Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
panD L-aspartate decarboxylase	H119N	-	decreased enzyme activity	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
panD L-aspartate decarboxylase	H11A	-	decreased enzyme activity, enzymatically inactive	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
panD aspartate decarboxylase	H21R	-	reduced affinity and residence time of POA	Mycobacterium tuberculosis	pyrazinamide	ResFinder DatabaseReslit	Confirmed
panD aspartate decarboxylase	I49V	-	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder DatabaseReslit	Confirmed
panD aspartate decarboxylase	K209E	A625G	The mutation in the C-terminal tail of PanD causes POA resistance and prevents drug binding.	Mycobacterium tuberculosis, Mycobacterium bovis	pyrazinamide	Reslit	Candidate
panD L-aspartate decarboxylase	K7A	-	partially decreased enzyme activity	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
panD L-aspartate decarboxylase	K9A	-	decreased enzyme activity, enzymatically inactive	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
panD L-aspartate decarboxylase	L132P	-	decreased enzyme activity	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
panD aspartate decarboxylase	L136R	-	The mutation in the C-terminal tail of PanD causes POA resistance and prevents drug binding.	Mycobacterium tuberculosis, Mycobacterium bovis	pyrazinamide	ResFinder DatabaseReslit	Confirmed
panD aspartate decarboxylase	M117I	-	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder DatabaseReslit	Confirmed