Browse AMR Genes

rpoB: p.S492L rpoB: p.Q148L rpoB: p.L511Q rpoB: p.D516G rpoB: p.H526L rpoB: p.P564L rpoB: p.I572L

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Invader assay
Source Database: Reslit

Compensatory evolution in rifampin-resistant Escherichia coli.

PMID 11102350 · 2000

The study focuses on compensatory evolution in rifampin-resistant E. coli, highlighting mutations in the rpoB gene.

rpoB

Mutation Information

Protein Change: S492L, Q148L, L511Q, D516G, H526L, P564L, I572L
Organisms: Escherichia coli, Shigella sonnei
Confers Resistance To: rifampicinrifampicin|rifamycinsrifamycins
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Validation Method: experimental validation through fitness measurements and sequencing
Source Database: ReslitReference Gene Catalog

Frequency of rpoB mutations inside and outside the cluster I region in rifampin-resistant clinical Mycobacterium tuberculosis isolates.

PMID 11136757 · 2001

Detected in one isolate and 5 of 18 RIF-resistant strains with no cluster I mutation

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.V176F rpoB: p.S450W rpoB: p.H445R rpoB: p.H445D rpoB: p.H445C rpoB: p.H445Y rpoB: p.S441Q rpoB: p.E592D rpoB: p.R552C rpoB: p.L490V

Protein Change: V176F, S450W, H445R, H445D, H445C, H445Y, S441Q, E592D, R552C, L490V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Validation Method: direct sequencing
Source Database: ReslitCard Database

Genetic diversity and evidence for acquired antimicrobial resistance in Mycobacterium tuberculosis at a large hospital in South India.

PMID 11179917 · 2000

Mutation Information

rpoB: p.D516E rpoB: p.S522L rpoB: p.H526P rpoB: p.K527Q

Protein Change: D516E, S522L, H526P, K527Q
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

Molecular basis of rifampin and isoniazid resistance in Mycobacterium bovis strains isolated in Sardinia, Italy.

PMID 11353606 · 2001

Mutation Information

rpoB: p.L521P

Protein Change: L521P
Organisms: Mycobacterium bovis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India.

PMID 11796356 · 2002

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.D516V rpoB: p.R447H rpoB: p.K446N rpoB: p.S441Q rpoB: p.N437T rpoB: p.L430V

Protein Change: D516V, R447H, K446N, S441Q, N437T, L430V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Validation Method: sequencing
Source Database: ReslitCard Database

Biological cost of rifampin resistance from the perspective of Staphylococcus aureus.

PMID 12384339 · 2002

Mutations in rpoB confer rifampin resistance

rpoB

Mutation Information

rpoB: p.H481N rpoB: p.S464P rpoB: p.Q468L rpoB: p.Q468R rpoB: p.D471E rpoB: p.D471G rpoB: p.D471Y rpoB: p.N474L rpoB: p.A477D rpoB: p.A477V rpoB: p.H481Y rpoB: p.R484H rpoB: p.S486L rpoB: p.I527F

Protein Change: H481N, S464P, Q468L, Q468R, D471E, D471G, D471Y, N474L, A477D, A477V, H481Y, R484H, S486L, I527F
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicinbeta lactams|rifampicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Validation Method: partial DNA sequencing of the rpoB gene
Source Database: ReslitReference Gene Catalog

Isolation of three Mycobacterium ulcerans strains resistant to rifampin after experimental chemotherapy of mice.

PMID 12654651 · 2003

Mutation Information

rpoB: p.S416F rpoB: p.H420Y

Protein Change: S416F, H420Y
Organisms: Mycobacterium ulcerans
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

Drug-susceptible Mycobacterium tuberculosis Beijing genotype does not develop mutation-conferred resistance to rifampin at an elevated rate.

PMID 12682139 · 2003

Mutations in rpoB gene associated with rifampin resistance

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: experimental validation
Source Database: Reslit

Multiple rpoB mutants of Mycobacterium tuberculosis and second-order selection.

PMID 15338545 · 2004

Mutations in rpoB are associated with rifampin resistance in M. tuberculosis.

Mutation Information

rpoB: p.I517M rpoB: p.V466A rpoB: p.D461N rpoB: p.H471N rpoB: p.H471L rpoB: p.H471Y rpoB: p.A467T

Protein Change: S531L, H526Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: experimental data from clinical isolates
Source Database: Reslit

Rifampin-resistant RNA polymerase mutants of Chlamydia trachomatis remain susceptible to the ansamycin rifalazil.

PMID 15728912 · 2005

Mutation Information

Protein Change: I517M, V466A, D461N, H471N, H471L, H471Y, A467T
Organisms: Chlamydia trachomatis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing and MIC testing
Source Database: Reslit

Cross-resistance of Escherichia coli RNA polymerases conferring rifampin resistance to different antibiotics.

PMID 15805525 · 2005

Mutations in the rpoB gene encoding the beta subunit of RNA polymerase confer resistance to rifampin and related antibiotics.

Mutation Information

rpoB: p.Q513L rpoB: p.Q513P rpoB: p.D516N rpoB: p.S522F rpoB: p.H526Y rpoB: p.R529C rpoB: p.S531F rpoB: p.T563P rpoB: p.P564L rpoB: p.I572F rpoB: p.R687H

Protein Change: Q513L, Q513P, D516N, S522F, H526Y, R529C, S531F, T563P, P564L, I572F, R687H
Organisms: Escherichia coli
Confers Resistance To: rifampicin|rifabutin|rifapentinerifampicin
Validation Method: in vitro transcription assay
Source Database: Reslit

Detection of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis using denaturing gradient gel electrophoresis.

PMID 15917513 · 2005

all mutations are in the rpoB gene and confer resistance to rifampin

Mutation Information

Protein Change: V146F, G438G, Q510H, H511Y, L511P, D516G, D516V, D516Y, D516E, H526N, H526R, H526D, H526C, H526Y, H526S, H526L, S526A, S531Y, S531L, S531W, S531F, E562L, P564S, I572F, I572L, P622Q, E641E, V642A, P646S, P646L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: dgge and dna sequencing
Source Database: Reslit

Acquisition of rifabutin resistance by a rifampicin resistant mutant of Mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency.

PMID 15958167 · 2005

Mutations in the rpoB gene were identified through sequencing of gene fragments.

Mutation Information

rpoB: p.S522L rpoB: p.H526Y rpoB: p.S531L rpoB: p.F505L rpoB: p.S512G rpoB: p.V144M rpoB: p.V146F rpoB: p.Q148H

Protein Change: S522L, H526Y, S531L, F505L, S512G, V144M, V146F, Q148H
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicinrifampicin|rifabutinrifabutin
Validation Method: sequencing of rpoB gene fragments
Source Database: Reslit

Molecular genetic and structural modeling studies of Staphylococcus aureus RNA polymerase and the fitness of rifampin resistance genotypes in relation to clinical prevalence.

PMID 16377701 · 2006

Mutations in the rpoB gene were identified as conferring rifampin resistance in Staphylococcus aureus.

Mutation Information

rpoB: p.H481N rpoB: p.H481Y rpoB: p.L466S rpoB: p.S529L rpoB: p.A477D rpoB: p.V850A

Protein Change: H481N, H481Y, L466S, S529L, A477D, V850A
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: PCR amplification and DNA sequencing; expression in laboratory strain and fitness cost assessment; identification in clinical isolate and fitness cost compensation; clinical prevalence analysis
Source Database: Reslit

Rapid detection of rifampin resistance in Mycobacterium tuberculosis by Pyrosequencing technology.

PMID 16757581 · 2006

Mutations in the rpoB gene are associated with rifampin resistance

Mutation Information

rpoB: p.L511P rpoB: p.D516G rpoB: p.S531L

Protein Change: L511P, D516G, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: pyrosequencing
Source Database: Reslit

Molecular epidemiological and antibiotic susceptibility characterization of Brucella isolates from humans in Sicily, Italy.

PMID 17634297 · 2007

The mutation was not associated with the RIF resistance phenotype.

Mutation Information

rpoB: p.M1249I

Protein Change: M1249I
Organisms: Brucella melitensis
Confers Resistance To: rifampicin
Validation Method: rpoB sequencing
Source Database: Reslit

Interstrain gene transfer in Chlamydia trachomatis in vitro: mechanism and significance.

PMID 18083799 · 2008

Mutation Information

rpoB: p.S467F

Protein Change: S467F
Organisms: Chlamydia trachomatis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.

PMID 18443108 · 2008

Mutation Information

rpoB: p.H502Y rpoB: p.H502N rpoB: p.H502R rpoB: p.R505K rpoB: p.S488T rpoB: p.I548M

Protein Change: H481Y
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: mutant selection and genotypic analysis
Source Database: Reslit

Rifampin and rifaximin resistance in clinical isolates of Clostridium difficile.

PMID 18559647 · 2008

Mutations in rpoB are associated with rifampin and rifaximin resistance in C. difficile

Clostridioides difficile rpoB with mutation conferring resistance to rifampicin; CARD accession: CARD:3004563

Mutation Information

Protein Change: H502Y, H502N, H502R, R505K, S488T, I548M
Organisms: Clostridium difficile, Clostridium ljungdahlii
Confers Resistance To: rifampicin|rifaximinrifampicin
Effect on Function: single resistance variant
Validation Method: sequence analysis
Source Database: ReslitCard Database

High frequency of rifampin resistance identified in an epidemic Clostridium difficile clone from a large teaching hospital.

PMID 19140738 · 2009

All rifampin-resistant isolates contained the R505K substitution

Clostridioides difficile rpoB with mutation conferring resistance to rifampicin; CARD accession: CARD:3004563

rpoB

Mutation Information

rpoB: p.R505K rpoB: p.H502N

Protein Change: R505K, H502N
Organisms: Clostridium difficile, Clostridium ljungdahlii, Clostridioides difficile
Confers Resistance To: rifampicin
Effect on Function: single resistance variant; DNA-directed RNA polymerase subunit beta RpoB
Validation Method: sequencing of rpoB gene and correlation with rifampin resistance
Source Database: ReslitCard DatabaseReference Gene Catalog

Genetic evaluation of relationship between mutations in rpoB and resistance of Mycobacterium tuberculosis to rifampin.

PMID 19146699 · 2009

Some mutations in the rpoB gene can reveal drug-resistant phenotype only in a specific genetic background of the host.

Mutation Information

rpoB: p.Q513L rpoB: p.D516V rpoB: p.D516Y rpoB: p.D516G rpoB: p.H526D rpoB: p.S531L

Protein Change: Q513L, D516V, D516Y, D516G, H526D, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: cloning in M. tuberculosis H37Ra and susceptibility testing
Source Database: Reslit

Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa.

PMID 19890396 · 2009

Mutation Information

rpoB: p.D435Y rpoB: p.D435G rpoB: p.L452P rpoB: p.I1106T

Protein Change: D435Y, D435G, L452P, I1106T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

Rapid screening of MDR-TB using molecular Line Probe Assay is feasible in Uganda.

PMID 20187922 · 2010

Mutation Information

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: line probe assay
Source Database: Reslit

Validation of the GenoType MTBDRplus assay for diagnosis of multidrug resistant tuberculosis in South Vietnam.

PMID 20525271 · 2010

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType MTBDR plus test
Source Database: Reslit

Drug resistant Mycobacterium tuberculosis of the Beijing genotype does not spread in Sweden.

PMID 20531942 · 2010

associated with multidrug resistance

Mutation Information

rpoB: p.S548F rpoB: p.H552R rpoB: p.H552N rpoB: p.H552L rpoB: p.H552Y rpoB: p.S557F rpoB: p.D542V rpoB: p.D542N rpoB: p.G560S rpoB: p.D543N rpoB: p.D543V rpoB: p.H553L rpoB: p.H553N rpoB: p.H553R rpoB: p.H553Y rpoB: p.S558F

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: association with drug resistance
Source Database: Reslit

Multicenter study for defining the breakpoint for rifampin resistance in Neisseria meningitidis by rpoB sequencing.

PMID 20606072 · 2010

Mutations in rpoB are associated with rifampin resistance in N. meningitidis.

rpoB

Mutation Information

Protein Change: S548F, H552R, H552N, H552L, H552Y, S557F, D542V, D542N, G560S, D543N, D543V, H553L, H553N, H553R, H553Y, S558F
Organisms: Neisseria meningitidis
Confers Resistance To: rifampicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Validation Method: transformation of N. meningitidis with rpoB amplicons and MIC testing
Source Database: ReslitReference Gene Catalog

Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.

PMID 20713679 · 2010

Previously reported

Mutation Information

rpoB: p.S531L rpoB: p.Q510P rpoB: p.L511V rpoB: p.D516V rpoB: p.H526Y

Protein Change: S531L, Q510P, L511V, D516V, H526Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

Rapid Detection of Multidrug-Resistant Mycobacterium tuberculosis by Use of Real-Time PCR and High-Resolution Melt Analysis.

PMID 20810777 · 2010

Mutation Information

rpoB: p.D516V rpoB: p.H526Y rpoB: p.S531L

Protein Change: D516V, H526Y, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: real-time PCR and high-resolution melt analysis
Source Database: Reslit

Rapid pneumococcal evolution in response to clinical interventions.

PMID 21273480 · 2011

Mutation Information

rpoB: p.H499R

Protein Change: H499R
Organisms: Streptococcus pneumoniae
Confers Resistance To: rifampicin
Validation Method: sequence analysis
Source Database: Reslit

Genetic variation of Mycobacterium tuberculosis circulating in Kharkiv Oblast, Ukraine.

PMID 21439097 · 2011

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

Mycobacterium tuberculosis spoligotypes and drug susceptibility pattern of isolates from tuberculosis patients in South-Western Uganda.

PMID 21453482 · 2011

Three isolates had this mutation.

Mutation Information

rpoB: p.D516V rpoB: p.D516Y rpoB: p.D516F rpoB: p.H526L rpoB: p.H526S rpoB: p.H526D rpoB: p.H526Y rpoB: p.H526R rpoB: p.S531L rpoB: p.S531W rpoB: p.L533P rpoB: p.V176F rpoB: p.P206T rpoB: p.Y314T rpoB: p.H323T

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotype MTBDRplus assay
Source Database: Reslit

Dynamics of antibiotic resistant Mycobacterium tuberculosis during long-term infection and antibiotic treatment.

PMID 21698208 · 2011

The GAC516GTC mutation in rpoB is responsible for rifampicin resistance.

Mutation Information

rpoB: p.H516Y

Protein Change: H516Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

Clonal population of Mycobacterium tuberculosis strains reside within multiple lung cavities.

PMID 21935462 · 2011

Mutation Information

rpoB: p.L531V

Protein Change: L531V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genetic sequence analysis
Source Database: Reslit

The beginning of the rpoB gene in addition to the rifampin resistance determination region might be needed for identifying rifampin/rifabutin cross-resistance in multidrug-resistant Mycobacterium tuberculosis isolates from Southern China.

PMID 22075601 · 2012

Mutation Information

Protein Change: D516V, D516Y, D516F, H526L, H526S, H526D, H526Y, H526R, S531L, S531W, L533P, V176F, P206T, Y314T, H323T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicinrifampicin|rifabutin
Validation Method: DNA sequencing
Source Database: Reslit

International spread of MDR TB from Tugela Ferry, South Africa.

PMID 22099091 · 2011

rpoB mutation associated with rifampin resistance

Mutation Information

rpoB: p.L533P

Protein Change: L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: automated sequencing
Source Database: Reslit

Comprehensive multicenter evaluation of a new line probe assay kit for identification of Mycobacterium species and detection of drug-resistant Mycobacterium tuberculosis.

PMID 22205814 · 2012

The I572F mutation was associated with rifampin resistance.

Mutation Information

rpoB: p.I572F

Protein Change: I572F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: LiPA and DNA sequencing
Source Database: Reslit

Rapid detection of rpoB mutations in rifampin resistant M. tuberculosis from sputum samples by denaturing gradient gel electrophoresis.

PMID 22253562 · 2012

mutations in rpoB gene associated with rifampin resistance

Mutation Information

rpoB: p.H526D rpoB: p.H526Y rpoB: p.H526L rpoB: p.S531L rpoB: p.S531W

Protein Change: H526D, H526Y, H526L, S531L, S531W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: dgge and dna sequencing
Source Database: Reslit

Molecular characterization of multidrug- and extensively drug-resistant Mycobacterium tuberculosis strains in Jiangxi, China.

PMID 22553245 · 2012

Includes several novel mutations

Mutation Information

rpoB: p.I569V rpoB: p.I572M rpoB: p.F584S rpoB: p.V615M rpoB: p.D626E rpoB: p.K972T

Protein Change: I569V, I572M, F584S, V615M, D626E, K972T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

Genetic determinants of drug-resistant tuberculosis among HIV-infected patients in Nigeria.

PMID 22740709 · 2012

Mutation Information

rpoB: p.H526Y rpoB: p.H526N rpoB: p.H526R rpoB: p.L533P rpoB: p.S531L rpoB: p.L511P rpoB: p.D516A

Protein Change: H526Y, H526N, H526R, L533P, S531L, L511P, D516A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

Molecular detection and drug resistance of Mycobacterium tuberculosis complex from cattle at a dairy farm in the Nkonkobe region of South Africa: a pilot study.

PMID 22829789 · 2012

Mutation Information

rpoB: p.S177L rpoB: p.S105T rpoB: p.M102I rpoB: p.A30V rpoB: p.T54A rpoB: p.T34I

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Genotype MTBDR plus assay
Source Database: Reslit

Drug-resistant tuberculosis transmission and resistance amplification within families.

PMID 22840848 · 2012

Mutation Information

Protein Change: S177L, S105T, M102I, A30V, T54A, T34I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicinisoniazidethambutolofloxacin
Validation Method: DNA sequencing
Source Database: Reslit

In vivo selection of rifamycin-resistant Clostridium difficile during rifaximin therapy.

PMID 22908175 · 2012

The patient developed resistance to rifaximin, leading to the emergence of resistant C. difficile isolates.

Clostridioides difficile rpoB with mutation conferring resistance to rifampicin; CARD accession: CARD:3004563

rpoB

Mutation Information

rpoB: p.H502Y rpoB: p.P496S

Protein Change: H502Y, P496S
Organisms: Clostridium difficile, Clostridium ljungdahlii, Clostridioides difficile
Confers Resistance To: rifampicinrifamycins
Effect on Function: single resistance variant; DNA-directed RNA polymerase subunit beta RpoB
Validation Method: sequencing
Source Database: ReslitCard DatabaseReference Gene Catalog

Characterization of Rif R Mutants of Photorhabdus luminescens LN2 and Their Effects on Nematicidal Activity

PMID 22912803 · 2012

Mutations in rpoB gene were responsible for Rif-resistance and loss of nematicidal activity.

Mutation Information

rpoB: p.P564L

Protein Change: P564L
Organisms: Photorhabdus luminescens
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

Contribution of selected gene mutations to resistance in clinical isolates of vancomycin-intermediate Staphylococcus aureus.

PMID 22948864 · 2012

Mutation Information

rpoB: p.H481Y rpoB: p.H481N rpoB: p.D471G rpoB: p.R483H rpoB: p.A477D rpoB: p.S464P

Protein Change: H481Y, H481N, D471G, R483H, A477D, S464P
Organisms: Staphylococcus aureus
Confers Resistance To: vancomycin
Validation Method: sequencing
Source Database: Reslit

Dominant incidence of multidrug and extensively drug-resistant specific Mycobacterium tuberculosis clones in Osaka Prefecture, Japan.

PMID 22952596 · 2012

Mutation Information

rpoB: p.D516V rpoB: p.S531L

Protein Change: D516V, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

Study of the rifampin monoresistance mechanism in Mycobacterium tuberculosis.

PMID 23208715 · 2013

Mutations in the rpoB gene are responsible for rifampin resistance.

Mutation Information

rpoB: p.H526D rpoB: p.H526G rpoB: p.H526L rpoB: p.H526R rpoB: p.L533P rpoB: p.S531L

Protein Change: H526D, H526G, H526L, H526R, L533P, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: disrupted the intermolecular hydrogen bond between wild-type His526 and the RIF molecule; had hydrogen bond contact with and electrostatic attraction to the RIF molecule; did not significantly change the intermolecular interaction between RpoB and RIF; disrupted the intermolecular hydrogen bond between wild-type Ser531 and the RIF molecule
Validation Method: DNA sequencing and MIC measurements
Source Database: Reslit

Primary multidrug-resistant leprosy, United States.

PMID 23260417 · 2013

Mutation Information

rpoB: p.S425L

Protein Change: S425L
Organisms: Mycobacterium leprae
Confers Resistance To: rifampicin
Validation Method: PCR/DNA sequencing
Source Database: Reslit

First Evaluation of GenoType MTBDRplus 2.0 Performed Directly on Respiratory Specimens in Central America.

PMID 27440816 · 2016

Mutation Information

rpoB: p.H526D rpoB: p.S531L

Protein Change: H526D, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genomic sequencing and GenoType MTBDR plus 2.0 assay
Source Database: Reslit

Evaluation of MTBDRplus and MTBDRsl in Detecting Drug-Resistant Tuberculosis in a Chinese Population.

PMID 27524852 · 2016

Mutation Information

rpoB: p.Q489K rpoB: p.D492V

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

Coinfection and Emergence of Rifamycin Resistance during a Recurrent Clostridium difficile Infection.

PMID 27558181 · 2016

Mutation Information

Protein Change: Q489K, D492V
Organisms: Clostridium difficile
Confers Resistance To: rifampicin|rifaximin
Validation Method: sequencing
Source Database: Reslit

Mechanisms of first-line antimicrobial resistance in multi-drug and extensively drug resistant strains of Mycobacterium tuberculosis in KwaZulu-Natal, South Africa.

PMID 27784282 · 2016

Multiple mutations in rpoB were associated with RIF resistance

Mutation Information

rpoB: p.D435G rpoB: p.L452P rpoB: p.S450L rpoB: p.D435Y rpoB: p.P454T rpoB: p.H445L rpoB: p.I491M rpoB: p.Y564H

Protein Change: D435G, L452P, S450L, D435Y, P454T, H445L, I491M, Y564H
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing and MIC testing
Source Database: Reslit

Novel rapid PCR for the detection of Ile491Phe rpoB mutation of Mycobacterium tuberculosis, a rifampicin-resistance-conferring mutation undetected by commercial assays.

PMID 27998822 · 2017

Mutation Information

rpoB: p.R505K rpoB: p.H502N rpoB: p.S485F

Protein Change: I491F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: real-time multiplex allele-specific PCR and rpoB sequencing
Source Database: Reslit

Comparative Genome Analysis and Global Phylogeny of the Toxin Variant Clostridium difficile PCR Ribotype 017 Reveals the Evolution of Two Independent Sublineages.

PMID 28031436 · 2017

Mutation Information

Protein Change: R505K, H502N, S485F
Organisms: Clostridium difficile
Confers Resistance To: rifampicin
Validation Method: SNP analysis and MIC testing
Source Database: Reslit

Evaluation of rifampicin resistance and 81-bp rifampicin resistant determinant region of rpoB gene mutations of Mycobacterium tuberculosis detected with XpertMTB/Rif in Cross River State, Nigeria.

PMID 28043515 · 2016

Mutations in the rpoB gene were identified as the primary cause of rifampicin resistance in Mycobacterium tuberculosis.

Mutation Information

rpoB: p.S531L rpoB: p.H529Y rpoB: p.R518L

Protein Change: S531L, H529Y, R518L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: XpertMTB/Rif assay
Source Database: Reslit

Molecular drug susceptibility testing against the first-line (rifampin and isoniazid) and second-line (ciprofloxacin-amikacin and kanamycin) treatment in different subtypes of Mycobacterium simiae.

PMID 28043563 · 2016

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium simiae
Confers Resistance To: rifampicin
Validation Method: molecular drug susceptibility testing
Source Database: Reslit

Antimicrobial Resistance Mechanisms in Mycobacterium tuberculosis: Role of Efflux Pumps and Mutations

PMID 28496433 · 2023

Mutation Information

rpoB: p.D516Y

Protein Change: D516Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MIC testing and mutation analysis
Source Database: Reslit

Clinical and bacteriological characteristics associated with clustering of multidrug-resistant tuberculosis.

PMID 28513421 · 2017

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: pyrosequencing
Source Database: Reslit

Frequency of multi-drug resistance and mutations in Mycobacterium tuberculosis isolates from Punjab state of India.

PMID 28756826 · 2017

Commonest known mutation for RIF resistance

Mutation Information

rpoB: p.S531L rpoB: p.D516Y rpoB: p.D516V rpoB: p.H526Y rpoB: p.D516G rpoB: p.H526G rpoB: p.H526P rpoB: p.S531W rpoB: p.S531C rpoB: p.D516A rpoB: p.S531A rpoB: p.H526Q rpoB: p.L533P

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: Reslit

Sequence analysis of the rifampicin resistance determining region (RRDR) of rpoB gene in multidrug resistance confirmed and newly diagnosed tuberculosis patients of Punjab, Pakistan.

PMID 28817723 · 2017

mutations in rpoB gene associated with rifampicin resistance

Mutation Information

Protein Change: S531L, D516Y, D516V, H526Y, D516G, H526G, H526P, S531W, S531C, D516A, S531A, H526Q, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing of rpoB gene
Source Database: Reslit

Emergence and clonal transmission of multi-drug-resistant tuberculosis among patients in Chad.

PMID 28830384 · 2017

Mutation Information

rpoB: p.L511P rpoB: p.D516G rpoB: p.H526N

Protein Change: H526Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

Rifabutin Resistance Associated with Double Mutations in rpoB Gene in Mycobacterium tuberculosis Isolates.

PMID 28959248 · 2017

Mutations in rpoB gene are associated with rifabutin resistance

Mutation Information

Protein Change: L511P, D516G, H526N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifabutin
Validation Method: DNA sequencing and MIC determination
Source Database: Reslit

Comparative Genomic Analysis of Two Clonally Related Multidrug Resistant Mycobacterium tuberculosis by Single Molecule Real Time Sequencing.

PMID 29188195 · 2017

Mutation Information

rpoB: p.S517F rpoB: p.Q518R rpoB: p.Q518L rpoB: p.D521G rpoB: p.H531Y rpoB: p.H531L rpoB: p.S536F rpoB: p.L538I rpoB: p.S579F rpoB: p.S579Y rpoB: p.N629S rpoB: p.D636Y

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Sanger sequencing and MIC testing
Source Database: Reslit

The Versatile Mutational Resistome of Pseudomonas aeruginosa.

PMID 29681898 · 2018

Mutation Information

Protein Change: S517F, Q518R, Q518L, D521G, H531Y, H531L, S536F, L538I, S579F, S579Y, N629S, D636Y
Organisms: Pseudomonas aeruginosa
Confers Resistance To: rifampicin
Validation Method: experimental data generated in this study
Source Database: Reslit

RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates.

PMID 32011233 · 2020

The rpoB R201H mutation was identified in CRO RS isolates and confirmed to confer resistance through transformation experiments.

rpoB

Mutation Information

rpoB: p.R201H rpoB: p.P157L rpoB: p.G158V

Protein Change: R201H, P157L, G158V
Organisms: Neisseria gonorrhoeae
Confers Resistance To: ceftriaxonecephalosporins
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Validation Method: whole genome sequencing and transformation experiments
Source Database: ReslitReference Gene Catalog

Genetic Identification and Drug-Resistance Characterization of Mycobacterium tuberculosis Using a Portable Sequencing Device. A Pilot Study.

PMID 32867304 · 2020

Mutation in rpoB gene associated with rifampicin resistance.

Mutation Information

rpoB: p.A477D rpoB: p.A621E

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing and analysis using MinION and previous whole genome analysis
Source Database: Reslit

Genomic and Long-Term Transcriptomic Imprints Related to the Daptomycin Mechanism of Action Occurring in Daptomycin- and Methicillin-Resistant Staphylococcus aureus Under Daptomycin Exposure.

PMID 32922373 · 2020

Mutations in rpoB gene leading to increased dlt operon expression and positive cell surface charge

Mutation Information

Protein Change: A477D, A621E
Confers Resistance To: daptomycin
Validation Method: whole-genome sequencing and molecular characterization
Source Database: Reslit

Identification and characterization of mutations responsible for the β-lactam resistance in oxacillin-susceptible mecA-positive Staphylococcus aureus.

PMID 33037239 · 2020

Mutation Information

rpoB: p.Q645H rpoB: p.V1016E rpoB: p.H1042Q

Protein Change: Q645H, V1016E, H1042Q
Organisms: Staphylococcus aureus
Confers Resistance To: oxacillin
Validation Method: MIC determination
Source Database: Reslit

Identification of a novel tedizolid resistance mutation in rpoB of MRSA after in vitro serial passage.

PMID 33057715 · 2021

The rpoB mutation was associated with resistance to multiple antimicrobials.

Mutation Information

rpoB: p.D449N

Protein Change: D449N
Organisms: Staphylococcus aureus
Confers Resistance To: phenicols|linezolid|retapamulin|quinupristin dalfopristin
Validation Method: whole genome sequencing and susceptibility testing
Source Database: Reslit

Prediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches.

PMID 33093532 · 2020

The mutation I491F was identified as a low confidence mutation in the Miotto et al. study, showing weak clinical resistance evidence.

Mutation Information

Protein Change: I491F
Organisms: Mycobacterium tuberculosis, Mycobacterium leprae, Pseudomonas aeruginosa, Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: structural analysis and computational modeling
Source Database: Reslit

Rifampin, Rifapentine, and Rifabutin Are Active against Intracellular Periprosthetic Joint Infection-Associated Staphylococcus epidermidis.

PMID 33199387 · 2021

The rpoB gene mutations were identified in rifampin-resistant isolates.

Mutation Information

rpoB: p.D471E

Protein Change: D471E
Organisms: Staphylococcus epidermidis
Confers Resistance To: rifampicin
Validation Method: experimental validation
Source Database: Reslit

Analysis of drug resistance and mutation profiles in Mycobacterium tuberculosis isolates in a surveillance site in Beijing, China.

PMID 33461383 · 2021

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: line probe assay
Source Database: Reslit

Drug Resistance Conferring Mutation and Genetic Diversity of Mycobacterium tuberculosis Isolates in Tuberculosis Lymphadenitis Patients; Ethiopia.

PMID 33623398 · 2021

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType MTBDRplus VER 2.0
Source Database: Reslit

Tale of compounding oddities.

PMID 33664024 · 2021

The S512T mutation in the rpoB gene was identified as a high-confidence mutation conferring rifampicin resistance.

Mutation Information

rpoB: p.S512T

Protein Change: S512T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: pyrosequencing and Xpert MTB/Rif
Source Database: Reslit

A platform for detecting cross-resistance in antibacterial drug discovery.

PMID 33755133 · 2021

Mutation Information

rpoB: p.V170F rpoB: p.I491F rpoB: p.S450L

Protein Change: H481Y
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: PCR amplification and DNA sequencing
Source Database: Reslit

Compensatory effects of M. tuberculosis rpoB mutations outside the rifampicin resistance-determining region.

PMID 33775224 · 2021

Mutations P45L, P45S, I480V, V534M, and R827L are compensatory mutations that improve the fitness of the S450L mutant.

Mutation Information

Protein Change: V170F, I491F, S450L
Organisms: Mycobacterium smegmatis
Confers Resistance To: rifampicin
Effect on Function: confers rifampicin resistance
Validation Method: transformation and MIC analysis
Source Database: Reslit

The DnaK Chaperone System Buffers the Fitness Cost of Antibiotic Resistance Mutations in Mycobacteria.

PMID 33785614 · 2021

Mutations in rpoB confer rifampin resistance and require DnaK system for fitness.

Mutation Information

rpoB: p.S447L

Protein Change: S447L
Organisms: Mycobacterium smegmatis
Confers Resistance To: rifampicin
Validation Method: competition experiments and fitness assays
Source Database: Reslit

DNA Breaks-Mediated Fitness Cost Reveals RNase HI as a New Target for Selectively Eliminating Antibiotic-Resistant Bacteria.

PMID 33830249 · 2021

Rif R mutation

Mutation Information

rpoB: p.H526L rpoB: p.H526Y rpoB: p.S531F rpoB: p.H526T

Protein Change: H526L, H526Y, S531F, H526T
Confers Resistance To: rifampicin
Validation Method: experimental validation; competitive fitness assays and SOS induction assays
Source Database: Reslit

Microevolution of Mycobacterium tuberculosis Subpopulations and Heteroresistance in a Patient Receiving 27 Years of Tuberculosis Treatment in Germany.

PMID 33903103 · 2021

Mutation Information

rpoB: p.L430P rpoB: p.D435G rpoB: p.F424V

Protein Change: L430P, D435G, F424V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

Computational modeling and bioinformatic analyses of functional mutations in drug target genes in Mycobacterium tuberculosis.

PMID 34025934 · 2021

Mutation Information

Protein Change: D441F, D441N, D441V, D441Y, H451R, H451N, H451Q, H451C, H451P, H451T, S456F, S456P, S456Q, S456W, S456Y, A75V, V976M, D1012G, L1128Q, D441C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: computational analysis; molecular docking and structural analysis; molecular docking and MIC testing
Source Database: Reslit

Dependence of Xpert MTB/RIF Accuracy for Detecting Rifampin Resistance in Bronchoalveolar Lavage Fluid on Bacterial Load: A Retrospective Study in Beijing, China.

PMID 34234473 · 2021

Mutations identified in rpoB gene associated with rifampicin resistance.

Mutation Information

rpoB: p.S531F rpoB: p.S531L rpoB: p.S531Y

Protein Change: H526Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Sanger sequencing
Source Database: Reslit

Antimicrobial Resistance Spectrum Conferred by pRErm46 of Emerging Macrolide (Multidrug)-Resistant Rhodococcus equi.

PMID 34319806 · 2021

Mutations in rpoB confer resistance to rifampin.

Mutation Information

Protein Change: S531F, S531L, S531Y
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

Investigation of the Rv3065, Rv2942, Rv1258c, Rv1410c, and Rv2459 efflux pump genes expression among multidrug-resistant Mycobacterium tuberculosis clinical isolates.

PMID 34337183 · 2021

Mutation Information

rpoB: p.S531L rpoB: p.H526T rpoB: p.L533P

Protein Change: S531L, H526T, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

Early detection of MDR Mycobacterium tuberculosis mutations in Pakistan.

PMID 34408186 · 2021

Mutations in rpoB are associated with Rifampicin resistance.

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

Comparative proteomic investigation of multiple methicillin-resistant Staphylococcus aureus strains generated through adaptive laboratory evolution.

PMID 34458699 · 2021

Mutations in rpoB confer resistance to rifampin.

Mutation Information

rpoB: p.Q458K rpoB: p.H471N rpoB: p.H471Y rpoB: p.A467E rpoB: p.S476L rpoB: p.I517L rpoB: p.Q458L rpoB: p.A467V rpoB: p.I517M rpoB: p.V466A rpoB: p.D461N rpoB: p.A467T rpoB: p.D461E rpoB: p.M515I

Protein Change: H481Y
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

Antimicrobial Resistance in Chlamydia trachomatis: Mechanisms and Mutations

PMID 34479551 · 2023

Mutations in rpoB are associated with rifampin resistance in C. trachomatis.

Mutation Information

Protein Change: Q458K, H471N, H471Y, A467E, S476L, I517L, Q458L, A467V, I517M, V466A, D461N, A467T, D461E, M515I
Organisms: Chlamydia trachomatis
Confers Resistance To: rifampicinrifamycins
Validation Method: PCR and sequencing; sequencing
Source Database: Reslit

Transmission of multidrug-resistant tuberculosis in Shimen community in Shanghai, China: a molecular epidemiology study.

PMID 34715793 · 2021

Mutation Information

Protein Change: S450L
Confers Resistance To: rifampicin
Validation Method: whole_genome_sequencing
Source Database: Reslit

Practical approach to detection and surveillance of emerging highly resistant Mycobacterium tuberculosis Beijing 1071-32-cluster.

PMID 34725411 · 2021

Mutation in rpoB

Mutation Information

rpoB: p.H481N rpoB: p.L466S rpoB: p.A473T rpoB: p.H481Y rpoB: p.A477D

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Rifoligotyping
Source Database: Reslit

Molecular Characteristics of Rifampin-Sensitive and -Resistant Isolates and Characteristics of rpoB Gene Mutations in Methicillin-Resistant Staphylococcus aureus.

PMID 34764656 · 2021

mutations in rpoB gene associated with rifampin resistance

Mutation Information

Protein Change: H481N, L466S, A473T, H481Y, A477D
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: MIC testing
Source Database: Reslit

The whole-genome sequencing in predicting Mycobacterium tuberculosis drug susceptibility and resistance in Papua, Indonesia.

PMID 34802420 · 2021

Mutation Information

rpoB: p.S450L rpoB: p.D435Y rpoB: p.H445Y rpoB: p.L430P rpoB: p.Q432K

Protein Change: S450L, D435Y, H445Y, L430P, Q432K
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing and mutation analysis
Source Database: Reslit

A Survey of Spontaneous Antibiotic-Resistant Mutants of the Halophilic, Thermophilic Bacterium Rhodothermus marinus.

PMID 34827322 · 2021

Mutations in rpoB gene

Mutation Information

rpoB: p.S450L rpoB: p.D435V rpoB: p.H445A rpoB: p.H445P rpoB: p.Q172R rpoB: p.Q432P rpoB: p.Q432K

Protein Change: S450L
Organisms: Rhodothermus marinus
Confers Resistance To: rifampicin
Validation Method: Sanger sequencing of PCR products
Source Database: Reslit

Whole-genome sequencing of Mycobacterium tuberculosis for prediction of drug resistance.

