Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pbp2 penicillin-binding protein 2	H371A	-	-	Acinetobacter baumannii	carbapenems\|cephalosporins	Reslit	Candidate
pbp2 penicillin-binding protein 2	H541N	-	-	Neisseria gonorrhoeae	ceftriaxone	Reslit	Candidate
pbp2	I259T	-	single resistance variant	Helicobacter pylori	amoxicillin	Card Database	Established
pbp2 penicillin-binding protein 2	I312M	-	lower affinity for ceftriaxone and restrict conformational changes that normally accompany acylation, single resistance variant	Neisseria gonorrhoeae, Neisseria meningitidis	ceftazidime\|ceftriaxonebeta lactams	Card DatabaseReslit	Confirmed
pbp2 penicillin-binding protein 2	I415F	-	-	Treponema pallidum	penicillin	Reslit	Candidate
pbp2 penicillin-binding protein 2	I415M	-	-	Treponema pallidum	penicillin	Reslit	Candidate
pbp2 penicillin-binding protein 2	L421P	-	-	Neisseria gonorrhoeae	ceftriaxone	Reslit	Candidate
pbp2 penicillin-binding protein 2	N512Y	-	lower affinity for ceftriaxone and restrict conformational changes that normally accompany acylation, single resistance variant	Neisseria gonorrhoeae, Neisseria meningitidis	ceftazidime\|ceftriaxonebeta lactams	Card DatabaseReslit	Confirmed
pbp2	N513Y	-	single resistance variant	Neisseria gonorrhoeae	beta lactams	Card Database	Established
pbp2 penicillin-binding protein 2	N598K	-	-	Staphylococcus aureus	oxacillin	Reslit	Candidate