Browse AMR Genes

embB: p.G406A embB: p.G406D embB: p.G406C embB: p.G406S embB: p.Q497R embB: p.M306V embB: p.P397S embB: p.D1024N embB: p.F320L embB: p.G324R embB: p.Q445R embB: p.R13L

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: phylogenetic analysis
Source Database: Reslit

Allelic Exchange and Mutant Selection Demonstrate that Common Clinical embCAB Gene Mutations Only Modestly Increase Resistance to Ethambutol in Mycobacterium tuberculosis.

PMID 19822701 · 2010

Mutation Information

Protein Change: G406A, G406D, G406C, G406S, Q497R, M306V, P397S, D1024N, F320L, G324R, Q445R, R13L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: allelic exchange and MIC testing; in vitro selection and sequencing; sequencing of in vitro-selected mutants
Source Database: Reslit

Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa.

PMID 19890396 · 2009

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

Detection by GenoType MTBDRsl test of complex mechanisms of resistance to second-line drugs and ethambutol in multidrug-resistant Mycobacterium tuberculosis complex isolates.

PMID 20335420 · 2010

Mutation Information

embB: p.M306L embB: p.M306V embB: p.M306I embB: p.D328Y embB: p.F330S embB: p.D354A embB: p.G406S embB: p.G406D embB: p.G406A embB: p.A439T embB: p.R469H embB: p.Q497P embB: p.Q497R embB: p.V508F embB: p.D534D embB: p.627fs embB: p.S651T embB: p.T667K embB: p.D1024N

Protein Change: M306V, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: DNA sequencing and MTBDR sl test
Source Database: Reslit

Characteristics of embB mutations in multidrug-resistant Mycobacterium tuberculosis isolates in Henan, China.

PMID 21778195 · 2011

Mutations in the embB gene are associated with ethambutol resistance in Mycobacterium tuberculosis.

Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol; CARD accession: CARD:3003326

Mutation Information

Protein Change: M306L, M306V, M306I, D328Y, F330S, D354A, G406S, G406D, G406A, A439T, R469H, Q497P, Q497R, V508F, D534D, 627fs, S651T, T667K, D1024N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Effect on Function: single resistance variant
Validation Method: sequencing and drug susceptibility testing
Source Database: ReslitCard Database

GenoType MTBDRsl for molecular detection of second-line-drug and ethambutol resistance in Mycobacterium tuberculosis strains and clinical samples.

PMID 22075597 · 2012

Mutations in embB were associated with resistance to ethambutol.

Mutation Information

embB: p.M306I embB: p.M306V embB: p.Y319C embB: p.A410P

Protein Change: M306I, M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: pyrosequencing
Source Database: Reslit

Drug-resistant tuberculosis transmission and resistance amplification within families.

PMID 22840848 · 2012

Mutation Information

embB: p.A30V

Protein Change: A30V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: DNA sequencing
Source Database: Reslit

Evaluation of MTBDRplus and MTBDRsl in Detecting Drug-Resistant Tuberculosis in a Chinese Population.

PMID 27524852 · 2016

Mutation Information

Protein Change: M306I, M306V, Y319C, A410P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: sequencing
Source Database: Reslit

Comparative Genomic Analysis of Two Clonally Related Multidrug Resistant Mycobacterium tuberculosis by Single Molecule Real Time Sequencing.

PMID 29188195 · 2017

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: emb
Validation Method: Sanger sequencing and MIC testing
Source Database: Reslit

Microevolution of Mycobacterium tuberculosis Subpopulations and Heteroresistance in a Patient Receiving 27 Years of Tuberculosis Treatment in Germany.

PMID 33903103 · 2021

Mutation Information

embB: p.G406A

Protein Change: G406A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

Transmission of multidrug-resistant tuberculosis in Shimen community in Shanghai, China: a molecular epidemiology study.

PMID 34715793 · 2021

Mutation Information

Protein Change: M306V
Confers Resistance To: emb
Validation Method: whole_genome_sequencing
Source Database: Reslit

Practical approach to detection and surveillance of emerging highly resistant Mycobacterium tuberculosis Beijing 1071-32-cluster.

PMID 34725411 · 2021

Mutation in embB

Mutation Information

embB: p.M306L embB: p.M306V embB: p.D1024N

Protein Change: Q497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: PCR-RFLP
Source Database: Reslit

The whole-genome sequencing in predicting Mycobacterium tuberculosis drug susceptibility and resistance in Papua, Indonesia.

PMID 34802420 · 2021

Mutation Information

Protein Change: M306L, M306V, D1024N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing and mutation analysis
Source Database: Reslit

Whole-genome sequencing of Mycobacterium tuberculosis for prediction of drug resistance.

PMID 35086603 · 2022

Mutations in embB were associated with ethambutol resistance.

Mutation Information

embB: p.M306V embB: p.M306L embB: p.D354A embB: p.M306I embB: p.Q497R embB: p.G406A embB: p.G406S

Protein Change: M306V, M306L, D354A, M306I, Q497R, G406A, G406S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing and phenotypic resistance testing
Source Database: Reslit

Snapshot of Mycobacterium tuberculosis Phylogenetics from an Indian State of Arunachal Pradesh Bordering China.

PMID 35205308 · 2022

Mutation Information

embB: p.M306I embB: p.M306V embB: p.D328G embB: p.D354A

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: emb
Validation Method: whole-genome sequencing
Source Database: Reslit

Molecular Epidemiology of Mycobacterium tuberculosis Complex Strains in Urban and Slum Settings of Nairobi, Kenya.

PMID 35328028 · 2022

Mutation Information

Protein Change: M306I, M306V, D328G, D354A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

Antimicrobial Resistance in Mycobacterium tuberculosis Clinical Isolates from HIV-Positive and HIV-Negative Patients in Russia

PMID 35590243 · 2021

Mutation Information

embB: p.M306V embB: p.M306L embB: p.Y319C embB: p.Y319S embB: p.D328Y embB: p.D328G embB: p.D354A embB: p.E378A embB: p.G406A embB: p.G406D embB: p.G406S embB: p.G406C embB: p.Q497K embB: p.Q497P embB: p.Q497R

Protein Change: M306V, M306L, Y319C, Y319S, D328Y, D328G, D354A, E378A, G406A, G406D, G406S, G406C, Q497K, Q497P, Q497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: Phenotypic drug susceptibility testing and mutation analysis
Source Database: Reslit

Transmission of multidrug-resistant tuberculosis in Jiangxi, China, and associated risk factors.

PMID 39356166 · 2024

Mutation Information

Protein Change: M306V, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

Performance of a broth microdilution assay for routine minimum inhibitory concentration determination of 14 anti-tuberculous drugs against the Mycobacterium tuberculosis complex based on the EUCAST reference protocol.

PMID 39692505 · 2025

Mutations in embB are associated with ethambutol resistance.

Mutation Information

embB: p.G307D embB: p.G307A embB: p.M354T / c.A1061C embB: p.N306H / c.A916C embB: p.N306S / c.A916G embB: p.S450W / c.C1350G embB: p.E406K / c.G1216A

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: emb
Validation Method: genotypic drug susceptibility testing and broth microdilution assay
Source Database: Reslit

Potential of nanopore sequencing for tuberculosis diagnosis and drug resistance detection.

PMID 39731145 · 2024

Mutation Information

Protein Change: G307D, G307A, M354T, N306H, N306S, S450W, E406K
Nucleotide Change: A1061C, A916C, A916G, C1350G, G1216A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: nanopore sequencing
Source Database: Reslit

Clinical and Mycobacterium tuberculosis strain characteristics of tuberculosis patients with diabetes mellitus in Changping District, Beijing, China.

PMID 39844060 · 2025

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole genome sequencing and drug susceptibility testing
Source Database: Reslit

Outbreak Caused by Multidrug-Resistant Mycobacterium Tuberculosis with Unusual Combination of Resistance Mutations, Northern Argentina, 2006-2022.

PMID 40023848 · 2025

associated with resistance

Mutation Information

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: emb
Validation Method: whole-genome sequencing and phenotypic drug-susceptibility testing
Source Database: Reslit

Nanopore-based targeted sequencing (NTS) for drug-resistant tuberculosis: an integrated tool for personalized treatment strategies and guidance for new drug development.

PMID 40596923 · 2025

Mutations include substitutions to valine, isoleucine, and leucine

Mutation Information

Protein Change: M306V, M306I, M306L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: targeted sequencing
Source Database: Reslit

Surveillance and analysis of drug resistance and drug resistance levels in multidrug resistant tuberculosis on the tropical islands of China.

PMID 40750855 · 2025

Mutation Information

Protein Change: M306I, M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

Whole-genome sequencing and machine learning reveal key drivers of delayed sputum conversion in rifampicin-resistant tuberculosis.