PMID 35086603 · 2022

Multiple mutations in rpoB were associated with rifampicin resistance.

Mutation Information

Protein Change: S450L, D435V, H445A, H445P, Q172R, Q432P, Q432K
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing and phenotypic resistance testing
Source Database: Reslit

The Regulation of ManLAM-Related Gene Expression in Mycobacterium tuberculosis with Different Drug Resistance Profiles Following Isoniazid Treatment.

PMID 35153492 · 2022

Mutation Information

rpoB: p.D516V rpoB: p.H526D

Protein Change: D516V, H526D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequence analysis
Source Database: Reslit

Drug-Resistant Characteristics, Genetic Diversity, and Transmission Dynamics of Rifampicin-Resistant Mycobacterium tuberculosis in Hunan, China, Revealed by Whole-Genome Sequencing.

PMID 35171016 · 2022

Mutation Information

rpoB: p.S450L rpoB: p.H445L rpoB: p.H445Y rpoB: p.I491F rpoB: p.V170F rpoB: p.E761D

Protein Change: S450L, H445L, H445Y, I491F, V170F, E761D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

Snapshot of Mycobacterium tuberculosis Phylogenetics from an Indian State of Arunachal Pradesh Bordering China.

PMID 35205308 · 2022

Mutation Information

rpoB: p.D203E rpoB: p.R184H rpoB: p.R184C rpoB: p.S186F rpoB: p.V471E rpoB: p.V474E

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

Rapid Decline of Ceftazidime Resistance in Antibiotic-Free and Sublethal Environments Is Contingent on Genetic Background.

PMID 35291010 · 2022

original mutation in MDR6-CAZ

Mutation Information

Protein Change: D203E, R184H, R184C, S186F, V471E, V474E
Organisms: Pseudomonas aeruginosa
Confers Resistance To: ceftazidimeceftazidime|rifampicin
Validation Method: whole-genome sequencing; molecular modeling and whole-genome sequencing; whole-genome sequencing and MIC measurements
Source Database: Reslit

Molecular Epidemiology of Mycobacterium tuberculosis Complex Strains in Urban and Slum Settings of Nairobi, Kenya.

PMID 35328028 · 2022

Mutation Information

rpoB: p.S450L rpoB: p.H445Y rpoB: p.H445R rpoB: p.H445D rpoB: p.Q432P

Protein Change: S450L, H445Y, H445R, H445D, Q432P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

Molecular mechanism of antibiotic resistance induced by mono- and twin-chained quaternary ammonium compounds.

PMID 35398118 · 2022

Mutation Information

rpoB: p.D342G

Protein Change: D342G
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Effect on Function: mutations in specific positions of the coding sequences are known to affect the binding of drugs to RNAP, leading to drug resistance
Validation Method: whole-genome sequencing
Source Database: Reslit

100

Antimicrobial Resistance in Mycobacterium tuberculosis Clinical Isolates from HIV-Positive and HIV-Negative Patients in Russia

PMID 35590243 · 2021

Mutation Information

rpoB: p.L511P rpoB: p.D516A rpoB: p.D516V rpoB: p.D516Y rpoB: p.S522L rpoB: p.H526D rpoB: p.H526P rpoB: p.H526L rpoB: p.H526Y rpoB: p.S531L rpoB: p.L533P

Protein Change: L511P, D516A, D516V, D516Y, S522L, H526D, H526P, H526L, H526Y, S531L, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Phenotypic drug susceptibility testing and mutation analysis
Source Database: Reslit

101

Transmission of multidrug-resistant tuberculosis in Jiangxi, China, and associated risk factors.

PMID 39356166 · 2024

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

102

Multidrug-resistant tuberculosis clusters and transmission in Taiwan: a population-based cohort study.

PMID 39360329 · 2024

This mutation is associated with rifampicin resistance.

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

103

A novel dual probe-based method for mutation detection using isothermal amplification.

PMID 39436873 · 2024

Mutations at codons 516, 526, and 531 of rpo B were analyzed.

Mutation Information

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: dual probe method with LAMP
Source Database: Reslit

104

Meningococcal C Disease Outbreak Caused by Multidrug-Resistant Neisseria meningitidis, Fiji.

PMID 39714270 · 2025

Only 1 strain contained the rpoB point mutation H553Y.

Mutation Information

rpoB: p.H553Y

Protein Change: H553Y
Organisms: Neisseria meningitidis
Confers Resistance To: penicillin
Validation Method: whole-genome sequencing
Source Database: Reslit

105

Potential of nanopore sequencing for tuberculosis diagnosis and drug resistance detection.

PMID 39731145 · 2024

Mutation Information

rpoB: p.L305P

Protein Change: L305P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: nanopore sequencing
Source Database: Reslit

106

Phenotypic drug resistance and genetic mutations linked to resistance among extrapulmonary tuberculosis patients in Ethiopia: Insights from Whole Genome Sequencing.

PMID 39764135 · 2024

This mutation is a group-2 WHO confidence grade mutation associated with borderline rifampicin resistance.

Mutation Information

rpoB: p.H445S

Protein Change: H445S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

107

Clinical and Mycobacterium tuberculosis strain characteristics of tuberculosis patients with diabetes mellitus in Changping District, Beijing, China.

PMID 39844060 · 2025

Mutation Information

rpoB: p.H445L rpoB: p.H445N rpoB: p.H445S rpoB: p.D435Y rpoB: p.L452P rpoB: p.L430P rpoB: p.I491F

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing and drug susceptibility testing
Source Database: Reslit

108

Speeding up drug susceptibility testing in Mycobacterium tuberculosis using RNA biomarkers.

PMID 40010155 · 2025

Mutation Information

Protein Change: H445L, H445N, H445S, D435Y, L452P, L430P, I491F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: TRACeR-TB assay
Source Database: Reslit

109

Outbreak Caused by Multidrug-Resistant Mycobacterium Tuberculosis with Unusual Combination of Resistance Mutations, Northern Argentina, 2006-2022.

PMID 40023848 · 2025

associated with resistance

Mutation Information

rpoB: p.H445D

Protein Change: H445D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing and phenotypic drug-susceptibility testing
Source Database: Reslit

110

Multi-drug resistance and compensatory mutations in Mycobacterium tuberculosis in Vietnam.

PMID 40078052 · 2025

Mutation Information

rpoB: p.D435V rpoB: p.H445D rpoB: p.H445Y

Protein Change: D435V, H445D, H445Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

111

Combination therapy delays antimicrobial resistance after adaptive laboratory evolution of Staphylococcus aureus.

PMID 40084881 · 2025

Mutation in rpoB was associated with high-level rifampicin resistance

Mutation Information

rpoB: p.S487L

Protein Change: S487L
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: genomic sequencing and MIC testing
Source Database: Reslit

112

Diagnostic Performance of TBseq Test for Tuberculosis Detection and Drug Resistance Prediction

PMID 40105344 · 2024

Multiple rpoB mutations associated with RIF resistance

Mutation Information

rpoB: p.S531L rpoB: p.S531A

Protein Change: S531L, S531A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: TBseq test and pDST
Source Database: Reslit

113

Direct detection from sputum for drug-resistant Mycobacterium tuberculosis using a CRISPR-Cas14a-based approach.

PMID 40175930 · 2025

Mutation detected in RIF-resistant isolates.

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Sanger sequencing
Source Database: Reslit

114

Classic and new candidate markers for drug resistance in a large cohort of leprosy patients from the Amazon state, Brazil.

PMID 40391941 · 2025

Previously reported as a rifampicin resistance mutation

Mutation Information

rpoB: p.H451D

Protein Change: H451D
Organisms: Mycobacterium leprae
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

115

In Vitro and In Silico Evaluation of Isatin-Derived Spirooxindoles as Antituberculosis Drug Candidates.

PMID 40591553 · 2025

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MIC testing against clinical isolates
Source Database: Reslit

116

Trehalose catalytic shift inherently enhances phenotypic heterogeneity and multidrug resistance in Mycobacterium tuberculosis.

PMID 40645928 · 2025

The L452P mutation in the rpoB gene was identified in Flux RIF #1 and #2 bacilli.

Mutation Information

rpoB: p.L452P

Protein Change: L452P
Organisms: Mycobacterium smegmatis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

117

Dissecting rifampicin heteroresistance in Mycobacterium tuberculosis: integrating whole-genome sequencing with phenotypic and clonal validation.

PMID 40737173 · 2025

D435Y mutation was found in isolate 1R and conferred low-level rifampicin resistance.

Mutation Information

rpoB: p.S450L rpoB: p.D435F rpoB: p.D435V rpoB: p.D435Y rpoB: p.H445S rpoB: p.L430P rpoB: p.H445Q rpoB: p.R384W rpoB: p.V170F

Protein Change: D435Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotyping and phenotypic analysis
Source Database: Reslit

118

Surveillance and analysis of drug resistance and drug resistance levels in multidrug resistant tuberculosis on the tropical islands of China.

PMID 40750855 · 2025

Mutation Information

Protein Change: S450L, D435F, D435V, D435Y, H445S, L430P, H445Q, R384W, V170F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

119

Whole-genome sequencing and machine learning reveal key drivers of delayed sputum conversion in rifampicin-resistant tuberculosis.

PMID 40851801 · 2025

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

120

Unraveling Epistatic Interactions Between Sites Under Drug-Dependent Selection in the Mycobacterium tuberculosis Genome.

PMID 41099138 · 2025

Mutation rpoB:S450L is associated with RIF resistance

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: phylogenetic GWAS
Source Database: Reslit

121

Molecular insights of drug-resistant tuberculosis: genetic mutations and their profile.

PMID 41113631 · 2025

Mutation Information

rpoB: p.Q473K rpoB: p.G482D rpoB: p.H486Y rpoB: p.S491L

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: line probe assay
Source Database: Reslit

122

Impeding pathways of intrinsic resistance in Escherichia coli confers antibiotic sensitization and resistance proofing.

PMID 41124183 · 2025

rpoB mutation leads to rifampicin resistance

Mutation Information

rpoB: p.S512P

Protein Change: S512P
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: genetic screen
Source Database: Reslit

123

Allele-specific effects of mutations in the rifampin resistance-determining region (RRDR) of RpoB on physiology and antibiotic resistance in Enterococcus faecium.

PMID 41342532 · 2025

Mutations in the RpoB gene's rifampin resistance-determining region (RRDR) were found to confer rifampin resistance in Enterococcus faecium.

Mutation Information

Protein Change: Q473K, G482D, H486Y, S491L
Organisms: Enterococcus faecium
Confers Resistance To: rifampicin
Validation Method: Genome sequencing and transcriptomic analysis
Source Database: Reslit

124

Beyond Hotspot Mutations: Diagnostic Relevance of High Frequency, Low Frequency, and Disputed rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis.

PMID 41599000 · 2025

Mutations in rpoB are responsible for rifampicin resistance in Mycobacterium tuberculosis.

Mutation Information

rpoB: p.S450L rpoB: p.H445Y rpoB: p.H445D rpoB: p.D435V rpoB: p.L430P rpoB: p.D435Y rpoB: p.H445N rpoB: p.H445L rpoB: p.L452P rpoB: p.I491F

Protein Change: S450L, H445Y, H445D, D435V, L430P, D435Y, H445N, H445L, L452P, I491F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: disrupts a key intermolecular hydrogen bond between serine and RIF and introduces a hydrophobic leucine residue that causes steric hindrance; disrupts an intermolecular hydrogen bond between histidine and rifampicin and introduces an aromatic ring that sterically interferes with rifampicin binding; replaces a neutral histidine with a negatively charged residue, weakening hydrogen bonding and destabilizing drug interactions; substitutes the negatively charged aspartate with a bulkier nonpolar valine residue causing steric hindrance within the rifampicin-binding pocket
Validation Method: Structural modeling and phenotypic analysis; Phenotypic analysis and structural modeling
Source Database: Reslit

125

Molecular characterization of rifampin-resistant Neisseria meningitidis.

PMID 8092823 · 1994

All mutations were identified in rifampin-resistant isolates and in vitro-generated mutants.

rpoB

Mutation Information

rpoB: p.H35N rpoB: p.H35Y rpoB: p.H35R rpoB: p.S35F rpoB: p.H553N rpoB: p.H553R rpoB: p.H553Y rpoB: p.S558F

Protein Change: H35N, H35Y, H35R, S35F, H553N, H553R, H553Y, S558F
Organisms: Neisseria meningitidis
Confers Resistance To: rifampicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Validation Method: DNA sequencing of isolates; DNA sequencing of in vitro mutants
Source Database: ReslitReference Gene Catalog

126

Mutations in the rpoB Gene of Rifampin-Resistant Mycobacterium tuberculosis Strains Isolated Mostly in Asian Countries and Their Rapid Detection by Line Probe Assay.

PMID 10405418 · 1999

Mutation Information

rpoB: p.L511P rpoB: p.Q513P rpoB: p.D516Y rpoB: p.D516V rpoB: p.S522L rpoB: p.H526R rpoB: p.H526D rpoB: p.H526Y rpoB: p.S531L rpoB: p.S531W

Protein Change: L511P, Q513P, D516Y, D516V, S522L, H526R, H526D, H526Y, S531L, S531W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: automated sequencing
Source Database: Reslit

127

Genetic antagonism and hypermutability in Mycobacterium smegmatis.

PMID 10852861 · 2000

reverted to wild type at high frequency

Mutation Information

rpoB: p.H526R rpoB: p.H526Y

Protein Change: H526R, H526Y
Organisms: Mycobacterium smegmatis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

128

Sequencing of the rpoB gene in Legionella pneumophila and characterization of mutations associated with rifampin resistance in the Legionellaceae.

PMID 10991843 · 2000

mutations in rpoB gene associated with rifampin resistance in Legionella species

Mutation Information

rpoB: p.Q528L rpoB: p.Q528K rpoB: p.D531N rpoB: p.S537F rpoB: p.H541Y rpoB: p.R544H

Protein Change: Q528L, Q528K, D531N, S537F, H541Y, R544H
Organisms: Legionella pneumophila
Confers Resistance To: rifampicin
Validation Method: sequencing of rpoB gene fragments
Source Database: Reslit

129

Characterization of spontaneous, In vitro-selected, rifampin-resistant mutants of Mycobacterium tuberculosis strain H37Rv.

PMID 11083630 · 2000

Mutation Information

rpoB: p.I545N rpoB: p.I545L rpoB: p.Q150R / c.C450T

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing of the rpoB gene
Source Database: Reslit

130

Low-level resistance to rifampin in Streptococcus pneumoniae.

PMID 12604513 · 2003

mutations in rpoB confer rifampin resistance

Mutation Information

Protein Change: I545N, I545L, Q150R
Nucleotide Change: C450T
Organisms: Streptococcus pneumoniae
Confers Resistance To: rifampicin
Validation Method: sequencing and transformation
Source Database: Reslit

131

Rapid detection of rpoB gene mutations in rifampin-resistant Mycobacterium tuberculosis isolates in shanghai by using the amplification refractory mutation system.

PMID 12624020 · 2003

Mutation Information

rpoB: p.S531L rpoB: p.H526Y rpoB: p.H526D rpoB: p.H526N rpoB: p.D516V rpoB: p.D516G rpoB: p.L511P rpoB: p.Q513L rpoB: p.L533P

Protein Change: S531L, H526Y, H526D, H526N, D516V, D516G, L511P, Q513L, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: ARMS assay and DNA sequencing
Source Database: Reslit

132

Direct detection of rifampin-resistant mycobacterium tuberculosis in respiratory specimens by PCR-DNA sequencing.

PMID 15472290 · 2004

Mutation Information

rpoB: p.Q513R rpoB: p.H526N rpoB: p.S531L rpoB: p.S531Y rpoB: p.H526R rpoB: p.H526D rpoB: p.D516V rpoB: p.S522L

Protein Change: Q513R, H526N, S531L, S531Y, H526R, H526D, D516V, S522L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: direct DNA sequencing
Source Database: Reslit

133

Reinfection and mixed infection cause changing Mycobacterium tuberculosis drug-resistance patterns.

PMID 15947286 · 2005

Mutation Information

rpoB: p.L531P rpoB: p.H516Y

Protein Change: L531P, H516Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

134

Protective properties of rifampin-resistant rough mutants of Brucella melitensis.

PMID 15972510 · 2005

Found in RBM9, RBM11, RBM15, RBM17, RBM19

Mutation Information

rpoB: p.D526Y rpoB: p.D574N rpoB: p.V154F rpoB: p.R539S rpoB: p.S541L rpoB: p.D526G rpoB: p.P574L

Protein Change: D526Y, D574N, V154F, R539S, S541L, D526G, P574L
Organisms: Brucella melitensis
Confers Resistance To: rifampicin
Validation Method: sequencing of rpoB gene
Source Database: Reslit

135

Rapid determination of rifampin resistance in clinical isolates of Mycobacterium tuberculosis by real-time PCR.

PMID 16333091 · 2005

Mutations in rpoB were associated with rifampin resistance

Mutation Information

rpoB: p.S531L rpoB: p.H526E rpoB: p.G513L rpoB: p.D516V rpoB: p.D516Y

Protein Change: S531L, H526E, G513L, D516V, D516Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: real-time PCR and DNA sequencing
Source Database: Reslit

136

Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape Province of South Africa.

PMID 16928967 · 2006

Mutation Information

rpoB: p.L177L

Protein Change: L177L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

137

Genetic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates in Hong Kong.

PMID 17360809 · 2007

Detected in multiple isolates

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.S531L rpoB: p.H526Y rpoB: p.D516Y rpoB: p.L531P rpoB: p.H526N rpoB: p.S493L rpoB: p.F505L

Protein Change: S531L, H526Y, D516Y, L531P, H526N, S493L, F505L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Validation Method: PCR-SSCP/MPAC and nucleotide sequencing; sequencing
Source Database: ReslitCard Database

138

Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing.

PMID 17517606 · 2007

Mutations in rpoB associated with rifampin resistance.

Mutation Information

rpoB: p.D471Y rpoB: p.A473S rpoB: p.A477S rpoB: p.E478D

Protein Change: D471Y, A473S, A477S, E478D
Confers Resistance To: rifampicin
Validation Method: PCR sequencing
Source Database: Reslit

139

Evaluation of methods for rapid detection of resistance to isoniazid and rifampin in Mycobacterium tuberculosis isolates collected in the Caribbean.

PMID 18701663 · 2008

Mutation Information

rpoB: p.H526D rpoB: p.H526N rpoB: p.H526L rpoB: p.H526Y rpoB: p.D516V rpoB: p.S531F

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MTBDRplus assay
Source Database: Reslit

140

Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureus.

PMID 19332678 · 2009

Mutation Information

rpoB: p.I953S

Protein Change: I953S
Organisms: Staphylococcus aureus
Confers Resistance To: daptomycin
Validation Method: experimental validation through MIC testing and gene expression analysis
Source Database: Reslit

141

Positive epistasis drives the acquisition of multidrug resistance.

PMID 19629166 · 2009

Mutation Information

Protein Change: H526D, H526N, H526L, H526Y, D516V, S531F
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: competition assay
Source Database: Reslit

142

Genomic diversity among drug sensitive and multidrug resistant isolates of Mycobacterium tuberculosis with identical DNA fingerprints.

PMID 19823582 · 2009

Please note that this corresponds to amino acid 458 based on the TIGR annotation of H37Rv.

Mutation Information

rpoB: p.L452P

Protein Change: L452P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

143

Selection of mutations to detect multidrug-resistant Mycobacterium tuberculosis strains in Shanghai, China.

PMID 20008778 · 2010

Mutation Information

rpoB: p.S531L rpoB: p.S531W rpoB: p.S531F rpoB: p.H526N rpoB: p.H526Y rpoB: p.H526R rpoB: p.D516V rpoB: p.L533P

Protein Change: S531L, S531W, S531F, H526N, H526Y, H526R, D516V, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

144

Involvement of the beta subunit of RNA polymerase in resistance to streptolydigin and streptovaricin in the producer organisms Streptomyces lydicus and Streptomyces spectabilis.

PMID 20176899 · 2010

Mutations in the beta subunit of RNA polymerase (rpoB) confer resistance to streptolydigin and streptovaricin in Streptomyces lydicus and Streptomyces spectabilis.

Mutation Information

rpoB: p.N474S rpoB: p.S475A rpoB: p.T638K rpoB: p.A639S rpoB: p.L463I rpoB: p.S470N rpoB: p.A471S

Protein Change: N474S, S475A, T638K, A639S, L463I, S470N, A471S
Organisms: Streptomyces lydicus, Streptomyces spectabilis
Confers Resistance To: streptovaricin|rifampicinrifampicin
Validation Method: site-directed mutagenesis and MIC determination
Source Database: Reslit

145

Use of the GenoType(R) MTBDRplus assay to assess drug resistance of Mycobacterium tuberculosis isolates from patients in rural Uganda.

PMID 20691055 · 2010

Mutation Information

rpoB: p.D516V rpoB: p.S531L rpoB: p.H526Y rpoB: p.H526D

Protein Change: D516V, S531L, H526Y, H526D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType MTBDRplus assay
Source Database: Reslit

146

An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus.

PMID 20837752 · 2010

The rpoB mutation was shown to confer heteroresistance to vancomycin and daptomycin in S. aureus.

Staphylococcus aureus rpoB mutants conferring resistance to daptomycin; CARD accession: CARD:3003287

Mutation Information

rpoB: p.A621E

Protein Change: A621E
Organisms: Staphylococcus aureus
Confers Resistance To: vancomycin|daptomycindaptomycin
Effect on Function: The rpoB(A621E) mutation conferred N315ΔIP with the phenotypes of reduced susceptibility to daptomycin and hetero-VISA.; single resistance variant
Validation Method: experimental validation
Source Database: ReslitCard Database

147

Utility of antibiotic resistance in chlamydial genetics, recombination & transformation

PMID 20860486 · 2020

Multiple mutations increase MIC significantly

Mutation Information

rpoB: p.E526K

Protein Change: E526K
Confers Resistance To: rifampicin
Source Database: Reslit

148

Improved rapid molecular diagnosis of multidrug-resistant tuberculosis using a new reverse hybridization assay, REBA MTB-MDR.

PMID 21596910 · 2011

Mutation Information

rpoB: p.S531L rpoB: p.H526Y rpoB: p.D516T rpoB: p.D516E

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: reverse blot hybridization assay
Source Database: Reslit

149

Rapid diagnosis of extensively drug-resistant tuberculosis by use of a reverse line blot hybridization assay.

PMID 21613436 · 2011

Mutation Information

Protein Change: S531L, H526Y, D516T, D516E
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: reverse line blot hybridization assay
Source Database: Reslit

150

Study of Genetic Evolution in Mycobacterium tuberculosis Isolates from Patients with Active Pulmonary Tuberculosis in the Iran and Belarus.

PMID 21760866 · 2011

mutations in rpoB gene confer resistance to rifampicin

Mutation Information

rpoB: p.G523A rpoB: p.H526Y rpoB: p.H526R rpoB: p.H526N rpoB: p.H526F rpoB: p.H526Q rpoB: p.S531C rpoB: p.S531L rpoB: p.G523E

Protein Change: G523A, H526Y, H526R, H526N, H526F, H526Q, S531C, S531L, G523E
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

151

Mutation analysis of mycobacterial rpoB genes and rifampin resistance using recombinant Mycobacterium smegmatis.

PMID 22252831 · 2012

All mutations were experimentally validated in this study.

Mutation Information

Protein Change: G507S, Q513V, D516N, Q517H, H526Y, S531L, S531W, A532S, L533P, V547I, G507D, T508H, T508A, Q510H, L511P, Q513N, Q513E, D516E, D516H, D516V, L521M, S522L, G523A, H526L, H526D, H526F, H526N, H526R, H526Q, R529K, S531F
Organisms: Mycobacterium smegmatis
Confers Resistance To: rifampicin
Validation Method: measurement of rifampin and rifabutin susceptibilities
Source Database: Reslit

152

Microevolution of extensively drug-resistant tuberculosis in Russia.

PMID 22294518 · 2012

Mutations promoted from gene entry 'rpoB' (model emitted mutations_found inside genes).

Mutation Information

rpoB: p.H516Y rpoB: p.D526V rpoB: p.S531L rpoB: p.V176F rpoB: p.I572F

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: decreased drug binding affinity
Validation Method: whole-genome sequencing and drug susceptibility testing
Source Database: Reslit

153

Variations in the occurrence of specific rpoB mutations in rifampicin-resistant Mycobacterium tuberculosis isolates from patients of different ethnic groups in Kuwait.

PMID 22771609 · 2012

Mutations in rpoB were detected by DNA sequencing.

Mutation Information

Protein Change: H516Y, D526V, S531L, V176F, I572F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

154

Visual detection of rpoB mutations in rifampin-resistant Mycobacterium tuberculosis strains by use of an asymmetrically split peroxidase DNAzyme.

PMID 22875898 · 2012

mutations in rpoB gene confer rifampin resistance

Mutation Information

rpoB: p.S531W rpoB: p.S531L rpoB: p.L533P rpoB: p.H526Y rpoB: p.Q513K

Protein Change: S531W, S531L, L533P, H526Y, Q513K
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: bacterial strains 531-2G (Ser531Trp, TCG→TGG); bacterial strains 531-2T (Ser531Leu, TCG→TTG); bacterial strains 533-2C (Leu533Pro, CTG→CCG); bacterial strains 526-1T (His526Tyr, CAC→TAC); bacterial strains 513-1A (Gln513Lys, CAA→AAA)
Source Database: Reslit

155

Drug resistance-conferring mutations in Mycobacterium tuberculosis from Madang, Papua New Guinea.

PMID 22943573 · 2012

Mutation Information

rpoB: p.D516F rpoB: p.D516Y rpoB: p.S531L

Protein Change: D516F, D516Y, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

156

Dynamic population changes in Mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients.

PMID 22984115 · 2012

Mutation Information

rpoB: p.D521G rpoB: p.D521A rpoB: p.L526V rpoB: p.H531C rpoB: p.H531Y rpoB: p.L538P rpoB: p.S579F

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

157

Evolutionary dynamics of separate and combined exposure of Pseudomonas fluorescens SBW25 to antibiotics and bacteriophage.

PMID 23028399 · 2012

Most common mutation in rif-resistant WT and mutS− ancestors

Mutation Information

Protein Change: D521G, D521A, L526V, H531C, H531Y, L538P, S579F
Organisms: Pseudomonas fluorescens
Confers Resistance To: rifampicin
Source Database: Reslit

158

Rapid and accurate detection of RMP- and INH- resistant Mycobacterium tuberculosis in spinal tuberculosis specimens by CapitalBio™ DNA microarray: a prospective validation study.

PMID 23151186 · 2012

Mutations in rpoB were detected in RMP-resistant M. tuberculosis isolates.

Mutation Information

rpoB: p.L531S rpoB: p.H526L rpoB: p.H516L rpoB: p.L533P rpoB: p.Q513P

Protein Change: L531S, H526L, H516L, L533P, Q513P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA microarray analysis
Source Database: Reslit

159

Nosocomial transmission of extensively drug-resistant tuberculosis in a rural hospital in South Africa.

PMID 23166374 · 2013

Mutation Information

rpoB: p.D516G rpoB: p.L533P rpoB: p.I1106T

Protein Change: D516G, L533P, I1106T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

160

Rapid Screening of MDR-TB in Cases of Extra Pulmonary Tuberculosis Using Geno Type MTBDRplus.

PMID 27441660 · 2016

Mutation Information

rpoB: p.S531L rpoB: p.H526D rpoB: p.H526R rpoB: p.D516V rpoB: p.L511R rpoB: p.T480I rpoB: p.S531F rpoB: p.L533P

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Geno Type MTBDR plus assay
Source Database: Reslit

161

Genotypic characterization of drug resistant Mycobacterium tuberculosis in Quebec, 2002-2012.

PMID 27459848 · 2016

most common mutation

Mutation Information

Protein Change: S531L, H526D, H526R, D516V, L511R, T480I, S531F, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

162

Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar.

PMID 27530852 · 2016

Mutation Information

rpoB: p.D516V rpoB: p.H526Y rpoB: p.H526D rpoB: p.S531L

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

163

Drug-resistant tuberculosis in Central Mozambique: the role of a rapid genotypic susceptibility testing.

PMID 27534745 · 2016

Mutation Information

Protein Change: D516V, H526Y, H526D, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Genotype MTBDRplus test
Source Database: Reslit

164

Genotypic Detection of rpoB and katG Gene Mutations Associated with Rifampicin and Isoniazid Resistance in Mycobacterium Tuberculosis Isolates: A Local Scenario (Kelantan).

PMID 27540322 · 2016

Mutation Information

rpoB: p.H119Y rpoB: p.R135W rpoB: p.S135L rpoB: p.D90V

Protein Change: H119Y, R135W, S135L, D90V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

165

Development and characterisation of highly antibiotic resistant Bartonella bacilliformis mutants.

PMID 27667026 · 2016

Mutation Information

rpoB: p.Q527R rpoB: p.H540Y rpoB: p.S545F rpoB: p.S588Y

Protein Change: Q527R, H540Y, S545F, S588Y
Organisms: Bartonella bacilliformis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

166

Leprosy Drug Resistance Surveillance in Colombia: The Experience of a Sentinel Country.

PMID 27706165 · 2016

Mutation Information

rpoB: p.D441Y rpoB: p.S456L rpoB: p.S458M rpoB: p.R505W rpoB: p.A426T

Protein Change: D441Y, S456L, S458M, R505W, A426T
Organisms: Mycobacterium leprae
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

167

Draft genome sequence of Mycobacterium tuberculosis strain B9741 of Beijing B0/W lineage from HIV positive patient from Siberia.

PMID 27761405 · 2016

Mutation Information

rpoB: p.H526Q rpoB: p.D516E rpoB: p.H526N / c.CAC-AAC rpoB: p.H526R / c.CAC-CGC rpoB: p.H526L / c.CAC-CTC rpoB: p.H526D / c.CAC-GAC rpoB: p.H526Y / c.CAC-TAC rpoB: p.L533P / c.CTG-CCG rpoB: p.D516V / c.GAC-GTC rpoB: p.D516Y / c.GAC-TAC rpoB: p.S531L / c.TCG-TTG

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: SNP analysis
Source Database: Reslit

168

Assessment of a 96-Well Plate Assay of Quantitative Drug Susceptibility Testing for Mycobacterium Tuberculosis Complex in China.

PMID 28081169 · 2017

Mutation Information

Protein Change: H526Q, D516E, H526N, H526R, H526L, H526D, H526Y, L533P, D516V, D516Y, S531L
Nucleotide Change: CAC-AAC, CAC-CGC, CAC-CTC, CAC-GAC, CAC-TAC, CTG-CCG, GAC-GTC, GAC-TAC, TCG-TTG
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifabutinrifampicin
Validation Method: sequencing
Source Database: Reslit

169

A joint cross-border investigation of a cluster of multidrug-resistant tuberculosis in Austria, Romania and Germany in 2014 using classic, genotyping and whole genome sequencing methods: lessons learnt.

PMID 28106529 · 2017

Mutation Information

rpoB: p.S450L rpoB: p.T400A

Protein Change: S450L, T400A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin|rifabutin
Validation Method: whole genome sequencing
Source Database: Reslit

170

Novel Mutation Sites in the Development of Vancomycin-Intermediate Resistance in Staphylococcus aureus.

PMID 28119680 · 2016

Mutation Information

rpoB: p.L466S

Protein Change: L466S
Organisms: Staphylococcus aureus
Confers Resistance To: vancomycin
Validation Method: sequencing and MIC testing
Source Database: Reslit

171

A Clostridium difficile Lineage Endemic to Costa Rican Hospitals Is Multidrug Resistant by Acquisition of Chromosomal Mutations and Novel Mobile Genetic Elements.

PMID 28137804 · 2017

rifampin resistance

Mutation Information

rpoB: p.H502N rpoB: p.R505K

Protein Change: H502N, R505K
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: Reslit

172

Rifampicin-Resistance Mutations in the rpoB Gene in Bacillus velezensis CC09 have Pleiotropic Effects.

PMID 28243227 · 2017

Mutations in rpoB confer rifampicin resistance in B. velezensis.

Mutation Information

rpoB: p.H485Y rpoB: p.H485C rpoB: p.H485R rpoB: p.H485D rpoB: p.S490L rpoB: p.Q472R rpoB: p.S617F

Protein Change: H485Y, H485C, H485R, H485D, S490L, Q472R, S617F
Organisms: Bacillus velezensis
Confers Resistance To: rifampicin
Effect on Function: The H485Y mutation in rpoB confers rifampicin resistance in B. velezensis.; The H485C mutation in rpoB confers rifampicin resistance in B. velezensis.; The H485R mutation in rpoB confers rifampicin resistance in B. velezensis.; The H485D mutation in rpoB confers rifampicin resistance in B. velezensis.; The S490L mutation in rpoB confers rifampicin resistance in B. velezensis.; The Q472R mutation in rpoB confers rifampicin resistance in B. velezensis.; The S617F mutation in rpoB confers rifampicin resistance in B. velezensis.
Validation Method: cloning in B. velezensis and MIC measurement; MIC testing
Source Database: Reslit

173

Direct Detection of Rifampin and Isoniazid Resistance in Sputum Samples from Tuberculosis Patients by High-Resolution Melt Curve Analysis.

PMID 28330890 · 2017

Mutation Information

rpoB: p.L511P rpoB: p.Q513L rpoB: p.D516V rpoB: p.D516Y rpoB: p.H526C rpoB: p.H526Y rpoB: p.H526G rpoB: p.H526L rpoB: p.H526N rpoB: p.H526R rpoB: p.H526D rpoB: p.H526Q rpoB: p.S531L rpoB: p.L533P

Protein Change: L511P, Q513L, D516V, D516Y, H526C, H526Y, H526G, H526L, H526N, H526R, H526D, H526Q, S531L, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: HRM and sequencing
Source Database: Reslit

174

In vitro and in vivo fitness costs associated with Mycobacterium tuberculosis RpoB mutation H526D.

PMID 28343421 · 2017

The mutation H526D in the rpoB gene was associated with reduced Mtb virulence and delayed resuscitation from nutrient starvation.

Mutation Information

Protein Change: H526D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: mutant strain isolation and complementation
Source Database: Reslit

175

Genome sequence comparisons of serial multi-drug-resistant Mycobacterium tuberculosis isolates over 21 years of infection in a single patient.

PMID 28348821 · 2015

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genome sequencing and phenotypic resistance testing
Source Database: Reslit

176

Evaluation of genotype MTBDRplus VER 2.0 line probe assay for the detection of MDR-TB in smear positive and negative sputum samples.

PMID 28415989 · 2017

Mutation Information

rpoB: p.S531L rpoB: p.S526P

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Genotype MTBDR plus VER 2.0 LPA and MGIT DST
Source Database: Reslit

177

Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis.

PMID 28545050 · 2017

Mutation Information

Protein Change: S531L, S526P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: next-generation sequencing
Source Database: Reslit

178

Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.

PMID 28559332 · 2017

The S531L mutation in rpoB confers resistance to rifampin.

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: exposure to rifampin and assessment of resistance
Source Database: Reslit

179

Use of DNA microarray chips for the rapid detection of Mycobacterium tuberculosis resistance to rifampicin and isoniazid.

PMID 28565846 · 2017

Mutation Information

rpoB: p.H526D rpoB: p.H526Y rpoB: p.S531L

Protein Change: H526Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA microarray chip detection
Source Database: Reslit

180

Combination of commercially available molecular assays and culture based methods in diagnosis of tuberculosis and drug resistant tuberculosis.

PMID 28689813 · 2017

Among the five isolates that were resistant to RMP various mutations of the rpoB gene were detected. The types of mutations were similar to those found in a previous study from Greek patients affecting most commonly codons 531 and 526.

Mutation Information

Protein Change: H526D, H526Y, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType MTBDR plus assay
Source Database: Reslit

181

Plasmid-based high-resolution melting analysis for accurate detection of rpoB mutations in Mycobacterium tuberculosis isolates from Moroccan patients.

PMID 28784099 · 2017

Five rifampicin-resistant isolates lacked mutations in the rpoB amplified region.

Mutation Information

rpoB: p.S531L rpoB: p.S531W rpoB: p.H526Y rpoB: p.H526L rpoB: p.H526C

Protein Change: S531L, S531W, H526Y, H526L, H526C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: qPCR-HRM and DNA sequencing
Source Database: Reslit

182

Finegoldia magna Isolated from Orthopedic Joint Implant-Associated Infections.

PMID 28904182 · 2017

Three strain-specific nucleotide polymorphisms in the rpoB gene were found in the resistant isolate, leading to the following amino acid substitutions: Gln135Arg, Ile629Val, and Gly1179Asp.

Mutation Information

rpoB: p.Q135R

Protein Change: Q135R
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

183

Insights into RNA polymerase catalysis and adaptive evolution gained from mutational analysis of a locus conferring rifampicin resistance.

PMID 29036608 · 2017

Enhances abortive initiation and reduces promoter clearance

Mutation Information

rpoB: p.S531D rpoB: p.S531E rpoB: p.S531R rpoB: p.S531K rpoB: p.S531H rpoB: p.R529A rpoB: p.R529S rpoB: p.R529E

Protein Change: S531D, S531E, S531R, S531K, S531H, R529A, R529S, R529E
Confers Resistance To: rifampicin
Validation Method: In vitro transcription assays and bacterial growth measurements
Source Database: Reslit

184

Detection of mutations in the rpoB gene of rifampicin-resistant Mycobacterium tuberculosis strains inhibiting wild type probe hybridization in the MTBDR plus assay by DNA sequencing directly from clinical specimens.

