Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
transcriptional regulator
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| D187H | - | - | Pseudomonas aeruginosa | aztreonam|carbenicillin|piperacillin tazobactam|meropenem | Reslit | Candidate |
| G125D | - | upregulation of the efflux pumps and being associated with β-lactam resistance | Pseudomonas aeruginosa | meropenem | Reslit | Candidate |
| F198L | - | loss of function, efflux system transcriptional repressor NalD | Pseudomonas aeruginosa | aztreonamaztreonam|carbapenems|phenicols|tetracycline|vaborbactam | ReslitReference Gene Catalog | Candidate |
| G423C | - | - | Pseudomonas aeruginosa | levofloxacin | Reslit | Candidate |
| S32N | - | deleterious | Pseudomonas aeruginosa | carbapenemsamikacin | Reslit | Candidate |
| T11N | - | mutations in regulators MexR, NalC, or NalD, regulator of the MexAB-OprM efflux pump, efflux system transcriptional repressor NalD | Pseudomonas aeruginosa | fluoroquinolones|cephalosporins|aminoglycosidesquinolones|macrolides|tetracycline|phenicolsceftazidime+1 more | ReslitReference Gene Catalog | Candidate |
| C92C | - | - | Pseudomonas aeruginosa | carbapenems|cephalosporins|fluoroquinolones | Reslit | Candidate |
| I111I | - | - | Pseudomonas aeruginosa | carbapenems|cephalosporins|fluoroquinolones | Reslit | Candidate |
| D180D | - | - | Pseudomonas aeruginosa | carbapenems|cephalosporins|fluoroquinolones | Reslit | Candidate |
| A95T | - | - | Pseudomonas aeruginosa | ceftolozane tazobactam|imipenem relebactam|ceftazidime avibactam | Reslit | Candidate |
| T11P | - | overexpression of MexAB-OprM efflux pump | Pseudomonas aeruginosa | cephalosporins|aztreonam|aztreonam avibactam | Reslit | Candidate |
| D147E | - | - | Pseudomonas aeruginosa | meropenem | Reslit | Candidate |
| T158P | - | regulator of the MexAB-OprM efflux pump | Pseudomonas aeruginosa | ceftazidimeaztreonam | Reslit | Candidate |
| V456A | - | - | Pseudomonas aeruginosa | quinolones|beta lactams | Reslit | Candidate |
| R504H | - | - | Pseudomonas aeruginosa | aztreonam | Reslit | Candidate |
| E19K | - | - | - | ciprofloxacin|ceftazidime|meropenem | Reslit | Candidate |
| L174Q | - | - | - | ciprofloxacin|ceftazidime|meropenem | Reslit | Candidate |
| L76P | - | - | - | meropenem | Reslit | Candidate |
| R164P | - | - | - | piperacillin|fluoroquinolones | Reslit | Candidate |
| G45D | - | efflux system transcriptional repressor NalD | Pseudomonas aeruginosa | aztreonam|carbapenems|phenicols|tetracycline|vaborbactam | Reference Gene Catalog | Candidate |
| Q114Ter | - | efflux system transcriptional repressor NalD | Pseudomonas aeruginosa | aztreonam|carbapenems|phenicols|tetracycline|vaborbactam | Reference Gene Catalog | Candidate |
| T158I | - | efflux system transcriptional repressor NalD | Pseudomonas aeruginosa | aztreonam|carbapenems|phenicols|tetracycline|vaborbactam | Reference Gene Catalog | Candidate |
| - | - | - | fluoroquinolones|tetracycline|phenicols|macrolides | Reslit | Candidate | |
| - | - | Pseudomonas aeruginosa | fluoroquinolones | Reslit | Candidate | |
| - | - | Pseudomonas aeruginosa | meropenem | Reslit | Candidate | |
| - | - | Pseudomonas aeruginosa | carbenicillin|cefuroxime|doripenem | Reslit | Candidate |
Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.