PMID 40851801 · 2025

Mutation Information

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

Unraveling Epistatic Interactions Between Sites Under Drug-Dependent Selection in the Mycobacterium tuberculosis Genome.

PMID 41099138 · 2025

Mutation Information

Protein Change: M306V
Confers Resistance To: emb
Validation Method: phylogenetic GWAS and analysis of substitution patterns; phylogenetic GWAS
Source Database: Reslit

Role of embB Codon 306 Mutations in Mycobacterium tuberculosis Revisited: a Novel Association with Broad Drug Resistance and IS6110 Clustering Rather than Ethambutol Resistance.

PMID 16127055 · 2005

embB codon 306 mutations are not linked to ethambutol resistance but are associated with broader drug resistance.

Mutation Information

embB: p.M306V embB: p.M306I embB: p.Y319N

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: sequencing and susceptibility testing
Source Database: Reslit

Genetic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates in Hong Kong.

PMID 17360809 · 2007

Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol; CARD accession: CARD:3003326

Mutation Information

Protein Change: M306V, M306I, Y319N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Effect on Function: single resistance variant
Validation Method: PCR-SSCP/MPAC and nucleotide sequencing
Source Database: ReslitCard Database

Mutations at embB Codon 306 Are an Important Molecular Indicator of Ethambutol Resistance in Mycobacterium tuberculosis.

PMID 19104018 · 2009

Mutation at codon 306 of embB gene leads to ethambutol resistance.

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Effect on Function: confers resistance
Validation Method: allelic exchange and MIC testing
Source Database: Reslit

Genomic diversity among drug sensitive and multidrug resistant isolates of Mycobacterium tuberculosis with identical DNA fingerprints.

PMID 19823582 · 2009

Mutation Information

Protein Change: Q497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole genome sequencing
Source Database: Reslit

Selection of mutations to detect multidrug-resistant Mycobacterium tuberculosis strains in Shanghai, China.

PMID 20008778 · 2010

Mutation Information

Protein Change: M306V, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

Nosocomial transmission of extensively drug-resistant tuberculosis in a rural hospital in South Africa.

PMID 23166374 · 2013

Mutation Information

embB: p.M306I embB: p.M306V embB: p.Y319S embB: p.D328Y embB: p.D354A embB: p.G406S

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: DNA sequencing
Source Database: Reslit

Genotypic characterization of drug resistant Mycobacterium tuberculosis in Quebec, 2002-2012.

PMID 27459848 · 2016

most common mutation

Mutation Information

Protein Change: M306I, M306V, Y319S, D328Y, D354A, G406S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: DNA sequencing
Source Database: Reslit

Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar.

PMID 27530852 · 2016

Mutation Information

embB: p.L402V embB: p.G406D embB: p.M306I embB: p.G406A embB: p.M306V

Protein Change: L402V, G406D, M306I, G406A, M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

Drug-resistant tuberculosis in Central Mozambique: the role of a rapid genotypic susceptibility testing.

PMID 27534745 · 2016

Mutation Information

embB: p.M306I embB: p.G406S embB: p.D1024N

Protein Change: M306I, M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: Genotype MTBDRsl test
Source Database: Reslit

A joint cross-border investigation of a cluster of multidrug-resistant tuberculosis in Austria, Romania and Germany in 2014 using classic, genotyping and whole genome sequencing methods: lessons learnt.

PMID 28106529 · 2017

Mutation Information

Protein Change: M306I, G406S, D1024N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole genome sequencing
Source Database: Reslit

Revisiting the mutant prevention concentration to guide dosing in childhood tuberculosis.

PMID 28333284 · 2017

EmbB mutations are associated with ethambutol resistance.

Mutation Information

embB: p.G306E

Protein Change: G306E
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: reported in cited literature
Source Database: Reslit

Genome sequence comparisons of serial multi-drug-resistant Mycobacterium tuberculosis isolates over 21 years of infection in a single patient.

PMID 28348821 · 2015

Mutation Information

embB: p.D306V embB: p.D406V

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genome sequencing and phenotypic resistance testing
Source Database: Reslit

Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis.

PMID 28545050 · 2017

Mutation Information

Protein Change: D306V, D406V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: next-generation sequencing
Source Database: Reslit

Clusters of Drug-Resistant Mycobacterium tuberculosis Detected by Whole-Genome Sequence Analysis of Nationwide Sample, Thailand, 2014-2017.

PMID 33622486 · 2021

mutations in embB associated with ethambutol resistance

Mutation Information

embB: p.G406D embB: p.M306V embB: p.M306I

Protein Change: G406D, M306V, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genotypic drug resistance profiling
Source Database: Reslit

Increasing prevalence of resistance to second-line drugs among multidrug-resistant Mycobacterium tuberculosis isolates in Kuwait.

PMID 33833390 · 2021

Mutation Information

embB: p.M306V embB: p.M306I embB: p.M306L embB: p.G406A embB: p.G406D embB: p.G406S embB: p.G246R embB: p.D328G embB: p.D354A embB: p.A495T embB: p.M575I

Protein Change: M306V, M306I, M306L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: PCR-sequencing
Source Database: Reslit

Prevalence and Molecular Characteristics Based on Whole Genome Sequencing of Mycobacterium tuberculosis Resistant to Four Anti-Tuberculosis Drugs from Southern Xinjiang, China.

PMID 34466004 · 2021

Mutations in the embB gene are associated with ethambutol resistance.

Mutation Information

Protein Change: M306V, M306I, M306L, G406A, G406D, G406S, G246R, D328G, D354A, A495T, M575I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: emb
Validation Method: whole genome sequencing
Source Database: Reslit

Genomic Profiling of Mycobacterium tuberculosis Strains, Myanmar.

PMID 34670644 · 2021

Mutation Information

embB: p.M306V embB: p.M306I embB: p.M306L embB: p.G406A embB: p.Q497R embB: p.D354A embB: p.D328H embB: p.D328Y embB: p.D328G

Protein Change: M306V, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genomic_analysis_and_phenotypic_confirmation
Source Database: Reslit

Performance Evaluation of GeneLEAD/Deeplex Myc-TB for Mycobacterium tuberculosis Complex Diagnosis and Drug Susceptibility Testing

PMID 34778100 · 2021

Mutation Information

embB: p.M306L

Protein Change: M306L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genotypic prediction and phenotypic DST correlation
Source Database: Reslit

Analysis on Drug-Resistance-Associated Mutations among Multidrug-Resistant Mycobacterium tuberculosis Isolates in China.

PMID 34827305 · 2021

Mutation Information

Protein Change: M306V, M306I, M306L, G406A, Q497R, D354A, D328H, D328Y, D328G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: DNA sequencing and MIC testing
Source Database: Reslit

A modified decision tree approach to improve the prediction and mutation discovery for drug resistance in Mycobacterium tuberculosis.

PMID 35016609 · 2022

Mutation Information

embB: p.M306V embB: p.M306L embB: p.M306I embB: p.Q497K embB: p.Q497R embB: p.D1024N

Protein Change: M306V, M306L, M306I, Q497K, Q497R, D1024N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genomic variant detection
Source Database: Reslit

Application of Amplicon-Based Targeted NGS Technology for Diagnosis of Drug-Resistant Tuberculosis Using FFPE Specimens.

PMID 35138166 · 2022

high-confidence mutation

Mutation Information

embB: p.G406S embB: p.M306V

Protein Change: G406S, M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: amplicon-based targeted NGS
Source Database: Reslit

Mycobacterium tuberculosis Lineages Associated with Mutations and Drug Resistance in Isolates from India.

PMID 35442078 · 2022

Mutation Information

embB: p.M306X embB: p.Q497R embB: p.T1082A embB: p.G406X embB: p.D354A embB: p.D1024N

Protein Change: M306X, Q497R, T1082A, G406X, D354A, D1024N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genotypic prediction
Source Database: Reslit

Whole genome sequencing analysis of Mycobacterium tuberculosis reveals circulating strain types and drug-resistance mutations in the Philippines.

PMID 39179783 · 2024

Common mutations underlying ethambutol resistance.

Mutation Information

embB: p.M306V embB: p.M306I embB: p.G406A embB: p.G406S embB: p.G406D embB: p.M306L embB: p.D1024N

Protein Change: M306V, M306I, G406A, G406S, G406D, M306L, D1024N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genotypic resistance characterisation using TB-Profiler software
Source Database: Reslit

Genetic diversities and drug resistance in Mycobacterium bovis isolates from zoonotic tuberculosis using whole genome sequencing.

PMID 39487429 · 2024

Mutation Information

embB: p.E378A embB: p.N13S

Protein Change: E378A, N13S
Organisms: Mycobacterium bovis
Confers Resistance To: ethambutol
Validation Method: genomic sequencing
Source Database: Reslit

Genotypes and drug resistance pattern of Mycobacterium tuberculosis complex among clinically diagnosed pulmonary tuberculosis patients.