PMID 32938393 · 2020

Mutations in the rpoB gene associated with rifampicin resistance

Mutation Information

Protein Change: S531L, D516V, H526Y
Nucleotide Change: A514C, A514T, A515C, A517T, A518G, A527T, C508A, C512G, C513G, C526A, C526T, C528T, CAA-GTA, CAC-TGC, G516T, G534T, T512C, TCG-TAT, TCG-TGC, TCG-TTC, TCG-TTT
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

185

Genotypic Distribution and a Potential Diagnostic Assay of Multidrug-Resistant Tuberculosis in Northern Thailand.

PMID 33061484 · 2020

Mutation Information

rpoB: p.S531L rpoB: p.H526Y rpoB: p.H526D rpoB: p.D516V rpoB: p.S522L rpoB: p.H526R

Protein Change: S531L, H526Y, H526D, D516V, S522L, H526R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

186

Prevalence and factors associated with multidrug-resistant tuberculosis in South India.

PMID 33067551 · 2020

Mutation Information

rpoB: p.S531L rpoB: p.H526R rpoB: p.L533P

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType MTBDRplus assay
Source Database: Reslit

187

Drug-resistant Mycobacterium tuberculosis and its genotypes isolated from an outbreak in western Thailand.

PMID 33320938 · 2021

Mutation Information

Protein Change: S531L, H526R, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Sequencing
Source Database: Reslit

188

Tissue specific diversification, virulence and immune response to Mycobacterium bovis BCG in a patient with an IFN-γ R1 deficiency.

PMID 33356838 · 2020

Mutation Information

rpoB: p.D435V rpoB: p.L452P

Protein Change: D435V, L452P
Organisms: Mycobacterium bovis
Confers Resistance To: rifampicin
Validation Method: Antibiotic susceptibility testing and whole genome sequencing; Whole-genome sequencing and susceptibility testing
Source Database: Reslit

189

Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population.

PMID 33441660 · 2021

Mutations in rpoB are associated with rifampicin resistance.

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

190

Should treatment of low-level rifampicin mono-resistant tuberculosis be different?

PMID 33598570 · 2021

The D435Y mutation in the rpoB gene is associated with low-level rifampicin resistance.

Mutation Information

Protein Change: D435Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing and phenotypic DST
Source Database: Reslit

191

Clusters of Drug-Resistant Mycobacterium tuberculosis Detected by Whole-Genome Sequence Analysis of Nationwide Sample, Thailand, 2014-2017.

PMID 33622486 · 2021

mutation in rpoB associated with rifampin resistance

Mutation Information

rpoB: p.S531L rpoB: p.S531F rpoB: p.Q513E

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic drug resistance profiling
Source Database: Reslit

192

Evaluation of the Roche cobas MTB and MTB-RIF/INH Assays in Samples from Germany and Sierra Leone.

PMID 33658264 · 2021

Mutation Information

Protein Change: S531L, S531F, Q513E
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

193

rpoB gene mutations in rifampin-resistant Mycobacterium tuberculosis isolates from rural areas of Zhejiang, China.

PMID 33715498 · 2021

Mutation Information

rpoB: p.S450L rpoB: p.S450W rpoB: p.S450F rpoB: p.H445D rpoB: p.H445Y rpoB: p.H445R rpoB: p.H445N rpoB: p.H445C rpoB: p.P280L rpoB: p.E521K rpoB: p.D595Y rpoB: p.S431T rpoB: p.D435V rpoB: p.S441Q rpoB: p.S441L

Protein Change: S450L, S450W, S450F, H445D, H445Y, H445R, H445N, H445C, P280L, E521K, D595Y, S431T, D435V, S441Q, S441L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: rpoB gene sequencing
Source Database: Reslit

194

Thin-Layer-Agar-Based Direct Phenotypic Drug Susceptibility Testing on Sputum in Eswatini Rapidly Detects Mycobacterium tuberculosis Growth and Rifampicin Resistance Otherwise Missed by WHO-Endorsed Diagnostic Tests.

PMID 33722892 · 2021

Detected in 8/28 (28.6%) of confirmed RR isolates

Mutation Information

rpoB: p.H445C rpoB: p.H445D rpoB: p.H445F rpoB: p.H445G rpoB: p.H445L rpoB: p.H445N rpoB: p.H445P rpoB: p.H445Q rpoB: p.H445R rpoB: p.H445Y

Protein Change: I491F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

195

Predicting rifampicin resistance mutations in bacterial RNA polymerase subunit beta based on majority consensus.

PMID 33888055 · 2021

Mutations in the rifampicin resistance-determining regions (RRDRs) of RpoB were analyzed.

Mutation Information

Protein Change: H445C, H445D, H445F, H445G, H445L, H445N, H445P, H445Q, H445R, H445Y
Confers Resistance To: rifampicin
Validation Method: computed features and molecular docking
Source Database: Reslit

196

Whole genome analysis of extensively drug resistant Mycobacterium tuberculosis strains in Peru.

PMID 33947918 · 2021

Mutation Information

rpoB: p.T441S rpoB: p.R456T

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic and phenotypic confirmation
Source Database: Reslit

197

Detection of genomic mutations in katG and rpoB genes among multidrug-resistant Mycobacterium tuberculosis isolates from Tehran, Iran.

PMID 34012550 · 2021

Mutation Information

Protein Change: T441S, R456T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: PCR and sequencing
Source Database: Reslit

198

Novel tigecycline resistance mechanisms in Acinetobacter baumannii mediated by mutations in adeS, rpoB and rrf.

PMID 34170209 · 2021

One SNP was observed in rpoB (G136D)

Mutation Information

rpoB: p.G136D

Protein Change: G136D
Confers Resistance To: tigecycline
Validation Method: MIC testing; reconstruction experiments
Source Database: Reslit

199

Expression Dysregulation as a Mediator of Fitness Costs in Antibiotic Resistance.

PMID 34228548 · 2021

Mutation Information

rpoB: p.G530E rpoB: p.D461A

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Genome-wide transcriptomic and proteomic profiling, growth assays, and mutagenesis experiments.
Source Database: Reslit

200

Generation of Tetracycline and Rifamycin Resistant Chlamydia Suis Recombinants.

PMID 34276577 · 2021

Mutation Information

Protein Change: G530E, D461A
Organisms: Chlamydia suis
Confers Resistance To: rifampicinrifamycins
Validation Method: Whole-genome sequencing and SNP analysis; whole genome sequencing and SNP analysis
Source Database: Reslit

201

Comparison of Culture With Antibiogram to Next-Generation Sequencing Using Bacterial Isolates and Formalin-Fixed, Paraffin-Embedded Gastric Biopsies.

PMID 34293298 · 2021

Mutation Information

rpoB: p.D479E rpoB: p.T593A rpoB: p.T593K rpoB: p.G595S

Protein Change: D479E, T593A, T593K, G595S
Organisms: Helicobacter pylori
Confers Resistance To: rifabutin
Validation Method: next-generation sequencing
Source Database: Reslit

202

False detection of rifampicin resistance using Xpert(®) MTB/RIF Ultra assay due to an A451V mutation in Mycobacterium tuberculosis.

PMID 34386770 · 2021

The A451V (A532V) mutation in the rpoB gene was identified in all three isolates but did not confer rifampicin resistance as confirmed by phenotypic drug susceptibility tests.

Mutation Information

rpoB: p.A451V rpoB: p.A532V

Protein Change: A451V, A532V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Sanger sequencing and WGS analysis
Source Database: Reslit

203

Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova.

PMID 34431762 · 2021

The rpoB S450L mutation confers resistance to rifampin and is part of the MDR phenotype.

Mutation Information

rpoB: p.L430P rpoB: p.D435V rpoB: p.H445D rpoB: p.H445Y rpoB: p.L449M rpoB: p.S450F rpoB: p.S450W rpoB: p.S450Y rpoB: p.D435Y rpoB: p.H445L rpoB: p.L452P rpoB: p.S493L

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: phylogenetic analysis
Source Database: Reslit

204

Rifampicin-Monoresistant Tuberculosis Is Not the Same as Multidrug-Resistant Tuberculosis: a Descriptive Study from Khayelitsha, South Africa.

PMID 34460307 · 2021

associated with low-level rifampin resistance

Mutation Information

rpoB: p.L430P

Protein Change: L430P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

205

Genetic Diversity of Multidrug-Resistant Pseudomonas aeruginosa Isolates Carrying bla (VIM-2) and bla (KPC-2) Genes That Spread on Different Genetic Environment in Colombia.

PMID 34512563 · 2021

Mutation Information

rpoB: p.V51I

Protein Change: V51I
Organisms: Pseudomonas aeruginosa
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

206

Molecular characterization of rpoB gene mutations in isolates from tuberculosis patients in Cubal, Republic of Angola.

PMID 34641802 · 2021

mutations in rpoB associated with rifampicin resistance

Mutation Information

Protein Change: L430P, D435V, H445D, H445Y, L449M, S450F, S450W, S450Y, D435Y, H445L, L452P, S493L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

207

Genomic Profiling of Mycobacterium tuberculosis Strains, Myanmar.

PMID 34670644 · 2021

Mutation Information

rpoB: p.S450L rpoB: p.H445D rpoB: p.H445Y rpoB: p.H445R rpoB: p.D435V

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genomic_analysis_and_phenotypic_confirmation
Source Database: Reslit

208

rpoB Mutations and Effects on Rifampin Resistance in Mycobacterium tuberculosis.

PMID 34675557 · 2021

These mutations were identified as contributing to rifampin resistance through experimental validation.

Mutation Information

Protein Change: S450L, H445D, H445Y, H445R, D435V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MIC testing and structural analysis
Source Database: Reslit

209

Performance Evaluation of GeneLEAD/Deeplex Myc-TB for Mycobacterium tuberculosis Complex Diagnosis and Drug Susceptibility Testing

PMID 34778100 · 2021

Mutation Information

rpoB: p.R505K rpoB: p.H502N

Protein Change: D435Y
Confers Resistance To: rifampicin
Validation Method: genotypic prediction and phenotypic DST correlation
Source Database: Reslit

210

A species-wide genetic atlas of antimicrobial resistance in Clostridioides difficile.

PMID 34793295 · 2021

Associated with rifamycin resistance

Mutation Information

Protein Change: R505K, H502N
Confers Resistance To: rifamycins
Source Database: Reslit

211

A Rapid Drug Resistance Genotyping Workflow for Mycobacterium tuberculosis, Using Targeted Isothermal Amplification and Nanopore Sequencing.

PMID 34817282 · 2021

Mutations in rpoB confer resistance to rifampin

Mutation Information

rpoB: p.S531L rpoB: p.H526L rpoB: p.S531W rpoB: p.D516G rpoB: p.D516V rpoB: p.H526R rpoB: p.D516Y rpoB: p.L533P rpoB: p.L511P rpoB: p.D516del

Protein Change: S531L, H526L, S531W, D516G, D516V, H526R, D516Y, L533P, L511P, D516del
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: nanopore sequencing
Source Database: Reslit

212

Analysis on Drug-Resistance-Associated Mutations among Multidrug-Resistant Mycobacterium tuberculosis Isolates in China.

PMID 34827305 · 2021

Mutation Information

rpoB: p.S531L rpoB: p.S531W rpoB: p.S531Y rpoB: p.L516P rpoB: p.Q513K rpoB: p.L533P

Protein Change: S531L, S531W, S531Y, L516P, Q513K, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing and MIC testing
Source Database: Reslit

213

Deciphering the Molecular Basis for Attenuation of Flavobacterium columnare Strain Fc1723 Used as Modified Live Vaccine against Columnaris Disease.

PMID 34835301 · 2021

Two mutations in rpoB were identified, which are associated with rifampin resistance.

Mutation Information

rpoB: p.N469K

Protein Change: N469K
Organisms: Flavobacterium columnare
Confers Resistance To: rifampicin
Validation Method: genomic sequencing and PROVEAN analysis
Source Database: Reslit

214

A modified decision tree approach to improve the prediction and mutation discovery for drug resistance in Mycobacterium tuberculosis.

PMID 35016609 · 2022

Mutation Information

rpoB: p.N163K rpoB: p.V170F rpoB: p.L430P rpoB: p.Q432K rpoB: p.Q432L rpoB: p.D435Y rpoB: p.D435V rpoB: p.S441L rpoB: p.H445D rpoB: p.H445N rpoB: p.H445Y rpoB: p.H445R rpoB: p.H445L rpoB: p.S450L rpoB: p.L452P rpoB: p.I491F

Protein Change: N163K, V170F, L430P, Q432K, Q432L, D435Y, D435V, S441L, H445D, H445N, H445Y, H445R, H445L, S450L, L452P, I491F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genomic variant detection
Source Database: Reslit

215

Transmission of multidrug-resistant Mycobacterium tuberculosis in Wuhan, China: A retrospective molecular epidemiological study.

PMID 35089253 · 2022

Mutation Information

rpoB: p.S450L rpoB: p.H445L rpoB: p.H445Y rpoB: p.D435V rpoB: p.D435Y rpoB: p.N437D

Protein Change: S450L, H445L, H445Y, D435V, D435Y, N437D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing of drug resistance-associated genes
Source Database: Reslit

216

Application of Amplicon-Based Targeted NGS Technology for Diagnosis of Drug-Resistant Tuberculosis Using FFPE Specimens.

PMID 35138166 · 2022

high-confidence mutation

Mutation Information

rpoB: p.H481Y rpoB: p.S464P rpoB: p.D471E

Protein Change: D435V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: amplicon-based targeted NGS
Source Database: Reslit

217

Proteomic Signatures of Antimicrobial Resistance in Yersinia pestis and Francisella tularensis.

PMID 35223919 · 2022

Mutation in rpoB leads to rifampicin resistance in FSC232.

Mutation Information

rpoB: p.S523L

Protein Change: S523L
Organisms: Francisella tularensis
Confers Resistance To: rifampicin
Validation Method: genomic sequencing and MIC testing
Source Database: Reslit

218

Comparative Genomic Reveals Clonal Heterogeneity in Persistent Staphylococcus aureus Infection.

PMID 35265532 · 2022

Mutation Information

Protein Change: H481Y, S464P, D471E
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: Table 1
Source Database: Reslit

219

Mycobacterium tuberculosis Lineages Associated with Mutations and Drug Resistance in Isolates from India.

PMID 35442078 · 2022

Mutation Information

rpoB: p.S450X rpoB: p.L430P rpoB: p.H445X rpoB: p.D435X rpoB: p.Q432L

Protein Change: S450X, L430P, H445X, D435X, Q432L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic prediction
Source Database: Reslit

220

First report of whole-genome analysis of an extensively drug-resistant Mycobacterium tuberculosis clinical isolate with bedaquiline, linezolid and clofazimine resistance from Uganda.

PMID 35550202 · 2022

Mutation Information

rpoB: p.S450L rpoB: p.D435G rpoB: p.D435F rpoB: p.D435V rpoB: p.D435E rpoB: p.H445Y rpoB: p.H445L rpoB: p.H445D

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

221

Genomic analysis of Staphylococcus aureus isolates from bacteremia reveals genetic features associated with the COVID-19 pandemic.

PMID 39108736 · 2024

Mutation Information

rpoB: p.S464P

Protein Change: S464P
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: genomic analysis
Source Database: Reslit

222

Whole genome sequencing analysis of Mycobacterium tuberculosis reveals circulating strain types and drug-resistance mutations in the Philippines.

PMID 39179783 · 2024

Common mutations underlying MDR-TB for rifampicin.

Mutation Information

Protein Change: S450L, D435G, D435F, D435V, D435E, H445Y, H445L, H445D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic resistance characterisation using TB-Profiler software
Source Database: Reslit

223

Drug-resistance characteristics, genetic diversity, and transmission dynamics of multidrug-resistant or rifampicin-resistant Mycobacterium tuberculosis from 2019 to 2021 in Sichuan, China.

PMID 39396971 · 2024

Mutation in rpoB gene associated with rifampicin resistance

Mutation Information

rpoB: p.S491F rpoB: p.G482D rpoB: p.H486Y rpoB: p.Q473L rpoB: p.T634K

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: Reslit

224

Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin.

PMID 39443798 · 2024

Mutations in rpoB lead to daptomycin resistance in VREfm.

Mutation Information

Protein Change: S491F, G482D, H486Y, Q473L, T634K
Organisms: Enterococcus faecium
Confers Resistance To: daptomycin
Effect on Function: upregulation of a previously uncharacterized operon (prdRAB) that leads to cell membrane remodelling and cross-resistance to daptomycin through reduced binding of the antibiotic
Validation Method: introduction into clinical isolate and MIC testing; mutant construction and susceptibility testing
Source Database: Reslit

225

Genetic diversities and drug resistance in Mycobacterium bovis isolates from zoonotic tuberculosis using whole genome sequencing.

PMID 39487429 · 2024

Mutation Information

rpoB: p.D435F rpoB: p.D435H

Protein Change: D435F, D435H
Organisms: Mycobacterium bovis
Confers Resistance To: rifampicin
Validation Method: genomic sequencing
Source Database: Reslit

226

Leveraging large-scale Mycobacterium tuberculosis whole genome sequence data to characterise drug-resistant mutations using machine learning and statistical approaches.

PMID 39511309 · 2024

Mutation Information

rpoB: p.P230L

Protein Change: P230L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: association analysis with resistance phenotypes
Source Database: Reslit

227

Analysis of antibiotic susceptibility and genomic characteristics of Helicobacter pylori by whole-genome resequencing in Northern China.

PMID 39661273 · 2025

Mutation Information

rpoB: p.E518D rpoB: p.N587S rpoB: p.D597N rpoB: p.D610N

Protein Change: E518D, N587S, D597N, D610N
Organisms: Helicobacter pylori
Confers Resistance To: rifampicin
Validation Method: whole-genome resequencing
Source Database: Reslit

228

Genotypes and drug resistance pattern of Mycobacterium tuberculosis complex among clinically diagnosed pulmonary tuberculosis patients.

PMID 39687724 · 2024

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

229

High-throughput method characterizes hundreds of previously unknown antibiotic resistance mutations.

PMID 39824824 · 2025

rpoB mutations were selected for by rifampicin

Mutation Information

rpoB: p.Q468K rpoB: p.Q468L rpoB: p.D471Y rpoB: p.H481C rpoB: p.H481N rpoB: p.H481Y rpoB: p.S486F rpoB: p.S486Y rpoB: p.L466S rpoB: p.D471E rpoB: p.I527M rpoB: p.S529L

Protein Change: H526Y
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

230

rpoB mutations and their association with rifampicin resistance in clinical Staphylococcus epidermidis.

PMID 39913260 · 2025

Mutations in the rpoB gene were associated with rifampicin resistance in clinical S. epidermidis isolates.

rpoB

Mutation Information

Protein Change: Q468K, Q468L, D471Y, H481C, H481N, H481Y, S486F, S486Y, L466S, D471E, I527M, S529L
Organisms: Staphylococcus epidermidis
Confers Resistance To: rifampicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Validation Method: whole-genome sequencing and antimicrobial susceptibility testing
Source Database: ReslitReference Gene Catalog

231

Genetic diversity and transmission pattern of multidrug-resistant tuberculosis based on whole-genome sequencing in Wuhan, China.

PMID 39935875 · 2025

Mutation Information

rpoB: p.L430P rpoB: p.D435Y rpoB: p.D435V rpoB: p.H445Y rpoB: p.H445D rpoB: p.H445C rpoB: p.H445S rpoB: p.S450L rpoB: p.L452P

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

232

Impact of rpoB gene mutations and Rifampicin-resistance levels on treatment outcomes in Rifampicin-resistant tuberculosis.

PMID 40016696 · 2025

Mutations in the rpoB gene were associated with rifampicin resistance and treatment outcomes.

Mutation Information

Protein Change: L430P, D435Y, D435V, H445Y, H445D, H445C, H445S, S450L, L452P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing and MIC testing
Source Database: Reslit

233

Adoption of an in-silico analysis approach to assess the functional and structural impacts of rpoB-encoded protein mutations on Chlamydia pneumoniae sensitivity to antibiotics.

PMID 40102727 · 2025

All mutations were identified in previous studies and analyzed in-silico.

Mutation Information

rpoB: p.R421S rpoB: p.F450S rpoB: p.S454F rpoB: p.D461E rpoB: p.S476F rpoB: p.L478S rpoB: p.S519Y

Protein Change: R421S, F450S, S454F, D461E, S476F, L478S, S519Y
Organisms: Chlamydia pneumoniae
Confers Resistance To: rifampicin|rifalazil
Validation Method: In-silico analysis using bioinformatics tools
Source Database: Reslit

234

Clinical characteristics and genomic epidemiological survey of tuberculosis in Wuzhou, China, 2022.

PMID 40207933 · 2025

Mutation Information

rpoB: p.S450L rpoB: p.L430P rpoB: p.S451L rpoB: p.D452N

Protein Change: S450L, L430P, S451L, D452N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

235

Next-generation rifamycins for the treatment of mycobacterial infections.

PMID 40310456 · 2025

Mutation Information

rpoB: p.H447Y

Protein Change: H447Y
Confers Resistance To: rifamycins
Validation Method: selection of spontaneous resistant mutants and targeted sequencing
Source Database: Reslit

236

Genomic characterization of multidrug-resistant tuberculosis in Shanghai, China: antibiotic resistance, virulence and transmission.

PMID 40342723 · 2025

Mutation Information

rpoB: p.S450L rpoB: p.A286V rpoB: p.V170F rpoB: p.I480V rpoB: p.E761D rpoB: p.E460D rpoB: p.P483L rpoB: p.T400A rpoB: p.R552C

Protein Change: S450L, A286V, V170F, I480V, E761D, E460D, P483L, T400A, R552C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: WGS and DST
Source Database: Reslit

237

Clostridioides difficile evolution in a tertiary German hospital through a retrospective genomic characterization.

PMID 40483626 · 2025

Mutation Information

rpoB: p.S485P rpoB: p.H502Y rpoB: p.H502N rpoB: p.R505K rpoB: p.I548M

Protein Change: S485P, H502Y, H502N, R505K, I548M
Organisms: Clostridioides difficile
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing and epsilometer MIC analysis
Source Database: Reslit

238

Mutations associated with resistance to rifampicin and isoniazid identified in strains of the Mycobacterium tuberculosis complex by GenoType MTBDRplus in Panama, 2015-2021.

PMID 40488462 · 2025

Mutation Information

Protein Change: H526D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType MTBDRplus assay
Source Database: Reslit

239

Genomic epidemiology analysis of extremely drug-resistant tuberculosis in Shanghai, China.

PMID 40548454 · 2025

Compensatory mutations in rpoB were associated with increased transmissibility of EDR-TB strains.

Mutation Information

rpoB: p.D531V

Protein Change: D531V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

240

Is Rifampin (Rifampicin) Essential for the Treatment of Rhodococcus equi Infections in Foals? A Critical Review of the Role of Rifampin.

PMID 40552784 · 2025

Mutations in rpoB are associated with rifampin resistance in R. equi.

Mutation Information

Protein Change: S531L
Organisms: Rhodococcus equi
Confers Resistance To: rifampicin
Validation Method: reported in cited literature
Source Database: Reslit

241

Whole-Genome Sequence-Based Diversity of Mycobacterium tuberculosis Strains Isolated from a Central Western Region of Mexico.

PMID 40559556 · 2025

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic resistance analysis
Source Database: Reslit

242

Mixed infections and heteroresistance of Mycobacterium tuberculosis among multidrug-resistant tuberculosis in China: a genomic epidemiology study.

PMID 40748858 · 2025

Mutation Information

rpoB: p.F424L rpoB: p.T427A rpoB: p.T427T rpoB: p.L430P rpoB: p.L430R rpoB: p.F433F rpoB: p.D435F rpoB: p.D435V rpoB: p.S450L rpoB: p.S450W rpoB: p.L452P rpoB: p.L452Q rpoB: p.D435E rpoB: p.Q432H rpoB: p.H445L

Protein Change: S450L
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

243

Off-label evaluation of the BD MAX MDR-TB assay for rapid diagnosis of rifampicin and isoniazid resistance of Mycobacterium tuberculosis clinical isolates in a high-volume reference laboratory.

PMID 40985744 · 2025

Detected in a RIF-R isolate

Mutation Information

Protein Change: F424L, T427A, T427T, L430P, L430R, F433F, D435F, D435V, S450L, S450W, L452P, L452Q, D435E, Q432H, H445L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Sequencing and phenotypic DST
Source Database: Reslit

244

Comprehensive analysis of mutations associated with rifampicin- and isoniazid-resistant tuberculosis in a high-burden setting.

PMID 40990696 · 2025

borderline mutation

Mutation Information

rpoB: p.H445N rpoB: p.L430P rpoB: p.F433F rpoB: p.Q432K rpoB: p.Q432R rpoB: p.Q432P rpoB: p.Q432H rpoB: p.Q432Q rpoB: p.D435Y rpoB: p.P439L rpoB: p.S441S rpoB: p.H445C rpoB: p.H445L rpoB: p.H445R rpoB: p.H445S rpoB: p.H445D rpoB: p.S450L rpoB: p.S450W rpoB: p.L452P

Protein Change: H445N, L430P, F433F, Q432K, Q432R, Q432P, Q432H, Q432Q, D435Y, P439L, S441S, H445C, H445L, H445R, H445S, H445D, S450L, S450W, L452P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

245

Genomic characterization of XDR Mycobacterium tuberculosis isolates in Argentina (2006-2015).

PMID 41249964 · 2025

Mutation Information

rpoB: p.S450L rpoB: p.D435V

Protein Change: S450L, D435V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

246

Whole genome sequencing-based detection of extensively drug-resistant tuberculosis from Ethiopia.

PMID 41354901 · 2025

Mutation Information

rpoB: p.S450L rpoB: p.S450W

Protein Change: S450L, S450W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

247

Association of D516V, H526Y, and S531L rpoB gene polymorphisms and risk factors with rifampicin resistance in Mycobacterium tuberculosis isolates from pulmonary TB patients in Northwest Amhara, Ethiopia: cross-sectional study.

PMID 41413475 · 2025

Mutation detected via ARMS-PCR.

Mutation Information

rpoB: p.F505L rpoB: p.L511P rpoB: p.D516A rpoB: p.T525N rpoB: p.H526Y rpoB: p.H526L rpoB: p.S531W rpoB: p.L533P

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: ARMS-PCR
Source Database: Reslit

248

Molecular evidence for heterogeneity of the multiple-drug-resistant Mycobacterium tuberculosis population in Scotland (1990 to 1997).

PMID 10074516 · 1999

Mutations in rpoB are associated with rifampin resistance.

Mutation Information

Protein Change: F505L, L511P, D516A, T525N, H526Y, H526L, S531W, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

249

Physiological cost of rifampin resistance induced in vitro in Mycobacterium tuberculosis.

PMID 10428904 · 1999

Mutation Information

rpoB: p.H526Y rpoB: p.H526R rpoB: p.H526D rpoB: p.S531L

Protein Change: H526Y, H526R, H526D, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: PCR-SSCP and sequencing
Source Database: Reslit

250

Use of real-time PCR and fluorimetry for rapid detection of rifampin and isoniazid resistance-associated mutations in Mycobacterium tuberculosis.

PMID 10970356 · 2000

Mutation Information

rpoB: p.H526N rpoB: p.D516V rpoB: p.H526D rpoB: p.S531L rpoB: p.H526Y rpoB: p.H526R

Protein Change: H526D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: real-time PCR and fluorimetry
Source Database: Reslit

251

Characterization of mutations in the rpoB gene associated with rifampin resistance in Rhodococcus equi isolated from foals.

PMID 11473992 · 2001

Mutations in the rpoB gene are associated with rifampin resistance in Rhodococcus equi.

Mutation Information

Protein Change: H526N, D516V, H526D, S531L, H526Y, H526R
Organisms: Rhodococcus equi
Confers Resistance To: rifampicin
Validation Method: sequencing and MIC testing
Source Database: Reslit

252

New real-time PCR able to detect in a single tube multiple rifampin resistance mutations and high-level isoniazid resistance mutations in Mycobacterium tuberculosis.

PMID 11880428 · 2002

Mutations in rpoB gene associated with rifampin resistance

Mutation Information

rpoB: p.S531L rpoB: p.H526Y rpoB: p.H526L rpoB: p.S531W rpoB: p.H526D rpoB: p.D516V

Protein Change: S531L, H526Y, H526L, S531W, H526D, D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: real-time PCR and DNA sequencing
Source Database: Reslit

253

High-efficiency generation of antibiotic-resistant strains of Streptococcus pneumoniae by PCR and transformation.

PMID 12654655 · 2003

Mutation Information

rpoB: p.S482P rpoB: p.Q486L rpoB: p.D489V rpoB: p.H499L rpoB: p.H499Y

Protein Change: S482P, Q486L, D489V, H499L, H499Y
Organisms: Streptococcus pneumoniae
Confers Resistance To: rifampicin
Validation Method: PCR and transformation
Source Database: Reslit

254

Emergence of rifampin-resistant Rhodococcus equi with several types of mutations in the rpoB gene among AIDS patients in northern Thailand.

PMID 12791846 · 2003

Novel mutation in R. equi

Mutation Information

rpoB: p.S531W rpoB: p.H526Y rpoB: p.S509P

Protein Change: S531W, H526Y, S509P
Organisms: Rhodococcus equi
Confers Resistance To: rifampicin
Validation Method: PCR and DNA sequencing
Source Database: Reslit

255

Effect of rpoB Mutations Conferring Rifampin Resistance on Fitness of Mycobacterium tuberculosis.

PMID 15047531 · 2004

Mutation Information

rpoB: p.S522L rpoB: p.H526Y rpoB: p.S531W

Protein Change: S522L, H526Y, S531W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: competition experiments and single cultures
Source Database: Reslit

256

Rapid detection of rifampin resistance in Mycobacterium tuberculosis isolates from India and Mexico by a molecular beacon assay.

PMID 15583274 · 2004

Mutations in the rpoB gene confer rifampin resistance

Mutation Information

rpoB: p.L511P rpoB: p.L530A rpoB: p.S531L rpoB: p.S531W rpoB: p.S531F rpoB: p.L533P rpoB: p.L533A rpoB: p.H526Q rpoB: p.N516A rpoB: p.I572F

Protein Change: L511P, L530A, S531L, S531W, S531F, L533P, L533A, H526Q, N516A, I572F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

257

Emergence of resistance to rifampin and rifalazil in Chlamydophila pneumoniae and Chlamydia trachomatis.

PMID 15728882 · 2005

No mutations were detected in the entire rpoB gene of rifampin-resistant BU-434/L 2.

Mutation Information

rpoB: p.L456I rpoB: p.H471Y

Protein Change: L456I, H471Y
Organisms: Chlamydia trachomatis
Confers Resistance To: rifampicinrifampicin|rifalazil
Validation Method: sequencing and MIC testing
Source Database: Reslit

258

Tuberculosis due to resistant Haarlem strain, Tunisia.

PMID 15963297 · 2005

Mutation Information

rpoB: p.D516V rpoB: p.H526Y rpoB: p.H526D rpoB: p.S531L

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

259

Multidrug-resistant tuberculosis detection, Latvia.

PMID 16229783 · 2005

Mutations detected by line probe assay for rpoB gene.

Mutation Information

Protein Change: D516V, H526Y, H526D, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: line probe assay
Source Database: Reslit

260

In vitro activity of novel rifamycins against rifamycin-resistant Staphylococcus aureus.

PMID 16495239 · 2006

Mutations in rpoB confer resistance to rifampin.

Mutation Information

rpoB: p.R484C rpoB: p.R484H rpoB: p.R484S rpoB: p.I527P / c.A1580C rpoB: p.I527M / c.A1580G rpoB: p.Q468K / c.C1403A rpoB: p.Q468R / c.C1403G rpoB: p.H481N / c.C1444A rpoB: p.H481D / c.C1444G rpoB: p.H481Y / c.C1444T rpoB: p.A477D / c.G1430A rpoB: p.S486L / c.T1457C

Protein Change: R484C, R484H, R484S, I527P, I527M, Q468K, Q468R, H481N, H481D, H481Y, A477D, S486L
Nucleotide Change: A1580C, A1580G, C1403A, C1403G, C1444A, C1444G, C1444T, G1430A, T1457C
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

261

Rifampin-resistant Neisseria meningitidis.

PMID 16710955 · 2006

Mutations in rpoB gene confer resistance to rifampin.

Mutation Information

rpoB: p.H552Y rpoB: p.H552N

Protein Change: H552Y, H552N
Organisms: Neisseria meningitidis
Confers Resistance To: rifampicin
Validation Method: sequencing of rpoB gene
Source Database: Reslit

262

Evaluation of the TB-Biochip oligonucleotide microarray system for rapid detection of rifampin resistance in Mycobacterium tuberculosis.

PMID 16825352 · 2006

Mutation Information

rpoB: p.S531L rpoB: p.D516V rpoB: p.H526Y rpoB: p.H526L rpoB: p.S531W rpoB: p.H526D rpoB: p.L511R rpoB: p.D516F

Protein Change: S531L, D516V, H526Y, H526L, S531W, H526D, L511R, D516F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: hybridization and sequencing
Source Database: Reslit

263

Molecular characterisation of Mycobacterium tuberculosis isolates in the First National Survey of Anti-tuberculosis Drug Resistance from Venezuela.

PMID 17032442 · 2006

Mutation Information

rpoB: p.S531L rpoB: p.D516V

Protein Change: S531L, D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

264

Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African Republic.

PMID 17073103 · 2006

Mutations in rpoB are responsible for rifampin resistance.

Mutation Information

rpoB: p.D516V rpoB: p.H526R rpoB: p.H526Y rpoB: p.S531L rpoB: p.L533P

Protein Change: D516V, H526R, H526Y, S531L, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

265

Detection of multidrug resistance in Mycobacterium tuberculosis.

PMID 17108078 · 2007

mutations in the 81-bp core region of rpoB are responsible for resistance in at least 96% of RIF-resistant M. tuberculosis isolates

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.S450L rpoB: p.S509R rpoB: p.S428R

Protein Change: S450L, S509R, S428R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Validation Method: DNA sequencing
Source Database: ReslitCard Database

266

Lateral gene transfer in vitro in the intracellular pathogen Chlamydia trachomatis.

PMID 17122345 · 2007

Single nucleotide change in the rpoB gene

Mutation Information

rpoB: p.L461V rpoB: p.S341L / c.A1022C

Protein Change: L461V, S341L
Nucleotide Change: A1022C
Organisms: Chlamydia trachomatis
Confers Resistance To: rifampicin
Validation Method: sequencing; sequencing of DNA from polyclonal doubly resistant isolates
Source Database: Reslit

267

Dramatic activation of antibiotic production in Streptomyces coelicolor by cumulative drug resistance mutations.

PMID 18310410 · 2008

Mutation Information

rpoB: p.H437Y

Protein Change: H437Y
Organisms: Streptomyces coelicolor
Confers Resistance To: rifampicin
Validation Method: DNA sequencing and antibiotic production assays
Source Database: Reslit

268

Correlation between rpoB gene mutation in Mycobacterium avium subspecies paratuberculosis and clinical rifabutin and rifampicin resistance for treatment of Crohn's disease.

PMID 18461657 · 2008

The mutation C1367T in the rpoB gene of MAP strain 18 leads to resistance to rifabutin and rifampicin.

Mutation Information

rpoB: p.T456I

Protein Change: T456I
Organisms: Mycobacterium avium
Confers Resistance To: rifabutin|rifampicin
Effect on Function: resistance
Validation Method: MIC testing and sequencing
Source Database: Reslit

269

Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF.

PMID 18611278 · 2008

Mutation Information

rpoB: p.R489H

Protein Change: R489H
Organisms: Enterococcus faecalis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

270

Direct susceptibility testing for multi drug resistant tuberculosis: a meta-analysis.

PMID 19457256 · 2009

Mutations in rpoB gene were detected in Genotype MTBDR and MTBDR plus tests.

Mutation Information

rpoB: p.L104P rpoB: p.L104F rpoB: p.L104V

Protein Change: L104P, L104F, L104V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: molecular test
Source Database: Reslit

271

Characterization of RPO B gene for detection of rifampicin drug resistance by SSCP and sequence analysis.

PMID 19584503 · 2009

Mutations in the rpoB gene were associated with rifampicin resistance.

Mutation Information

rpoB: p.Q513P rpoB: p.D516V rpoB: p.G507D rpoB: p.H526D rpoB: p.H526Y rpoB: p.S531L rpoB: p.S531W rpoB: p.S522W rpoB: p.V533P

Protein Change: Q513P, D516V, G507D, H526D, H526Y, S531L, S531W, S522W, V533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: PCR-SSCP and DNA sequencing
Source Database: Reslit

272

Molecular detection of rifampin and isoniazid resistance to guide chronic TB patient management in Burkina Faso.

PMID 19715569 · 2009

Mutation Information

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType MTBDR plus assay
Source Database: Reslit

273

Pyrosequencing for rapid detection of Mycobacterium tuberculosis resistance to rifampin, isoniazid, and fluoroquinolones.

PMID 19846642 · 2009

Mutation Information

rpoB: p.S512T

Protein Change: S512T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: pyrosequencing
Source Database: Reslit

274

Associations between Mycobacterium tuberculosis strains and phenotypes.