A Large-Scale Whole-Genome Comparison Shows that Experimental Evolution in Response to Antibiotics Predicts Changes in Naturally Evolved Clinical Pseudomonas aeruginosa.
Systems-level analysis of NalD mutation, a recurrent driver of rapid drug resistance in acute Pseudomonas aeruginosa infection.
Mutation in NalD leads to loss of function and overexpression of MexAB-OprM efflux system.
The F198L mutation in NalD was shown to confer aztreonam resistance by derepressing the mexAB-oprM efflux system.
nalD
Novel Molecular Markers Linked to Pseudomonas aeruginosa Epidemic High-Risk Clones.
associated with high-risk clones
Genomic surveillance of Pseudomonas aeruginosa in the Philippines, 2013-2014.
Efflux Pump-Driven Antibiotic and Biocide Cross-Resistance in Pseudomonas aeruginosa Isolated from Different Ecological Niches: A Case Study in the Development of Multidrug Resistance in Environmental Hotspots.
mutation in nalD leads to overexpression of mexAB-oprM
Nucleotide substitutions in the mexR, nalC and nalD regulator genes of the MexAB-OprM efflux pump are maintained in Pseudomonas aeruginosa genetic lineages.
Mutations leading to ceftolozane/tazobactam and imipenem/cilastatin/relebactam resistance during in vivo exposure to ceftazidime/avibactam in Pseudomonas aeruginosa.
Analysis of intrahospital and global dissemination and resistome dynamics of NDM-1-producing ST773 Pseudomonas aeruginosa high-risk clone.
mutation leads to overexpression of MexAB-OprM efflux pump
The predictive potential of different molecular markers linked to amikacin susceptibility phenotypes in Pseudomonas aeruginosa.
Mutation-Driven Evolution of Pseudomonas aeruginosa in the Presence of either Ceftazidime or Ceftazidime-Avibactam.
mutation in the gene that regulates the expression of the efflux pump
Epidemiological and Genetic Characteristics of Clinical Carbapenem-Resistant Pseudomonas aeruginosa Strains in Guangdong Province, China.
Mutations in nalD were associated with meropenem resistance
Ceftazidime resistance in Pseudomonas aeruginosa is multigenic and complex.
The balance between antibiotic resistance and fitness/virulence in Pseudomonas aeruginosa: an update on basic knowledge and fundamental research.
Mutations in nalD lead to overexpression of the MexAB-OprM efflux pump, resulting in resistance to quinolones and β-lactams.
Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa.
Multidrug-resistant Pseudomonas aeruginosa is predisposed to lasR mutation through up-regulated activity of efflux pumps in non-cystic fibrosis bronchiectasis patients.
mutations in nalD are associated with increased efflux pump activity and reduced susceptibility to multiple antibiotics
Keeping up with the pathogens: improved antimicrobial resistance detection and prediction from Pseudomonas aeruginosa genomes.
missense mutation
Mutant prevention concentrations and phenotypic and genomic profiling of first-step resistance mechanisms to classical and novel β-lactams in Pseudomonas aeruginosa.
nalD
Direct prediction of carbapenem resistance in Pseudomonas aeruginosa by whole genome sequencing and metagenomic sequencing.
nalD
Overexpression of MexAB-OprM efflux pump in carbapenem-resistant Pseudomonas aeruginosa.
nalD
Interplay between MexAB-OprM and MexEF-OprN in clinical isolates of Pseudomonas aeruginosa.
Deletions in nalD were associated with increased expression of mexAB-oprM and multidrug resistance.
Mutation Analysis in Regulator DNA-Binding Regions for Antimicrobial Efflux Pumps in 17,000 Pseudomonas aeruginosa Genomes.
mutations in regulator DNA-binding regions
Combining antibiotics with antivirulence compounds can have synergistic effects and reverse selection for antibiotic resistance in Pseudomonas aeruginosa.
High potency of sequential therapy with only β-lactam antibiotics.