PMID 39687724 · 2024

Mutation Information

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole genome sequencing
Source Database: Reslit

Genetic diversity and transmission pattern of multidrug-resistant tuberculosis based on whole-genome sequencing in Wuhan, China.

PMID 39935875 · 2025

Mutation Information

embB: p.M306I embB: p.M306L embB: p.M306V embB: p.G406A embB: p.G406D embB: p.Q497R embB: p.G406S embB: p.V50A embB: p.D328Y embB: p.D354A embB: p.Q497H embB: p.Q497P embB: p.L402V embB: p.F330I embB: p.T581A embB: p.D1024N

Protein Change: M306V, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

The implications of mutations in multiple genes associated with ethambutol resistance among multidrug-resistant tuberculosis isolates from China.

PMID 40025456 · 2025

Mutations in embB are strongly associated with ethambutol resistance.

Mutation Information

Protein Change: M306I, M306L, M306V, G406A, G406D, Q497R, G406S, V50A, D328Y, D354A, Q497H, Q497P, L402V, F330I, T581A, D1024N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole genome sequencing and PCR confirmation
Source Database: Reslit

Clinical characteristics and genomic epidemiological survey of tuberculosis in Wuzhou, China, 2022.

PMID 40207933 · 2025

Mutation Information

embB: p.M306V embB: p.M305I embB: p.Q497R embB: p.G406D embB: p.G407S

Protein Change: M306V, M305I, Q497R, G406D, G407S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

Genomic characterization of multidrug-resistant tuberculosis in Shanghai, China: antibiotic resistance, virulence and transmission.

PMID 40342723 · 2025

Mutation Information

embB: p.M306V embB: p.M306I embB: p.G406D

Protein Change: M306V, M306I, G406D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: WGS and DST
Source Database: Reslit

Whole-Genome Sequence-Based Diversity of Mycobacterium tuberculosis Strains Isolated from a Central Western Region of Mexico.

PMID 40559556 · 2025

Mutation Information

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genotypic resistance analysis
Source Database: Reslit

Mixed infections and heteroresistance of Mycobacterium tuberculosis among multidrug-resistant tuberculosis in China: a genomic epidemiology study.

PMID 40748858 · 2025

Mutation Information

embB: p.G406A embB: p.M306I

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: emb
Validation Method: whole-genome sequencing
Source Database: Reslit

Genomic characterization of XDR Mycobacterium tuberculosis isolates in Argentina (2006-2015).

PMID 41249964 · 2025

Mutation Information

Protein Change: G406A, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

Whole genome sequencing-based detection of extensively drug-resistant tuberculosis from Ethiopia.

PMID 41354901 · 2025

Mutation Information

embB: p.D328G embB: p.G406S

Protein Change: D328G, G406S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

Molecular epidemiology of drug resistance and transmission of Mycobacterium tuberculosis in Meigu County, Sichuan Province, China.

PMID 41459972 · 2026

Mutation Information

embB: p.D345D embB: p.D534D embB: p.M306V embB: p.M306I embB: p.E378A embB: p.V492L embB: p.A680T embB: p.A1007V embB: p.D1024N

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: WGS
Source Database: Reslit

Detection of multidrug resistance in Mycobacterium tuberculosis.

PMID 17108078 · 2007

mutations in embB are associated with ethambutol resistance

Mutation Information

Protein Change: D345D, D534D, M306V, M306I, E378A, V492L, A680T, A1007V, D1024N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: DNA sequencing
Source Database: Reslit

Mycobacterium tuberculosis embB codon 306 mutations confer moderately increased resistance to ethambutol in vitro and in vivo.

PMID 21444710 · 2011

Mutations in codon 306 of embB confer resistance to ethambutol.

Mutation Information

embB: p.M306I embB: p.M306V embB: p.Y319C embB: p.Y319D embB: p.P404S embB: p.G406A embB: p.Q497K embB: p.Q497P embB: p.Q497R embB: p.S565G embB: p.N624D embB: p.V602A / c.GTT -> GCA

Protein Change: M306I, M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: allelic exchange experiments, MIC measurements, in vivo mouse model
Source Database: Reslit

Performance assessment of the GenoType MTBDRsl test and DNA sequencing for detection of second-line and ethambutol drug resistance among patients infected with multidrug-resistant Mycobacterium tuberculosis.

PMID 21562102 · 2011

Mutation Information

Protein Change: M306I, M306V, Y319C, Y319D, P404S, G406A, Q497K, Q497P, Q497R, S565G, N624D, V602A
Nucleotide Change: GTT -> GCA
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: GenoType MTBDR sl test and DNA sequencing
Source Database: Reslit

FIND Tuberculosis Strain Bank: a Resource for Researchers and Developers Working on Tests To Detect Mycobacterium tuberculosis and Related Drug Resistance.

PMID 28100602 · 2017

Mutation Information

embB: p.D306V embB: p.E406D

Protein Change: M306V, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

Comprehensive Whole-Genome Sequencing and Reporting of Drug Resistance Profiles on Clinical Cases of Mycobacterium tuberculosis in New York State.

PMID 28381603 · 2017

Mutation Information

Protein Change: D306V, E406D
Confers Resistance To: emb
Validation Method: Whole-genome sequencing (WGS) and comparison with culture-based drug susceptibility testing (DST)
Source Database: Reslit

Diagnostic Performance of the GenoType MTBDRplus and MTBDRsl Assays to Identify Tuberculosis Drug Resistance in Eastern China.

PMID 28639565 · 2017

Mutation Information

embB: p.M306V embB: p.Q497H

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: GenoType MTBDR sl assay
Source Database: Reslit

Dynamics of Extensive Drug Resistance Evolution of Mycobacterium tuberculosis in a Single Patient During 9 Years of Disease and Treatment.

PMID 33045067 · 2022

Mutation Information

embB: p.T1082A

Protein Change: T1082A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

Analysis of Serial Multidrug-Resistant Tuberculosis Strains Causing Treatment Failure and Within-Host Evolution by Whole-Genome Sequencing.

PMID 33361124 · 2020

Mutation Information

Protein Change: M306V, Q497H
Organisms: Mycobacterium tuberculosis
Confers Resistance To: emb
Validation Method: whole_genome_sequencing
Source Database: Reslit

In-host population dynamics of Mycobacterium tuberculosis complex during active disease.

PMID 33522489 · 2021

Mutation Information

embB: p.S315R

Protein Change: S315R
Confers Resistance To: isoniazid
Validation Method: whole-genome sequencing and analysis of allele frequency changes
Source Database: Reslit

Whole genome sequencing of clinical samples reveals extensively drug resistant tuberculosis (XDR TB) strains from the Beijing lineage in Nigeria, West Africa.

PMID 34462504 · 2021

Mutation Information

Protein Change: Q497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole genome sequencing
Source Database: Reslit

Performance of GenoType MTBDRsl assay for detection of second-line drugs and ethambutol resistance directly from sputum specimens of MDR-TB patients in Bangladesh.

PMID 34914803 · 2021

Mutation Information

embB: p.I306V embB: p.V306I

Protein Change: M306V, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: MTBDR sl assay
Source Database: Reslit

Epidemiological cut-off values for a 96-well broth microdilution plate for high-throughput research antibiotic susceptibility testing of M. tuberculosis.

PMID 35301246 · 2022

Mutation Information

Protein Change: I306V, V306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genetic variant analysis
Source Database: Reslit

Use of Whole-Genome Sequencing to Predict Mycobacterium tuberculosis Complex Drug Resistance from Early Positive Liquid Cultures.

PMID 35311541 · 2022

Mutation Information

embB: p.Q497R embB: p.M306V embB: p.M306I

Protein Change: M306V, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

Evolution and spread of a highly drug resistant strain of Mycobacterium tuberculosis in Papua New Guinea.

PMID 35524232 · 2022

associated with Ethambutol resistance

Mutation Information

embB: p.Q497P

Protein Change: Q497P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genotypic and phenotypic correlation
Source Database: Reslit

Whole genomic analysis uncovers high genetic diversity of rifampicin-resistant Mycobacterium tuberculosis strains in Botswana.

PMID 40008038 · 2025

Mutation Information

Protein Change: Q497R, M306V, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genotypic resistance
Source Database: Reslit

Genotypic drug resistance and transmission clusters of Mycobacterium tuberculosis isolates among Ethiopian returnees from Saudi Arabia.

PMID 40238782 · 2025

Mutation Information

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genotypic drug resistance prediction
Source Database: Reslit

Longitudinal phenotypic and genomic evidence revealing increased risk of drug resistance accumulation in tuberculosis patients in the counties of central China.