PMID 20113558 · 2010

Mutations in rpoB gene associated with rifampin resistance

Mutation Information

rpoB: p.H481N rpoB: p.A477T rpoB: p.Q468K rpoB: p.I527L

Protein Change: S531L, H526Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: determined by using the resistance ratio method
Source Database: Reslit

275

The genome of Streptococcus mitis B6--what is a commensal?

PMID 20195536 · 2010

Mutation Information

rpoB: p.H486N

Protein Change: H486N
Organisms: Streptococcus mitis
Confers Resistance To: rifampicin
Validation Method: genomic analysis
Source Database: Reslit

276

Molecular characterization of resistance to Rifampicin in an emerging hospital-associated Methicillin-resistant Staphylococcus aureus clone ST228, Spain.

PMID 20202188 · 2010

Additional mutations in rpoB are associated with high-level rifampicin resistance

Mutation Information

Protein Change: H481N, A477T, Q468K, I527L
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: DNA sequencing and MIC testing
Source Database: Reslit

277

High-resolution melting curve analysis for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis clinical isolates.

PMID 20844231 · 2010

Mutations in rpoB gene are associated with rifampin resistance.

Mutation Information

rpoB: p.D516V rpoB: p.H526D rpoB: p.S531L rpoB: p.S531E rpoB: p.H526Y rpoB: p.H526L rpoB: p.H526Q

Protein Change: D516V, H526D, S531L, S531E, H526Y, H526L, H526Q
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

278

Rifaximin disc diffusion test for in vitro susceptibility testing of Clostridium difficile.

PMID 21292853 · 2011

Mutation Information

rpoB: p.R505K

Protein Change: R505K
Organisms: Clostridium difficile
Confers Resistance To: rifaximin|rifampicin
Validation Method: sequencing
Source Database: Reslit

279

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters.

PMID 21342466 · 2011

Mutation Information

rpoB: p.S433L

Protein Change: S433L
Organisms: Streptomyces coelicolor
Confers Resistance To: rifampicin
Validation Method: site-directed mutagenesis and homologous recombination
Source Database: Reslit

280

Who's Winning the War? Molecular Mechanisms of Antibiotic Resistance in Helicobacter pylori.

PMID 21765819 · 2008

Mutations in rpoB are responsible for rifamycin resistance in H. pylori.

Mutation Information

rpoB: p.L525P rpoB: p.Q527K rpoB: p.Q527R rpoB: p.D530V rpoB: p.D530N rpoB: p.H540Y rpoB: p.H540N rpoB: p.S545L rpoB: p.I586N rpoB: p.I586L rpoB: p.V149F rpoB: p.R701H

Protein Change: L525P, Q527K, Q527R, D530V, D530N, H540Y, H540N, S545L, I586N, I586L, V149F, R701H
Organisms: Helicobacter pylori
Confers Resistance To: rifampicin|rifabutin
Validation Method: mutation within the rpoB gene, which encodes the β-subunit of RNA polymerase
Source Database: Reslit

281

Rapid identification of mycobacteria and drug-resistant Mycobacterium tuberculosis by use of a single multiplex PCR and DNA sequencing.

PMID 22162548 · 2012

Mutation Information

rpoB: p.Q513K

Protein Change: Q513K
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

282

Molecular characteristics of rifampin- and isoniazid-resistant mycobacterium tuberculosis strains isolated in Vietnam.

PMID 22170905 · 2012

Mutation Information

rpoB: p.S531L rpoB: p.H526D rpoB: p.H526Y rpoB: p.D516F rpoB: p.D516V

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

283

Use of multiplex allele-specific polymerase chain reaction (MAS-PCR) to detect multidrug-resistant tuberculosis in Panama.

PMID 22792333 · 2012

Detected in 53/67 isolates

Mutation Information

Protein Change: S531L, H526D, H526Y, D516F, D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

284

Detection of antibiotic resistance in leprosy using GenoType LepraeDR, a novel ready-to-use molecular test.

PMID 22860144 · 2012

Mutation Information

rpoB: p.S456L

Protein Change: S456L
Organisms: Mycobacterium leprae
Confers Resistance To: rifampicin
Validation Method: PCR sequencing and DNA strip test
Source Database: Reslit

285

Molecular characterization of rifampicin-resistant Staphylococcus aureus isolates in a Chinese teaching hospital from Anhui, China.

PMID 23082766 · 2012

mutations in rpoB gene are associated with rifampicin resistance

Mutation Information

rpoB: p.H481N rpoB: p.L466S rpoB: p.A477D rpoB: p.S486L

Protein Change: H481N, L466S, A477D, S486L
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

286

Increased survival of antibiotic-resistant Escherichia coli inside macrophages.

PMID 23089747 · 2013

The mutation was found to confer resistance to rifampin.

Mutation Information

Protein Change: H526D
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: competition assays with susceptible strain
Source Database: Reslit

287

Genotypic detection of rifampicin-resistant M. tuberculosis strains in Syrian and Lebanese patients.

PMID 23287608 · 2012

Mutations in the rpoB gene were identified in rifampicin-resistant M. tuberculosis isolates.

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: pyrosequencing
Source Database: Reslit

288

Rapid genotypic detection of rpoB and katG gene mutations in Mycobacterium tuberculosis clinical isolates from Northern India as determined by MAS-PCR.

PMID 23325741 · 2013

Mutation Information

rpoB: p.Q469K rpoB: p.Q469L rpoB: p.Q469R rpoB: p.H482D rpoB: p.H482R rpoB: p.H482Y rpoB: p.R485H rpoB: p.S487F rpoB: p.S487Y rpoB: p.D472Y rpoB: p.S487C rpoB: p.E461Q

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MAS-PCR and DNA sequencing
Source Database: Reslit

289

Cultivation of Staphylococcus epidermidis in the Human Spaceflight Environment Leads to Alterations in the Frequency and Spectrum of Spontaneous Rifampicin-Resistance Mutations in the rpoB Gene.

PMID 27446039 · 2016

Mutations in the rpoB gene leading to rifampicin resistance in S. epidermidis.

Mutation Information

Protein Change: Q469K, Q469L, Q469R, H482D, H482R, H482Y, R485H, S487F, S487Y, D472Y, S487C, E461Q
Organisms: Staphylococcus epidermidis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

290

Mutational Consequences of Ciprofloxacin in Escherichia coli.

PMID 27480851 · 2016

Mutations in rpoB contribute to rifampin resistance

Mutation Information

rpoB: p.G1576C

Protein Change: G1576C
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

291

Rifampicin resistance mutations in the 81 bp RRDR of rpoB gene in Mycobacterium tuberculosis clinical isolates using Xpert MTB/RIF in Khyber Pakhtunkhwa, Pakistan: a retrospective study.

PMID 27519406 · 2016

Mutations in the rpoB gene were identified as the cause of rifampicin resistance in Mycobacterium tuberculosis isolates.

Mutation Information

rpoB: p.S531L rpoB: p.S533L rpoB: p.P513S rpoB: p.D526N rpoB: p.G511S rpoB: p.G522S

Protein Change: S531L, S533L, P513S, D526N, G511S, G522S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Xpert MTB/RIF assay and drug susceptibility testing
Source Database: Reslit

292

Prevalence of Drug Resistance Mycobacterium Tuberculosis among Patients Seen in Coast Provincial General Hospital, Mombasa, Kenya.

PMID 27711122 · 2016

Mutation in rpoB gene associated with rifampicin resistance.

Mutation Information

Protein Change: S531L
Confers Resistance To: rifampicin
Validation Method: MTBDRplus assay
Source Database: Reslit

293

De Novo Emergence of Genetically Resistant Mutants of Mycobacterium tuberculosis from the Persistence Phase Cells Formed against Antituberculosis Drugs In Vitro.

PMID 27895008 · 2017

Mutation in the rifampin resistance-determining region (RRDR) of the rpoB gene

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

294

Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.

PMID 28009073 · 2017

The wild-type rpoB gene is susceptible to rifampicin.

Mutation Information

rpoB: p.D531N rpoB: p.S526P

Protein Change: S531L, H526Y, D516V
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: structural analysis and transcription assays
Source Database: Reslit

295

Comparative proteomic analysis of sequential isolates of Mycobacterium tuberculosis sensitive and resistant Beijing type from a patient with pulmonary tuberculosis.

PMID 28043501 · 2016

Mutation Information

Protein Change: D531N, S526P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

296

FIND Tuberculosis Strain Bank: a Resource for Researchers and Developers Working on Tests To Detect Mycobacterium tuberculosis and Related Drug Resistance.

PMID 28100602 · 2017

Mutation Information

rpoB: p.V251F rpoB: p.I572F

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

297

Rapid Sputum Multiplex Detection of the M. tuberculosis Complex (MTBC) and Resistance Mutations for Eight Antibiotics by Nucleotide MALDI-TOF MS.

PMID 28134321 · 2017

Mutation Information

rpoB: p.H513R

Protein Change: H513R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MALDI-TOF MS and Sanger sequencing
Source Database: Reslit

298

Comprehensive Whole-Genome Sequencing and Reporting of Drug Resistance Profiles on Clinical Cases of Mycobacterium tuberculosis in New York State.

PMID 28381603 · 2017

Mutation Information

Protein Change: V251F, I572F
Confers Resistance To: rifampicin
Validation Method: Whole-genome sequencing (WGS) and comparison with culture-based drug susceptibility testing (DST)
Source Database: Reslit

299

Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition.

PMID 28392175 · 2017

Mutation in rpoB gene leading to rifampicin resistance

Mutation Information

rpoB: p.R637A

Protein Change: R637A
Organisms: Mycobacterium smegmatis
Confers Resistance To: rifampicin
Validation Method: PCR amplification and sequencing
Source Database: Reslit

300

Multidrug-resistant bacteria compensate for the epistasis between resistances.

PMID 28419091 · 2017

Confers resistance to rifampicin

Mutation Information

Protein Change: H526Y
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: experimental evolution and whole-genome sequencing
Source Database: Reslit

301

Diagnostic Performance of the GenoType MTBDRplus and MTBDRsl Assays to Identify Tuberculosis Drug Resistance in Eastern China.

PMID 28639565 · 2017

Mutation Information

rpoB: p.H445Y rpoB: p.H450Y rpoB: p.H464Y rpoB: p.H490Y rpoB: p.S507L rpoB: p.S508L

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType MTBDR plus assay
Source Database: Reslit

302

Genotypic distribution of multidrug-resistant and extensively drug-resistant tuberculosis in northern Thailand.

PMID 28706448 · 2017

Mutation Information

Protein Change: H445Y, H450Y, H464Y, H490Y, S507L, S508L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

303

Frequency and Type of Disputed rpoB Mutations in Mycobacterium tuberculosis Isolates from South Korea.

PMID 28747960 · 2017

Disputed rpoB mutations causing low-level resistance to rifampin

Mutation Information

rpoB: p.L511P rpoB: p.D516Y rpoB: p.L533P rpoB: p.H526L rpoB: p.H526N rpoB: p.M515V

Protein Change: L511P, D516Y, L533P, H526L, H526N, M515V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing analysis
Source Database: Reslit

304

Transmission is a Noticeable Cause of Resistance Among Treated Tuberculosis Patients in Shanghai, China.

PMID 28794425 · 2017

Mutation Information

rpoB: p.S526L

Protein Change: S526L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

305

Antimicrobial resistance determinants and susceptibility profiles of pneumococcal isolates recovered in Trinidad and Tobago.

PMID 28818574 · 2017

A change in the rpoB gene (H499Y) resulted in resistance to rifampicin.

Mutation Information

rpoB: p.H499Y

Protein Change: H499Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: Reslit

306

Mutations in rpoB and katG genes of multidrug resistant mycobacterium tuberculosis undetectable using genotyping diagnostic methods.

PMID 28904673 · 2017

All mutations were identified through sequencing and are associated with rifampicin resistance.

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

Protein Change: S531L, D516G, D516Y, H526D, H526L, S531F, G507S, T508A, T508N, L511P, L511V, S512N, N518H, P520P, P520T, L524L, R528H, R529Q, T427N, S431N, P439T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Validation Method: sequencing
Source Database: ReslitCard Database

307

Extensively drug resistant tuberculosis in Mali: a case report.

PMID 29110699 · 2017

Mutation Information

rpoB: p.D516V rpoB: p.H526Y rpoB: p.H526L

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic analysis
Source Database: Reslit

308

Dynamics of Extensive Drug Resistance Evolution of Mycobacterium tuberculosis in a Single Patient During 9 Years of Disease and Treatment.

PMID 33045067 · 2022

Mutation Information

Protein Change: D516V, H526Y, H526L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

309

Extreme Antagonism Arising from Gene-Environment Interactions.

PMID 33068537 · 2020

Mutations in rpoB confer resistance to rifampicin

Mutation Information

rpoB: p.T1037P rpoB: p.Q148L rpoB: p.L511R rpoB: p.D516G rpoB: p.H526Y rpoB: p.I572S rpoB: p.I572N rpoB: p.I572F

Protein Change: T1037P, Q148L, L511R, D516G, H526Y, I572S, I572N, I572F
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing and growth rate measurements
Source Database: Reslit

310

Mutations Associated with Rifampicin Resistance in Mycobacterium tuberculosis Isolates from Moroccan Patients: Systematic Review.

PMID 33133185 · 2020

Other mutations were found in a limited number and had frequencies of less than 1% among phenotypically resistant isolates.

Mutation Information

rpoB: p.H531L rpoB: p.R516H rpoB: p.S526P

Protein Change: H531L, R516H, S526P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic testing and phenotypic drug susceptibility testing
Source Database: Reslit

311

Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response.

PMID 33221850 · 2021

These mutations in rpoB were shown to reduce susceptibility to ciprofloxacin through a ppGpp-independent stringent-like response.

Mutation Information

rpoB: p.442-445del rpoB: p.455dup

Protein Change: 442-445del, 455dup
Organisms: Escherichia coli
Confers Resistance To: ciprofloxacin
Validation Method: evolution experiment and MIC determination
Source Database: Reslit

312

Comparative Analytical Evaluation of Four Centralized Platforms for the Detection of Mycobacterium tuberculosis Complex and Resistance to Rifampicin and Isoniazid.

PMID 33268535 · 2021

Mutation Information

rpoB: p.S450L rpoB: p.S450W rpoB: p.S450F rpoB: p.Q432P rpoB: p.D435V rpoB: p.D435G rpoB: p.D435F rpoB: p.S441L rpoB: p.H445D rpoB: p.H445L rpoB: p.H445R rpoB: p.H445Y rpoB: p.H445G rpoB: p.L452P

Protein Change: S450L, S450W, S450F, Q432P, D435V, D435G, D435F, S441L, H445D, H445L, H445R, H445Y, H445G, L452P
Organisms: Mycobacterium tuberculosis, Mycobacterium bovis
Confers Resistance To: rifampicin
Validation Method: testing of resistant strain panel
Source Database: Reslit

313

Genomic Insights Into Last-Line Antimicrobial Resistance in Multidrug-Resistant Staphylococcus and Vancomycin-Resistant Enterococcus.

PMID 33796088 · 2021

Mutation Information

rpoB: p.D471E rpoB: p.I527M rpoB: p.H481Y rpoB: p.H481L rpoB: p.H481N

Protein Change: D471E, I527M, H481Y, H481L, H481N
Organisms: Staphylococcus epidermidis, Staphylococcus aureus
Confers Resistance To: rifampicinvancomycin
Validation Method: reported in cited literature
Source Database: Reslit

314

Disputed rpoB Mutations in Mycobacterium tuberculosis and Tuberculosis Treatment Outcomes.

PMID 33846134 · 2021

Mutations in the rpoB gene were associated with rifampin resistance in Mycobacterium tuberculosis.

Mutation Information

rpoB: p.L533P rpoB: p.L511P rpoB: p.D516Y rpoB: p.H526N rpoB: p.H526L

Protein Change: L533P, L511P, D516Y, H526N, H526L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: agar-based phenotypic DST and MIC testing
Source Database: Reslit

315

Five-year microevolution of a multidrug-resistant Mycobacterium tuberculosis strain within a patient with inadequate compliance to treatment.

PMID 33926375 · 2021

Mutation Information

rpoB: p.S450L rpoB: p.S450W rpoB: p.S450F rpoB: p.R552L rpoB: p.S874Y rpoB: p.K891Q rpoB: p.P471R rpoB: p.H445D rpoB: p.H445L rpoB: p.H445R

Protein Change: D435V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Whole genome sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

316

Characterization of rifampicin-resistant Mycobacterium tuberculosis in Khyber Pakhtunkhwa, Pakistan.

PMID 34244539 · 2021

All mutations are in the rifampicin resistance determining region (RRDR)

Mutation Information

Protein Change: S450L, S450W, S450F, R552L, S874Y, K891Q, P471R, H445D, H445L, H445R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

317

Rarity of rpoB Mutations Outside the Rifampicin Resistance-Determining Region of Mycobacterium tuberculosis Isolates from Patients Responding Poorly to First-Line Tuberculosis Regimens in Beijing, China: A Retrospective Study.

PMID 34262305 · 2021

Mutation Information

rpoB: p.I491F rpoB: p.S450L

Protein Change: I491F, S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing and MIC testing
Source Database: Reslit

318

Whole genome sequencing of clinical samples reveals extensively drug resistant tuberculosis (XDR TB) strains from the Beijing lineage in Nigeria, West Africa.

PMID 34462504 · 2021

Mutation Information

rpoB: p.H482Y rpoB: p.S487L

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

319

Polyribosome-Dependent Clustering of Membrane-Anchored RNA Degradosomes To Form Sites of mRNA Degradation in Escherichia coli.

PMID 34488454 · 2021

Mutation Information

rpoB: p.D516Y

Protein Change: D516Y
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: genetic analysis
Source Database: Reslit

320

The Spectrum of Spontaneous Rifampin Resistance Mutations in the Bacillus subtilis rpoB Gene Depends on the Growth Environment.

PMID 34495706 · 2021

Mutations in the rpoB gene were found to confer rifampin resistance.

Mutation Information

Protein Change: H482Y, S487L
Organisms: Bacillus subtilis
Confers Resistance To: rifampicin
Validation Method: sequencing of rpoB mutants
Source Database: Reslit

321

Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study.

PMID 34504243 · 2021

Mutation Information

rpoB: p.S531W

Protein Change: S531W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA microarray chip method
Source Database: Reslit

322

Analysing the fitness cost of antibiotic resistance to identify targets for combination antimicrobials.

PMID 34697460 · 2021

The H526Y mutation in rpoB was identified as a cause of rifampicin resistance.

Mutation Information

rpoB: p.D542E rpoB: p.H552N

Protein Change: H526Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: mutant_isolation_and_sequencing
Source Database: Reslit

323

Antibiotic resistance among invasive Neisseria meningitidis isolates in England, Wales and Northern Ireland (2010/11 to 2018/19).

PMID 34843604 · 2021

Mutations in rpoB contribute to rifampicin resistance.

Mutation Information

Protein Change: D542E, H552N
Organisms: Neisseria meningitidis
Confers Resistance To: rifampicin
Validation Method: sequencing and MIC testing
Source Database: Reslit

324

Putative extensive and pre-extensive drug resistant-tuberculosis associated with unusual genotypes on the Thailand-Myanmar border.

PMID 34878043 · 2021

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing and LPA
Source Database: Reslit

325

Multidrug-resistant tuberculosis control in Rwanda overcomes a successful clone that causes most disease over a quarter century.

PMID 35146133 · 2022

Mutation Information

rpoB: p.D441V rpoB: p.H451G rpoB: p.H451P rpoB: p.R454Q rpoB: p.S456Q rpoB: p.S456W

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing and resistance profiling
Source Database: Reslit

326

The Structural Basis of Mycobacterium tuberculosis RpoB Drug-Resistant Clinical Mutations on Rifampicin Drug Binding.

PMID 35164151 · 2022

All mutations were identified in the RIF resistance-determining region (RRDR) of rpoB.

Mutation Information

Protein Change: D441V, H451G, H451P, R454Q, S456Q, S456W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Molecular docking and molecular dynamics simulations
Source Database: Reslit

327

Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.

PMID 35175750 · 2022

Mutation Information

rpoB: p.Q489K

Protein Change: Q489K
Confers Resistance To: rifampicin
Validation Method: MIC testing
Source Database: Reslit

328

Epidemiological cut-off values for a 96-well broth microdilution plate for high-throughput research antibiotic susceptibility testing of M. tuberculosis.

PMID 35301246 · 2022

Mutation Information

rpoB: p.H481N rpoB: p.H481L

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genetic variant analysis
Source Database: Reslit

329

Virulence Determinants in Staphylococcus aureus Clones Causing Osteomyelitis in Italy.

PMID 35308345 · 2022

Mutation Information

Protein Change: H481N, H481L
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

330

Use of Whole-Genome Sequencing to Predict Mycobacterium tuberculosis Complex Drug Resistance from Early Positive Liquid Cultures.

PMID 35311541 · 2022

Mutation Information

rpoB: p.L464M

Protein Change: L464M
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

331

Global evolutionary dynamics and resistome analysis of Clostridioides difficile ribotype 017.

PMID 35316173 · 2022

Mutation Information

rpoB: p.R505K

Protein Change: R505K
Organisms: Clostridioides difficile
Confers Resistance To: rifamycins
Validation Method: genotypic AMR data and association with spread
Source Database: Reslit

332

Molecular Epidemiology and Antimicrobial Resistance of Clostridioides difficile in Hospitalized Patients From Mexico.

PMID 35360652 · 2021

Mutation Information

rpoB: p.I750M rpoB: p.R505K rpoB: p.I548M rpoB: p.D1232E rpoB: p.D1160E / c.T3480A

Protein Change: I750M, R505K, I548M, D1232E, D1160E
Nucleotide Change: T3480A
Organisms: Clostridioides difficile
Confers Resistance To: rifampicin
Validation Method: genomic analysis; genome analysis
Source Database: Reslit

333

Evolution and spread of a highly drug resistant strain of Mycobacterium tuberculosis in Papua New Guinea.

PMID 35524232 · 2022

associated with Rifampicin resistance

Mutation Information

rpoB: p.S450L rpoB: p.S450A rpoB: p.S450T rpoB: p.Q432L rpoB: p.D435G

Protein Change: S450L, S450A, S450T, Q432L, D435G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic and phenotypic correlation
Source Database: Reslit

334

Identification of echinoderm metabolites as potential inhibitors targeting wild-type and mutant forms of Escherichia coli RNA polymerase (RpoB) for tuberculosis treatment.

PMID 39213289 · 2024

Mutations in RpoB were analyzed for their impact on binding affinity of echinoderm metabolites.

Mutation Information

rpoB: p.D516V rpoB: p.H526Y rpoB: p.S531L

Protein Change: D516V, H526Y, S531L
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: molecular docking and MD simulation; Molecular docking and MD simulations
Source Database: Reslit

335

Dissecting the genetic features and evolution of Staphylococcus aureus sequence type 88: a global perspective.

PMID 39530695 · 2024

Found in one rifampicin-resistant ST88 isolate.

Mutation Information

rpoB: p.H481N

Protein Change: H481N
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: genomic analysis
Source Database: Reslit

336

The tigecycline resistance mechanisms in Gram-negative bacilli.

PMID 39635040 · 2024

associated with tigecycline resistance

Mutation Information

rpoB: p.G136D

Protein Change: G136D
Organisms: Acinetobacter baumannii
Confers Resistance To: tigecycline
Source Database: Reslit

337

A mutation in RNA polymerase imparts resistance to β-lactams by preventing dysregulation of amino acid and nucleotide metabolism.

PMID 39908144 · 2025

Mutation Information

rpoB: p.H482Y

Protein Change: H482Y
Organisms: Bacillus subtilis
Confers Resistance To: cef
Validation Method: suppressor analysis and whole genome sequencing
Source Database: Reslit

338

Whole genomic analysis uncovers high genetic diversity of rifampicin-resistant Mycobacterium tuberculosis strains in Botswana.

PMID 40008038 · 2025

Mutation Information

rpoB: p.S450L rpoB: p.H445L rpoB: p.I491F rpoB: p.I170V

Protein Change: S450L, H445L, I491F, I170V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic resistance
Source Database: Reslit

339

Evaluation of the cobas MTB and MTB-RIF/INH assay in clinical samples for the detection of Mycobacterium tuberculosis in respiratory specimens.

PMID 40130921 · 2025

Detected in strain TB 6466

Mutation Information

rpoB: p.T508A

Protein Change: T508A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: molecular analysis of the relevant genes (GenoType MTBDR, Sanger sequencing)
Source Database: Reslit

340

Genotypic drug resistance and transmission clusters of Mycobacterium tuberculosis isolates among Ethiopian returnees from Saudi Arabia.

PMID 40238782 · 2025

Mutation Information

rpoB: p.K2068R rpoB: p.I837V rpoB: p.Q2079K

Protein Change: S450L
Confers Resistance To: rifampicin
Validation Method: genotypic drug resistance prediction
Source Database: Reslit

341

Identification of genetic mutations conferring tedizolid resistance in MRSA mutants.

PMID 40360924 · 2025

Mutation Information

rpoB: p.S529L

Protein Change: S529L
Organisms: Staphylococcus aureus
Confers Resistance To: tedizolid|linezolid
Validation Method: whole genome sequencing
Source Database: Reslit

342

Antibiotic Resistance and Genetic Determinants of Helicobacter pylori in Oman: Insights from Phenotypic and Whole-Genome Analysis.

PMID 40565090 · 2025

Mutation Information

Protein Change: K2068R, I837V, Q2079K
Organisms: Helicobacter pylori
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

343

Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda.

PMID 40672307 · 2025

Mutations in rpoB are associated with rifampicin resistance.

Mutation Information

rpoB: p.S531L rpoB: p.H526D rpoB: p.H526L rpoB: p.H526Y rpoB: p.H526R rpoB: p.H526G rpoB: p.D516Y rpoB: p.D516V rpoB: p.E513K rpoB: p.L511P rpoB: p.L492L rpoB: p.Q490R rpoB: p.K1025E

Protein Change: S531L, H526D, H526L, H526Y, H526R, H526G, D516Y, D516V, E513K, L511P, L492L, Q490R, K1025E
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Sanger DNA sequencing and WGS
Source Database: Reslit

344

RpoB mutation patterns in Rifampicin-resistant tuberculosis: a Jiangxi Province study, 2021-2023.

PMID 40745428 · 2025

Mutations in the rpoB gene are associated with rifampicin resistance

Mutation Information

rpoB: p.S450L rpoB: p.D435Y rpoB: p.D435V

Protein Change: S450L, D435Y, D435V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GeneXpert MTB/RIF assay
Source Database: Reslit

345

Allele-Specific Effects of Mutations in the Rifampin Resistance-Determining Region (RRDR) of RpoB on Physiology and Antibiotic Resistance in Enterococcus faecium.

PMID 40799600 · 2025

Mutations in the rifampin resistance-determining region (RRDR) of RpoB confer resistance to rifampin.

Mutation Information

rpoB: p.Q473K rpoB: p.G482D rpoB: p.H486Y rpoB: p.S491L

Protein Change: Q473K, G482D, H486Y, S491L
Organisms: Enterococcus faecium
Confers Resistance To: rifampicin
Validation Method: generation of isogenic strains and assessment of antibiotic susceptibility
Source Database: Reslit

346

Rapid, accurate, and reproducible de novo prediction of resistance to antituberculars.

PMID 40980905 · 2025

Mutations in rpoB gene associated with rifampicin resistance

Mutation Information

rpoB: p.V170F rpoB: p.S450L rpoB: p.I491F

Protein Change: V170F, S450L, I491F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: computed ΔΔG values and clinical data
Source Database: Reslit

347

Correlation Between Xpert MTB/RIF Results and rpoB Mutations within Probe-Targeted Regions in Mycobacterium tuberculosis Isolates from Sichuan Basin.

PMID 41048203 · 2025

Mutations in the rpoB gene are responsible for rifampicin resistance.

Mutation Information

rpoB: p.S450L rpoB: p.R552H

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Xpert MTB/RIF assay
Source Database: Reslit

348

Characteristics of compensatory mutations in rifampicin-resistant tuberculosis and their association with compensated transmission in Ningbo, China.

PMID 41053587 · 2025

putative compensatory mutation

Mutation Information

rpoB: p.D574E

Protein Change: D574E
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

349

Genomic characterization and epidemiology of Mycobacterium tuberculosis lineage 2 isolates from Kazakhstan.

PMID 41152417 · 2025

Most prevalent mutation in RR-determining region

Mutation Information

Protein Change: S450L, R552H
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic prediction; whole-genome sequencing and association with resistance
Source Database: Reslit

350

Assessment of target-enrichment library preparation and next-generation sequencing of paraffin-embedded gastric biopsies for H. pylori diagnosis and evaluation of virulome and resistome.

PMID 41233511 · 2025

Detected in sample 12

Mutation Information

Protein Change: L525I, L525P, S526T, Q527H, Q527K, Q527R, F528E, D530A, D530E, D530G, D530N, D530V, T539A, H540C, H540N, H540Y, S545L, L547F, I586N, I586L
Organisms: Helicobacter pylori
Confers Resistance To: rifampicinrifabutin
Validation Method: targeted sequencing and mutation analysis; target enrichment
Source Database: Reslit

351

Application of FreezeTB, a targeted nanopore sequencing assay, for identification of drug resistance and lineages among pulmonary tuberculosis cases in Alaska.

PMID 41247050 · 2026

Mutations in rpoB are associated with rifampin resistance.

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: targeted next-generation sequencing
Source Database: Reslit

352

Tracking the evolution of an extensively drug-resistant cross-border Mycobacterium tuberculosis cluster, Europe, January 2016 up to August 2025: implications for European surveillance.

PMID 41267660 · 2025

Mutation Information

rpoB: p.S531L rpoB: p.H526D rpoB: p.H526L rpoB: p.H526Y rpoB: p.H526R rpoB: p.H526G rpoB: p.D516Y rpoB: p.D516V rpoB: p.E513K rpoB: p.L511P rpoB: p.L492L rpoB: p.Q490R rpoB: p.K1025E

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genomic analysis
Source Database: Reslit

353

Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda.

PMID 41343595 · 2025

Some mutations are classified as low-level resistance-conferring.

Mutation Information

Protein Change: S531L, H526D, H526L, H526Y, H526R, H526G, D516Y, D516V, E513K, L511P, L492L, Q490R, K1025E
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Sanger DNA sequencing and WGS
Source Database: Reslit

354

Characterization of Drug Resistance Patterns, Mutation Profiles and Prevalence of Mycobacterium tuberculosis in Shaoxing.

PMID 41394331 · 2025

Mutation Information

rpoB: p.L511P rpoB: p.L511Q rpoB: p.D516A rpoB: p.D516G rpoB: p.D516V rpoB: p.D516Y rpoB: p.D516E rpoB: p.H526N rpoB: p.H526D rpoB: p.H526Y rpoB: p.H526R rpoB: p.H526L rpoB: p.S531L rpoB: p.S531W rpoB: p.S531A rpoB: p.L533P rpoB: p.L533Q

Protein Change: L511P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA microarray chip assay
Source Database: Reslit

355

A novel one-tube nested fluorescence melting curve analysis for rapid detection of drug-resistant Mycobacterium tuberculosis.

PMID 41420205 · 2025

All mutations were confirmed by DNA sequencing.

Mutation Information

Protein Change: L511P, L511Q, D516A, D516G, D516V, D516Y, D516E, H526N, H526D, H526Y, H526R, H526L, S531L, S531W, S531A, L533P, L533Q
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: OTN-FMCA and Sanger sequencing; DNA sequencing
Source Database: Reslit

356

Genetic identification of mutations and MLST types associated with decreased susceptibility to ceftriaxone in Neisseria gonorrhoeae.

PMID 41648021 · 2025

Mutations in RpoB are associated with ceftriaxone resistance.

Mutation Information

rpoB: p.G248D rpoB: p.H553N rpoB: p.E1175D

Protein Change: G248D, H553N, E1175D
Organisms: Neisseria gonorrhoeae
Confers Resistance To: ceftriaxone
Validation Method: statistical analysis of amino acid frequencies
Source Database: Reslit

357

Evaluation of Mycobacterium tuberculosis cross-resistance to isoniazid, rifampicin and levofloxacin with their respective structural analogs.

PMID 24894185 · 2014

Mutation Information

rpoB: p.S531L rpoB: p.S540R rpoB: p.L511P rpoB: p.D516G rpoB: p.L533P rpoB: p.H513L rpoB: p.S533L

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

358

Characterization of extensively drug-resistant Mycobacterium tuberculosis isolates circulating in Siberia.

PMID 25186134 · 2014

associated with high-level rifampicin resistance

Mutation Information

Protein Change: S531L, S540R, L511P, D516G, L533P, H513L, S533L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing; sequencing and MIC testing
Source Database: Reslit

359

Molecular detection and characterization of resistant genes in Mycobacterium tuberculosis complex from DNA isolated from tuberculosis patients in the Eastern Cape province South Africa.

PMID 25186245 · 2014

Mutation Information

rpoB: p.Y42D rpoB: p.G52A rpoB: p.H87G rpoB: p.L92S rpoB: p.L441S rpoB: p.L450P rpoB: p.L457P

Protein Change: Y42D, G52A, H87G, L92S, L441S, L450P, L457P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

360

Rifampicin resistance mutations in the 81 bp RRDR of rpoB gene in Mycobacterium tuberculosis clinical isolates using Xpert® MTB/RIF in Kampala, Uganda: a retrospective study.

PMID 25190040 · 2014

Mutations in the 81 bp RRDR of rpoB gene were associated with rifampicin resistance.

Mutation Information

rpoB: p.H531Y rpoB: p.S513L rpoB: p.R526W rpoB: p.T511A

Protein Change: H531Y, S513L, R526W, T511A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Xpert MTB/RIF assay and agar proportion method
Source Database: Reslit

361

Assessment of the genotype MTBDRplus assay for rifampin and isoniazid resistance detection on sputum samples in Cote d'Ivoire.

PMID 25215193 · 2014

Mutation Information

rpoB: p.D516V rpoB: p.H526Y rpoB: p.H526D rpoB: p.S531L

Protein Change: D516V, H526Y, H526D, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MTBDRplus assay
Source Database: Reslit

362

Evaluation of gene mutations involved in drug resistance in mycobacterium tuberculosis strains derived from tuberculosis patients in mazandaran, iran, 2013.

PMID 25317406 · 2014

Mutation Information

rpoB: p.L516V rpoB: p.H531R

Protein Change: L516V, H531R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: line probe assay
Source Database: Reslit

363

Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting.

PMID 25407810 · 2014

Mutations in rpoB are associated with rifampicin resistance.

Mutation Information

rpoB: p.S450L rpoB: p.D435V rpoB: p.L731P

Protein Change: S450L, D435V, L731P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genomic analysis
Source Database: Reslit

364

Could high-concentration rifampicin kill rifampicin-resistant M. tuberculosis? Rifampicin MIC test in rifampicin-resistant isolates from patients with osteoarticular tuberculosis.

PMID 25467069 · 2014

Mutation Information

rpoB: ?

Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: detection of rpoB gene mutations using a DNA probe array
Source Database: Reslit

365

Linking system-wide impacts of RNA polymerase mutations to the fitness cost of rifampin resistance in Pseudomonas aeruginosa.

PMID 25491352 · 2014

All mutations in rpoB were associated with reduced transcriptional efficiency and fitness costs.

Mutation Information

rpoB: p.H531C rpoB: p.Q518R / c.A1553G rpoB: p.Q518L / c.A1553T rpoB: p.H531R / c.A1592G rpoB: p.H531L / c.A1592T rpoB: p.H531Y / c.C1591T rpoB: p.S536F / c.C1607T rpoB: p.S579F / c.C1736T rpoB: p.D521N / c.G1561A rpoB: p.D521G / c.G1562G

Protein Change: H531C, Q518R, Q518L, H531R, H531L, H531Y, S536F, S579F, D521N, D521G
Nucleotide Change: A1553G, A1553T, A1592G, A1592T, C1591T, C1607T, C1736T, G1561A, G1562G
Organisms: Pseudomonas aeruginosa
Confers Resistance To: rifampicin
Validation Method: competition assays and luciferase reporter gene assays
Source Database: Reslit

366

Added value of whole-genome sequencing for management of highly drug-resistant TB.

PMID 25492392 · 2015

Strong evidence for a causal association with a drug-resistant phenotype

Mutation Information

rpoB: p.S450W

Protein Change: S450W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

367

Molecular analysis of codon 548 in the rpoB gene involved in Mycobacterium tuberculosis resistance to rifampin.

PMID 25534743 · 2015

The mutation was found in a clinical isolate and validated by constructing recombinant strains.

Mutation Information

rpoB: p.R548H

Protein Change: R548H
Organisms: Mycobacterium tuberculosis, Mycobacterium smegmatis
Confers Resistance To: rifampicin
Effect on Function: increased MIC for rifampin
Validation Method: cloning in M. smegmatis and M. tuberculosis + drug susceptibility testing
Source Database: Reslit

368

GWAMAR: genome-wide assessment of mutations associated with drug resistance in bacteria.

PMID 25559874 · 2014

Mutation Information

rpoB: p.L430P rpoB: p.S450L

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: literature
Source Database: Reslit

369

Tuberculous spondylitis in Russia and prominent role of multidrug-resistant clone Mycobacterium tuberculosis Beijing B0/W148.

