ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeF198L

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: loss of function, efflux system transcriptional repressor NalD
Resistance To: aztreonam, aztreonam|carbapenems|phenicols|tetracycline|vaborbactam
Organisms: Pseudomonas aeruginosa
Papers: 1

Paper Information1

Systems-level analysis of NalD mutation, a recurrent driver of rapid drug resistance in acute Pseudomonas aeruginosa infection.

Mutation in NalD leads to loss of function and overexpression of MexAB-OprM efflux system.

The F198L mutation in NalD was shown to confer aztreonam resistance by derepressing the mexAB-oprM efflux system.

nalD

Protein Change: F198L
Organisms: Pseudomonas aeruginosa
Confers Resistance To: aztreonamaztreonam|carbapenems|phenicols|tetracycline|vaborbactam
Effect on Function: loss of function; efflux system transcriptional repressor NalD
Validation Method: experimental validation in PA14; engineered mutation in PA14 and MIC increase
Source Database: ReslitReference Gene Catalog

Comments (0)

No comments yet. Be the first to comment!

Browse AMR Mutations