PMID 40548705 · 2025

Mutation Information

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

Tracking the evolution of an extensively drug-resistant cross-border Mycobacterium tuberculosis cluster, Europe, January 2016 up to August 2025: implications for European surveillance.

PMID 41267660 · 2025

Mutation Information

embB: p.M306V embB: p.P397T embB: p.M423T

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genomic analysis
Source Database: Reslit

Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting.

PMID 25407810 · 2014

Mutations in embB are associated with ethambutol resistance.

Mutation Information

Protein Change: M306V, P397T, M423T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genomic analysis
Source Database: Reslit

Diversity of Mycobacterium tuberculosis and drug resistance in different provinces of Papua New Guinea.

PMID 25476850 · 2014

Non-synonymous mutation found in EMB resistant sample.

Mutation Information

embB: p.G406S

Protein Change: G406S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: sequencing
Source Database: Reslit

Added value of whole-genome sequencing for management of highly drug-resistant TB.

PMID 25492392 · 2015

Theoretical possibility of causal association with a drug-resistant phenotype, but insufficient evidence

Mutation Information

embB: p.D328G embB: p.E378A embB: p.G406S

Protein Change: D328G, E378A, G406S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

Clinical application of whole-genome sequencing to inform treatment for multidrug-resistant tuberculosis cases.

PMID 25673793 · 2015

Mutation Information

embB: p.M306I embB: p.L406P

Protein Change: M306I, L406P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

Whole genome sequencing based characterization of extensively drug-resistant Mycobacterium tuberculosis isolates from Pakistan.

PMID 25719196 · 2015

Mutations in the embB gene associated with ethambutol resistance

Mutation Information

embB: p.M306I embB: p.M306V embB: p.M306L embB: p.E378A embB: p.G406A embB: p.Q497P embB: p.D1024T

Protein Change: M306I, M306V, M306L, E378A, G406A, Q497P, D1024T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole genome sequencing
Source Database: Reslit

Integration of published information into a resistance-associated mutation database for Mycobacterium tuberculosis.

PMID 25765106 · 2015

Mutation Information

embB: p.M406I

Protein Change: M406I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Source Database: Reslit

Mutations conferring resistance to first- and second-line drugs in multidrug-resistant Mycobacterium tuberculosis clinical isolates in southeast Mexico.

PMID 25819011 · 2015

Mutation Information

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: sequencing
Source Database: Reslit

Draft Genome Sequence of Mycobacterium tuberculosis Strain E186hv of Beijing B0/W Lineage with Reduced Virulence.

PMID 25953188 · 2015

associated with ethambutol resistance

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genomic analysis
Source Database: Reslit

Transmitted Extended-Spectrum Extensively Drug-Resistant Tuberculosis in Beijing, China, with Discordant Whole-Genome Sequencing Analysis Results.

PMID 26063862 · 2015

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: phenotypic DST
Source Database: Reslit

Genome Analysis of the First Extensively Drug-Resistant (XDR) Mycobacterium tuberculosis in Malaysia Provides Insights into the Genetic Basis of Its Biology and Drug Resistance.

PMID 26110649 · 2015

associated with ethambutol resistance

Mutation Information

Protein Change: Q497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genomic analysis; polymorphism analysis
Source Database: Reslit

Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study.

PMID 26116186 · 2015

Mutation Information

embB: p.M916V embB: p.M918V embB: p.M918I embB: p.D983G embB: p.F988L

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing and phenotypic drug-susceptibility testing
Source Database: Reslit

Mutation at embB codon 306, a potential marker for the identification of multidrug resistance associated with ethambutol in Mycobacterium tuberculosis.

PMID 26124153 · 2015

Mutations in embB codon 306 are associated with ethambutol resistance.

Mutation Information

Protein Change: M916V, M918V, M918I, D983G, F988L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: sequencing
Source Database: Reslit

Whole-genome sequencing targets drug-resistant bacterial infections.

PMID 26243131 · 2015

Mutation Information

embB: p.D1024N

Protein Change: D1024N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: reported in cited literature
Source Database: Reslit

Reduced turn-around time for Mycobacterium tuberculosis drug susceptibility testing with a proportional agar microplate assay.

PMID 26348263 · 2015

Mutation Information

embB: p.M306V embB: p.Q497R

Protein Change: M306V, Q497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: sequencing and MIC determination
Source Database: Reslit

Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal.

PMID 26418737 · 2015

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole genome sequencing and drug susceptibility testing
Source Database: Reslit

Within patient microevolution of Mycobacterium tuberculosis correlates with heterogeneous responses to treatment.

PMID 26620446 · 2015

Mutation Information

embB: p.V502A

Protein Change: V502A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: SNP genotyping
Source Database: Reslit

Clinical features, Outcomes and Molecular Profiles of Drug Resistance in Tuberculous Meningitis in non-HIV Patients.

PMID 26738994 · 2016

2 cases of resistance to ethambutol had a genotype of embB at codon 306

Mutation Information

embB: p.M306I embB: p.M306V embB: p.G406S embB: p.Q497P embB: p.Q497R embB: p.D1024N embB: p.V306M

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: MTBDRsl assay
Source Database: Reslit

Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance.

PMID 27005572 · 2016

Mutation Information

Protein Change: M306I, M306V, G406S, Q497P, Q497R, D1024N, V306M
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genome-wide association analysis; genetic association and structural analysis
Source Database: Reslit

Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Beijing, China: 2006 versus 2012.

PMID 27176471 · 2016

Mutation Information

Protein Change: M306V, M306I, M306L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: DNA sequencing
Source Database: Reslit

Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico.

PMID 31166945 · 2019

Mutation Information

embB: p.H1002R

Protein Change: H1002R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: WGS analysis
Source Database: Reslit

100

Genetic diversity and drug susceptibility profiles of Mycobacterium tuberculosis obtained from Saint Peter's TB specialized Hospital, Ethiopia.

PMID 31233535 · 2019

Common mutation in EMB resistant isolates

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: emb
Validation Method: GenoType MTBDRsl assay
Source Database: Reslit

101

Diagnostic predictive values of the Hain genotype MTBDRsl assay in mycobacterial strains isolated from Sudan.

PMID 31236189 · 2019

Mutation Information

embB: p.M306I embB: p.M306V embB: p.Q497K embB: p.D328G embB: p.G406D

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: MTBDRsl assay
Source Database: Reslit

102

Mycobacterium tuberculosis whole genome sequencing provides insights into the Manila strain and drug-resistance mutations in the Philippines.

PMID 31243306 · 2019

Confirmed in the study

Mutation Information

Protein Change: M306I, M306V, Q497K, D328G, G406D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole genome sequencing and drug susceptibility testing
Source Database: Reslit

103

Whole-genome sequencing-based epidemiological analysis of anti-tuberculosis drug resistance genes in Japan in 2007: Application of the Genome Research for Asian Tuberculosis (GReAT) database.

PMID 31492902 · 2019

Mutation Information

embB: p.G991S

Protein Change: G991S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genomic analysis
Source Database: Reslit

104

Prevalence, risk and genetic characteristics of drug-resistant tuberculosis in a tertiary care tuberculosis hospital in China.

PMID 31496759 · 2019

Mutation Information

embB: p.M306V embB: p.G406A

Protein Change: M306V, G406A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: DNA sequencing
Source Database: Reslit

105

Whole genome sequencing of drug resistant Mycobacterium tuberculosis isolates from a high burden tuberculosis region of North West Pakistan.

PMID 31628383 · 2019

Mutation Information

embB: p.M306I embB: p.M306V embB: p.M306L

Protein Change: M306I, M306V, M306L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole genome sequencing and drug susceptibility testing
Source Database: Reslit

106

Molecular characterization of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates identifies local transmission of infection in Kuwait, a country with a low incidence of TB and MDR-TB.

PMID 31806020 · 2019

Mutation Information

embB: p.M306V embB: p.M306I embB: p.M306L embB: p.G406D embB: p.G406S embB: p.Q497R embB: p.Q497K embB: p.Q497H embB: p.Y319S embB: p.L355L embB: p.E378A

Protein Change: M306V, M306I, M306L, G406D, G406S, Q497R, Q497K, Q497H, Y319S, L355L, E378A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: PCR sequencing
Source Database: Reslit

107

A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status.

PMID 31910804 · 2020

Mutation Information

embB: p.G406S embB: p.G406C embB: p.G406D embB: p.G406A embB: p.Q497R embB: p.M306L embB: p.M306V embB: p.M306I

Protein Change: G406S, G406C, G406D, G406A, Q497R, M306L, M306V, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genomic variant analysis
Source Database: Reslit

108

Tuberculosis in Liberia: high multidrug-resistance burden, transmission and diversity modelled by multiple importation events.