PMID 25645851 · 2015

Mutation Information

rpoB: p.H531Y

Protein Change: H531Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: biochip analysis
Source Database: Reslit

370

Low resistance to first and second line anti-tuberculosis drugs among treatment naive pulmonary tuberculosis patients in southwestern Uganda.

PMID 25658921 · 2015

One isolate showed isoniazid resistance via MTBDR plus, linked to katG mutation

Mutation Information

rpoB: p.Y531N

Protein Change: Y531N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MTBDR plus PCR assay
Source Database: Reslit

371

Clinical application of whole-genome sequencing to inform treatment for multidrug-resistant tuberculosis cases.

PMID 25673793 · 2015

Mutation Information

Protein Change: L430P, S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

372

Understanding Rifampicin Resistance in Tuberculosis through a Computational Approach.

PMID 25705170 · 2014

Mutation Information

rpoB: p.S450L rpoB: p.H445Y

Protein Change: S450L, H445Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: in silico docking and molecular dynamics simulations
Source Database: Reslit

373

Whole genome sequencing based characterization of extensively drug-resistant Mycobacterium tuberculosis isolates from Pakistan.

PMID 25719196 · 2015

Mutation in the rifampicin-resistance determining region (RRDR)

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

374

Convergent adaptation in the dominant global hospital clone ST239 of methicillin-resistant Staphylococcus aureus.

PMID 25736880 · 2015

Mutation Information

rpoB: p.D516V rpoB: p.D516Y rpoB: p.D516F rpoB: p.D516A rpoB: p.H526Y rpoB: p.H526D rpoB: p.H526C rpoB: p.H526N rpoB: p.H526R rpoB: p.S531L rpoB: p.L533P

Protein Change: H481Y
Organisms: Staphylococcus aureus
Confers Resistance To: vancomycin
Validation Method: genetic manipulation experiments
Source Database: Reslit

375

Defining multidrug-resistant tuberculosis: correlating GenoType MTBDRplus assay results with minimum inhibitory concentrations.

PMID 25749461 · 2015

mutations in the rpoB gene are associated with rifampicin resistance

Mutation Information

Protein Change: D516V, D516Y, D516F, D516A, H526Y, H526D, H526C, H526N, H526R, S531L, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: Reslit

376

Report of rpoB mutation in clinically suspected cases of drug resistant leprosy: a study from Eastern India.

PMID 25751332 · 2015

mutation in rpoB gene associated with rifampicin resistance

Mutation Information

rpoB: p.E442H

Protein Change: E442H
Organisms: Mycobacterium leprae
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

377

Integration of published information into a resistance-associated mutation database for Mycobacterium tuberculosis.

PMID 25765106 · 2015

Mutation Information

rpoB: p.S450W rpoB: p.Q432K rpoB: p.Q432L rpoB: p.H445D rpoB: p.S441L rpoB: p.H445Y rpoB: p.H445R rpoB: p.D435G rpoB: p.D435V rpoB: p.Q432P rpoB: p.H445L rpoB: p.L452P rpoB: p.H445N rpoB: p.S450L rpoB: p.L430P rpoB: p.D435Y

Protein Change: S450W, Q432K, Q432L, H445D, S441L, H445Y, H445R, D435G, D435V, Q432P, H445L, L452P, H445N, S450L, L430P, D435Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: Reslit

378

Mutations conferring resistance to first- and second-line drugs in multidrug-resistant Mycobacterium tuberculosis clinical isolates in southeast Mexico.

PMID 25819011 · 2015

Mutation Information

rpoB: p.H526D rpoB: p.S531L

Protein Change: H526D, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

379

Application of Deletion- Targeted Multiplex PCR technique for detection of Mycobacterium tuberculosis Beijing strains in samples from tuberculosis patients.

PMID 25848523 · 2014

Mutation Information

rpoB: p.L527F rpoB: p.S531L

Protein Change: L527F, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: PCR and sequencing
Source Database: Reslit

380

Modified Proofreading PCR for Detection of Point Mutations, Insertions and Deletions Using a ddNTP-Blocked Primer.

PMID 25915410 · 2015

Detected in Mycobacterium tuberculosis

Mutation Information

rpoB: p.L511P rpoB: p.Q513K rpoB: p.Q513L rpoB: p.D516L rpoB: p.D516V rpoB: p.D516Y rpoB: p.H526R rpoB: p.H526L rpoB: p.H526D rpoB: p.H526Y rpoB: p.S531W rpoB: p.S531L rpoB: p.L533Q rpoB: p.L533P

Protein Change: H526Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: PCR and sequencing
Source Database: Reslit

381

Comparative Evaluation of Sloppy Molecular Beacon and Dual-Labeled Probe Melting Temperature Assays to Identify Mutations in Mycobacterium tuberculosis Resulting in Rifampin, Fluoroquinolone and Aminoglycoside Resistance.

PMID 25938476 · 2015

Mutation Information

Protein Change: L511P, Q513K, Q513L, D516L, D516V, D516Y, H526R, H526L, H526D, H526Y, S531W, S531L, L533Q, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: melting temperature assay; analytical sensitivity testing; heteroresistance detection
Source Database: Reslit

382

Draft Genome Sequence of Mycobacterium tuberculosis Strain E186hv of Beijing B0/W Lineage with Reduced Virulence.

PMID 25953188 · 2015

associated with rifampin resistance

Mutation Information

rpoB: p.A477D rpoB: p.H481Y

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genomic analysis
Source Database: Reslit

383

Causes and Implications of the Disappearance of Rifampin Resistance in a Rat Model of Methicillin-Resistant Staphylococcus aureus Foreign Body Osteomyelitis.

PMID 25987614 · 2015

Mutations in rpoB confer rifampin resistance.

Mutation Information

Protein Change: A477D, H481Y
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

384

The impact of drug resistance on Mycobacterium tuberculosis physiology: what can we learn from rifampicin?

PMID 26038512 · 2014

Mutations in rpoB are associated with rifampicin resistance in Mycobacterium tuberculosis.

Mutation Information

rpoB: p.S531L rpoB: p.H526Y rpoB: p.F584S

Protein Change: S531L, H526Y, F584S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: clinical isolate analysis
Source Database: Reslit

385

Transmitted Extended-Spectrum Extensively Drug-Resistant Tuberculosis in Beijing, China, with Discordant Whole-Genome Sequencing Analysis Results.

PMID 26063862 · 2015

Mutation Information

rpoB: p.S450L rpoB: p.A1075A

Protein Change: S450L, A1075A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: phenotypic DST
Source Database: Reslit

386

Genome Analysis of the First Extensively Drug-Resistant (XDR) Mycobacterium tuberculosis in Malaysia Provides Insights into the Genetic Basis of Its Biology and Drug Resistance.

PMID 26110649 · 2015

associated with rifampicin resistance

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genomic analysis; polymorphism analysis
Source Database: Reslit

387

Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study.

PMID 26116186 · 2015

Mutation Information

rpoB: p.D516V rpoB: p.H526Y rpoB: p.S531L rpoB: p.N413H rpoB: p.R511C rpoB: p.E521D

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing and phenotypic drug-susceptibility testing
Source Database: Reslit

388

Molecular analysis of rpoB gene mutations in rifampicin resistant Mycobacterium tuberculosis isolates by multiple allele specific polymerase chain reaction in Puducherry, South India.

PMID 26117709 · 2015

Mutations in the rpoB gene were associated with rifampicin resistance in Mycobacterium tuberculosis isolates.

Mutation Information

Protein Change: D516V, H526Y, S531L, N413H, R511C, E521D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MAS-PCR and DNA sequencing
Source Database: Reslit

389

Multidrug-resistant and heteroresistant Mycobacterium tuberculosis and associated gene mutations in Ethiopia.

PMID 26119857 · 2015

Mutation Information

rpoB: p.S531L rpoB: p.S531W rpoB: p.H526Y rpoB: p.H526D rpoB: p.D516V rpoB: p.F505V rpoB: p.D516F rpoB: p.S512G rpoB: p.H526N rpoB: p.I572V

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: line probe assay
Source Database: Reslit

390

Molecular profiling of drug resistant isolates of Mycobacterium tuberculosis in the state of Santa Catarina, southern Brazil.

PMID 26154743 · 2015

Mutations in rpoB are associated with rifampicin resistance.

Mutation Information

Protein Change: S531L, S531W, H526Y, H526D, D516V, F505V, D516F, S512G, H526N, I572V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

391

Evaluation of GenoType MTBDRplus for the rapid detection of drug-resistant tuberculosis in Ghana.

PMID 26162362 · 2015

Mutation Information

rpoB: p.S450L rpoB: p.H445Y rpoB: p.H445D rpoB: p.H445R rpoB: p.D435V rpoB: p.S388L rpoB: p.Q409R

Protein Change: S450L, H445Y, H445D, H445R, D435V, S388L, Q409R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

392

Phenotypic and genotypic analysis of anti-tuberculosis drug resistance in Mycobacterium tuberculosis isolates in Myanmar.

PMID 26206685 · 2015

Mutation Information

Protein Change: S531L, H526Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

393

Whole-genome sequencing targets drug-resistant bacterial infections.

PMID 26243131 · 2015

Mutation Information

rpoB: p.H481Y rpoB: p.H481L rpoB: p.H481D rpoB: p.A477D rpoB: p.Q468K rpoB: p.Q468L rpoB: p.Q468R rpoB: p.S486L rpoB: p.R484H

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: reported in cited literature
Source Database: Reslit

394

RNA polymerase B subunit gene mutations in biofilm-embedded methicillin-resistant Staphylococcus aureus following rifampin treatment.

PMID 26303044 · 2016

Mutations in the rpoB gene were associated with rifampin resistance in biofilm-embedded MRSA isolates.

Mutation Information

Protein Change: H481Y, H481L, H481D, A477D, Q468K, Q468L, Q468R, S486L, R484H
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: sequencing and MIC testing
Source Database: Reslit

395

Emergence of primary drug resistance to rifampicin in Mycobacterium leprae strains from leprosy patients in India.

PMID 26314915 · 2015

Mutations identified in rpoB gene in Mycobacterium leprae strains from leprosy patients in India.

Mutation Information

rpoB: p.A411V rpoB: p.A425G rpoB: p.V424G rpoB: p.Q442H rpoB: p.L455P rpoB: p.S437Q rpoB: p.Q438Y

Protein Change: A411V, A425G, V424G, Q442H, L455P, S437Q, Q438Y
Organisms: Mycobacterium leprae
Confers Resistance To: rifampicin
Validation Method: DNA sequencing and PCR amplification
Source Database: Reslit

396

Reduced turn-around time for Mycobacterium tuberculosis drug susceptibility testing with a proportional agar microplate assay.

PMID 26348263 · 2015

Mutation Information

rpoB: p.S492F rpoB: p.Q474R rpoB: p.D477Y rpoB: p.P496S

Protein Change: L511P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing and MIC determination
Source Database: Reslit

397

Potential mechanisms of attenuation for rifampicin-passaged strains of Flavobacterium psychrophilum.

PMID 26377311 · 2015

Mutations in rpoB are associated with rifampicin resistance and attenuation.

Mutation Information

Protein Change: S492F, Q474R, D477Y, P496S
Organisms: Flavobacterium psychrophilum
Confers Resistance To: rifampicin
Validation Method: genome sequencing
Source Database: Reslit

398

Fitness Cost of Rifampin Resistance in Neisseria meningitidis: In Vitro Study of Mechanisms Associated with rpoB H553Y Mutation.

PMID 26416867 · 2015

The H553Y mutation in rpoB confers rifampin resistance.

Mutation Information

rpoB: p.H553Y

Protein Change: H553Y
Organisms: Neisseria meningitidis
Confers Resistance To: rifampicin
Effect on Function: The H553Y mutation in rpoB confers rifampin resistance.
Validation Method: MIC testing
Source Database: Reslit

399

Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal.

PMID 26418737 · 2015

Mutation Information

rpoB: p.L452P rpoB: p.D435G rpoB: p.S450L

Protein Change: L452P, D435G, S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing and drug susceptibility testing; phylogenetic analysis and parsimony
Source Database: Reslit

400

Predicting differential rifamycin resistance in clinical Mycobacterium tuberculosis isolates by specific rpoB mutations.

PMID 26459537 · 2015

Mutation Information

rpoB: p.H516V rpoB: p.H516Y rpoB: p.H526L rpoB: p.S522L

Protein Change: H516V, H516Y, H526L, S522L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: quantitative drug susceptibility testing
Source Database: Reslit

401

Whole genome sequencing reveals genomic heterogeneity and antibiotic purification in Mycobacterium tuberculosis isolates.

PMID 26496891 · 2015

Mutation Information

rpoB: p.S531L rpoB: p.H526Y rpoB: p.L533P

Protein Change: S531L, H526Y, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Sanger sequencing
Source Database: Reslit

402

Microscale insights into pneumococcal antibiotic mutant selection windows.

PMID 26514094 · 2015

Single point mutations in rpoB were responsible for rifampicin resistance.

Mutation Information

rpoB: p.G601V

Protein Change: G601V
Confers Resistance To: rifampicin
Validation Method: Sanger sequencing
Source Database: Reslit

403

Within patient microevolution of Mycobacterium tuberculosis correlates with heterogeneous responses to treatment.

PMID 26620446 · 2015

Mutation Information

rpoB: p.P45L rpoB: p.S450L rpoB: p.S450W

Protein Change: P45L, S450L, S450W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: SNP genotyping
Source Database: Reslit

404

Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis.

PMID 26686880 · 2015

Mutation in rpoB gene associated with rifampicin resistance.

Mutation Information

rpoB: p.N474K

Protein Change: N474K
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: experimental validation
Source Database: Reslit

405

Drug resistance characteristics and cluster analysis of M. tuberculosis in Chinese patients with multiple episodes of anti-tuberculosis treatment.

PMID 26739444 · 2016

Mutation Information

rpoB: p.S531L rpoB: p.D516V

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

406

Multidrug-Resistant Tuberculosis Complicated by Nosocomial Infection with Multidrug-Resistant Enterobacteriaceae.

PMID 26755567 · 2016

Mutation Information

Protein Change: S531L, D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: molecular testing
Source Database: Reslit

407

MTBDRplus and MTBDRsl Assays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis.

PMID 26763971 · 2016

Mutation Information

rpoB: p.S531L rpoB: p.H526D

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: line probe assay and pyrosequencing
Source Database: Reslit

408

Detection of multidrug-resistant Mycobacterium tuberculosis strains isolated in Brazil using a multimarker genetic assay for katG and rpoB genes.

PMID 26874220 · 2016

associated with rifampicin resistance

Mutation Information

Protein Change: S531L, H526D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: Reslit

409

Genotypic, Phenotypic and Clinical Validation of GeneXpert in Extra-Pulmonary and Pulmonary Tuberculosis in India.

PMID 26894283 · 2016

Mutations in rpoB gene were identified through sequencing and were associated with Rifampicin resistance.

Mutation Information

rpoB: p.H517N rpoB: p.N519H rpoB: p.R529G rpoB: p.L530F rpoB: p.L531L rpoB: p.R533P

Protein Change: H517N, N519H, R529G, L530F, L531L, R533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

410

Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis.

PMID 26919135 · 2016

Mutation in rpoB gene contributes to rifampicin resistance.

Mutation Information

rpoB: p.S450W rpoB: p.S450L rpoB: p.H445D rpoB: p.H445Y rpoB: p.D435V rpoB: p.T400A rpoB: p.I491V rpoB: p.I491F

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: Reslit

411

Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance.

PMID 27005572 · 2016

Mutation Information

Protein Change: S450W, S450L, H445D, H445Y, D435V, T400A, I491V, I491F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genome-wide association analysis; genetic association and structural analysis
Source Database: Reslit

412

Rifabutin and rifampin resistance levels and associated rpoB mutations in clinical isolates of Mycobacterium tuberculosis complex.

PMID 27036978 · 2016

Mutation Information

rpoB: p.D516V rpoB: p.D516F rpoB: p.S522L rpoB: p.H526A rpoB: p.H526C rpoB: p.H526G rpoB: p.H526L rpoB: p.H526S

Protein Change: D516V, D516F, S522L, H526A, H526C, H526G, H526L, H526S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MGIT 960 MIC testing
Source Database: Reslit

413

Complete Reconstitution of the Vancomycin-Intermediate Staphylococcus aureus Phenotype of Strain Mu50 in Vancomycin-Susceptible S. aureus.

PMID 27067329 · 2016

Mutation Information

Protein Change: H481Y
Organisms: Staphylococcus aureus
Confers Resistance To: vancomycin
Effect on Function: increased vancomycin resistance
Validation Method: mutant construction and MIC testing
Source Database: Reslit

414

Primary Multidrug Resistant Tuberculosis and Utility of Line Probe Assay for Its Detection in Smear-Positive Sputum Samples in a Tertiary Care Hospital in South India.

PMID 27099794 · 2016

Mutation Information

rpoB: p.S518L rpoB: p.R521G rpoB: p.P531L rpoB: p.E531G

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Line Probe Assay
Source Database: Reslit

415

Enhanced Survival of Rifampin- and Streptomycin-Resistant Escherichia coli Inside Macrophages.

PMID 27161646 · 2016

Mutation Information

rpoB: p.I572F

Protein Change: I572F
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: experimental validation through survival assays inside macrophages
Source Database: Reslit

416

Epistasis between antibiotic resistance mutations and genetic background shape the fitness effect of resistance across species of Pseudomonas.

PMID 27170722 · 2016

Mutation Information

Protein Change: S518L, R521G, P531L, E531G
Organisms: Pseudomonas aeruginosa, P. stutzeri, P. mendocina, P. putida, P. protegens, P. fluorescens
Confers Resistance To: rifampicin
Validation Method: competition experiments and transcriptional efficiency assays
Source Database: Reslit

417

Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Beijing, China: 2006 versus 2012.

PMID 27176471 · 2016

Mutation Information

rpoB: p.Q513E rpoB: p.H526Y rpoB: p.S531L

Protein Change: S531L, H526Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

418

Rifampin Resistance Mutations Are Associated with Broad Chemical Remodeling of Mycobacterium tuberculosis.

PMID 27226566 · 2016

Mutation Information

Protein Change: Q513E, H526Y, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

419

Antimicrobial Resistance Mechanisms

PMID 27227291 · 2023

Mutation Information

rpoB: p.D526V

Protein Change: D526V
Confers Resistance To: rifampicin
Validation Method: sequencing and MIC testing
Source Database: Reslit

420

Antibiotic resistance mutations induced in growing cells of Bacillus-related thermophiles.

PMID 29348523 · 2018

Mutation Information

rpoB: p.G469C

Protein Change: G469C
Organisms: Geobacillus kaustophilus, Bacillus subtilis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

421

Characterization of Mutations Conferring Resistance to Rifampin in Mycobacterium tuberculosis Clinical Strains.

PMID 30061294 · 2018

Mutations in the rpoB gene were analyzed for their role in rifampin resistance.

Mutation Information

rpoB: p.Q429H rpoB: p.M434I rpoB: p.D435Y rpoB: p.H445Y rpoB: p.S450L rpoB: p.R827C

Protein Change: Q429H, M434I, D435Y, H445Y, S450L, R827C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: construction of M. tuberculosis mutants and their phenotypes; in silico docking analysis and construction of M. tuberculosis mutants and their phenotypes
Source Database: Reslit

422

Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico.

PMID 31166945 · 2019

Mutation Information

rpoB: p.S450W

Protein Change: S450W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: WGS analysis
Source Database: Reslit

423

Genetic diversity and drug susceptibility profiles of Mycobacterium tuberculosis obtained from Saint Peter's TB specialized Hospital, Ethiopia.

PMID 31233535 · 2019

Common mutation in RIF resistant isolates

Mutation Information

rpoB: p.S450L rpoB: p.H445Y rpoB: p.D435F rpoB: p.S441L rpoB: p.1295-1303del

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType MTBDRplus assay
Source Database: Reslit

424

Mycobacterium tuberculosis whole genome sequencing provides insights into the Manila strain and drug-resistance mutations in the Philippines.

PMID 31243306 · 2019

Confirmed in the study

Mutation Information

Protein Change: S450L, H445Y, D435F, S441L, 1295-1303del
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing and drug susceptibility testing
Source Database: Reslit

425

Retrospective Analysis of Archived Pyrazinamide Resistant Mycobacterium tuberculosis Complex Isolates from Uganda-Evidence of Interspecies Transmission.

PMID 31362370 · 2019

The D435Y mutation is disputed regarding its association with rifampin resistance.

Mutation Information

rpoB: p.S450L rpoB: p.D435Y

Protein Change: S450L, D435Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genomic analysis
Source Database: Reslit

426

Development and evaluation of novel bio-safe filter paper-based kits for sputum microscopy and transport to directly detect Mycobacterium tuberculosis and associated drug resistance.

PMID 31408508 · 2019

Mutation Information

rpoB: p.S531L rpoB: p.L533P

Protein Change: S531L, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Molecular Drug Susceptibility (Mol-DST) assay; Mol-DST assay
Source Database: Reslit

427

How Well Do Routine Molecular Diagnostics Detect Rifampin Heteroresistance in Mycobacterium tuberculosis?

PMID 31413081 · 2019

Mutation S450L in rpoB was identified in the study.

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: targeted_deep_sequencing
Source Database: Reslit

428

Evaluation of GenoType MTBDRplus for the detection of drug-resistant Mycobacterium tuberculosis on isolates from Karachi, Pakistan.

PMID 31425565 · 2019

most frequent mutation

Mutation Information

rpoB: p.S531L rpoB: p.D516V rpoB: p.H526D rpoB: p.H526S rpoB: p.H526N rpoB: p.S531W

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: Reslit

429

Prevalence, risk and genetic characteristics of drug-resistant tuberculosis in a tertiary care tuberculosis hospital in China.

PMID 31496759 · 2019

Mutation Information

Protein Change: S531L, D516V, H526D, H526S, H526N, S531W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

430

Characterization of Helicobacter pylori strains and their antimicrobial resistance mechanisms

PMID 31528091 · 2023

Mutation Information

rpoB: p.I837L

Protein Change: I837L
Organisms: Helicobacter pylori
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

431

Evolution of resistance mechanisms and biological characteristics of rifampicin-resistant Staphylococcus aureus strains selected in vitro.

PMID 31533633 · 2019

Other mutations included H481L, H481Y, S464P, R484H

Mutation Information

rpoB: p.H481F

Protein Change: H481F
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: PCR and DNA sequencing
Source Database: Reslit

432

Whole genome sequencing data and analysis of a rifampicin-resistant Mycobacterium tuberculosis strain SBH162 from Sabah, Malaysia.

PMID 31534995 · 2019

Mutation site, S450L, for rifampicin resistance was detected in the rpoB gene.

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: variant calling using bioinformatics tools
Source Database: Reslit

433

Multicenter Study of the Accuracy of the BD MAX Multidrug-resistant Tuberculosis Assay for Detection of Mycobacterium tuberculosis Complex and Mutations Associated With Resistance to Rifampin and Isoniazid.

PMID 31560049 · 2020

Mutation Information

Protein Change: D435Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: bidirectional sequencing
Source Database: Reslit

434

First insights into the genetic characteristics and drug resistance of Mycobacterium tuberculosis population collected during the first national tuberculosis prevalence survey of Lao PDR (2010-2011).

PMID 31615439 · 2019

Mutation Information

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic testing
Source Database: Reslit

435

Clonal Confinement of a Highly Mobile Resistance Element Driven by Combination Therapy in Rhodococcus equi.

PMID 31615959 · 2019

Confers high-level resistance to rifampin.

Mutation Information

rpoB: p.S443F

Protein Change: S443F
Organisms: Rhodococcus equi
Confers Resistance To: rifampicin
Validation Method: sequencing and correlation with resistance phenotype
Source Database: Reslit

436

Whole genome sequencing of drug resistant Mycobacterium tuberculosis isolates from a high burden tuberculosis region of North West Pakistan.

PMID 31628383 · 2019

Mutation Information

rpoB: p.L452P rpoB: p.D435G rpoB: p.I1106T

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing and drug susceptibility testing
Source Database: Reslit

437

Pre-detection history of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa.

PMID 31659018 · 2019

Mutation Information

Protein Change: L452P, D435G, I1106T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: phylogenetic analysis and mutation timing
Source Database: Reslit

438

Diversity of Mycobacterium tuberculosis in the Middle Fly District of Western Province, Papua New Guinea: microbead-based spoligotyping using DNA from Ziehl-Neelsen-stained microscopy preparations.

PMID 31664101 · 2019

All RIF-resistant samples belonged to the L2/Beijing Lineage.

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

439

Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients.

PMID 31700189 · 2019

A non-synonymous SNP in the rpoB gene of a blood isolate from Patient R1 was identified, which is associated with rifampin resistance.

Mutation Information

rpoB: p.H487D

Protein Change: H487D
Organisms: Lactobacillus rhamnosus
Confers Resistance To: rifampicin
Validation Method: genomic analysis and structural prediction
Source Database: Reslit

440

Prevalence of mutations in genes associated with rifampicin and isoniazid resistance in Mycobacterium tuberculosis clinical isolates.

PMID 31723707 · 2017

Mutation Information

rpoB: p.D471E rpoB: p.I527M

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Genotype MTBDRplus V.2.0 assay
Source Database: Reslit

441

Genomic diversity of prevalent Staphylococcus epidermidis multidrug-resistant strains isolated from a Children's Hospital in México City in an eight-years survey.

PMID 31768302 · 2019

Mutation Information

Protein Change: D471E, I527M
Organisms: Staphylococcus epidermidis
Confers Resistance To: rifampicin
Validation Method: genomic analysis
Source Database: Reslit

442

Molecular characterization of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates identifies local transmission of infection in Kuwait, a country with a low incidence of TB and MDR-TB.

PMID 31806020 · 2019

Mutation Information

rpoB: p.S456L rpoB: p.H451Y rpoB: p.D441V rpoB: p.H451D rpoB: p.S456W rpoB: p.Q438K rpoB: p.V176F rpoB: p.Q438E rpoB: p.Q438P rpoB: p.H451R

Protein Change: S456L, H451Y, D441V, H451D, S456W, Q438K, V176F, Q438E, Q438P, H451R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: PCR sequencing
Source Database: Reslit

443

Genomic insights on heterogeneous resistance to vancomycin and teicoplanin in Methicillin-resistant Staphylococcus aureus: A first report from South India.

PMID 31887179 · 2019

novel mutation

Mutation Information

rpoB: p.N474S rpoB: p.L466S rpoB: p.S486L rpoB: p.H481Y rpoB: p.H481N

Protein Change: N474S, L466S, S486L, H481Y, H481N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicinteicoplanin
Validation Method: genomic analysis; whole-genome sequencing
Source Database: Reslit

444

Spoligotyping and drug sensitivity of Mycobacterium tuberculosis isolated from pulmonary tuberculosis patients in the Arsi Zone of southeastern Ethiopia.

PMID 31908780 · 2020

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType MTBDRplus assay
Source Database: Reslit

445

A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status.

PMID 31910804 · 2020

Mutation Information

rpoB: p.L531P rpoB: p.H526R

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genomic variant analysis
Source Database: Reslit

446

Evolution of Mycobacterium tuberculosis complex lineages and their role in an emerging threat of multidrug resistant tuberculosis in Bamako, Mali.

PMID 31941887 · 2020

Mutation Information

Protein Change: L531P, H526R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

447

Genomic Analysis of Mycobacterium tuberculosis Isolates and Construction of a Beijing Lineage Reference Genome.

PMID 31971587 · 2020

The S450L mutation in rpoB was found in TCDC4, TCDC10, and TCDC11.

Mutation Information

rpoB: p.S450L rpoB: p.D435V rpoB: p.S450W

Protein Change: S450L, D435V, S450W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: experimental assay; functional assays
Source Database: Reslit

448

Isoniazid and Rifampin-Resistance Mutations Associated With Resistance to Second-Line Drugs and With Sputum Culture Conversion.

PMID 32002554 · 2020

Mutation Information

rpoB: p.S531L rpoB: p.D516V rpoB: c.C1576T

Protein Change: S531L, D516V
Nucleotide Change: C1576T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicinrifampicin|ethambutol
Validation Method: line probe assay
Source Database: Reslit

449

A landscape of genomic alterations at the root of a near-untreatable tuberculosis epidemic.

PMID 32014024 · 2020

Mutation Information

rpoB: p.T433I rpoB: p.D441Y

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MIC testing
Source Database: Reslit

450

Case Report: Multidrug-Resistant Mycobacterium leprae in a Case of Smear-Negative Relapse.

PMID 32043454 · 2020

Mutation Information

Protein Change: T433I, D441Y
Organisms: Mycobacterium leprae
Confers Resistance To: rifampicin
Validation Method: DNA sequencing and HRM analysis
Source Database: Reslit

451

Molecular characterization of pre-extensive drug resistant Mycobacterium tuberculosis in Northeast Brazil.

PMID 32049255 · 2020

Mutation Information

rpoB: p.D516Y rpoB: p.D516V rpoB: p.H526Y rpoB: p.H526R rpoB: p.S531L

Protein Change: D516Y, D516V, H526Y, H526R, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

452

Dysbiosis individualizes the fitness effect of antibiotic resistance in the mammalian gut.

PMID 32632259 · 2020

Confers resistance to rifampicin

Mutation Information

Protein Change: H526Y
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: competition assay in mice
Source Database: Reslit

453

Metabolic Rewiring of Mycobacterium tuberculosis upon Drug Treatment and Antibiotics Resistance.

PMID 38248866 · 2024

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: reported in cited literature
Source Database: Reslit

454

Prevalence of Beijing Central Asian/Russian Cluster 94-32 among Multidrug-Resistant M. tuberculosis in Kazakhstan.

PMID 38275319 · 2023

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: allele-specific real-time PCR and Sanger sequencing
Source Database: Reslit

455

The positivity rates and drug resistance patterns of Mycobacterium tuberculosis using nucleotide MALDI-TOF MS assay among suspected tuberculosis patients in Shandong, China: a multi-center prospective study.

PMID 38304182 · 2024

Mutation Information

rpoB: p.Y737S rpoB: p.S526L

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: nucleotide MALDI-TOF MS assay
Source Database: Reslit

456

Resistome, mobilome, and virulome explored in clinical isolates derived from acne patients in Egypt: unveiling unique traits of an emerging coagulase-negative Staphylococcus pathogen.

PMID 38371297 · 2024

Mutation Information

Protein Change: Y737S, S526L
Confers Resistance To: rifampicin
Validation Method: genomic detection; genomic analysis
Source Database: Reslit

457

Mutational Dynamics Related to Antibiotic Resistance in M. tuberculosis Isolates from Serial Samples of Patients with Tuberculosis and Type 2 Diabetes Mellitus.

PMID 38399727 · 2024

found in four isolates from individuals with DM2-TB and in one isolate from one individual with TB

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genomic analysis
Source Database: Reslit

458

Rapid detection of multidrug resistance in tuberculosis using nanopore-based targeted next-generation sequencing: a multicenter, double-blind study.

PMID 38495513 · 2024

Most frequent mutation in rpoB

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: Reslit

459

Compensatory evolution in NusG improves fitness of drug-resistant M. tuberculosis.

PMID 38509362 · 2024

Mutations in rpoB are associated with rifampicin resistance.

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: mutant construction and in vitro transcription assays
Source Database: Reslit

460

Genomic Insights into Staphylococcus aureus Isolates Exhibiting Diminished Daptomycin Susceptibility.

PMID 38535549 · 2024

Mutation Information

rpoB: p.F737Y

Protein Change: F737Y
Organisms: Staphylococcus aureus
Confers Resistance To: daptomycin
Validation Method: PCR and sequencing
Source Database: Reslit

461

Patterns and profiles of drug resistance-conferring mutations in Mycobacterium tuberculosis genotypes isolated from tuberculosis-suspected attendees of spiritual holy water sites in Northwest Ethiopia.

PMID 38566794 · 2024

Most frequent mutation in RIF-resistant isolates

Mutation Information

Protein Change: S531L, H526Y, D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType®MTBDR plus VER2.0; LPAs and sequencing
Source Database: Reslit

462

Comparison of targeted next-generation sequencing and the Xpert MTB/RIF assay for detection of Mycobacterium tuberculosis in clinical isolates and sputum specimens.

PMID 38602399 · 2024

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

463

Transmission characteristics in Tuberculosis by WGS: nationwide cross-sectional surveillance in China.

PMID 38686553 · 2024

Mutations in rpoB were identified in MDR/RR-TB isolates.

Mutation Information

rpoB: p.L430P rpoB: p.H445N rpoB: p.D435Y rpoB: p.Q429H rpoB: p.L452P rpoB: p.H445L rpoB: p.H445G rpoB: p.D435G

Protein Change: H526Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genomic clustering and resistance mutation analysis
Source Database: Reslit

464

The complete genome sequence of unculturable Mycoplasma faucium obtained through clinical metagenomic next-generation sequencing.

PMID 38694516 · 2024

Consistent with observations in other Mycoplasma species.

Mutation Information

rpoB: p.H526N

Protein Change: H526N
Organisms: Mycoplasma faucium
Confers Resistance To: rifampicin
Validation Method: sequence analysis
Source Database: Reslit

465

Discordant results between Xpert MTB/RIF assay and Bactec MGIT 960 culture system regarding the detection of rifampin-resistant Mycobacterium tuberculosis isolates in Wenzhou, China.

PMID 38738892 · 2024

Mutations in rpoB are associated with rifampin resistance.

Mutation Information

Protein Change: L430P, H445N, D435Y, Q429H, L452P, H445L, H445G, D435G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing and molecular dynamics analysis
Source Database: Reslit

466

Genotypic and phenotypic drug resistance patterns of Mycobacterium tuberculosis isolated from presumptive pulmonary tuberculosis patients in Ethiopia: A multicenter study.

PMID 38753615 · 2024

Mutation Information

Protein Change: S531L, H526Y, D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic DST
Source Database: Reslit

467

Drug Susceptibility and Mutation Profiles in Mycobacterium tuberculosis Isolates from a Tertiary Care Hospital in Kerala, India.

PMID 38772358 · 2024

Mutation Information

Protein Change: D435Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Sanger sequencing
Source Database: Reslit

468

Large-scale statistical analysis of Mycobacterium tuberculosis genome sequences identifies compensatory mutations associated with multi-drug resistance.

PMID 38811658 · 2024

This mutation is associated with rifampicin resistance.

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: association and mediation analysis
Source Database: Reslit

469

Drug Resistance and Epidemiological Success of Modern Mycobacterium tuberculosis Lineages in Western India.

PMID 38819323 · 2025

Mutation Information

rpoB: p.L430P

Protein Change: L430P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic and phenotypic testing
Source Database: Reslit

470

Infection by a multidrug-resistant Corynebacterium diphtheriae strain: prediction of virulence factors, CRISPR-Cas system analysis, and structural implications of mutations conferring rifampin resistance.

PMID 39196424 · 2024

Mutation in rpoB gene causes rifampin resistance

Mutation Information

rpoB: p.S442Y

Protein Change: S442Y
Organisms: Corynebacterium diphtheriae
Confers Resistance To: rifampicin
Effect on Function: The mutation causes a serine to tyrosine substitution at position 442, leading to a more hydrophobic environment in the rifampin binding pocket, which reduces the effectiveness of rifampin.
Validation Method: genomic analysis and structural modeling
Source Database: Reslit

471

Rapid detection of rifampicin resistance in sputum and biopsy specimens from tuberculosis patients by PCR and line probe assay.

PMID 7496004 · 1995

Mutations detected in the rpoB gene included Ser531Leu, His526Tyr, His526Asp, and His526Cys.

Mutation Information

rpoB: p.Q468R rpoB: p.D471Y rpoB: p.A477V rpoB: p.A477D rpoB: p.H481Y rpoB: p.R484H rpoB: p.D550G

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

472

Characterization of mutations in the rpoB gene that confer rifampin resistance in Staphylococcus aureus.

PMID 9756760 · 1998

Mutations in the rpoB gene confer rifampin resistance in Staphylococcus aureus.

Mutation Information

Protein Change: Q468R, D471Y, A477V, A477D, H481Y, R484H, D550G
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Effect on Function: Target modification
Validation Method: gene amplification and sequencing
Source Database: ReslitResFinder Database

473

Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolated from south-central in China.

PMID 24326341 · 2014

mutations in the rpoB gene are associated with rifampicin resistance

Mutation Information

rpoB: p.S531L rpoB: p.H526L rpoB: p.D516V

Protein Change: S531L, H526L, D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing and MIC determination
Source Database: Reslit

474

Elucidating emergence and transmission of multidrug-resistant tuberculosis in treatment experienced patients by whole genome sequencing.

PMID 24349420 · 2013

Mutation in rpoB associated with rifampicin resistance.

Mutation Information

rpoB: p.S531L rpoB: p.D516G rpoB: p.D516V rpoB: p.H526Y rpoB: p.H526R rpoB: p.S531W

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole_genome_sequencing
Source Database: Reslit

475

Predicting extensively drug-resistant Mycobacterium tuberculosis phenotypes with genetic mutations.

PMID 24353002 · 2014

Mutation Information

Protein Change: S531L, D516G, D516V, H526Y, H526R, S531W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

476

Direct sequencing for rapid detection of multidrug resistant Mycobacterium tuberculosis strains in Morocco.

PMID 24399879 · 2013

Mutation Information

rpoB: p.D516Y rpoB: p.H526D rpoB: p.S531L

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

477

Evaluation of the AID TB resistance line probe assay for rapid detection of genetic alterations associated with drug resistance in Mycobacterium tuberculosis strains.

