ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeT456I

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: resistance
Resistance To: rifabutin|rifampicin
Organisms: Mycobacterium avium
Papers: 1

Paper Information1

Correlation between rpoB gene mutation in Mycobacterium avium subspecies paratuberculosis and clinical rifabutin and rifampicin resistance for treatment of Crohn's disease.

PMID 18461657 · 2008

The mutation C1367T in the rpoB gene of MAP strain 18 leads to resistance to rifabutin and rifampicin.

Mutation Information

rpoB: p.T456I

Protein Change: T456I
Organisms: Mycobacterium avium
Confers Resistance To: rifabutin|rifampicin
Effect on Function: resistance
Validation Method: MIC testing and sequencing
Source Database: Reslit

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