PMID 31935183 · 2020

Mutation Information

embB: p.D1024N

Protein Change: D1024N
Confers Resistance To: emb
Validation Method: phenotypic DST
Source Database: Reslit

109

Epidemiological cut-offs for Sensititre susceptibility testing of Mycobacterium tuberculosis: interpretive criteria cross validated with whole genome sequencing.

PMID 31974497 · 2020

Mutation Information

embB: p.R306L embB: p.E405Q embB: p.G497R

Protein Change: R306L, E405Q, G497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole genome sequencing and MIC testing
Source Database: Reslit

110

A landscape of genomic alterations at the root of a near-untreatable tuberculosis epidemic.

PMID 32014024 · 2020

Mutation Information

embB: p.E149K

Protein Change: E149K
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: MIC testing
Source Database: Reslit

111

The positivity rates and drug resistance patterns of Mycobacterium tuberculosis using nucleotide MALDI-TOF MS assay among suspected tuberculosis patients in Shandong, China: a multi-center prospective study.

PMID 38304182 · 2024

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: nucleotide MALDI-TOF MS assay
Source Database: Reslit

112

Transmission dynamics of drug-resistant tuberculosis in Ningbo, China: an epidemiological and genomic analysis.

PMID 38384306 · 2024

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole_genome_sequencing
Source Database: Reslit

113

Rapid detection of multidrug resistance in tuberculosis using nanopore-based targeted next-generation sequencing: a multicenter, double-blind study.

PMID 38495513 · 2024

Common mutation in embB

Mutation Information

Protein Change: M306V, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Source Database: Reslit

114

Development of a multiplex droplet digital PCR method for detection and monitoring of Mycobacterium tuberculosis and drug-resistant tuberculosis.

PMID 38581051 · 2024

Mutation Information

embB: p.M306I embB: p.M306L embB: p.G406S embB: p.Q497R

Protein Change: M306V, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: ddPCR and Sanger sequencing
Source Database: Reslit

115

Drug Susceptibility and Mutation Profiles in Mycobacterium tuberculosis Isolates from a Tertiary Care Hospital in Kerala, India.

PMID 38772358 · 2024

Mutation Information

Protein Change: M306I, M306L, G406S, Q497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: Sanger sequencing; whole-genome sequencing
Source Database: Reslit

116

Mutations in the embB gene and their association with ethambutol resistance in multidrug-resistant Mycobacterium tuberculosis clinical isolates from Poland.

PMID 24392447 · 2013

Only mutations in codons 406 and 507 were found exclusively in EMB-resistant isolates.

Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol; CARD accession: CARD:3003326

Mutation Information

embB: p.M306V embB: p.M306I embB: p.G406A embB: p.R507G embB: p.L413P embB: p.Q497R embB: p.E504Q

Protein Change: M306V, M306I, G406A, R507G, L413P, Q497R, E504Q
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Effect on Function: single resistance variant
Validation Method: sequencing and comparison with reference strain
Source Database: ReslitCard Database

117

Evaluation of the AID TB resistance line probe assay for rapid detection of genetic alterations associated with drug resistance in Mycobacterium tuberculosis strains.

PMID 24403306 · 2014

Mutation Information

Protein Change: M306V, M306I, M306L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: DNA sequencing
Source Database: Reslit

118

Pyrosequencing for rapid detection of tuberculosis resistance in clinical isolates and sputum samples from re-treatment pulmonary tuberculosis patients.

PMID 24725975 · 2014

Mutation Information

Protein Change: M306I, M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: pyrosequencing
Source Database: Reslit

119

Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Hunan, China.

PMID 24733464 · 2014

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: DNA sequencing
Source Database: Reslit

120

Sequence analysis for detection of drug resistance in Mycobacterium tuberculosis complex isolates from the Central Region of Cameroon.

PMID 24884632 · 2014

mutated in EMB-resistant isolates

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: DNA sequencing
Source Database: Reslit

121

Optimizing multiplex SNP-based data analysis for genotyping of Mycobacterium tuberculosis isolates.

PMID 25001491 · 2014

Mutation Information

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: MLPA and phenotypic DST
Source Database: Reslit

122

A complete high-quality MinION nanopore assembly of an extensively drug-resistant Mycobacterium tuberculosis Beijing lineage strain identifies novel variation in repetitive PE/PPE gene regions.

PMID 29906261 · 2018

Mutation Information

embB: p.M306I embB: p.M306V embB: p.Q497R

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: sequencing
Source Database: Reslit

123

Validating a 14-Drug Microtiter Plate Containing Bedaquiline and Delamanid for Large-Scale Research Susceptibility Testing of Mycobacterium tuberculosis.

PMID 29941636 · 2018

Mutations in embB gene associated with ethambutol resistance.

Mutation Information

Protein Change: M306I, M306V, Q497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genotype-phenotype correlation; MIC testing
Source Database: Reslit

124

Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance.

PMID 30333483 · 2018

Mutation Information

embB: p.G352D

Protein Change: G352D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: machine learning and structural analysis
Source Database: Reslit

125

Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.

PMID 30337678 · 2018

Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol; CARD accession: CARD:3003326

Mutation Information

Protein Change: D406V, D354A, G406D, G406C, G406A, F330S, A454T, D1024N, D328Y, Y334H, Y319S, Y319C, S347I, S22C, Q497R, Q497K, N296H, M306V, M306L, M306I, L402V, G406S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Effect on Function: single resistance variant
Validation Method: variant calling and annotation
Source Database: ReslitCard Database

126

New epidemic cluster of pre-extensively drug resistant isolates of Mycobacterium tuberculosis Ural family emerging in Eastern Europe.

PMID 30348088 · 2018

Mutation Information

embB: p.S297A embB: p.S297T

Protein Change: S297A, S297T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genotypic resistance profile
Source Database: Reslit

127

Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia.

PMID 30373719 · 2018

Mutation Information

embB: p.M306I embB: p.M306V embB: p.S297A embB: p.D354A embB: p.Q497R embB: p.Q497K

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genotypic and phenotypic analysis
Source Database: Reslit

128

A Diagnostic Algorithm To Investigate Pyrazinamide and Ethambutol Resistance in Rifampin-Resistant Mycobacterium tuberculosis Isolates in a Low-Incidence Setting.

PMID 30455227 · 2019

mutations in embB are associated with ethambutol resistance

Mutation Information

Protein Change: M306I, M306V, S297A, D354A, Q497R, Q497K
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: Sanger sequencing and phenotypic DST; NGS and phenotypic DST
Source Database: Reslit

129

Molecular drug susceptibility testing and strain typing of tuberculosis by DNA hybridization.

PMID 30730960 · 2019

Mutation Information

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: microarray hybridization
Source Database: Reslit

130

Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012-2016.

PMID 30789128 · 2019

Mutation Information

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

131

Longitudinal Outbreak of Multidrug-Resistant Tuberculosis in a Hospital Setting, Serbia.

PMID 30789133 · 2019

Mutation Information

Protein Change: Q497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

132

Genomic analysis of the emergence of drug-resistant strains of Mycobacterium tuberculosis in the Middle East.

PMID 30872748 · 2019

Mutation Information

embB: p.G406D

Protein Change: G406D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: Whole genome sequencing and phenotypic testing
Source Database: Reslit

133

Whole genome sequencing identifies bacterial factors affecting transmission of multidrug-resistant tuberculosis in a high-prevalence setting.

PMID 30944370 · 2019

Most common mutation

Mutation Information

embB: p.Y319S

Protein Change: Y319S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genetic distance and phylogenetic analysis
Source Database: Reslit

134

Genomic characterization of MDR/XDR-TB in Kazakhstan by a combination of high-throughput methods predominantly shows the ongoing transmission of L2/Beijing 94-32 central Asian/Russian clusters.

PMID 31234780 · 2019

Mutation Information

embB: p.N13S embB: p.P351L embB: p.E378A embB: p.M306V

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genotypic detection via TB-SPRINT and TB-SNPID assays
Source Database: Reslit

135

Genomic analysis of Mycobacterium tuberculosis variant bovis strains isolated from bovine in the state of Mato Grosso, Brazil.

PMID 36467663 · 2022

associated with ethambutol resistance

Mutation Information

Protein Change: N13S, P351L, E378A, M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genomic analysis; genomic sequencing
Source Database: Reslit

136

Comparative genomics of drug-resistant strains of Mycobacterium tuberculosis in Ecuador.

PMID 36544084 · 2022

Mutation Information

Protein Change: M306V, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

137

New insights on tuberculosis transmission dynamics and drug susceptibility profiles among the prison population in Southern Brazil based on whole-genome sequencing.

PMID 36820651 · 2023

Mutation Information

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole_genome_sequencing
Source Database: Reslit

138

Clinical utility of target-based next-generation sequencing for drug-resistant TB.

PMID 36853141 · 2023

Mutations in embB were identified as a key determinant of ethambutol resistance.

