Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
phoQ sensor kinase | I175F | - | - | Escherichia coli | colistin | Reslit | Candidate |
| I421Ter | - | two-component system sensor histidine kinase PhoQ | Pseudomonas aeruginosa | colistin | Reference Gene Catalog | Established | |
phoQ histidine kinase | I88N | - | - | - | colistin | Reslit | Candidate |
| K123Q | - | single resistance variant, two-component system sensor histidine kinase PhoQ | Pseudomonas aeruginosa | colistin | Card DatabaseReference Gene Catalog | Confirmed | |
phoQ sensor histidine kinase | K46E | - | neutral | Klebsiella pneumoniae | colistin | Reslit | Candidate |
phoQ Two-component system sensor kinase | K46Q | - | disrupts the phosphatase domain, allowing continuous PhoP activation of downstream genes such as those that modify lipid A, thereby providing colistin resistance | Klebsiella pneumoniae | colistin | Reslit | Candidate |
phoQ transmembrane protein | K46T | - | deleterious | Escherichia coli | colistin | Reslit | Candidate |
phoQ sensor histidine kinase | L105Q | - | deleterious | Klebsiella pneumoniae | colistin | Reslit | Candidate |
phoQ histidine kinase | L10R | - | - | - | colistin | Reslit | Candidate |
phoQ histidine kinase | L224Q | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
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