PMID 24403306 · 2014

Mutation Information

Protein Change: D516Y, H526D, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

478

Rifampicin mono-resistant tuberculosis in France: a 2005-2010 retrospective cohort analysis.

PMID 24410906 · 2014

Mutations identified in rpoB were associated with rifampicin resistance.

Mutation Information

rpoB: p.S531L rpoB: p.H526Y rpoB: p.H526D rpoB: p.L533P rpoB: p.D516V

Protein Change: S531L, H526Y, H526D, L533P, D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: molecular analysis
Source Database: Reslit

479

Fitness costs of rifampicin resistance in Mycobacterium tuberculosis are amplified under conditions of nutrient starvation and compensated by mutation in the β' subunit of RNA polymerase.

PMID 24417450 · 2014

Mutations in rpoB are associated with rifampicin resistance

Mutation Information

rpoB: p.S531L rpoB: p.S531W rpoB: p.Q526D rpoB: p.Q526Y rpoB: p.Q526L rpoB: p.Q526R rpoB: p.Q526V rpoB: p.D516G rpoB: p.L511P

Protein Change: S531L
Organisms: Mycobacterium tuberculosis, Mycobacterium smegmatis
Confers Resistance To: rifampicin
Validation Method: sequencing of clinical isolates and functional assays in M. smegmatis
Source Database: Reslit

480

Epistasis between antibiotic resistance mutations drives the evolution of extensively drug-resistant tuberculosis.

PMID 24481187 · 2013

Mutation Information

rpoB: p.H526R

Protein Change: H526R
Organisms: Mycobacterium smegmatis, Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: PCR and sequencing
Source Database: Reslit

481

Sequence analysis of the drug‑resistant rpoB gene in the Mycobacterium tuberculosis L‑form among patients with pneumoconiosis complicated by tuberculosis.

PMID 24535137 · 2014

Mutation Information

Protein Change: S531L, S531W, Q526D, Q526Y, Q526L, Q526R, Q526V, D516G, L511P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: direct sequencing
Source Database: Reslit

482

Concomitant multidrug-resistant pulmonary tuberculosis and susceptible tuberculous meningitis.

PMID 24565423 · 2014

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: line probe assay
Source Database: Reslit

483

A multi-site validation in India of the line probe assay for the rapid diagnosis of multi-drug resistant tuberculosis directly from sputum specimens.

PMID 24586360 · 2014

Mutation Information

rpoB: p.S531L rpoB: p.D516V rpoB: p.H526Y rpoB: p.H526D rpoB: p.S531W rpoB: p.H526L rpoB: p.L511P rpoB: p.S531Q rpoB: p.T508A rpoB: p.T508T rpoB: p.F514L rpoB: p.H526C rpoB: p.H526R rpoB: p.M515T rpoB: p.Q513K rpoB: p.S222L

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Sequencing and LPA
Source Database: Reslit

484

Correlation between genotypic and phenotypic testing for resistance to rifampin in Mycobacterium tuberculosis clinical isolates in Haiti: investigation of cases with discrepant susceptibility results.

PMID 24599230 · 2014

all mutations are in the rpoB gene

Mutation Information

Protein Change: S531L, D516V, H526Y, H526D, S531W, H526L, L511P, S531Q, T508A, T508T, F514L, H526C, H526R, M515T, Q513K, S222L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

485

Comparison of Xpert MTB/RIF with line probe assay for detection of rifampin-monoresistant Mycobacterium tuberculosis.

PMID 24648554 · 2014

Mutation Information

rpoB: p.S531L rpoB: p.D516V rpoB: p.H526Y rpoB: p.H526D rpoB: p.L533P

Protein Change: S531L, D516V, H526Y, H526D, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

486

Pyrosequencing for rapid detection of tuberculosis resistance in clinical isolates and sputum samples from re-treatment pulmonary tuberculosis patients.

PMID 24725975 · 2014

Mutation Information

Protein Change: L511P, Q513H, D516N, D516A, D516G, D516V, D516Y, D516F, N518S, H526N, H526Q, H526R, H526D, H526Y, H526C, H526F, S531T, S531Y, S531W, S531L, L533P, L533R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: pyrosequencing
Source Database: Reslit

487

Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Hunan, China.

PMID 24733464 · 2014

Mutation Information

rpoB: p.H531Y rpoB: p.H526R rpoB: p.H516Y

Protein Change: H531Y, H526R, H516Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

488

Profiling of rpoB mutations and MICs for rifampin and rifabutin in Mycobacterium tuberculosis.

PMID 24740074 · 2014

mutations in rpoB are associated with resistance to rifampin and rifabutin

Mutation Information

rpoB: p.S531L rpoB: p.S531W rpoB: p.H526Y rpoB: p.H526D rpoB: p.D516V rpoB: p.H526L rpoB: p.H526N rpoB: p.L511P rpoB: p.S522L rpoB: p.V146F

Protein Change: S531L, S531W, H526Y, H526D, D516V, H526L, H526N, L511P, S522L, V146F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin|rifabutinrifampicin
Validation Method: Sanger sequencing and MIC determination; whole-genome sequencing
Source Database: Reslit

489

Dissecting vancomycin-intermediate resistance in staphylococcus aureus using genome-wide association.

PMID 24787619 · 2014

The rpoB H481Y mutation was significantly associated with VISA phenotype.

Mutation Information

rpoB: p.L511P rpoB: p.Y513D rpoB: p.S516L rpoB: p.S516G rpoB: p.G516V rpoB: p.D526G rpoB: p.D526Y rpoB: p.P526R rpoB: p.P526S rpoB: p.S531L rpoB: p.S531F rpoB: p.L533P

Protein Change: H481Y
Organisms: Staphylococcus aureus
Confers Resistance To: vancomycin
Validation Method: genome-wide association study
Source Database: Reslit

490

Distinguishing nontuberculous mycobacteria from multidrug-resistant Mycobacterium tuberculosis, China.

PMID 24856951 · 2014

Mutation Information

Protein Change: L511P, Y513D, S516L, S516G, G516V, D526G, D526Y, P526R, P526S, S531L, S531F, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: drug resistance detection array kit
Source Database: Reslit

491

Sequence analysis for detection of drug resistance in Mycobacterium tuberculosis complex isolates from the Central Region of Cameroon.

PMID 24884632 · 2014

mutated in RIF-resistant isolates

Mutation Information

rpoB: p.S531L rpoB: p.H526D rpoB: p.D516V

Protein Change: S531L, H526D, D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

492

Molecular patterns of multidrug resistance of Mycobacterium tuberculosis in Georgia.

PMID 24904758 · 2013

Most common mutation responsible for RIF resistance

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType® MTBDR plus assay
Source Database: Reslit

493

Optimizing multiplex SNP-based data analysis for genotyping of Mycobacterium tuberculosis isolates.

PMID 25001491 · 2014

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MLPA and phenotypic DST
Source Database: Reslit

494

Multidrug resistant Mycobacterium tuberculosis: a retrospective katG and rpoB mutation profile analysis in isolates from a reference center in Brazil.

PMID 25093512 · 2014

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

495

A complete high-quality MinION nanopore assembly of an extensively drug-resistant Mycobacterium tuberculosis Beijing lineage strain identifies novel variation in repetitive PE/PPE gene regions.

PMID 29906261 · 2018

Mutation Information

rpoB: p.S450L rpoB: c.T450C

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

496

Validating a 14-Drug Microtiter Plate Containing Bedaquiline and Delamanid for Large-Scale Research Susceptibility Testing of Mycobacterium tuberculosis.

PMID 29941636 · 2018

Mutation in rpoB gene associated with high-level rifampin resistance.

Mutation Information

Protein Change: S450L
Nucleotide Change: T450C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin|rifabutin
Validation Method: genotype-phenotype correlation; MIC testing
Source Database: Reslit

497

Mutations of rpob Gene Associated with Rifampin Resistance among Mycobacterium Tuberculosis Isolated in Tuberculosis Regional Reference Laboratory in Northeast of Iran during 2015-2016.

PMID 29983529 · 2018

Mutation Information

rpoB: p.S531L rpoB: p.D516Y rpoB: p.H526D rpoB: p.H526Y

Protein Change: S531L, D516Y, H526D, H526Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

498

Successful Treatment with a High-dose Rifampin-containing Regimen for Pulmonary Tuberculosis with a Disputed rpoB Mutation.

PMID 29984742 · 2018

Disputed rpoB mutation

Mutation Information

rpoB: p.S531L rpoB: p.L511P rpoB: p.H526Y rpoB: p.L533P

Protein Change: L511P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

499

Performance of an Xpert-based diagnostic algorithm for the rapid detection of drug-resistant tuberculosis among high-risk populations in a low-incidence setting.

PMID 30011319 · 2018

Mutation Information

Protein Change: S531L, L511P, H526Y, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Gene sequencing
Source Database: Reslit

500

Detection of Rifampicin- and Isoniazid-Resistant Mycobacterium tuberculosis Using the Quantamatrix Multiplexed Assay Platform System.

PMID 30027701 · 2018

Mutation Information

rpoB: p.S531L rpoB: p.Y516H

Protein Change: S531L, Y516H
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing analysis
Source Database: Reslit

501

Mixed Mycobacterium tuberculosis-Strain Infections Are Associated With Poor Treatment Outcomes Among Patients With Newly Diagnosed Tuberculosis, Independent of Pretreatment Heteroresistance.

PMID 30085153 · 2018

Mutations in the rpoB gene were associated with rifampicin resistance.

Mutation Information

rpoB: p.H526N rpoB: p.S531L

Protein Change: H526N, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: deep sequencing
Source Database: Reslit

502

Genomic exploration of sequential clinical isolates reveals a distinctive molecular signature of persistent Staphylococcus aureus bacteraemia.

PMID 30103826 · 2018

Mutation in rpoB was associated with increased vancomycin resistance.

Mutation Information

rpoB: p.R503H

Protein Change: R503H
Organisms: Staphylococcus aureus
Confers Resistance To: vancomycin
Validation Method: observed in relapsing strain with increased vancomycin MIC
Source Database: Reslit

503

Characterization of rifampin-resistant Staphylococcus aureus nasal carriage in patients receiving rifampin-containing regimens for tuberculosis.

PMID 30147345 · 2018

Mutation Information

rpoB: p.S486L

Protein Change: S486L
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Source Database: Reslit

504

Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq).

PMID 30165908 · 2018

Confirmed by genetic reconstruction

Mutation Information

rpoB: p.D471G rpoB: p.Q468K rpoB: p.P519L rpoB: p.L488S rpoB: p.G489V rpoB: p.A477V rpoB: p.H481N rpoB: p.L466S rpoB: p.D471E rpoB: p.G442W rpoB: p.H445N rpoB: p.S450L rpoB: p.P471Q rpoB: p.I31F rpoB: p.R29S rpoB: p.H102P rpoB: c.338del rpoB: c.485del rpoB: c.487del

Protein Change: D471G, Q468K, P519L, L488S, G489V, A477V, H481N, L466S, D471E, G442W, H445N, S450L, P471Q, I31F, R29S, H102P
Nucleotide Change: 338del, 485del, 487del
Organisms: Staphylococcus aureus, Mycobacterium tuberculosis
Confers Resistance To: rifampicindaptomycinpyrazinamideethionamide
Validation Method: genetic reconstruction and MIC testing; RM-seq and daptomycin time kill assays; RM-seq; RM-seq and in vivo tracking; RM-seq and MIC testing
Source Database: Reslit

505

Global spread of three multidrug-resistant lineages of Staphylococcus epidermidis.

PMID 30177740 · 2018

rpoB

Mutation Information

rpoB: p.D471E rpoB: p.I527M

Protein Change: D471E, I527M
Organisms: Staphylococcus epidermidis
Confers Resistance To: rifampicin|vancomycinrifampicin|teicoplanin|vancomycin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Validation Method: allelic exchange and phenotypic testing
Source Database: ReslitReference Gene Catalog

506

Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes.

PMID 30224802 · 2018

The rpoB-H445Y mutation was identified in rifampicin-resistant Mtb HN878 clones.

Mutation Information

rpoB: p.H445Y

Protein Change: H445Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Sanger sequencing and drug susceptibility testing
Source Database: Reslit

507

A rapid identification technique for drug-resistant Mycobacterium tuberculosis isolates using mismatch specific cleavage enzyme.

PMID 30262979 · 2018

Mutations in rpoB are associated with rifampicin resistance.

Mutation Information

rpoB: p.H315N

Protein Change: H315N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Mismatch-specific cleavage enzyme assay
Source Database: Reslit

508

Phenotypic and genotypic drug sensitivity of Mycobacterium tuberculosis complex isolated from South Omo Zone, Southern Ethiopia.

PMID 30288068 · 2018

Mutation Information

rpoB: p.H526D rpoB: p.D516V

Protein Change: H526D, D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic DST using GenoType MTBDR plus assay
Source Database: Reslit

509

Efficiently activated ε-poly-L-lysine production by multiple antibiotic-resistance mutations and acidic pH shock optimization in Streptomyces albulus.

PMID 30298553 · 2019

Mutation Information

rpoB: p.Q856H

Protein Change: Q856H
Organisms: Streptomyces albulus
Confers Resistance To: rifampicin
Validation Method: sequencing of rpoB gene
Source Database: Reslit

510

Cross-sectional Whole-genome Sequencing and Epidemiological Study of Multidrug-resistant Mycobacterium tuberculosis in China.

PMID 30321294 · 2019

Mutation Information

rpoB: p.S450L rpoB: p.L452P rpoB: p.I1106T rpoB: p.H1028R

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing and statistical analysis
Source Database: Reslit

511

Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis.

PMID 30337649 · 2018

Mutations at position 445 in rpoB are associated with rifampicin resistance.

Mutation Information

Protein Change: S450L, L452P, I1106T, H1028R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: in-silico analysis
Source Database: Reslit

512

Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.

PMID 30337678 · 2018

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

Protein Change: S531L, D435G, D435V, D435Y, F503S, G836S, H445D, H445L, H445R, H445Y, H835R, I1106T, I480V, L430P, L452P, L731P, M434I, P45L, P45S, Q432P, Q975H, R827H, S450L, S450W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Validation Method: variant calling and annotation
Source Database: ReslitCard Database

513

New epidemic cluster of pre-extensively drug resistant isolates of Mycobacterium tuberculosis Ural family emerging in Eastern Europe.

PMID 30348088 · 2018

Mutation Information

rpoB: p.S450L rpoB: p.S450W

Protein Change: S450L, S450W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic resistance profile
Source Database: Reslit

514

Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia.

PMID 30373719 · 2018

Mutation Information

rpoB: p.N518D rpoB: p.S512F rpoB: p.D516G rpoB: p.R529H rpoB: p.I572L rpoB: p.P564L

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic and phenotypic analysis
Source Database: Reslit

515

Evolution of Rifampin Resistance in Escherichia coli and Mycobacterium smegmatis Due to Substandard Drugs.

PMID 30397062 · 2019

Mutation Information

Protein Change: N518D, S512F, D516G, R529H, I572L, P564L
Organisms: Escherichia coli, Mycobacterium smegmatis
Confers Resistance To: rifampicin
Validation Method: Sanger sequencing
Source Database: Reslit

516

Molecular detection of rifampin, isoniazid, and ofloxacin resistance in Iranian isolates of Mycobacterium tuberculosis by high-resolution melting analysis.

PMID 30425535 · 2018

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: HRM and sequencing
Source Database: Reslit

517

Phenotypic and genomic comparison of Photorhabdus luminescens subsp. laumondii TT01 and a widely used rifampicin-resistant Photorhabdus luminescens laboratory strain.

PMID 30497380 · 2018

Mutations in rpoB confer rifampicin resistance

Mutation Information

rpoB: p.D516G rpoB: p.S512F rpoB: p.Q490P rpoB: p.S512P rpoB: p.E523D rpoB: p.H526L rpoB: p.S499F rpoB: p.E142A rpoB: p.G713C

Protein Change: H526Y
Organisms: Photorhabdus luminescens
Confers Resistance To: rifampicin
Validation Method: genomic analysis
Source Database: Reslit

518

Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB.

PMID 30504835 · 2018

Mutation Information

Protein Change: D516G, S512F, Q490P, S512P, E523D, H526L, S499F, E142A, G713C
Organisms: Salmonella enterica
Confers Resistance To: rifampicin
Validation Method: sequencing and fitness measurement; sequencing and MIC measurement
Source Database: Reslit

519

Emergence of a dalbavancin induced glycopeptide/lipoglycopeptide non-susceptible Staphylococcus aureus during treatment of a cardiac device-related endocarditis.

PMID 30514923 · 2018

Mutation Information

rpoB: p.R436H

Protein Change: R436H
Organisms: Staphylococcus aureus
Confers Resistance To: dalbavancin|teicoplanin
Validation Method: whole genome sequencing
Source Database: Reslit

520

Line-probe assay and molecular typing reveal a potential drug resistant clone of Mycobacterium tuberculosis in Ethiopia.

PMID 30534412 · 2018

Mutation detected in strains with rifampicin resistance

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: line probe assay
Source Database: Reslit

521

Reconstruction of the Vancomycin-Susceptible Staphylococcus aureus Phenotype From a Vancomycin-Intermediate S. aureus XN108.

PMID 30546356 · 2018

RpoB(H481N) mutation was identified as a contributor to the VISA phenotype

Mutation Information

rpoB: p.H481N

Protein Change: H481N
Organisms: Staphylococcus aureus
Confers Resistance To: vancomycin
Validation Method: allelic replacement and antimicrobial susceptibility testing
Source Database: Reslit

522

Transcriptional Approach for Decoding the Mechanism of rpoC Compensatory Mutations for the Fitness Cost in Rifampicin-Resistant Mycobacterium tuberculosis.

PMID 30555440 · 2018

Mutation in rpoB leads to rifampin resistance

Mutation Information

rpoB: p.S526L

Protein Change: S526L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: transcriptomic analysis
Source Database: Reslit

523

First insights on the genetic diversity of MDR Mycobacterium tuberculosis in Lebanon.

PMID 30594126 · 2018

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

524

Rapid detection of multidrug resistant tuberculosis in respiratory specimens at a tertiary care centre in south coastal Karnataka using Genotype MTBDR plus assay.

PMID 30675322 · 2018

Most common mutation in rifampicin resistant isolates

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType MTBDR plus assay
Source Database: Reslit

525

Molecular drug susceptibility testing and strain typing of tuberculosis by DNA hybridization.

PMID 30730960 · 2019

Mutation Information

rpoB: p.H516L rpoB: p.S526L rpoB: p.L531P

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: microarray hybridization
Source Database: Reslit

526

Investigation of the rpoB Mutations Causing Rifampin Resistance by Rapid Screening in Mycobacterium Tuberculosis in North-East of Iran.

PMID 30774682 · 2018

Mutation Information

Protein Change: H516L, S526L, L531P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MAS-PCR
Source Database: Reslit

527

Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012-2016.

PMID 30789128 · 2019

Mutation Information

rpoB: p.S450W rpoB: p.S450L

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

528

Longitudinal Outbreak of Multidrug-Resistant Tuberculosis in a Hospital Setting, Serbia.

PMID 30789133 · 2019

Mutation Information

Protein Change: S450W, S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

529

Rifampicin and rifabutin resistance in 1003 Mycobacterium tuberculosis clinical isolates.

PMID 30793747 · 2019

The D435V mutation was associated with decreased susceptibility to both rifampicin and rifabutin.

Mutation Information

rpoB: p.D435V rpoB: p.S450L

Protein Change: D435V, S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin|rifabutin
Effect on Function: increased IC 50 of both rifamycins
Validation Method: alamarBlue reduction assay
Source Database: Reslit

530

Lab-on-a-Film disposable for genotyping multidrug-resistant Mycobacterium tuberculosis from sputum extracts.

PMID 30801596 · 2019

Mutation Information

rpoB: p.Q432P rpoB: p.I1491S

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotyping via hybridization on gel elements
Source Database: Reslit

531

Molecular epidemiology and whole genome sequencing analysis of clinical Mycobacterium bovis from Ghana.

PMID 30830912 · 2019

Mutation Information

Protein Change: Q432P, I1491S
Organisms: Mycobacterium bovis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

532

Genomic analysis of the emergence of drug-resistant strains of Mycobacterium tuberculosis in the Middle East.

PMID 30872748 · 2019

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Whole genome sequencing and phenotypic testing
Source Database: Reslit

533

Cryptic Resistance Mutations Associated With Misdiagnoses of Multidrug-Resistant Tuberculosis.

PMID 30875421 · 2019

noncanonical RIF resistance mutation

Mutation Information

Protein Change: I491F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: ultra-deep amplicon sequencing and phenotypic DST
Source Database: Reslit

534

Prevalence and detection of drug resistant mutations in Mycobacterium tuberculosis among drug naïve patients in Nairobi, Kenya.

PMID 30909867 · 2019

Mutation Information

rpoB: p.D435V rpoB: p.S450L

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Hain Genotype MTBDR plus assay
Source Database: Reslit

535

Whole genome sequencing identifies bacterial factors affecting transmission of multidrug-resistant tuberculosis in a high-prevalence setting.

PMID 30944370 · 2019

Acquired at least twice

Mutation Information

Protein Change: D435V, S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genetic distance and phylogenetic analysis
Source Database: Reslit

536

Speeding up the diagnosis of multidrug-resistant tuberculosis in a high-burden region with the use of a commercial line probe assay.

PMID 31017225 · 2019

Mutation Information

rpoB: p.H526N

Protein Change: H526N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

537

High prevalence of multi drug resistant tuberculosis in people living with HIV in Western India.

PMID 31068153 · 2019

Mutations in rpoB gene were identified as a cause of rifampicin resistance.

Mutation Information

rpoB: p.L531F

Protein Change: L531F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: line probe assay
Source Database: Reslit

538

Prevalence and molecular characterization of multidrug-resistant M. tuberculosis in Jiangxi province, China.

PMID 31086215 · 2019

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

539

Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture.

PMID 31109296 · 2019

Mutation Information

rpoB: p.V382I rpoB: p.H491N rpoB: p.H491D rpoB: p.H491Y rpoB: p.H491R rpoB: p.R494K rpoB: p.G502K rpoB: p.S539Y rpoB: p.S539F

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic DST
Source Database: Reslit

540

Rifampin resistance and its fitness cost in Riemerella anatipestifer.

PMID 31122209 · 2019

Some mutations were found to confer varying levels of fitness costs.

Mutation Information

Protein Change: V382I, H491N, H491D, H491Y, H491R, R494K, G502K, S539Y, S539F
Organisms: Riemerella anatipestifer
Confers Resistance To: rifampicin
Validation Method: MIC testing
Source Database: Reslit

541

Fitness of Spontaneous Rifampicin-Resistant Staphylococcus aureus Isolates in a Biofilm Environment.

PMID 31134027 · 2019

Mutation detected in RifR1 and RifR2

Mutation Information

rpoB: p.A477D

Protein Change: A477D
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: sequencing and MIC measurement
Source Database: Reslit

542

Transmission and Drug Resistance Genotype of Multidrug-Resistant or Rifampicin-Resistant Mycobacterium tuberculosis in Chongqing, China.

PMID 36214695 · 2022

Mutation Information

rpoB: p.S435L rpoB: p.S445L rpoB: p.S450L

Protein Change: S435L, S445L, S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotyping
Source Database: Reslit

543

Genomic characterization of two community-acquired methicillin-resistant Staphylococcus aureus with novel sequence types in Kenya.

PMID 36226152 · 2022

Mutation Information

rpoB: p.S529L rpoB: p.G767S

Protein Change: S529L, G767S
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: genotypic resistance
Source Database: Reslit

544

First insights into the phylogenetic diversity of Mycobacterium tuberculosis in Kuwait and evaluation of REBA MTB-MDR assay for rapid detection of MDR-TB.

PMID 36264939 · 2022

Mutation Information

rpoB: p.D441V rpoB: p.S450L rpoB: p.L452P rpoB: p.D435V

Protein Change: D441V, S450L, L452P, D435V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: PCR sequencing
Source Database: Reslit

545

An in silico analysis of rpoB mutations to affect Chlamydia trachomatis sensitivity to rifamycin.

PMID 36282371 · 2022

Mutation Information

rpoB: p.V136F rpoB: p.Q458K rpoB: p.V466A rpoB: p.A467T rpoB: p.H471N rpoB: p.H471K rpoB: p.H471L rpoB: p.I517M

Protein Change: V136F, Q458K, V466A, A467T, H471N, H471K, H471L, I517M
Organisms: Chlamydia trachomatis
Confers Resistance To: rifampicin
Validation Method: in silico analysis
Source Database: Reslit

546

Prevalence and genetic basis of first-line drug resistance of Mycobacterium tuberculosis in Ca Mau, Vietnam.

PMID 36299370 · 2022

Mutation Information

rpoB: p.S450L rpoB: p.V170F

Protein Change: D435V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

547

MycoVarP: Mycobacterium Variant and Drug Resistance Prediction Pipeline for Whole-Genome Sequence Data Analysis.

PMID 36303799 · 2021

Mutation Information

Protein Change: S450L, V170F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: variant calling and filtration
Source Database: Reslit

548

Natural Products Lysobactin and Sorangicin A Show In Vitro Activity against Mycobacterium abscessus Complex.

PMID 36342177 · 2022

Mutation Information

rpoB: p.D523E

Protein Change: D523E
Organisms: Mycobacterium abscessus
Confers Resistance To: rifampicin|rifabutin
Validation Method: whole-genome sequencing and Sanger sequencing
Source Database: Reslit

549

Concordance between Antimicrobial Resistance Phenotype and Genotype of Staphylococcus pseudintermedius from Healthy Dogs.

PMID 36421269 · 2022

associated with reduced susceptibility to vancomycin

Mutation Information

rpoB: p.V1032I

Protein Change: V1032I
Organisms: Staphylococcus pseudintermedius
Confers Resistance To: vancomycin
Validation Method: sequencing
Source Database: Reslit

550

Distribution and frequency of common mutations in rpoB gene of Mycobacterium tuberculosis detected by Xpert MTB/RIF and identification of residential areas of rifampicin resistant-TB cases: A first retrospective study from Mizoram, Northeast India.

PMID 36457842 · 2022

Mutation detected in probe A region.

Mutation Information

rpoB: p.S450L rpoB: p.H445D rpoB: p.H445Y rpoB: p.H445R rpoB: p.D435V rpoB: p.L452P rpoB: p.Q432K rpoB: p.Q432L rpoB: p.V170F

Protein Change: L511P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Xpert MTB/RIF assay
Source Database: Reslit

551

rpoB Mutations are Associated with Variable Levels of Rifampin and Rifabutin Resistance in Mycobacterium tuberculosis.

PMID 36465812 · 2022

Mutation Information

Protein Change: S450L, H445D, H445Y, H445R, D435V, L452P, Q432K, Q432L, V170F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin|rifabutinrifampicinrifabutin
Validation Method: MIC testing
Source Database: Reslit

552

Genomic analysis of Mycobacterium tuberculosis variant bovis strains isolated from bovine in the state of Mato Grosso, Brazil.

PMID 36467663 · 2022

associated with rifampicin resistance

Mutation Information

rpoB: p.L3225P rpoB: p.S531L

Protein Change: L3225P, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genomic analysis; genomic sequencing
Source Database: Reslit

553

Genome-resolved insight into the reservoir of antibiotic resistance genes in aquatic microbial community.

PMID 36473884 · 2022

Mutation Information

rpoB: p.S450L rpoB: p.D483G

Protein Change: S450L, D483G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: multiple sequence alignment and reference gene comparison
Source Database: Reslit

554

Purine Nucleosides Interfere with c-di-AMP Levels and Act as Adjuvants To Re-Sensitize MRSA To β-Lactam Antibiotics.

PMID 36507833 · 2023

Mutation Information

rpoB: p.T480K rpoB: p.T622I

Protein Change: T480K, T622I
Organisms: Staphylococcus aureus
Confers Resistance To: oxacillin
Validation Method: mutant analysis
Source Database: Reslit

555

Comparative genomics of drug-resistant strains of Mycobacterium tuberculosis in Ecuador.

PMID 36544084 · 2022

Mutation Information

rpoB: p.D516V rpoB: p.H526D rpoB: p.H526Y rpoB: p.S531L

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

556

Ultrasensitive Detection of Multidrug-Resistant Mycobacterium tuberculosis Using SuperSelective Primer-Based Real-Time PCR Assays.

PMID 36555395 · 2022

Mutation Information

Protein Change: D516V, H526D, H526Y, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: RT-PCR with molecular beacon probes
Source Database: Reslit

557

Drug Resistance and Molecular Characteristics of Mycobacterium tuberculosis: A Single Center Experience.

PMID 36556308 · 2022

Mutation Information

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: PCR-reverse membrane hybridization
Source Database: Reslit

558

TBProfiler for automated calling of the association with drug resistance of variants in Mycobacterium tuberculosis.

PMID 36584023 · 2022

Variant classified as associated with resistance in the WHO catalogue.

Mutation Information

rpoB: p.D435Y rpoB: p.H445L rpoB: p.L430P rpoB: p.D435V rpoB: p.S450L

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: variant classification in WHO catalogue
Source Database: Reslit

559

Antibiotic perseverance increases the risk of resistance development.

PMID 36595701 · 2023

Mutations in rpoB were identified as the mechanism of rifampicin resistance.

Mutation Information

rpoB: p.S485L

Protein Change: S485L
Organisms: Escherichia coli, Salmonella enterica
Confers Resistance To: rifampicin
Validation Method: local sequencing of rpoB gene
Source Database: Reslit

560

Performance Evaluation of the BACTEC MGIT 960 System for Rifampin Drug-Susceptibility Testing of Mycobacterium tuberculosis Using the Current WHO Critical Concentration.

PMID 36602360 · 2023

mutations in rpoB gene associated with rifampin resistance

Mutation Information

Protein Change: D435Y, H445L, L430P, D435V, S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: rpoB gene sequencing
Source Database: Reslit

561

Analysis of drug resistance among difficult-to-treat tuberculosis patients in Ghana identifies several pre-XDR TB cases.

PMID 36713197 · 2022

Mutation Information

rpoB: p.S487L rpoB: p.H482Y rpoB: p.Q469R

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotyping
Source Database: Reslit

562

Clinical Evaluation of the XDR-LFC Assay for the Molecular Detection of Isoniazid, Rifampin, Fluoroquinolone, Kanamycin, Capreomycin, and Amikacin Drug Resistance in a Prospective Cohort.

PMID 36757183 · 2023

Mutation Information

rpoB: p.L452P

Protein Change: L452P
Confers Resistance To: rifampicin
Validation Method: XDR-LFC assay
Source Database: Reslit

563

Mutations in rpoB That Confer Rifampicin Resistance Can Alter Levels of Peptidoglycan Precursors and Affect β-Lactam Susceptibility.

PMID 36779708 · 2023

Confers high-level resistance to both CEF and RIF

Mutation Information

Protein Change: S487L, H482Y, Q469R
Organisms: Bacillus subtilis
Confers Resistance To: cefotaxime|rifampicincefotaxime
Validation Method: whole-genome sequencing, MIC determination, disk diffusion assay
Source Database: Reslit

564

New insights on tuberculosis transmission dynamics and drug susceptibility profiles among the prison population in Southern Brazil based on whole-genome sequencing.

PMID 36820651 · 2023

Mutation Information

rpoB: p.I65T rpoB: p.D441V rpoB: p.H451D rpoB: p.H451L rpoB: p.H451N rpoB: p.H451R rpoB: p.H451Y rpoB: p.S456L rpoB: p.D551E

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole_genome_sequencing
Source Database: Reslit

565

Investigation of Multi-Subunit Mycobacterium tuberculosis DNA-Directed RNA Polymerase and Its Rifampicin Resistant Mutants.

PMID 36834726 · 2023

All mutations are located in the RIF-resistance-determining region (RRDR) of rpoB.

Mutation Information

Protein Change: I65T, D441V, H451D, H451L, H451N, H451R, H451Y, S456L, D551E
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Molecular dynamics simulations and binding energy calculations
Source Database: Reslit

566

Clinical utility of target-based next-generation sequencing for drug-resistant TB.

PMID 36853141 · 2023

Mutations in rpoB were identified as a key determinant of rifampicin resistance.

Mutation Information

rpoB: p.L511P rpoB: p.H526N rpoB: p.H526L rpoB: p.H526D rpoB: p.H526Y rpoB: p.D516V rpoB: p.S531L rpoB: p.L533P

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Targeted next-generation sequencing (tNGS) with correlation to phenotypic drug susceptibility testing (pDST)
Source Database: Reslit

567

A rapid, accurate, and low-cost method for detecting Mycobacterium tuberculosis and its drug-resistant genes in pulmonary tuberculosis: Applications of MassARRAY DNA mass spectrometry.

PMID 36910195 · 2023

Consistent with phenotypic results

Poor correlation with phenotype

Mutation Information

Protein Change: L511P, H526N, H526L, H526D, H526Y, D516V, S531L, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

568

The Evolution and Transmission Dynamics of Multidrug-Resistant Tuberculosis in an Isolated High-Plateau Population of Tibet, China.

PMID 36912683 · 2023

RpoB Gln409Arg is a common rifampicin resistance mutation.

Mutation Information

rpoB: p.Q409R

Protein Change: Q409R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

569

Discrepancy in the transmissibility of multidrug-resistant mycobacterium tuberculosis in urban and rural areas in China.

PMID 36924242 · 2023

No significant association with MDR-TB clustering

Mutation Information

rpoB: p.S450X rpoB: p.H445X rpoB: p.D435X

Protein Change: S450L
Confers Resistance To: rifampicin
Validation Method: statistical analysis of clustering rates
Source Database: Reslit

570

Synthesis and Characterization of Phenylalanine Amides Active against Mycobacterium abscessus and Other Mycobacteria.

PMID 37001025 · 2023

Mutation in RpoB subunit of RNAP responsible for resistance to MMV688845

Mutation Information

rpoB: p.P473L

Protein Change: P473L
Organisms: Mycobacterium abscessus
Confers Resistance To: rifamycins
Validation Method: testing against MMV688845-resistant mutant
Source Database: Reslit

571

FLASH-TB: an Application of Next-Generation CRISPR to Detect Drug Resistant Tuberculosis from Direct Sputum.

PMID 37010411 · 2023

Mutation Information

Protein Change: S450X, H445X, D435X
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

572

The relative transmission fitness of multidrug-resistant Mycobacterium tuberculosis in a drug resistance hotspot.

PMID 37031225 · 2023

mutation in the RNA polymerase beta subunit

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: phylogenomic analysis and phylodynamic models
Source Database: Reslit

573

Drug Resistance in Tuberculous Lymphadenitis: Molecular Characterization.

PMID 37032734 · 2023

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic drug susceptibility testing
Source Database: Reslit

574

Evolution and epidemic success of Mycobacterium tuberculosis in eastern China: evidence from a prospective study.

PMID 37147590 · 2023

Mutations in rpoB are associated with rifampicin resistance.

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genomic analysis
Source Database: Reslit

575

A Clinically Selected Staphylococcus aureus clpP Mutant Survives Daptomycin Treatment by Reducing Binding of the Antibiotic and Adapting a Rod-Shaped Morphology.

PMID 37184389 · 2023

The A477D substitution in RpoB was shown to cause resistance to rifampin.

Mutation Information

rpoB: p.A477D

Protein Change: A477D
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: MIC testing
Source Database: Reslit

576

Profile and Frequency of Mutations Conferring Drug-Resistant Tuberculosis in the Central, Southeastern and Eastern Ethiopia.

PMID 37201127 · 2023

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic drug susceptibility testing
Source Database: Reslit

577

Heteroresistance to rifampicin & isoniazid in clinical samples of patients with presumptive drug-resistant tuberculosis in Central India.

PMID 37202936 · 2023

Mutation Information

rpoB: p.S531W rpoB: p.S531L rpoB: p.S531Y rpoB: p.F506L rpoB: p.E509H rpoB: p.D516V rpoB: p.H526D rpoB: p.S531F

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: line probe assay (LPA)
Source Database: Reslit

578

Mutation patterns of resistance genes for macrolides, aminoglycosides, and rifampicin in non-tuberculous mycobacteria isolates from Kenya.

PMID 37224326 · 2022

Mutation Information

Protein Change: S531W, S531L, S531Y, F506L, E509H, D516V, H526D, S531F
Organisms: Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium yongonense, Mycobacterium gastri
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

579

Mycobacterium tuberculosis Adaptation in Response to Isoniazid Treatment in a Multi-Stress System That Mimics the Host Environment.

PMID 37237755 · 2023

The MDR strain has an amino acid change in RpoB (D516V).

Mutation Information

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotyping
Source Database: Reslit

580

Adaptive Laboratory Evolution of Staphylococcus aureus Resistance to Vancomycin and Daptomycin: Mutation Patterns and Cross-Resistance.

PMID 37237831 · 2023

Mutation detected in derivatives selected for vancomycin.

Mutation Information

rpoB: p.R406H

Protein Change: R406H
Confers Resistance To: vancomycin
Validation Method: whole-genome sequencing
Source Database: Reslit

581

In Vivo Emergence of Dual Resistance to Rifampin and Levofloxacin in Osteoarticular Cutibacterium avidum.

PMID 37289061 · 2023

Mutation Information

rpoB: p.S446P

Protein Change: S446P
Organisms: Cutibacterium avidum
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing and susceptibility testing
Source Database: Reslit

582

Effect of compensatory evolution in the emergence and transmission of rifampicin-resistant Mycobacterium tuberculosis in Cape Town, South Africa: a genomic epidemiology study.