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: Targeted next-generation sequencing (tNGS) with correlation to phenotypic drug susceptibility testing (pDST)
Source Database: Reslit

139

A rapid, accurate, and low-cost method for detecting Mycobacterium tuberculosis and its drug-resistant genes in pulmonary tuberculosis: Applications of MassARRAY DNA mass spectrometry.

PMID 36910195 · 2023

Poor correlation with phenotype

Mutation Information

Protein Change: M306I, M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Source Database: Reslit

140

Evolution and epidemic success of Mycobacterium tuberculosis in eastern China: evidence from a prospective study.

PMID 37147590 · 2023

Mutations in embB are associated with ethambutol resistance.

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genomic analysis
Source Database: Reslit

141

Rapid Identification of Lineage and Drug Resistance in Clinical Samples of Mycobacterium tuberculosis.

PMID 37374968 · 2023

The mutation embB (Gln497Arg) was described as conferring resistance, but the strain was susceptible to ethambutol.

Mutation Information

embB: p.M306I embB: p.M306L

Protein Change: Q497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genomic analysis
Source Database: Reslit

142

Using Microfluidic Chip and Allele-Specific PCR to Rapidly Identify Drug Resistance-Associated Mutations of Mycobacterium tuberculosis.

PMID 37424666 · 2023

Mutation Information

Protein Change: M306I, M306L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: chip scanning and Sanger sequencing
Source Database: Reslit

143

Molecular Analysis of Anti-Tuberculosis Drug Resistance of Mycobacterium tuberculosis Isolated in the Republic of Korea.

PMID 37627744 · 2023

Mutation Information

Protein Change: M306V, M306I, M306L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: emb
Validation Method: DNA sequencing and MIC testing
Source Database: Reslit

144

Analysis of Drug-Resistance Characteristics and Genetic Diversity of Multidrug-Resistant Tuberculosis Based on Whole-Genome Sequencing on the Hainan Island, China.

PMID 37692467 · 2023

Mutation Information

Protein Change: M306I, M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: Whole-genome sequencing (WGS) and drug susceptibility testing (DST)
Source Database: Reslit

145

Insight into the drug-resistant characteristics and genetic diversity of multidrug-resistant Mycobacterium tuberculosis in China.

PMID 37732780 · 2023

Mutation Information

embB: p.M306V embB: p.M306I embB: p.M306L embB: p.Q497R

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole genome sequencing
Source Database: Reslit

146

Genomic markers of drug resistance in Mycobacterium tuberculosis populations with minority variants.

PMID 37750734 · 2023

Detected in 65/1831 strains

Mutation Information

embB: p.D354A

Protein Change: D354A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: LoFreq and manual review
Source Database: Reslit

147

Genotypic and phenotypic comparison of drug resistance profiles of clinical multidrug-resistant Mycobacterium tuberculosis isolates using whole genome sequencing in Latvia.

PMID 37770850 · 2023

Mutation Information

Protein Change: M306V, M306I, M306L, Q497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: WGS and phenotypic DST
Source Database: Reslit

148

Mixed infections in genotypic drug-resistant Mycobacterium tuberculosis.

PMID 37816829 · 2023

Mutation Information

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genotypic resistance prediction using TB-Profiler software
Source Database: Reslit

149

Evaluating the Sensitivity of Different Molecular Techniques for Detecting Mycobacterium tuberculosis Complex in Patients with Pulmonary Infection.

PMID 37934050 · 2023

Mutation Information

embB: p.R306H

Protein Change: R306H
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: multiplex allele-specific PCR
Source Database: Reslit

150

The MAGMA pipeline for comprehensive genomic analyses of clinical Mycobacterium tuberculosis samples.

PMID 38019772 · 2023

Mutation Information

embB: p.Y319S embB: p.D328Y

Protein Change: M306V
Confers Resistance To: emb
Validation Method: variant calling and resistance annotation
Source Database: Reslit

151

A preliminary evaluation of targeted nanopore sequencing technology for the detection of Mycobacterium tuberculosis in bronchoalveolar lavage fluid specimens.

PMID 38029234 · 2023

Mutation Information

Protein Change: Y319S, D328Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: targeted nanopore sequencing
Source Database: Reslit

152

Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique.

PMID 38048599 · 2024

Mutation Information

embB: p.M306I embB: p.G406D embB: p.M306L embB: p.D354A embB: p.M306V

Protein Change: M306I, G406D, M306L, D354A, M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

153

A precision overview of genomic resistance screening in Ecuadorian isolates of Mycobacterium tuberculosis using web-based bioinformatics tools.

PMID 38051742 · 2023

Mutation Information

embB: p.M306I embB: p.M306V embB: p.V7A

Protein Change: M306I, M306V, V7A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

154

Role of the first WHO mutation catalogue in the diagnosis of antibiotic resistance in Mycobacterium tuberculosis in the Valencia Region, Spain: a retrospective genomic analysis.

PMID 38061383 · 2024

mutations in embB are associated with ethambutol resistance

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genomic_prediction_and_phenotypic_testing
Source Database: Reslit

155

Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach.

PMID 38216576 · 2024

mutations

Mutation Information

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Source Database: Reslit

156

Effect of mutation and genetic background on drug resistance in Mycobacterium tuberculosis.

PMID 22470121 · 2012

EmbB mutations are associated with ethambutol resistance

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: sequencing
Source Database: Reslit

157

Emergence and spread of extensively and totally drug-resistant tuberculosis, South Africa.

PMID 23622714 · 2013

Mutation Information

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: sequencing
Source Database: Reslit

158

Resistance of Mycobacterium tuberculosis to antibiotics in Lao PDR: first multicentric study conducted in 3 hospitals.

PMID 23782980 · 2013

The M306V mutation in embB is associated with ethambutol resistance.

Mutation Information

embB: p.T506N embB: p.Q445R embB: p.Q306R embB: p.M306L embB: p.M306V embB: p.M306T embB: p.M306I embB: p.D354A embB: p.E378K embB: p.E378A embB: p.G406S embB: p.G406C embB: p.G406D embB: p.G406A embB: p.Q497K embB: p.Q497P embB: p.Q497R embB: p.Q853P embB: p.T1082A

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: sequencing
Source Database: Reslit

159

Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-β-D-arabinose biosynthetic and utilization pathway genes.

PMID 23995136 · 2013

Mutation Information

Protein Change: T506N, Q445R, Q306R, M306L, M306V, M306T, M306I, D354A, E378K, E378A, G406S, G406C, G406D, G406A, Q497K, Q497P, Q497R, Q853P, T1082A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: Genome sequencing and mutagenesis
Source Database: ReslitResFinder Database

160

Magnitude of gene mutations conferring drug resistance in mycobacterium tuberculosis isolates from lymph node aspirates in ethiopia.

PMID 24046537 · 2013

Mutation Information

embB: p.D354A embB: p.M306V embB: p.M306I embB: p.G406S embB: p.G406A embB: p.G406C

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genotyping using GenoType MTBDRsl assay
Source Database: Reslit

161

Primary multidrug-resistant Mycobacterium tuberculosis in 2 regions, Eastern Siberia, Russian Federation.

PMID 24047678 · 2013

Conventional susceptibility testing was unavailable for pyrazinamide and the fluoroquinolones.

Mutation Information

Protein Change: D354A, M306V, M306I, G406S, G406A, G406C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: DNA sequencing
Source Database: Reslit

162

Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis.

PMID 24055765 · 2014

Mutations in embB confer resistance to ethambutol

Mutation Information

embB: p.M306I embB: p.M306V embB: p.M306L embB: p.M306T embB: p.G406S embB: p.G406C embB: p.G406D embB: p.G406A embB: p.Q497K embB: p.Q497P embB: p.Q497R

Protein Change: M306I, M306V, M306L, M306T, G406S, G406C, G406D, G406A, Q497K, Q497P, Q497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: MIC measurement
Source Database: ReslitResFinder Database

163

Mutations within embCAB Are Associated with Variable Level of Ethambutol Resistance in Mycobacterium tuberculosis Isolates from China.

PMID 29084750 · 2018

mutations in embB are associated with ethambutol resistance

Mutation Information

Protein Change: M306V, M306I, M306L, G406A, G406D, Y319C, D328Y, V18F, T270I, N394D, G406S, Q497H, Q497R, Y334H, D354A, S412P
Nucleotide Change: C-11A, C-12T, C-16G, C-16T, G-43C, G-5A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: MIC testing
Source Database: Reslit

164

Multi-clonal evolution of multi-drug-resistant/extensively drug-resistant Mycobacterium tuberculosis in a high-prevalence setting of Papua New Guinea for over three decades.

PMID 29310751 · 2018

Mutations promoted from gene entry 'embB' (model emitted mutations_found inside genes).

