Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pgsA CDP-diacylglycerol-glycerol-3-phosphate-3-phosphatidyltransferase	G52S	-	-	Streptococcus mitis, S. oralis	daptomycin	Reslit	Candidate
pgsA CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase	K135E	-	-	Staphylococcus aureus	daptomycin	Reslit	Candidate
pgsA CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase	K65R	-	-	Staphylococcus aureus	daptomycin	Reslit	Candidate
pgsA	K66R	-	single resistance variant, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA	Staphylococcus aureus	daptomycin	Card DatabaseReference Gene Catalog	Confirmed
pgsA phosphatidylglycerophosphate synthase	R579L	-	-	Staphylococcus aureus	daptomycin	Reslit	Candidate
pgsA CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase	S177F	-	single resistance variant, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA	Staphylococcus aureus	daptomycin	Card DatabaseReference Gene CatalogReslit	Confirmed
pgsA CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase	T33N	-	-	Staphylococcus aureus	daptomycin	Reslit	Candidate
pgsA phosphatidylglycerolphosphate synthase	T70P	-	decreased PgsA activity	Enterococcus faecium	daptomycin	Reslit	Candidate
pgsA phosphatidylglycerolphosphate synthase	V44P	-	-	Escherichia coli	gentamicin	Reslit	Candidate
pgsA CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase	V59N	-	single resistance variant, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA	Staphylococcus aureus	daptomycin	Card DatabaseReference Gene CatalogReslit	Confirmed