PMID 37295446 · 2023

mutations_in_rpoB_are_associated_with_rifampicin_resistance

Mutation Information

rpoB: p.S531L rpoB: p.D516V rpoB: p.D516Y rpoB: p.H526D rpoB: p.H526L rpoB: p.H526Y

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole_genome_sequencing
Source Database: Reslit

583

Prevalence of Mycobacterium tuberculosis mutations associated with isoniazid and rifampicin resistance: A systematic review and meta-analysis.

PMID 37389010 · 2023

Mutation Information

Protein Change: S531L, D516V, D516Y, H526D, H526L, H526Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: The study analyzed mutations in the rpoB gene, including S531L, which was identified as one of the most prevalent mutations associated with rifampicin resistance.; The study analyzed mutations in the rpoB gene, including D516V, which was identified as one of the most prevalent mutations associated with rifampicin resistance.; The study analyzed mutations in the rpoB gene, including D516Y, which was identified as one of the most prevalent mutations associated with rifampicin resistance.; The study analyzed mutations in the rpoB gene, including H526D, which was identified as one of the most prevalent mutations associated with rifampicin resistance.; The study analyzed mutations in the rpoB gene, including H526L, which was identified as one of the most prevalent mutations associated with rifampicin resistance.; The study analyzed mutations in the rpoB gene, including H526Y, which was identified as one of the most prevalent mutations associated with rifampicin resistance.
Source Database: Reslit

584

Using Microfluidic Chip and Allele-Specific PCR to Rapidly Identify Drug Resistance-Associated Mutations of Mycobacterium tuberculosis.

PMID 37424666 · 2023

Mutation Information

rpoB: p.S531L rpoB: p.H526R rpoB: p.S522Q rpoB: p.H526Y

Protein Change: S531L, H526R, S522Q, H526Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: chip scanning and Sanger sequencing
Source Database: Reslit

585

Selective Pressure by Rifampicin Modulates Mutation Rates and Evolutionary Trajectories of Mycobacterial Genomes.

PMID 37436169 · 2023

Mutations in rpoB were associated with increased rifampicin resistance.

Mutation Information

rpoB: p.H442R rpoB: p.D432G rpoB: p.S447L rpoB: p.S438L rpoB: p.Q429H rpoB: p.L449P rpoB: p.G450D rpoB: p.V167M

Protein Change: H442R, D432G, S447L, S438L, Q429H, L449P, G450D, V167M
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing and MIC testing
Source Database: Reslit

586

GeneXpert MTB/RIF Ultra performance to detect uncommon rpoB mutations in Mycobacterium tuberculosis.

PMID 37452349 · 2023

Mutations in rpoB gene that affect rifampicin resistance detection by Xpert Ultra.

Mutation Information

rpoB: p.Q432L rpoB: p.Q432P rpoB: p.Q432K rpoB: p.Q432E rpoB: p.K446Q rpoB: p.P439L rpoB: p.M434T rpoB: p.H445D rpoB: p.S428R rpoB: p.D435A

Protein Change: Q432L, Q432P, Q432K, Q432E, K446Q, P439L, M434T, H445D, S428R, D435A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Xpert Ultra and phenotypic drug-susceptibility testing
Source Database: Reslit

587

Host-pathogen relationship in retreated tuberculosis with major rifampicin resistance-conferring mutations.

PMID 37469437 · 2023

Both mutations are linked to rifampicin resistance and differ in prevalence across Mtb lineages.

Mutation Information

rpoB: p.H445Y rpoB: p.S450L

Protein Change: H445Y, S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: The rpoB H445Y mutation in Mtb is associated with an increased transcription elongation rate; The rpoB S450L mutation is located in the 81-bp RIF resistance–determining region (RRDR) of the rpoB gene
Validation Method: whole-genome sequencing
Source Database: Reslit

588

Molecular Analysis of Anti-Tuberculosis Drug Resistance of Mycobacterium tuberculosis Isolated in the Republic of Korea.

PMID 37627744 · 2023

Mutation Information

rpoB: p.D516V rpoB: p.D516Y rpoB: p.H526D rpoB: p.H526L rpoB: p.L533P

Protein Change: D516V, D516Y, H526D, H526L, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing and MIC testing
Source Database: Reslit

589

High-resolution landscape of an antibiotic binding site.

PMID 37648864 · 2023

These mutations increase sensitivity to rifampicin, leading to bactericidal effects.

Mutation Information

rpoB: p.L521Y rpoB: p.T525D

Protein Change: L521Y, T525D
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Effect on Function: enhances rifampicin binding
Validation Method: Mutant reconstruction and MIC testing
Source Database: Reslit

590

Analysis of Drug-Resistance Characteristics and Genetic Diversity of Multidrug-Resistant Tuberculosis Based on Whole-Genome Sequencing on the Hainan Island, China.

PMID 37692467 · 2023

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Whole-genome sequencing (WGS) and drug susceptibility testing (DST)
Source Database: Reslit

591

Comparative Study on Tuberculosis Drug Resistance and Molecular Detection Methods Among Different Mycobacterium Tuberculosis Lineages.

PMID 37700800 · 2023

Mutation Information

rpoB: p.S450L rpoB: p.H445N

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Whole genome sequencing
Source Database: Reslit

592

Insight into the drug-resistant characteristics and genetic diversity of multidrug-resistant Mycobacterium tuberculosis in China.

PMID 37732780 · 2023

Mutation Information

rpoB: p.I491M

Protein Change: I491M
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

593

Genomic markers of drug resistance in Mycobacterium tuberculosis populations with minority variants.

PMID 37750734 · 2023

Detected in 65/1831 strains

Mutation Information

rpoB: p.H445N

Protein Change: H445N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: LoFreq and manual review
Source Database: Reslit

594

Mixed infections in genotypic drug-resistant Mycobacterium tuberculosis.

PMID 37816829 · 2023

Mutation Information

Protein Change: S450L, H445N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic resistance prediction using TB-Profiler software
Source Database: Reslit

595

Characterization of a Tigecycline-, Linezolid- and Vancomycin-Resistant Clinical Enteroccoccus faecium Isolate, Carrying vanA and vanB Genes.

PMID 37821741 · 2023

Mutation Information

rpoB: p.S491F

Protein Change: S491F
Organisms: Enterococcus faecium
Confers Resistance To: daptomycin|rifampicin
Effect on Function: mutated
Validation Method: genomic analysis and susceptibility testing
Source Database: Reslit

596

Antimicrobial drug resistant features of Mycobacterium tuberculosis associated with treatment failure.

PMID 37883448 · 2023

Mutation Information

rpoB: p.T508I

Protein Change: T508I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

597

Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach.

PMID 37886522 · 2023

Mutation Information

rpoB: p.V170F rpoB: p.L430P rpoB: p.D435Y rpoB: p.H445L rpoB: p.H445N rpoB: p.H445S rpoB: p.L452P rpoB: p.I491F

Protein Change: V170F, L430P, D435Y, H445L, H445N, H445S, L452P, I491F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Multivariable linear mixed model analysis of WGS and MIC data
Source Database: Reslit

598

Molecular Characteristics and Prevalence of Rifampin Resistance in Staphylococcus aureus Isolates from Patients with Bacteremia in South Korea.

PMID 37887212 · 2023

mutations in the rifampin resistance-determining region (RRDR) of the rpoB gene

Mutation Information

rpoB: p.A477D rpoB: p.H481Y rpoB: p.S468P rpoB: p.R484H rpoB: p.S486L rpoB: p.D471G rpoB: p.Q486L rpoB: p.Q486R rpoB: p.H481R rpoB: p.E568K rpoB: p.R197L

Protein Change: A477D, H481Y, S468P, R484H, S486L, D471G, Q486L, Q486R, H481R, E568K, R197L
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: sequencing and MIC testing
Source Database: Reslit

599

Genomic Characterization of Drug-Resistant Mycobacterium tuberculosis L2/Beijing Isolates from Astana, Kazakhstan.

PMID 37887224 · 2023

This mutation is associated with rifampicin resistance.

Mutation Information

rpoB: p.S450L rpoB: p.H445Y rpoB: p.D435V

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic prediction
Source Database: Reslit

600

Basal level of ppGpp coordinates Escherichia coli cell heterogeneity and ampicillin resistance and persistence.

PMID 37933276 · 2023

The mutation D675A in rpoB was identified as a suppressor mutation in the ppGpp 0 strain, which restored ampicillin MIC and reduced persistence.

Mutation Information

rpoB: p.D675A

Protein Change: D675A
Organisms: Escherichia coli
Confers Resistance To: ampicillin
Effect on Function: restored ampicillin MIC and reduced persistence
Validation Method: whole genome sequencing and functional testing; Sanger sequencing and MIC testing
Source Database: Reslit

601

Molecular characterization of genetic mutations with fitness loss in pulmonary tuberculosis patients associated with HIV co-infection in Northwest Amhara, Ethiopia.

PMID 37933292 · 2023

Detected in MDR-TB isolates

Mutation Information

Protein Change: S450L, H445Y, D435V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: hybridization of MUT probe bands; GenoType MTBDRplus v.2.0 LPA
Source Database: Reslit

602

Evaluating the Sensitivity of Different Molecular Techniques for Detecting Mycobacterium tuberculosis Complex in Patients with Pulmonary Infection.

PMID 37934050 · 2023

Mutation Information

rpoB: p.L430P rpoB: p.D435Y rpoB: p.H445N rpoB: p.H445L rpoB: p.L452P rpoB: p.H445C rpoB: p.N438K rpoB: p.T444A rpoB: p.S428I

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: multiplex allele-specific PCR
Source Database: Reslit

603

Phenotype versus genotype discordant rifampicin susceptibility testing in tuberculosis: implications for a diagnostic accuracy.

PMID 37982632 · 2024

Mutations in rpoB associated with rifampicin resistance

Mutation Information

Protein Change: L430P, D435Y, H445N, H445L, L452P, H445C, N438K, T444A, S428I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing and DST
Source Database: Reslit

604

The MAGMA pipeline for comprehensive genomic analyses of clinical Mycobacterium tuberculosis samples.

PMID 38019772 · 2023

Mutation Information

rpoB: p.L511P rpoB: p.S531L rpoB: p.Q513P rpoB: p.H526Y

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: variant calling and resistance annotation
Source Database: Reslit

605

A preliminary evaluation of targeted nanopore sequencing technology for the detection of Mycobacterium tuberculosis in bronchoalveolar lavage fluid specimens.

PMID 38029234 · 2023

Mutation Information

Protein Change: L511P, S531L, Q513P, H526Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: targeted nanopore sequencing
Source Database: Reslit

606

Adaptive laboratory evolution of Salmonella enterica in acid stress.

PMID 38033570 · 2023

Mutation in rpoB was observed in EL2.

Mutation Information

rpoB: p.S662A

Protein Change: S662A
Organisms: Salmonella enterica
Confers Resistance To: ciprofloxacin|meropenem
Validation Method: genomic analysis
Source Database: Reslit

607

Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique.

PMID 38048599 · 2024

Mutation Information

rpoB: p.S450L rpoB: p.V170F rpoB: p.D435F rpoB: p.H445N rpoB: p.H445D rpoB: p.H445Y rpoB: p.I491F

Protein Change: S450L, V170F, D435F, H445N, H445D, H445Y, I491F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

608

A precision overview of genomic resistance screening in Ecuadorian isolates of Mycobacterium tuberculosis using web-based bioinformatics tools.

PMID 38051742 · 2023

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

609

Epidemiology and genetic diversity of invasive Neisseria meningitidis strains circulating in Portugal from 2003 to 2020.

PMID 38057459 · 2024

Mutation Information

rpoB: p.H552Y

Protein Change: H552Y
Organisms: Neisseria meningitidis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing and antimicrobial susceptibility testing
Source Database: Reslit

610

Role of the first WHO mutation catalogue in the diagnosis of antibiotic resistance in Mycobacterium tuberculosis in the Valencia Region, Spain: a retrospective genomic analysis.

PMID 38061383 · 2024

mutations in rpoB are associated with rifampicin resistance

Mutation Information

Protein Change: I491F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genomic_prediction_and_phenotypic_testing
Source Database: Reslit

611

Bedaquiline for treatment of non-tuberculous mycobacteria (NTM): a systematic review and meta-analysis.

PMID 38134888 · 2024

Mutation Information

rpoB: p.D776N

Protein Change: D776N
Confers Resistance To: bedaquiline
Validation Method: Genotypic analysis and MIC testing; mutational analysis and MIC testing
Source Database: Reslit

612

Rapid detection of drug-resistant Mycobacterium tuberculosis by Modified MODS assay suitable for resource-poor settings.

PMID 38175831 · 2024

Mutation Information

rpoB: p.S450X rpoB: p.L430P rpoB: p.D435G

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType MTBDR plus assay
Source Database: Reslit

613

Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach.

PMID 38216576 · 2024

mutations in the RRDR region

Mutation Information

Protein Change: S450X, L430P, D435G
Confers Resistance To: rifampicin|rifabutinrifabutin
Validation Method: association with increased MIC
Source Database: Reslit

614

Genetic Determinants in MRSA Carriage and Their Association with Decolonization Outcome.

PMID 38217690 · 2024

Mutation Information

rpoB: p.I527L rpoB: p.D471Y

Protein Change: I527L, D471Y
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

615

Insights into the in-vitro Susceptibility and Drug-Drug Interaction Profiles Against Drug-Resistant and Susceptible Mycobacterium tuberculosis Clinical Isolates in Amhara, Ethiopia.

PMID 38223563 · 2024

Mutation Information

rpoB: p.S450L rpoB: p.D435V rpoB: p.H445Y

Protein Change: S450L, D435V, H445Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotyping and MIC testing
Source Database: Reslit

616

Commensal antimicrobial resistance mediates microbiome resilience to antibiotic disruption.

PMID 38232140 · 2024

Mutation Information

rpoB: p.H445N rpoB: p.S450Y / c.AGT->TAT

Protein Change: H445N, S450Y
Nucleotide Change: AGT->TAT
Confers Resistance To: rifampicin
Validation Method: SNP detection; SNP analysis
Source Database: Reslit

617

Simultaneous species identification and detection of rifampicin resistance in staphylococci by sequencing of the rpoB gene.

PMID 18716806 · 2009

mutations in rpoB gene associated with rifampicin resistance

Mutation Information

rpoB: p.H481Y rpoB: p.M470T rpoB: p.D471G rpoB: p.ins475H rpoB: c.ins1419CAC rpoB: c.ins1419CAT

Protein Change: H481Y, M470T, D471G, ins475H
Nucleotide Change: ins1419CAC, ins1419CAT
Organisms: Staphylococcus aureus, Staphylococcus lugdunensis
Confers Resistance To: rifampicin
Effect on Function: confers resistance to rifampicin; Target modification
Validation Method: sequencing of rpoB gene
Source Database: ReslitResFinder Database

618

Comparative genomics and drug resistance of a geographic variant of ST239 methicillin-resistant Staphylococcus aureus emerged in Russia.

PMID 22276107 · 2012

Mutation in rpoB gene leads to rifampicin resistance.

Mutation Information

rpoB: p.L466S

Protein Change: L466S
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: genomic analysis
Source Database: Reslit

619

First evaluation of an improved assay for molecular genetic detection of tuberculosis as well as rifampin and isoniazid resistances.

PMID 22301019 · 2012

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MTBDRplus 2.0 assay
Source Database: Reslit

620

Use of a molecular diagnostic test in AFB smear positive tuberculosis suspects greatly reduces time to detection of multidrug resistant tuberculosis.

PMID 22347495 · 2012

Mutation Information

rpoB: p.H481Y rpoB: p.H481N rpoB: p.I527M rpoB: p.K579R

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Genotype MTBDR plus assay
Source Database: Reslit

621

Genetic basis of rifampicin resistance in methicillin-resistant Staphylococcus aureus suggests clonal expansion in hospitals in Cape Town, South Africa.

PMID 22448673 · 2012

novel

Mutation Information

Protein Change: H481Y, H481N, I527M, K579R
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

622

Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolated in Nepal.

PMID 22450970 · 2012

Mutation Information

rpoB: p.H526D rpoB: p.H526Y rpoB: p.S531L

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

623

Drug susceptibility of Mycobacterium tuberculosis Beijing genotype and association with MDR TB.

PMID 22469099 · 2012

Mutations in rpoB were identified in rifampin-resistant mutants.

Mutation Information

Protein Change: H526D, H526Y, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType MTBDR plus assay
Source Database: Reslit

624

Effect of mutation and genetic background on drug resistance in Mycobacterium tuberculosis.

PMID 22470121 · 2012

RpoB mutations are associated with rifampin resistance

Mutation Information

rpoB: p.S531L rpoB: p.H526D rpoB: p.I572M

Protein Change: S531L, H526D, I572M
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

625

Estimating fitness by competition assays between drug susceptible and resistant Mycobacterium tuberculosis of predominant lineages in Mumbai, India.

PMID 22479407 · 2012

Mutation Information

rpoB: p.S531L rpoB: p.D516V rpoB: p.H526D

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic analysis
Source Database: Reslit

626

Comparison of line probe assay with liquid culture for rapid detection of multi-drug resistance in Mycobacterium tuberculosis.

PMID 23391803 · 2012

Mutations in rpoB gene confer resistance to rifampicin.

Mutation Information

Protein Change: S531L, D516V, H526D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Genotype MTBDR plus assay
Source Database: Reslit

627

Evolution of Rifampicin Resistance and Its Ecological Consequences

PMID 23433244 · 2023

Mutations in rpoB alter RNA polymerase function, affecting fitness in different environmental contexts.

Mutation Information

rpoB: p.I572F rpoB: p.I572L rpoB: p.I572N

Protein Change: I572F, I572L, I572N
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Effect on Function: confer resistance to rifampicin and a fitness advantage in the absence of rifampicin at 42.2°C in DM25; Target modification
Validation Method: relative fitness measurements and frequency trajectory analysis
Source Database: ReslitResFinder Database

628

The rationale for using rifabutin in the treatment of MDR and XDR tuberculosis outbreaks.

PMID 23527189 · 2013

mutations in rpoB gene are associated with rifampicin resistance

Mutation Information

rpoB: p.H437Y rpoB: p.H437R rpoB: p.Q424K

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: determination of minimum inhibitory concentrations (MICs) by MGIT 960
Source Database: Reslit

629

Activation and products of the cryptic secondary metabolite biosynthetic gene clusters by rifampin resistance (rpoB) mutations in actinomycetes.

PMID 23603745 · 2013

These mutations were found to activate cryptic secondary metabolite biosynthetic gene clusters and increase antibiotic production in various actinomycetes.

Mutation Information

Protein Change: H437Y, H437R, Q424K
Organisms: Streptomyces coelicolor, Streptomyces griseus, Streptomyces antibioticus, Streptomyces parvulus, Streptomyces lavendulae, Amycolatopsis orientalis, Streptomyces erythraea
Confers Resistance To: streptomycin|actinorhodin|erythromycin|formycin|vancomycinstreptomycin
Validation Method: transcriptional analysis and metabolite profiling
Source Database: Reslit

630

Emergence and spread of extensively and totally drug-resistant tuberculosis, South Africa.

PMID 23622714 · 2013

Mutation Information

Protein Change: D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

631

From multidrug- to extensively drug-resistant tuberculosis: upward trends as seen from a 15-year nationwide study.

PMID 23671662 · 2013

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin|rifabutin
Validation Method: sequencing of the rpoB gene
Source Database: Reslit

632

MDR TB transmission, Singapore.

PMID 23763791 · 2013

Mutation Information

rpoB: p.H531L

Protein Change: H531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic drug-susceptibility testing (GenoType MTDR plus)
Source Database: Reslit

633

Rifampin-resistant Mycobacterium bovis BCG-induced disease in HIV-infected infant, Vietnam.

PMID 23764043 · 2013

Mutation associated with rifampin resistance

Mutation Information

rpoB: p.S531Y

Protein Change: S531Y
Organisms: Mycobacterium bovis
Confers Resistance To: rifampicin
Validation Method: partial sequencing of the rpoB gene
Source Database: Reslit

634

Resistance of Mycobacterium tuberculosis to antibiotics in Lao PDR: first multicentric study conducted in 3 hospitals.

PMID 23782980 · 2013

The H526Y mutation in rpoB is a known mutation associated with rifampicin resistance.

Mutation Information

rpoB: p.N967I rpoB: p.R644H

Protein Change: H526Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

635

Mutation of RNA polymerase β-subunit gene promotes heterogeneous-to-homogeneous conversion of β-lactam resistance in methicillin-resistant Staphylococcus aureus.

PMID 23877693 · 2013

The rpoB (N967I) mutation was shown to confer high-dose methicillin tolerance and promote heterogeneous-to-homogeneous conversion of β-lactam resistance.

rpoB

Mutation Information

Protein Change: N967I, R644H
Organisms: Staphylococcus aureus
Confers Resistance To: methicillinbeta lactams
Effect on Function: confers high-dose methicillin tolerance and promotes heterogeneous-to-homogeneous conversion of β-lactam resistance; DNA-directed RNA polymerase subunit beta RpoB
Validation Method: construction of revertant and mutant strains
Source Database: ReslitReference Gene Catalog

636

Multidrug-resistant tuberculosis in panama is driven by clonal expansion of a multidrug-resistant Mycobacterium tuberculosis strain related to the KZN extensively drug-resistant M. tuberculosis strain from South Africa.

PMID 23884993 · 2013

Mutation Information

rpoB: p.S531L rpoB: p.H526D rpoB: p.D516F

Protein Change: S531L, H526D, D516F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genomic analysis
Source Database: Reslit

637

Rifampicin-resistant Mycobacterium leprae in an elderly leprosy patient in the people's Republic of China.

PMID 23986632 · 2013

Mutation in rpoB gene associated with rifampicin resistance

Mutation Information

rpoB: p.D441N

Protein Change: D441N
Organisms: Mycobacterium leprae
Confers Resistance To: rifampicin
Validation Method: sequence analysis
Source Database: Reslit

638

A simple, rapid and economic method for detecting multidrug-resistant tuberculosis.

PMID 24029439 · 2013

Detected in 80 isolates

Mutation Information

rpoB: p.S531L rpoB: p.H526D rpoB: p.H526Y rpoB: p.D516F rpoB: p.D516V

Protein Change: S531L, H526D, H526Y, D516F, D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

639

Genome analysis of a transmissible lineage of pseudomonas aeruginosa reveals pathoadaptive mutations and distinct evolutionary paths of hypermutators.

PMID 24039595 · 2013

Mutation Information

rpoB: p.E123K

Protein Change: E123K
Confers Resistance To: rifampicin
Validation Method: mutation detected via genomic analysis
Source Database: Reslit

640

Magnitude of gene mutations conferring drug resistance in mycobacterium tuberculosis isolates from lymph node aspirates in ethiopia.

PMID 24046537 · 2013

Mutation Information

rpoB: p.S531L rpoB: p.Q513L

Protein Change: S531L, Q513L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotyping using GenoType MTBDRplus assay
Source Database: Reslit

641

Primary multidrug-resistant Mycobacterium tuberculosis in 2 regions, Eastern Siberia, Russian Federation.

PMID 24047678 · 2013

Mutations in the resistance-determining region of rpoB (codons 511–533) were present in only 79%.

Mutation Information

rpoB: p.S531L rpoB: p.T481A rpoB: p.T480I rpoB: p.S531W rpoB: p.Q513K rpoB: p.L533P rpoB: p.H516Y rpoB: p.L511P

Protein Change: S531L, T481A, T480I, S531W, Q513K, L533P, H516Y, L511P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

642

Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis.

PMID 24055765 · 2014

Mutations in rpoB confer resistance to rifampicin

Mutation Information

Protein Change: D516V, H526Y, S531L, Q510H, D516Y, H526D, Q513L, Q429K, Q429H, S431R, S431G, S431I, S431T, Q432N, Q432K, Q432*, Q432E, Q432L, Q432P, Q432R, Q432H, M434T, M434I, D435F, D435N, D435Y, D435H, D435V, D435A, D435G, D435E, H445F, H445G, H445N, H445Y, H445D, H445L, H445P, H445R, H445Q, S450Q, S450L, S450W, S450F, S450Y, I491F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MIC measurement
Source Database: ReslitResFinder Database

643

Characterization of multi-drug resistant Mycobacterium tuberculosis from immigrants residing in the USA using Ion Torrent full-gene sequencing.

PMID 24073633 · 2014

Case 1 and 3

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Ion Torrent sequencing and phenotypic DST
Source Database: Reslit

644

High-resolution melting analysis for molecular detection of multidrug resistance tuberculosis in Peruvian isolates.

PMID 27278526 · 2016

Mutation Information

rpoB: p.R451S rpoB: p.S509R rpoB: p.G537C rpoB: p.L511R rpoB: p.G534S rpoB: p.L571Q rpoB: p.Q148L rpoB: p.Q148P

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

645

Diagnostic Molecular Mycobacteriology in Regions With Low Tuberculosis Endemicity: Combining Real-time PCR Assays for Detection of Multiple Mycobacterial Pathogens With Line Probe Assays for Identification of Resistance Mutations.

PMID 27333026 · 2016

Mutation Information

rpoB: p.S516L

Protein Change: S516L
Confers Resistance To: rifampicin
Validation Method: line probe assay and sequencing
Source Database: Reslit

646

Lambda gpP-DnaB Helicase Sequestration and gpP-RpoB Associated Effects: On Screens for Auxotrophs, Selection for Rif(R), Toxicity, Mutagenicity, Plasmid Curing.

PMID 27338450 · 2016

Mutations in rpoB gene lead to rifampicin resistance

Mutation Information

Protein Change: R451S, S509R, G537C, L511R, G534S, L571Q, Q148L, Q148P
Confers Resistance To: rifampicin
Validation Method: sequencing of rpoB gene from Rif R mutants; sequencing and phenotypic analysis
Source Database: Reslit

647

Correlation between the BACTEC MGIT 960 culture system with Genotype MTBDRplus and TB-SPRINT in multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil.

PMID 29091137 · 2017

Mutation Information

rpoB: p.S531L rpoB: p.H526D rpoB: p.H526Y rpoB: p.D516V

Protein Change: S531L, H526D, H526Y, D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MTBDR plus and TB-SPRINT
Source Database: Reslit

648

Prevalence of rifampicin-resistant Mycobacterium tuberculosis among human-immunodeficiency-virus-seropositive patients and their treatment outcomes.

PMID 29110871 · 2017

Mutations in the rpoB gene were associated with rifampicin resistance.

Mutation Information

rpoB: p.L511P rpoB: p.D516Y rpoB: p.D516V rpoB: p.H526Y rpoB: p.H526R rpoB: p.H526D rpoB: p.S531P rpoB: p.S531L

Protein Change: L511P, D516Y, D516V, H526Y, H526R, H526D, S531P, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Genotype MTBDRplus assay version 2.0
Source Database: Reslit

649

What Is Resistance? Impact of Phenotypic versus Molecular Drug Resistance Testing on Therapy for Multi- and Extensively Drug-Resistant Tuberculosis.

PMID 29133554 · 2018

Mutation Information

rpoB: p.L430P rpoB: p.L452P rpoB: p.H445L rpoB: p.H445Y

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MIC testing
Source Database: Reslit

650

Evaluation of Whole-Genome Sequencing for Mycobacterial Species Identification and Drug Susceptibility Testing in a Clinical Setting: a Large-Scale Prospective Assessment of Performance against Line Probe Assays and Phenotyping.

PMID 29167290 · 2018

Mutation Information

Protein Change: L430P, L452P, H445L, H445Y
Confers Resistance To: rifampicin
Validation Method: WGS in silico prediction
Source Database: Reslit

651

Molecular & genetic characteristics of Mycobacterium tuberculosis strains circulating in the southern part of West Siberia.

PMID 29168460 · 2017

Mutation Information

rpoB: p.L531P

Protein Change: L531P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: PCR-restriction fragment length polymorphism (RFLP) analysis
Source Database: Reslit

652

Performance of MTBDRplus assay in detecting multidrug resistant tuberculosis at hospital level.

PMID 29191227 · 2017

Mutations in rpoB gene infer RIF resistance

Mutation Information

rpoB: p.S513L rpoB: p.D516F rpoB: p.D516Y rpoB: p.D516V rpoB: p.N518D rpoB: p.H526D rpoB: p.H526L rpoB: p.H526Y rpoB: p.S531L rpoB: p.S531W rpoB: p.I572F rpoB: p.S572T rpoB: p.S572G rpoB: p.F572I rpoB: p.S315T rpoB: p.S315G rpoB: p.D94G rpoB: p.D94Y rpoB: p.D94N

Protein Change: S531L, H526Y, D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MTBDR plus assay and phenotypic DST
Source Database: Reslit

653

Rapid Microarray-Based Detection of Rifampin, Isoniazid, and Fluoroquinolone Resistance in Mycobacterium tuberculosis by Use of a Single Cartridge.

PMID 29212699 · 2018

Mutations in rpoB, katG, and gyrA were analyzed for their association with resistance to rifampin, isoniazid, and fluoroquinolones.

Mutation Information

Protein Change: S513L, D516F, D516Y, D516V, N518D, H526D, H526L, H526Y, S531L, S531W, I572F, S572T, S572G, F572I, S315T, S315G, D94G, D94Y, D94N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicinisoniazidfluoroquinolones
Validation Method: melting curve assay and sequencing
Source Database: Reslit

654

Direct detection of Mycobacterium tuberculosis rifampin resistance in bio-safe stained sputum smears.

PMID 29216262 · 2017

Mutations at codons 526 and 531 in the rpoB gene were associated with rifampin resistance.

Mutation Information

rpoB: p.L511P rpoB: p.H526L rpoB: p.L533P

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

655

Absence of hybridization with the wild-type and mutant rpoB probes in the Genotype MTBDRplus assay detects 'disputed' rifampicin mutations.

PMID 29217277 · 2018

Mutations in rpoB were identified in isolates that failed to hybridize to rpoB wild-type probes, and some of these mutations were 'disputed' as they did not consistently correlate with rifampicin resistance.

Mutation Information

Protein Change: L511P, H526L, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing and MIC determination
Source Database: Reslit

656

Multi-clonal evolution of multi-drug-resistant/extensively drug-resistant Mycobacterium tuberculosis in a high-prevalence setting of Papua New Guinea for over three decades.

PMID 29310751 · 2018

Mutations promoted from gene entry 'rpoB' (model emitted mutations_found inside genes).

Mutation Information

rpoB: p.S450L rpoB: p.D435V rpoB: p.D435Y rpoB: p.H445R rpoB: p.I480V rpoB: p.H445D

Protein Change: S450L, D435V, D435Y, H445R, I480V, H445D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

657

Whole-Genome Analysis of Mycobacterium tuberculosis from Patients with Tuberculous Spondylitis, Russia.

PMID 29460750 · 2018

Mutation Information

rpoB: p.S450L rpoB: p.D435V rpoB: p.H445D rpoB: p.H445R rpoB: p.D574E

Protein Change: S450L, D435V, H445D, H445R, D574E
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

658

Alterations in the Spectrum of Spontaneous Rifampicin-Resistance Mutations in the Bacillus subtilis rpoB Gene after Cultivation in the Human Spaceflight Environment.

PMID 29491852 · 2018

mutations in rpoB conferring rifampicin resistance

Mutation Information

rpoB: p.Q137R rpoB: p.L489S

Protein Change: Q137R, L489S
Organisms: Bacillus subtilis
Confers Resistance To: rifampicin
Validation Method: sequencing and retransformation
Source Database: Reslit

659

Efflux Activity Differentially Modulates the Levels of Isoniazid and Rifampicin Resistance among Multidrug Resistant and Monoresistant Mycobacterium tuberculosis Strains.

PMID 29510519 · 2018

Mutation Information

rpoB: p.S531L rpoB: p.H526Y / c.C1576T

Protein Change: S531L, H526Y
Nucleotide Change: C1576T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: mutagenesis and MIC testing
Source Database: Reslit

660

Multi- and Extensively Drug Resistant Mycobacterium tuberculosis in South Africa: a Molecular Analysis of Historical Isolates.

PMID 29514936 · 2018

Mutation Information

rpoB: p.H526L rpoB: p.S531L

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

661

Genotypic drug resistance using whole-genome sequencing of Mycobacterium tuberculosis clinical isolates from North-western Tanzania.

PMID 29559127 · 2018

compensatory mutation in MDR-TB isolate

Mutation Information

Protein Change: H526L, S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

662

Mutations of rpoB, katG, inhA and ahp genes in rifampicin and isoniazid-resistant Mycobacterium tuberculosis in Kyrgyz Republic.

PMID 29566660 · 2018

Mutation Information

rpoB: p.S531L rpoB: p.H526Y rpoB: p.H526D rpoB: p.H526R rpoB: p.H526L rpoB: p.H526P rpoB: p.D516Y rpoB: p.D516V rpoB: p.L511P rpoB: p.L533P rpoB: p.S522L rpoB: p.Q513L

Protein Change: S531L, H526Y, H526D, H526R, H526L, H526P, D516Y, D516V, L511P, L533P, S522L, Q513L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: TB-BIOCHIP analysis
Source Database: Reslit

663

Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae.

PMID 29567948 · 2018

Mutations in the rpoB gene were identified in relapsed leprosy cases and analyzed for their structural and functional effects on rifampin resistance.

Mutation Information

rpoB: p.D441Y rpoB: p.D441V rpoB: p.S437L rpoB: p.H476R

Protein Change: D441Y, D441V, S437L, H476R
Organisms: Mycobacterium leprae
Confers Resistance To: rifampicin
Validation Method: sequence analysis and structural modeling
Source Database: Reslit

664

Validation of the FluoroType MTBDR Assay for Detection of Rifampin and Isoniazid Resistance in Mycobacterium tuberculosis Complex Isolates.

PMID 29593055 · 2018

Mutation Information

rpoB: p.S531L rpoB: p.H526L rpoB: p.Q513K rpoB: p.D516Y rpoB: p.H526D rpoB: p.H526P rpoB: p.H526R rpoB: p.D516V rpoB: p.S531F rpoB: p.S531W rpoB: p.L533E rpoB: p.L533P

Protein Change: S531L, H526L, Q513K, D516Y, H526D, H526P, H526R, D516V, S531F, S531W, L533E, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: FluoroType MTBDR and Sanger sequencing; Sanger sequencing; Genotype MTBDRplus and Sanger sequencing; FluoroType MTBDR
Source Database: Reslit

665

Altered Mycobacterium tuberculosis Cell Wall Metabolism and Physiology Associated With RpoB Mutation H526D.

PMID 29616007 · 2018

Mutation Information

Protein Change: H526D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: vancomycin
Validation Method: MIC determination
Source Database: Reslit

666

Genotyping and molecular detection of multidrug-resistant Mycobacterium tuberculosis among tuberculosis lymphadenitis cases in Addis Ababa, Ethiopia.

PMID 29675262 · 2018

detected in 80% of rifampicin-resistant isolates

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: line probe assay and sequencing
Source Database: Reslit

667

Experimental platform utilising melting curve technology for detection of mutations in Mycobacterium tuberculosis isolates.

PMID 29675789 · 2018

Mutation Information

rpoB: p.R505K rpoB: p.H502N

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: melting curve analysis
Source Database: Reslit

668

Clostridium difficile Infections: A Global Overview of Drug Sensitivity and Resistance Mechanisms.

PMID 29682562 · 2018

Mutation Information

Protein Change: R505K, H502N
Organisms: Clostridium difficile
Confers Resistance To: rifamycins
Validation Method: reported in cited literature
Source Database: Reslit

669

Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains.

PMID 29755957 · 2018

Mutation in codon 531 (serine to leucine) confers cross-resistance to rifabutin.

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: experimental validation
Source Database: Reslit

670

Predictable Phenotypes of Antibiotic Resistance Mutations.

PMID 29764951 · 2018

Mutation in rpoB reduces susceptibility to rifampin

Mutation Information

rpoB: p.S531L rpoB: p.H526D rpoB: p.H526Y rpoB: p.H526R rpoB: p.H526G rpoB: p.H526L rpoB: p.D516Y rpoB: p.L511P rpoB: p.E588G

Protein Change: S531L
Organisms: Salmonella enterica
Confers Resistance To: rifampicin
Effect on Function: reduces susceptibility
Validation Method: MIC testing
Source Database: Reslit

671

Accuracy of whole genome sequencing versus phenotypic (MGIT) and commercial molecular tests for detection of drug-resistant Mycobacterium tuberculosis isolated from patients in Brazil and Mozambique.

PMID 29779775 · 2018

Detected in two isolates from Mozambique

Mutation Information

rpoB: p.V170F

Protein Change: V170F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

672

Prevalence and patterns of rifampicin and isoniazid resistance conferring mutations in Mycobacterium tuberculosis isolates from Uganda.

PMID 29847567 · 2018

Mutations in rpoB RRDR region associated with rifampicin resistance.

Mutation Information

Protein Change: S531L, H526D, H526Y, H526R, H526G, H526L, D516Y, L511P, E588G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequence analysis; DNA sequencing and alignment with H37Rv reference
Source Database: Reslit

673

Direct Whole-Genome Sequencing of Sputum Accurately Identifies Drug-Resistant Mycobacterium tuberculosis Faster than MGIT Culture Sequencing.

PMID 29848567 · 2018

Mutation Information

rpoB: p.H445Y

Protein Change: H445Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

674

Whole-genome sequencing and antimicrobial resistance in Brucella melitensis from a Norwegian perspective.