Mutation Information

embB: p.M306V embB: p.M306I embB: p.G406A embB: p.Q497R

Protein Change: M306V, M306I, G406A, Q497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole genome sequencing
Source Database: Reslit

165

Whole-Genome Analysis of Mycobacterium tuberculosis from Patients with Tuberculous Spondylitis, Russia.

PMID 29460750 · 2018

Mutation Information

embB: p.M306I embB: p.G406A embB: p.G406D embB: p.N399T embB: p.Q497R embB: p.A453A

Protein Change: M306I, G406A, G406D, N399T, Q497R, A453A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

166

Multi- and Extensively Drug Resistant Mycobacterium tuberculosis in South Africa: a Molecular Analysis of Historical Isolates.

PMID 29514936 · 2018

Mutation Information

embB: p.M306I embB: p.M306V embB: p.Q51P

Protein Change: M306I, M306V, Q51P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

167

Genotypic drug resistance using whole-genome sequencing of Mycobacterium tuberculosis clinical isolates from North-western Tanzania.

PMID 29559127 · 2018

Mutation Information

Protein Change: M306V, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Source Database: Reslit

168

Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains.

PMID 29755957 · 2018

Mutation at codon 306 (Met to Val) is the primary cause of EMB resistance.

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: experimental validation
Source Database: Reslit

169

Accuracy of whole genome sequencing versus phenotypic (MGIT) and commercial molecular tests for detection of drug-resistant Mycobacterium tuberculosis isolated from patients in Brazil and Mozambique.

PMID 29779775 · 2018

Most frequent mutation related to ethambutol resistance in Mozambican isolates

Mutation Information

embB: p.G406D embB: p.Q497R

Protein Change: Q497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole genome sequencing
Source Database: Reslit

170

Direct Whole-Genome Sequencing of Sputum Accurately Identifies Drug-Resistant Mycobacterium tuberculosis Faster than MGIT Culture Sequencing.

PMID 29848567 · 2018

Mutation Information

Protein Change: G406D, Q497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

171

Phylogenomic assessment of drug-resistant Mycobacterium tuberculosis strains from Beira, Mozambique.

PMID 32063558 · 2020

Mutation Information

embB: p.M306L

Protein Change: M306L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole genome sequencing
Source Database: Reslit

172

Mycobacterium tuberculosis Complex Lineage 3 as Causative Agent of Pulmonary Tuberculosis, Eastern Sudan

PMID 32091355 · 2020

Mutation Information

embB: p.Q497R embB: p.M306I embB: p.M306V embB: p.G406D

Protein Change: Q497R, M306I, M306V, G406D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

173

Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015.

PMID 32091369 · 2020

Mutations promoted from gene entry 'embB' (model emitted mutations_found inside genes).

Mutation Information

embB: p.Y334H

Protein Change: Y334H
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genotypic resistance prediction
Source Database: Reslit

174

Detection of drug resistant Mycobacterium tuberculosis by high-throughput sequencing of DNA isolated from acid fast bacilli smears.

PMID 32384098 · 2020

Mutations in embB are associated with ethambutol resistance.

Mutation Information

embB: p.M306V embB: p.M306I embB: p.G406D

Protein Change: M306V, M306I, G406D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: high-throughput sequencing
Source Database: Reslit

175

Emergence of multidrug-resistant Mycobacterium tuberculosis of the Beijing lineage in Portugal and Guinea-Bissau: a snapshot of moving clones by whole-genome sequencing.

PMID 32538300 · 2020

Present in GC2 isolates.

Mutation Information

embB: p.M306V embB: p.G406S

Protein Change: M306V, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutolemb
Validation Method: whole genome sequencing
Source Database: Reslit

176

Exploiting Homoplasy in Genome-Wide Association Studies to Enhance Identification of Antibiotic-Resistance Mutations in Bacterial Genomes.

PMID 32782426 · 2020

Mutation Information

Protein Change: M306V, G406S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: association testing
Source Database: Reslit

177

Characterisation of drug-resistant Mycobacterium tuberculosis mutations and transmission in Pakistan.

PMID 35545649 · 2022

Mutation Information

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genotypic prediction
Source Database: Reslit

178

Genetic Diversity of Mycobacterium tuberculosis Isolates From an Amerindian Population in Chiapas, México.

PMID 35909960 · 2022

Mutation in embB was observed in SIT42 and orphan isolates.

Mutation Information

embB: p.E136K

Protein Change: E136K
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: whole-genome sequencing
Source Database: Reslit

179

Prediction of drug resistance by Sanger sequencing of Mycobacterium tuberculosis complex strains isolated from multidrug resistant tuberculosis suspect patients in Ethiopia.

PMID 35930613 · 2022

Common mutation

Mutation Information

embB: p.D1024N embB: p.Q497R embB: p.L359I embB: p.M306I

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: Sanger sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

180

Phylogenetic lineages of tuberculosis isolates and their association with patient demographics in Tanzania.

PMID 35931954 · 2022

Mutation Information

Protein Change: D1024N, Q497R, L359I, M306I
Confers Resistance To: emb
Validation Method: genomic sequencing
Source Database: Reslit

181

A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.

PMID 35944069 · 2022

mutations in embB are associated with ethambutol resistance

Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol; CARD accession: CARD:3003326

Mutation Information

embB: p.M306V embB: p.M306I embB: p.Q497R embB: p.G406A embB: p.G406D embB: p.Q497K embB: p.N1033K embB: p.D328Y embB: p.D354A embB: p.G406S embB: p.M306Var

Protein Change: M306V, M306I, Q497R, G406A, G406D, Q497K, N1033K, D328Y, D354A, G406S, M306Var
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Effect on Function: single resistance variant
Validation Method: genomic and phenotypic data; genotyping and phenotypic resistance testing
Source Database: ReslitCard Database

182

High fluoroquinolone resistance proportions among multidrug-resistant tuberculosis driven by dominant L2 Mycobacterium tuberculosis clones in the Mumbai Metropolitan Region.

PMID 35989319 · 2022

Mutation in embB is associated with ethambutol resistance.

Mutation Information

Protein Change: M306V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genomic analysis
Source Database: Reslit

183

Evaluation of whole-genome sequence to predict drug resistance of nine anti-tuberculosis drugs and characterize resistance genes in clinical rifampicin-resistant Mycobacterium tuberculosis isolates from Ningbo, China.

PMID 36062095 · 2022

Mutation Information

Protein Change: M306V, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: emb
Validation Method: whole-genome sequencing
Source Database: Reslit

184

Rapid Identification of Drug Resistance and Phylogeny in M. tuberculosis, Directly from Sputum Samples.

PMID 36102651 · 2022

Mutation Information

embB: p.M306I embB: p.M306V embB: p.M306L embB: p.D354A embB: p.Q497K embB: p.D1024N

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: targeted sequencing
Source Database: Reslit

185

Deep Amplicon Sequencing Reveals Culture-dependent Clonal Selection of Mycobacterium tuberculosis in Clinical Samples.

PMID 38870522 · 2025

Mutation Information

Protein Change: M306I, M306V, M306L, D354A, Q497K, D1024N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: emb
Validation Method: deep amplicon sequencing and molecular drug susceptibility testing
Source Database: Reslit

186

Evaluation of Whole Genome Sequencing-Based Predictions of Antimicrobial Resistance to TB First Line Agents: A Lesson from 5 Years of Data.

PMID 38892433 · 2024

Mutation Information

embB: p.M306V embB: p.M306I embB: p.M306L embB: p.G406D embB: p.G406E embB: p.Q497R

Protein Change: M306V, M306I, M306L, G406D, G406E, Q497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: WGS-based AMR prediction and phenotypic DST
Source Database: Reslit

187

Different Contributions of embB and ubiA Mutations to Variable Level of Ethambutol Resistance in Mycobacterium tuberculosis Isolates.

PMID 39050826 · 2024

Mutation Information

embB: p.M306V embB: p.M306I embB: p.M306L embB: p.G406A embB: p.G406D embB: p.G406S embB: p.Q497R embB: p.Q497P embB: p.Q497H embB: p.D328G embB: p.D328Y embB: p.F330I embB: p.D354A embB: p.L402V embB: p.A505V embB: p.G246R embB: p.D300G

Protein Change: M306V, M306I, M306L, G406A, G406D, G406S, Q497R, Q497P, Q497H, D328G, D328Y, F330I, D354A, L402V, A505V, G246R, D300G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: statistical analysis
Source Database: Reslit

188

Targeted next-generation sequencing of Mycobacterium tuberculosis from patient samples: lessons learned from high drug-resistant burden clinical settings in Bangladesh.

PMID 39136526 · 2024

Mutation Information

Protein Change: M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: tNGS and pDST
Source Database: Reslit

189

Whole-genome sequencing-based genetic diversity, transmission dynamics, and drug-resistant mutations in Mycobacterium tuberculosis isolated from extrapulmonary tuberculosis patients in western Ethiopia.

