	aminoglycosides	Reslit	Candidate
mexZ Transcriptional regulator of the mexXY operon	D83E	-	-	Pseudomonas aeruginosa	cefepime\|gentamicin\|ciprofloxacin	Reslit	Candidate
mexZ	E8Ter	-	efflux pump transcriptional repressor MexZ	Pseudomonas aeruginosa	aminoglycosides\|cefepime\|fluoroquinolones	Reference Gene Catalog	Established
mexZ local repressor of the operon mexXY	F192Y	-	disturb the 3D structure of MexZ	Pseudomonas aeruginosa	aminoglycosides	Reslit	Candidate
mexZ local repressor of the operon mexXY	G172D	-	strongly impair the dimerization of MexZ and its subsequent binding to the regulatory sequences upstream of mexXY	Pseudomonas aeruginosa	aminoglycosides	Reslit	Candidate
mexZ	G195D	-	-	Pseudomonas aeruginosa	piperacillin tazobactam\|ceftazidime\|cefepime\|imipenem\|meropenem\|ciprofloxacinpiperacillin tazobactam\|ceftazidime\|cefepime\|meropenem\|imipenem\|tobramycin\|ciprofloxacin	Reslit	Candidate
mexZ regulator of efflux pump	G195E	-	overexpression of MexXY, strongly impair the dimerization of MexZ and its subsequent binding to the regulatory sequences upstream of mexXY, efflux pump transcriptional repressor MexZ	Pseudomonas aeruginosa	cefepime\|aminoglycosidesciprofloxacin\|levofloxacinaminoglycosides+1 more	Reference Gene CatalogReslit	Confirmed
mexZ local repressor of the operon mexXY	G46S	-	abrogate DNA binding, efflux pump transcriptional repressor MexZ	Pseudomonas aeruginosa	aminoglycosidesaminoglycosides\|cefepime\|fluoroquinolones	Reference Gene CatalogReslit	Confirmed
mexZ local repressor of the operon mexXY	G50D	-	abrogate DNA binding	Pseudomonas aeruginosa	aminoglycosides	Reslit	Candidate