PMID 39185123 · 2024

Mutation Information

embB: p.A221G embB: p.A225S embB: p.V227G embB: p.L239P embB: p.D240H embB: p.R257W embB: p.A271V embB: p.S272C embB: p.S272I embB: p.R274P embB: p.A281P embB: p.V282L embB: p.V282G embB: p.F285L embB: p.F287V embB: p.F287C embB: p.I293N embB: p.G294S embB: p.N296H embB: p.N296K embB: p.S297A embB: p.S297L embB: p.D299E embB: p.M306L embB: p.M306V embB: p.M306T embB: p.M306I embB: p.V309G embB: p.D311H embB: p.D311G embB: p.H312R embB: p.G314A embB: p.S317T embB: p.N318H embB: p.N318S embB: p.N318K embB: p.Y319N embB: p.Y319S embB: p.Y319C embB: p.D328Y embB: p.D328V embB: p.D328G embB: p.F330V embB: p.G331R embB: p.W332L embB: p.Y333H embB: p.Y334H embB: p.S347C embB: p.S347I embB: p.S347T embB: p.A356S embB: p.A356V embB: p.A357S embB: p.A357V embB: p.G358V embB: p.L359I embB: p.V360M embB: p.S366P embB: p.R367P embB: p.E368Q embB: p.E368A embB: p.E368D embB: p.V369L embB: p.V369A embB: p.L370R embB: p.P371R embB: p.G374V embB: p.P375A embB: p.V377M embB: p.V377G embB: p.E378K embB: p.E378A embB: p.A379T embB: p.A379D embB: p.S380R embB: p.S380N embB: p.Y384N embB: p.A388G embB: p.W395R embB: p.W395C embB: p.P397T embB: p.P397Q embB: p.F398Y embB: p.N399H embB: p.N399D embB: p.N400K embB: p.G401S embB: p.G406S embB: p.G406C embB: p.G406D embB: p.G406A embB: p.M423I embB: p.P430L embB: p.A431T embB: p.V435G embB: p.V436G embB: p.T437A embB: p.P446H embB: p.G448V embB: p.V452L embB: p.G459A embB: p.R460C embB: p.R460L embB: p.P461S embB: p.R469P embB: p.R471P embB: p.Q497K embB: p.Q497P embB: p.Q497R embB: p.A659T embB: p.G745D embB: p.D959A embB: p.M1000R embB: p.D1024N embB: c.del983A

Protein Change: Q497R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: sequencing analysis
Source Database: Reslit

190

The catalogue of Mycobacterium tuberculosis mutations associated with drug resistance to 12 drugs in China from a nationwide survey: a genomic analysis.

PMID 39353459 · 2024

Mutation Information

embB: p.Y319S

Protein Change: Y319S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Validation Method: genotyping and MIC testing
Source Database: Reslit

191

Tuberculosis drug resistance mutation database.

PMID 19209951 · 2009

Mutation Information

Protein Change: A221G, A225S, V227G, L239P, D240H, R257W, A271V, S272C, S272I, R274P, A281P, V282L, V282G, F285L, F287V, F287C, I293N, G294S, N296H, N296K, S297A, S297L, D299E, M306L, M306V, M306T, M306I, V309G, D311H, D311G, H312R, G314A, S317T, N318H, N318S, N318K, Y319N, Y319S, Y319C, D328Y, D328V, D328G, F330V, G331R, W332L, Y333H, Y334H, S347C, S347I, S347T, A356S, A356V, A357S, A357V, G358V, L359I, V360M, S366P, R367P, E368Q, E368A, E368D, V369L, V369A, L370R, P371R, G374V, P375A, V377M, V377G, E378K, E378A, A379T, A379D, S380R, S380N, Y384N, A388G, W395R, W395C, P397T, P397Q, F398Y, N399H, N399D, N400K, G401S, G406S, G406C, G406D, G406A, M423I, P430L, A431T, V435G, V436G, T437A, P446H, G448V, V452L, G459A, R460C, R460L, P461S, R469P, R471P, Q497K, Q497P, Q497R, A659T, G745D, D959A, M1000R, D1024N
Nucleotide Change: del983A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Source Database: ResFinder Database

192

[Metastases to the mediastinal lymph nodes in a series of two-hundred-consecutive operations for primary lung cancer].

PMID 1920995 · 1991

Mutation Information

Protein Change: S272C, S272I, V282L, V282G, F287V, F287C, N296H, N296K, S297A, S297L, A356S, A356V, A357S, A357V, V369L, V369A, V377M, V377G, A379T, A379D, W395R, W395C, P397T, P397Q, N399H, N399D, R460C, R460L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Source Database: ResFinder Database

193

Characterization of mutations in multi- and extensive drug resistance among strains of Mycobacterium tuberculosis clinical isolates in Republic of Korea.

PMID 23561273 · 2013

Mutation Information

Protein Change: S298W, Y319N, Y319S, Y319C, F320L, D328Y, D328V, D328G, S347C, S347I, S347T, D354A, P404S, E405D, G406S, G406C, G406D, G406A, S412L, M482I, Q497K, Q497P, Q497R, E504D, R507K
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Source Database: ResFinder Database

194

Detection of first- and second-line drug resistance in Mycobacterium tuberculosis clinical isolates by pyrosequencing.

PMID 22461677 · 2012

Mutation Information

embB: p.M306L embB: p.M306V embB: p.M306T embB: p.M306I embB: p.A313V embB: p.Y315C

Protein Change: M306L, M306V, M306T, M306I, A313V, Y315C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Source Database: ResFinder Database

195

Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance.

PMID 23995137 · 2013

Mutation Information

embB: p.M306L embB: p.M306V embB: p.M306T embB: p.M306I embB: p.A313V embB: p.D354A embB: p.Q497K embB: p.Q497P embB: p.Q497R embB: p.E504D embB: p.H1002R

Protein Change: M306L, M306V, M306T, M306I, A313V, D354A, Q497K, Q497P, Q497R, E504D, H1002R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Source Database: ResFinder Database

196

Evaluation of genotype MTBDRsl assay to detect drug resistance associated with fluoroquinolones, aminoglycosides and ethambutol on clinical sediments.

PMID 23166667 · 2012

Mutation Information

embB: p.M306L embB: p.M306V embB: p.M306T embB: p.M306I

Protein Change: M306L, M306V, M306T, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Source Database: ResFinder Database

197

A potential role for RNA turnover in the light regulation of plant gene expression: ribulose-1,5-bisphosphate carboxylase small subunit in soybean.

PMID 2356127 · 1990

Mutation Information

embB: p.D311H embB: p.D311G embB: p.S380R embB: p.S380N

Protein Change: D311H, D311G, S380R, S380N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Source Database: ResFinder Database

198

Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosis.

PMID 10639358 · 2000

Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol; CARD accession: CARD:3003326

Mutation Information

embB: p.G406C embB: p.D328Y embB: p.F330V embB: p.Y334H embB: p.D1024N embB: p.Q497R embB: p.G406S embB: p.Q497K embB: p.G745D embB: p.D959A embB: p.S297A embB: p.D328G embB: p.M1000R

Protein Change: G406C, D328Y, F330V, Y334H, D1024N, Q497R, G406S, Q497K, G745D, D959A, S297A, D328G, M1000R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Effect on Function: single resistance variant
Source Database: Card Database

199

Nucleotide polymorphism associated with ethambutol resistance in clinical isolates of Mycobacterium tuberculosis.

PMID 16972132 · 2006

Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol; CARD accession: CARD:3003326

Mutation Information

embB: p.S380R embB: p.P397Q embB: p.D299E embB: p.E378A embB: p.P446H embB: p.I465D embB: p.R469P embB: p.R471P embB: p.L239P embB: p.D311H embB: p.D240H embB: p.E368A

Protein Change: S380R, P397Q, D299E, E378A, P446H, I465D, R469P, R471P, L239P, D311H, D240H, E368A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Effect on Function: single resistance variant
Source Database: Card Database

200

PMID 978-92-4-008241-0

Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol; CARD accession: CARD:3003326

Mutation Information

embB: p.D328Y embB: p.G406S embB: p.G406C embB: p.G406D embB: p.G406A embB: p.Q497R embB: p.Q497K embB: p.M306I embB: p.M306V embB: p.M306L embB: p.Y319S embB: p.D354A embB: p.Y319C

Protein Change: D328Y, G406S, G406C, G406D, G406A, Q497R, Q497K, M306I, M306V, M306L, Y319S, D354A, Y319C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethambutol
Effect on Function: single resistance variant
Source Database: Card Database

201

Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis.

PMID 21300839 · 2011

Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol; CARD accession: CARD:3003326

Mutation Information