PMID 29867163 · 2018

Mutations in rpoB were not associated with rifampicin resistance as determined by phenotypic testing.

Mutation Information

rpoB: p.E392D

Protein Change: E392D
Organisms: Brucella melitensis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

675

Expression Profiles and Mutational Analysis of Daptomycin-Nonsusceptible Staphylococcus aureus Strains

PMID 29879195 · 2023

nonsynonymous mutation

Mutation Information

rpoB: p.E478D

Protein Change: E478D
Organisms: Staphylococcus aureus
Confers Resistance To: daptomycin
Validation Method: whole genome sequencing
Source Database: Reslit

676

Genetic Determinants and Prediction of Antibiotic Resistance Phenotypes in Helicobacter pylori.

PMID 30621024 · 2019

Mutation Information

rpoB: p.L525P rpoB: p.H540N

Protein Change: L525P, H540N
Organisms: Helicobacter pylori
Confers Resistance To: rifampicin
Effect on Function: Target modification
Validation Method: WGS and phenotypic DST
Source Database: ReslitResFinder Database

677

Phylogenomic assessment of drug-resistant Mycobacterium tuberculosis strains from Beira, Mozambique.

PMID 32063558 · 2020

Mutation Information

rpoB: p.S450L rpoB: p.H445T

Protein Change: S450L, H445T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

678

Mycobacterium tuberculosis Complex Lineage 3 as Causative Agent of Pulmonary Tuberculosis, Eastern Sudan

PMID 32091355 · 2020

Mutation Information

rpoB: p.S450L rpoB: p.H445Y rpoB: p.H445N rpoB: p.H445D

Protein Change: S450L, H445Y, H445N, H445D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

679

Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015.

PMID 32091369 · 2020

Mutations promoted from gene entry 'rpoB' (model emitted mutations_found inside genes).

Mutation Information

rpoB: p.Q438H rpoB: c.C1414A

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic resistance prediction
Source Database: Reslit

680

Metagenomics of Imported Multidrug-Resistant Mycobacterium leprae, Saudi Arabia, 2017

PMID 32091380 · 2020

Mutation Information

Protein Change: Q438H
Nucleotide Change: C1414A
Organisms: Mycobacterium leprae
Confers Resistance To: rifampicincapreomycin
Validation Method: genomic analysis and clinical correlation
Source Database: Reslit

681

A Benchtop Automated Sputum-to-Genotype System Using a Lab-on-a-Film Assembly for Detection of Multidrug-Resistant Mycobacterium tuberculosis.

PMID 32142258 · 2020

Mutation Information

rpoB: p.S531W

Protein Change: S531W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: PCR and hybridization
Source Database: Reslit

682

Distribution and Frequency of rpoB Mutations Detected by Xpert MTB/RIF Assay Among Beijing and Non-Beijing Rifampicin Resistant Mycobacterium tuberculosis Isolates in Bangladesh.

PMID 32210593 · 2020

Most frequent mutation in both Beijing and non-Beijing isolates

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Xpert MTB/RIF assay and GenoType MTBDR plus assay
Source Database: Reslit

683

Artificial Intelligence and Machine learning based prediction of resistant and susceptible mutations in Mycobacterium tuberculosis.

PMID 32218465 · 2020

Mutation Information

rpoB: p.V490L

Protein Change: V490L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: machine learning prediction
Source Database: Reslit

684

Inhibition of RNA Polymerase by Rifampicin and Rifamycin-Like Molecules.

PMID 32342856 · 2020

Mutations in the rpoB gene confer resistance to rifampicin.

Mutation Information

Protein Change: S531L
Organisms: Escherichia coli, Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: disorders the RIF-binding pocket upon RMP binding and therefore reduces the binding affinity for RMP
Validation Method: mapping of mutations to rpoB gene
Source Database: Reslit

685

Dynamics of within-host Mycobacterium tuberculosis diversity and heteroresistance during treatment.

PMID 32361247 · 2020

Mutation Information

rpoB: p.D516G rpoB: p.H526T rpoB: p.L511R rpoB: p.S450L

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Whole genome sequencing
Source Database: Reslit

686

Genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis from Malaysia.

PMID 32371951 · 2020

shared variant in twelve strains

Mutation Information

Protein Change: D516G, H526T, L511R, S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: screening against curated collections of drug resistance genes in CARD
Source Database: Reslit

687

Detection of drug resistant Mycobacterium tuberculosis by high-throughput sequencing of DNA isolated from acid fast bacilli smears.

PMID 32384098 · 2020

Mutations in rpoB are associated with rifampicin resistance.

Mutation Information

rpoB: p.L430P rpoB: p.Q432P rpoB: p.D435V rpoB: p.H445D rpoB: p.H445Y rpoB: p.H445N rpoB: p.S450L rpoB: p.L452P

Protein Change: L430P, Q432P, D435V, H445D, H445Y, H445N, S450L, L452P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: high-throughput sequencing
Source Database: Reslit

688

Individualized Treatment of Multidrug-resistant Tuberculosis Using Whole-Genome Sequencing and Expanded Drug-Susceptibility Testing.

PMID 32384148 · 2020

Mutation Information

rpoB: p.D531N

Protein Change: D531N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

689

Probing the Molecular Mechanism of Rifampin Resistance Caused by the Point Mutations S456L and D441V on Mycobacterium tuberculosis RNA Polymerase through Gaussian Accelerated Molecular Dynamics Simulation.

PMID 32393493 · 2020

The D441V mutation in rpoB was shown to confer rifampin resistance.

Mutation Information

rpoB: p.D441V

Protein Change: D441V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: molecular dynamics simulation
Source Database: Reslit

690

Substantial improvement of tetraene macrolide production in Streptomyces diastatochromogenes by cumulative drug resistance mutations.

PMID 32396566 · 2020

Mutation Information

rpoB: p.Q424L rpoB: p.D427V

Protein Change: Q424L, D427V
Organisms: Streptomyces diastatochromogenes
Confers Resistance To: rifampicin
Validation Method: DNA sequence analysis
Source Database: Reslit

691

Detection of low-frequency resistance-mediating SNPs in next-generation sequencing data of Mycobacterium tuberculosis complex strains with binoSNP.

PMID 32398743 · 2020

Detected in in-vitro datasets with 1% resistant subpopulation.

Mutation Information

rpoB: p.H526P

Protein Change: H526P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: in-vitro validation
Source Database: Reslit

692

Frequency of first and second-line drug resistance-associated mutations among resistant Mycobacterium tuberculosis clinical isolates from São Paulo, Brazil.

PMID 32401997 · 2020

Mutation Information

rpoB: p.H445R rpoB: p.S450L

Protein Change: S531L, H526Y, D516V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Sequencing of the rpoB gene and correlation with phenotypic drug susceptibility testing.
Source Database: Reslit

693

Whole Genome and Transcriptome Sequencing of Two Multi-Drug Resistant Mycobacterium tuberculosis Strains to Facilitate Illustrating Their Virulence in vivo.

PMID 32500039 · 2020

Mutation Information

Protein Change: H445R, S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome re-sequencing
Source Database: Reslit

694

Frequency of genomic mutations mediating resistance of Mycobacterium tuberculosis isolates to rifampicin in Northern Morocco.

PMID 32520212 · 2020

Mutations in the rpoB gene were identified as the primary cause of rifampicin resistance in Mycobacterium tuberculosis isolates.

Mutation Information

rpoB: p.Q513E rpoB: p.D516V rpoB: p.D516Y rpoB: p.H526D rpoB: p.H526Y rpoB: p.H526L rpoB: p.H526S rpoB: p.S531L rpoB: p.S531W

Protein Change: Q513E, D516V, D516Y, H526D, H526Y, H526L, H526S, S531L, S531W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: PCR and sequencing
Source Database: Reslit

695

Single-nucleotide polymorphisms in a vancomycin-resistant Staphylococcus aureus strain based on whole-genome sequencing.

PMID 32535788 · 2020

Mutation Information

rpoB: p.R917C

Protein Change: R917C
Organisms: Staphylococcus aureus
Confers Resistance To: vancomycin
Validation Method: whole-genome sequencing and phenotypic analysis
Source Database: Reslit

696

Emergence of multidrug-resistant Mycobacterium tuberculosis of the Beijing lineage in Portugal and Guinea-Bissau: a snapshot of moving clones by whole-genome sequencing.

PMID 32538300 · 2020

Present in GC1 isolates.

Mutation Information

rpoB: p.S450L rpoB: p.V496A

Protein Change: S450L, V496A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

697

Radial Expansion Facilitates the Maintenance of Double Antibiotic Resistances

PMID 32540973 · 2020

Mutation Information

rpoB: p.H526Y rpoB: p.I572F rpoB: p.K43T rpoB: p.R529H

Protein Change: H526Y, I572F, K43T, R529H
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: competition assay with susceptible strain
Source Database: Reslit

698

Detection of heterogeneous vancomycin intermediate resistance in MRSA isolates from Latin America.

PMID 32562543 · 2020

Mutation Information

Protein Change: H481Y
Organisms: Staphylococcus aureus
Confers Resistance To: vancomycin
Validation Method: genomic analysis
Source Database: Reslit

699

Xpert Mycobacterium tuberculosis/Rifampicin-Detected Rifampicin Resistance is a Suboptimal Surrogate for Multidrug-resistant Tuberculosis in Eastern Democratic Republic of the Congo: Diagnostic and Clinical Implications.

PMID 32590841 · 2021

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MTBDR plus assay
Source Database: Reslit

700

Targeted next-generation sequencing of sputum for diagnosis of drug-resistant TB: results of a national survey in Democratic Republic of the Congo.

PMID 32612134 · 2020

Mutation Information

rpoB: p.S444F rpoB: p.Q511K rpoB: p.S444N rpoB: p.S442F rpoB: p.S442N

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

701

Strong Environment-Genotype Interactions Determine the Fitness Costs of Antibiotic Resistance In Vitro and in an Insect Model of Infection.

PMID 32661001 · 2020

Mutant ID: 11c

Mutation Information

rpoB: p.E18K

Protein Change: E18K
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

702

Antimicrobial Susceptibility and Characterization of Resistance Mechanisms of Corynebacterium urealyticum Clinical Isolates.

PMID 32668585 · 2020

rpoB

Mutation Information

Protein Change: S444F, Q511K, S444N, S442F, S442N
Organisms: Corynebacterium urealyticum, Corynebacterium diphtheriae
Confers Resistance To: rifampicinrifamycins
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Validation Method: sequencing
Source Database: ReslitReference Gene Catalog

703

Spoligotype and Drug Susceptibility Profiles of Mycobacterium tuberculosis Complex Isolates in Golestan Province, North Iran.

PMID 32669860 · 2020

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

704

Correlation of drug resistance with single nucleotide variations through genome analysis and experimental validation in a multi-drug resistant clinical isolate of M. tuberculosis.

PMID 32711461 · 2020

Mutation Information

rpoB: p.D441A

Protein Change: D441A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: loss of interactions with drug except Gly438, Phe439 and Arg465
Validation Method: molecular docking analysis
Source Database: Reslit

705

Molecular detection of multidrug resistance pattern and associated gene mutations in M. tuberculosis isolates from newly diagnosed pulmonary tuberculosis patients in Addis Ababa, Ethiopia.

PMID 32750053 · 2020

Mutation Information

rpoB: p.S531W rpoB: p.S531F rpoB: p.L530P rpoB: p.A532V rpoB: p.L533P

Protein Change: H526Y
Organisms: M. tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA-STRIP technology
Source Database: Reslit

706

Diagnostic Evaluation of Non-Interpretable Results Associated with rpoB Gene in Genotype MTBDRplus Ver 2.0.

PMID 32752603 · 2020

Mutations in rpoB gene were identified in non-interpretable (NI) results and confirmed to confer rifampicin resistance through phenotypic drug susceptibility testing (pDST) and sequencing.

Mutation Information

Protein Change: S531W, S531F, L530P, A532V, L533P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

707

Interpretation of Discordant Rifampicin Susceptibility Test Results Obtained Using GeneXpert vs Phenotypic Drug Susceptibility Testing.

PMID 32766385 · 2020

mutations in the rifampin resistance-determining region of the rpoB gene

Mutation Information

rpoB: p.L511P rpoB: p.L533P rpoB: p.H526L rpoB: p.D516Y rpoB: p.Q517Q

Protein Change: L511P, L533P, H526L, D516Y, Q517Q
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing and MIC testing
Source Database: Reslit

708

Evolution of Multi-Resistance to Vancomycin, Daptomycin, and Linezolid in Methicillin-Resistant Staphylococcus aureus Causing Persistent Bacteremia.

PMID 32774327 · 2020

Mutation Information

rpoB: p.R130C rpoB: p.N1012S

Protein Change: R130C, N1012S
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicinvancomycin
Validation Method: Whole genome sequencing and phenotypic analysis
Source Database: Reslit

709

Exploiting Homoplasy in Genome-Wide Association Studies to Enhance Identification of Antibiotic-Resistance Mutations in Bacterial Genomes.

PMID 32782426 · 2020

Mutation in the RDRR region of rpoB leads to resistance to rifampicin.

Mutation Information

rpoB: p.L177L rpoB: p.D172G rpoB: p.H175C rpoB: p.I191L rpoB: p.L177F rpoB: p.R431G rpoB: p.K460Q

Protein Change: S450L
Confers Resistance To: rifampicin
Validation Method: association testing with drug resistance phenotypes; association testing
Source Database: Reslit

710

Rapid Identification of Drug-Resistant Tuberculosis Genes Using Direct PCR Amplification and Oxford Nanopore Technology Sequencing.

PMID 35386470 · 2022

Mutation Information

Protein Change: L177L, D172G, H175C, I191L, L177F, R431G, K460Q
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Nanopore sequencing and Sanger sequencing comparison
Source Database: Reslit

711

Characterisation of drug-resistant Mycobacterium tuberculosis mutations and transmission in Pakistan.

PMID 35545649 · 2022

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic prediction
Source Database: Reslit

712

Epidemiological and laboratory characteristics of multidrug-resistant tuberculosis patients in Bhutan, 2015-2019.

PMID 35755459 · 2022

Common mutation in rpoB gene

Mutation Information

rpoB: p.S450L rpoB: p.D435V rpoB: p.H445L rpoB: p.H445N rpoB: p.D435Y rpoB: p.L452P rpoB: p.L430P

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Line Probe Assay and liquid drug susceptibility testing
Source Database: Reslit

713

Minos: variant adjudication and joint genotyping of cohorts of bacterial genomes.

PMID 35791022 · 2022

Mutations in the rpoB gene's rrdr region are associated with rifampicin resistance.

Mutation Information

Protein Change: S450L, D435V, H445L, H445N, D435Y, L452P, L430P
Confers Resistance To: rifampicin
Validation Method: joint_genotyping_and_phenotype_analysis
Source Database: Reslit

714

Evolutionary Instability of Collateral Susceptibility Networks in Ciprofloxacin-Resistant Clinical Escherichia coli Strains.

PMID 35862779 · 2022

Mutation Information

rpoB: p.I668F rpoB: p.F668S rpoB: p.F668V rpoB: p.F668L rpoB: p.V857E / c.G2570A

Protein Change: I668F, F668S, F668V, F668L, V857E
Nucleotide Change: G2570A
Confers Resistance To: fluoroquinolones
Validation Method: whole-genome sequencing
Source Database: Reslit

715

Hit Compounds and Associated Targets in Intracellular Mycobacterium tuberculosis.

PMID 35889319 · 2022

mutations in rpoB known to confer resistance to rifampicin are commonly reported in MDR and XDR Mtb strains

Mutation Information

rpoB: p.D574N

Protein Change: D574N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: Reslit

716

Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observational study.

PMID 35907429 · 2022

Mutation associated with rifampicin resistance.

Mutation Information

rpoB: p.L450P rpoB: p.D435V rpoB: p.H445L rpoB: p.D435Y rpoB: p.H445N rpoB: p.L452P

Protein Change: L450P, D435V, H445L, D435Y, H445N, L452P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genomic resistance prediction based on mutation catalogue
Source Database: Reslit

717

Isolation of multidrug-resistant (MDR) Mycobacterium bovis from a dog in Korea

PMID 35922936 · 2022

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium bovis
Confers Resistance To: rifampicin
Validation Method: Anyplex II MTB/MDR/XDR detection assay
Source Database: Reslit

718

Prediction of drug resistance by Sanger sequencing of Mycobacterium tuberculosis complex strains isolated from multidrug resistant tuberculosis suspect patients in Ethiopia.

PMID 35930613 · 2022

Most prevalent mutation

Mutation Information

rpoB: p.A477D rpoB: p.H481Y rpoB: p.P475S rpoB: p.T518S

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Sanger sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

719

Impact of vancomycin use trend change due to the availability of alternative antibiotics on the prevalence of Staphylococcus aureus with reduced vancomycin susceptibility: a 14-year retrospective study.

PMID 35932086 · 2022

Mutation Information

Protein Change: A477D, H481Y, P475S, T518S
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: full-length sequencing
Source Database: Reslit

720

A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.

PMID 35944069 · 2022

mutations in rpoB are associated with rifampicin resistance

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.S450L rpoB: p.D435V rpoB: p.H445D rpoB: p.H445Y rpoB: p.D435Y rpoB: p.D435A rpoB: p.D435F rpoB: p.D435N rpoB: p.D545E rpoB: p.H445C rpoB: p.H445F rpoB: p.H445G rpoB: p.H445N rpoB: p.H445P rpoB: p.I491F rpoB: p.G981D rpoB: p.T676P rpoB: p.V170F rpoB: p.V359A rpoB: p.Q432K rpoB: p.Q432L rpoB: p.S431T rpoB: p.S441L rpoB: p.S441Q rpoB: p.S450F rpoB: p.S450Q rpoB: p.S450Y rpoB: p.D435G rpoB: p.F425Var rpoB: p.G426Var rpoB: p.T427Var rpoB: p.S428Var rpoB: p.Q429Var rpoB: p.L430Var rpoB: p.S431Var rpoB: p.Q432Var rpoB: p.F433Var rpoB: p.M434Var rpoB: p.D435Var rpoB: p.Q436Var rpoB: p.N437Var rpoB: p.N438Var rpoB: p.P439Var rpoB: p.L440Var rpoB: p.S441Var rpoB: p.G442Var rpoB: p.L443Var rpoB: p.T444Var rpoB: p.H445Var rpoB: p.K446Var rpoB: p.R447Var rpoB: p.R448Var rpoB: p.L449Var rpoB: p.S450Var rpoB: p.A451Var rpoB: p.L452Var rpoB: p.H445L rpoB: p.H445R rpoB: p.L430P rpoB: p.L452P rpoB: p.M434I rpoB: p.Q432P rpoB: p.S450W

Protein Change: S450L, D435V, H445D, H445Y, D435Y, D435A, D435F, D435N, D545E, H445C, H445F, H445G, H445N, H445P, I491F, G981D, T676P, V170F, V359A, Q432K, Q432L, S431T, S441L, S441Q, S450F, S450Q, S450Y, D435G, F425Var, G426Var, T427Var, S428Var, Q429Var, L430Var, S431Var, Q432Var, F433Var, M434Var, D435Var, Q436Var, N437Var, N438Var, P439Var, L440Var, S441Var, G442Var, L443Var, T444Var, H445Var, K446Var, R447Var, R448Var, L449Var, S450Var, A451Var, L452Var, H445L, H445R, L430P, L452P, M434I, Q432P, S450W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Validation Method: genomic and phenotypic data; genotyping and phenotypic resistance testing
Source Database: ReslitCard Database

721

High fluoroquinolone resistance proportions among multidrug-resistant tuberculosis driven by dominant L2 Mycobacterium tuberculosis clones in the Mumbai Metropolitan Region.

PMID 35989319 · 2022

Mutation in rpoB is associated with rifampicin resistance.

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genomic analysis
Source Database: Reslit

722

Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis.

PMID 36042200 · 2022

Mutation Information

rpoB: p.S526P

Protein Change: S526P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic resistance profiling
Source Database: Reslit

723

Predicting antibiotic resistance in complex protein targets using alchemical free energy methods.

PMID 36054249 · 2022

Resistant to rifampicin

Mutation Information

rpoB: p.V170F

Protein Change: V170F
Confers Resistance To: rifampicin
Validation Method: alchemical free energy calculations
Source Database: Reslit

724

Evaluation of whole-genome sequence to predict drug resistance of nine anti-tuberculosis drugs and characterize resistance genes in clinical rifampicin-resistant Mycobacterium tuberculosis isolates from Ningbo, China.

PMID 36062095 · 2022

Mutation Information

Protein Change: S531L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

725

Rapid Identification of Drug Resistance and Phylogeny in M. tuberculosis, Directly from Sputum Samples.

PMID 36102651 · 2022

Mutation Information

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: targeted sequencing
Source Database: Reslit

726

Structural Design and Synthesis of Novel Cyclic Peptide Inhibitors Targeting Mycobacterium tuberculosis Transcription.

PMID 36143370 · 2022

Mutations in rpoB gene affect rifampicin binding

Mutation Information

rpoB: p.L430P rpoB: p.S431T rpoB: p.H445N rpoB: p.S450L rpoB: p.D435V rpoB: p.D435G rpoB: p.L452P

Protein Change: S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: molecular docking simulation
Source Database: Reslit

727

Characterization of Genetic Variants Associated with Rifampicin Resistance Level in Mycobacterium tuberculosis Clinical Isolates Collected in Guangzhou Chest Hospital, China.

PMID 36193294 · 2022

All mutations were experimentally validated in this study.

Mutation Information

Protein Change: L430P, D435V, D435E, D435G, D435N, H445N, H445D, H445Y, H445R, H445L, S450L, S450F, Q432K, M434V, N437D, R448L, L452P, K274Q, I491M, A286V, L494P, P454L, I491L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing analysis
Source Database: Reslit

728

Deep Amplicon Sequencing Reveals Culture-dependent Clonal Selection of Mycobacterium tuberculosis in Clinical Samples.

PMID 38870522 · 2025

Mutation Information

Protein Change: L430P, S431T, H445N, S450L, D435V, D435G, L452P
Confers Resistance To: rifampicin
Validation Method: deep amplicon sequencing and molecular drug susceptibility testing
Source Database: Reslit

729

The novel 2024 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations and superseded WHO N. gonorrhoeae reference strains-phenotypic, genetic and reference genome characterization.

PMID 38889110 · 2024

carried H552N mutation leading to rifampicin resistance

Mutation Information

rpoB: p.H552N

Protein Change: H552N
Confers Resistance To: rifampicin
Source Database: Reslit

730

Evaluation of Whole Genome Sequencing-Based Predictions of Antimicrobial Resistance to TB First Line Agents: A Lesson from 5 Years of Data.

PMID 38892433 · 2024

Mutation Information

rpoB: p.H432Y rpoB: p.H435Y rpoB: p.H445Y rpoB: p.H450Y

Protein Change: H432Y, H435Y, H445Y, H450Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: WGS-based AMR prediction and phenotypic DST
Source Database: Reslit

731

Culture-Free Whole Genome Sequencing of Mycobacterium tuberculosis Using Ligand-Mediated Bead Enrichment Method.

PMID 38957687 · 2024

Detected in 2 samples classified as rifampicin sensitive by Xpert MTB/RIF.

Mutation Information

rpoB: p.S441A

Protein Change: S441A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

732

Metabolic remodeling by RNA polymerase gene mutations is associated with reduced β-lactam susceptibility in oxacillin-susceptible MRSA.

PMID 38988221 · 2024

Mutation Information

rpoB: p.Q645H rpoB: p.H929P

Protein Change: Q645H, H929P
Organisms: Staphylococcus aureus
Confers Resistance To: oxacillin|cefoxitin|imipenem
Effect on Function: dysregulation of RNAP transcription activity
Validation Method: MIC testing; metabolomics analysis and antibiotic susceptibility testing
Source Database: Reslit

733

Whole-genome sequencing-based genetic diversity, transmission dynamics, and drug-resistant mutations in Mycobacterium tuberculosis isolated from extrapulmonary tuberculosis patients in western Ethiopia.

PMID 39185123 · 2024

Mutation Information

rpoB: p.L443F

Protein Change: L443F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing analysis
Source Database: Reslit

734

The performance of Xpert MTB/RIF and MTBDRplus within a Programmatic setting at TB Laboratory in Rio de Janeiro, Brazil.

PMID 39292021 · 2024

Mutation Information

rpoB: p.L430P

Protein Change: L430P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

735

The catalogue of Mycobacterium tuberculosis mutations associated with drug resistance to 12 drugs in China from a nationwide survey: a genomic analysis.

PMID 39353459 · 2024

Mutation Information

rpoB: p.H445L

Protein Change: H445L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotyping and MIC testing
Source Database: Reslit

736

Mapping and sequencing of mutations in the Escherichia coli rpoB gene that lead to rifampicin resistance.

PMID 3050121 · 1988

Escherichia coli rpoB mutants conferring resistance to rifampicin; CARD accession: CARD:3003288

rpoB

Mutation Information

rpoB: p.V146F rpoB: p.Q513L rpoB: p.Q513P rpoB: p.H526Y rpoB: p.R529C rpoB: p.R529S rpoB: p.S531F rpoB: p.L533P rpoB: p.T563P rpoB: p.P564L rpoB: p.R687H rpoB: p.Q517QDQ

Protein Change: V146F, Q513L, Q513P, H526Y, R529C, R529S, S531F, L533P, T563P, P564L, R687H, Q517QDQ
Organisms: Escherichia coli, Shigella sonnei
Confers Resistance To: rifampicinrifamycins
Effect on Function: Target modification; single resistance variant; DNA-directed RNA polymerase subunit beta RpoB
Source Database: ResFinder DatabaseCard DatabaseReference Gene Catalog

737

MUBII-TB-DB: a database of mutations associated with antibiotic resistance in Mycobacterium tuberculosis.

PMID 24731071 · 2014

Mutation Information

rpoB: p.V170F rpoB: p.A286V rpoB: p.G426S rpoB: p.G426D rpoB: p.T427S rpoB: p.T427P rpoB: p.T427A rpoB: p.T427H rpoB: p.S428R rpoB: p.S428Q rpoB: p.S428I rpoB: p.S428T rpoB: p.Q432N rpoB: p.Q432K rpoB: p.Q432*rpoB: p.Q432E rpoB: p.Q432L rpoB: p.Q432P rpoB: p.Q432R rpoB: p.Q432H rpoB: p.D435F rpoB: p.D435N rpoB: p.D435Y rpoB: p.D435H rpoB: p.D435V rpoB: p.D435A rpoB: p.D435G rpoB: p.D435E rpoB: p.S441Q rpoB: p.S441L rpoB: p.S441W rpoB: p.H445F rpoB: p.H445G rpoB: p.H445N rpoB: p.H445Y rpoB: p.H445D rpoB: p.H445L rpoB: p.H445P rpoB: p.H445R rpoB: p.H445Q rpoB: p.R447P rpoB: p.R447H rpoB: p.S450Q rpoB: p.S450L rpoB: p.S450W rpoB: p.S450F rpoB: p.S450Y rpoB: p.L452P rpoB: p.E592D rpoB: p.S431G / c.A1291G rpoB: c.del1275CGGCAC rpoB: c.del1276GGCACC rpoB: c.del1294CAATTC rpoB: c.del1295AATTCATGG rpoB: c.del1297TTC rpoB: c.del1297TTCATGGAC rpoB: c.del1299CAT rpoB: c.del1299CATGGACCAGAA rpoB: c.del1300ATGGACCAGAAC rpoB: c.del1303GACCAG rpoB: c.del1306CAG rpoB: c.del1306CAGAAC rpoB: c.del1308GAACAA rpoB: c.del1312AAC rpoB: c.del1336AAG rpoB: c.ins1294TTC rpoB: c.ins1294TTCATG rpoB: c.ins1297CGG rpoB: c.ins1300TTC

Protein Change: V170F, A286V, G426S, G426D, T427S, T427P, T427A, T427H, S428R, S428Q, S428I, S428T, Q432N, Q432K, Q432*, Q432E, Q432L, Q432P, Q432R, Q432H, D435F, D435N, D435Y, D435H, D435V, D435A, D435G, D435E, S441Q, S441L, S441W, H445F, H445G, H445N, H445Y, H445D, H445L, H445P, H445R, H445Q, R447P, R447H, S450Q, S450L, S450W, S450F, S450Y, L452P, E592D, S431G
Nucleotide Change: A1291G, del1275CGGCAC, del1276GGCACC, del1294CAATTC, del1295AATTCATGG, del1297TTC, del1297TTCATGGAC, del1299CAT, del1299CATGGACCAGAA, del1300ATGGACCAGAAC, del1303GACCAG, del1306CAG, del1306CAGAAC, del1308GAACAA, del1312AAC, del1336AAG, ins1294TTC, ins1294TTCATG, ins1297CGG, ins1300TTC
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: systematic review of literature
Source Database: ResFinder DatabaseReslit

738

Characterization of mutations in multi- and extensive drug resistance among strains of Mycobacterium tuberculosis clinical isolates in Republic of Korea.

PMID 23561273 · 2013

Mutation Information

Protein Change: T400A, F424L, F424V, F424S, S428R, S428Q, S428I, S428T, L430V, L430P, L430R, Q432N, Q432K, Q432*, Q432E, Q432L, Q432P, Q432R, Q432H, M434T, M434I, D435F, D435N, D435Y, D435H, D435V, D435A, D435G, D435E, S441Q, S441L, S441W, H445F, H445G, H445N, H445Y, H445D, H445L, H445P, H445R, H445Q, S450Q, S450L, S450W, S450F, S450Y, L452P, P454S, P454H, P454L, P454R, T482P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: ResFinder Database

739

Tuberculosis drug resistance mutation database.

PMID 19209951 · 2009

Mutation Information

rpoB: p.Q409H rpoB: p.E423A rpoB: p.F424L rpoB: p.F424V rpoB: p.F424S rpoB: p.G426S rpoB: p.G426D rpoB: p.T427S rpoB: p.T427P rpoB: p.T427A rpoB: p.T427H rpoB: p.S428R rpoB: p.S428Q rpoB: p.S428I rpoB: p.S428T rpoB: p.Q429K rpoB: p.Q429H rpoB: p.L430V rpoB: p.L430P rpoB: p.L430R rpoB: p.S431R rpoB: p.S431G rpoB: p.S431I rpoB: p.S431T rpoB: p.Q432N rpoB: p.Q432K rpoB: p.Q432*rpoB: p.Q432E rpoB: p.Q432L rpoB: p.Q432P rpoB: p.Q432R rpoB: p.Q432H rpoB: p.F433L rpoB: p.F433V rpoB: p.M434T rpoB: p.M434I rpoB: p.D435F rpoB: p.D435N rpoB: p.D435Y rpoB: p.D435H rpoB: p.D435V rpoB: p.D435A rpoB: p.D435G rpoB: p.D435E rpoB: p.Q436L rpoB: p.Q436H rpoB: p.N437Y rpoB: p.N437H rpoB: p.N437D rpoB: p.N437I rpoB: p.N437T rpoB: p.N438K rpoB: p.L440M rpoB: p.L440L rpoB: p.L440P rpoB: p.S441Q rpoB: p.S441L rpoB: p.S441W rpoB: p.G442W rpoB: p.G442A rpoB: p.L443S rpoB: p.L443W rpoB: p.T444P rpoB: p.T444I rpoB: p.H445F rpoB: p.H445G rpoB: p.H445N rpoB: p.H445Y rpoB: p.H445D rpoB: p.H445L rpoB: p.H445P rpoB: p.H445R rpoB: p.H445Q rpoB: p.K446Q rpoB: p.K446N rpoB: p.R447P rpoB: p.R447H rpoB: p.S450Q rpoB: p.S450L rpoB: p.S450W rpoB: p.S450F rpoB: p.S450Y rpoB: p.L452P rpoB: p.P454S rpoB: p.P454H rpoB: p.P454L rpoB: p.P454R rpoB: p.L457P rpoB: p.E460G rpoB: p.L464M rpoB: p.S472A rpoB: p.I480V rpoB: p.I480T rpoB: p.E481G rpoB: p.P483L rpoB: p.L490V rpoB: p.I491F rpoB: p.S493L rpoB: p.R552C rpoB: c.del1276GGCACC rpoB: c.del1294CAATTC rpoB: c.del1295AATTCATGG rpoB: c.del1297TTC rpoB: c.del1297TTCATGGAC rpoB: c.del1299CAT rpoB: c.del1299CATGGACCAGAA rpoB: c.del1300ATGGACCAGAAC rpoB: c.del1303GACCAG rpoB: c.del1306CAG rpoB: c.del1306CAGAAC rpoB: c.del1308GAACAA rpoB: c.del1312AAC rpoB: c.del1336AAG

Protein Change: Q409H, E423A, F424L, F424V, F424S, G426S, G426D, T427S, T427P, T427A, T427H, S428R, S428Q, S428I, S428T, Q429K, Q429H, L430V, L430P, L430R, S431R, S431G, S431I, S431T, Q432N, Q432K, Q432*, Q432E, Q432L, Q432P, Q432R, Q432H, F433L, F433V, M434T, M434I, D435F, D435N, D435Y, D435H, D435V, D435A, D435G, D435E, Q436L, Q436H, N437Y, N437H, N437D, N437I, N437T, N438K, L440M, L440L, L440P, S441Q, S441L, S441W, G442W, G442A, L443S, L443W, T444P, T444I, H445F, H445G, H445N, H445Y, H445D, H445L, H445P, H445R, H445Q, K446Q, K446N, R447P, R447H, S450Q, S450L, S450W, S450F, S450Y, L452P, P454S, P454H, P454L, P454R, L457P, E460G, L464M, S472A, I480V, I480T, E481G, P483L, L490V, I491F, S493L, R552C
Nucleotide Change: del1276GGCACC, del1294CAATTC, del1295AATTCATGG, del1297TTC, del1297TTCATGGAC, del1299CAT, del1299CATGGACCAGAA, del1300ATGGACCAGAAC, del1303GACCAG, del1306CAG, del1306CAGAAC, del1308GAACAA, del1312AAC, del1336AAG
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: ResFinder Database

740

Detection of first- and second-line drug resistance in Mycobacterium tuberculosis clinical isolates by pyrosequencing.

PMID 22461677 · 2012

Mutations in rpoB are associated with rifampin resistance.

Mutation Information

Protein Change: S428R, S428Q, S428I, S428T, Q429K, Q429H, L430V, L430P, L430R, Q432N, Q432K, Q432*, Q432E, Q432L, Q432P, Q432R, Q432H, D435F, D435N, D435Y, D435H, D435V, D435A, D435G, D435E, H445F, H445G, H445N, H445Y, H445D, H445L, H445P, H445R, H445Q, S450Q, S450L, S450W, S450F, S450Y, L452P, P454S, P454H, P454L, P454R
Nucleotide Change: A1401G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicinamikacin|kanamycin|capreomycin
Validation Method: pyrosequencing
Source Database: ResFinder DatabaseReslit

741

Rapid detection of Mycobacterium tuberculosis and rifampin resistance by use of on-demand, near-patient technology.

PMID 19864480 · 2010

Mutation Information

Protein Change: Q429K, Q429H, L430V, L430P, L430R, Q432N, Q432K, Q432*, Q432E, Q432L, Q432P, Q432R, Q432H, D435F, D435N, D435Y, D435H, D435V, D435A, D435G, D435E, S441Q, S441L, S441W, H445F, H445G, H445N, H445Y, H445D, H445L, H445P, H445R, H445Q, S450Q, S450L, S450W, S450F, S450Y, L452P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: ResFinder Database

742

Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance.

PMID 23995137 · 2013

Mutation Information

Protein Change: L430V, L430P, L430R, S431R, S431G, S431I, S431T, D435F, D435N, D435Y, D435H, D435V, D435A, D435G, D435E, H445F, H445G, H445N, H445Y, H445D, H445L, H445P, H445R, H445Q, S450Q, S450L, S450W, S450F, S450Y, I480V, I480T, E761D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: ResFinder Database

743

PMID Shi_et_al._2013

Mutation Information

Protein Change: L430V, L430P, L430R, D435F, D435N, D435Y, D435H, D435V, D435A, D435G, D435E, H445F, H445G, H445N, H445Y, H445D, H445L, H445P, H445R, H445Q, S450Q, S450L, S450W, S450F, S450Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: ResFinder Database

744

[Metastases to the mediastinal lymph nodes in a series of two-hundred-consecutive operations for primary lung cancer].

PMID 1920995 · 1991

Mutation Information

rpoB: p.F433L rpoB: p.F433V rpoB: p.Q436L rpoB: p.Q436H rpoB: p.G442W rpoB: p.G442A rpoB: p.L443S rpoB: p.L443W rpoB: p.T444P rpoB: p.T444I rpoB: p.K446Q rpoB: p.K446N

Protein Change: F433L, F433V, Q436L, Q436H, G442W, G442A, L443S, L443W, T444P, T444I, K446Q, K446N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: ResFinder Database

745

PMID Wang_et_al._2013

Mutation Information

Protein Change: D435F, D435N, D435Y, D435H, D435V, D435A, D435G, D435E, H445F, H445G, H445N, H445Y, H445D, H445L, H445P, H445R, H445Q, S450Q, S450L, S450W, S450F, S450Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: ResFinder Database

746

PMID Jin_et_al._2012

Mutation Information

Protein Change: D435F, D435N, D435Y, D435H, D435V, D435A, D435G, D435E, H445F, H445G, H445N, H445Y, H445D, H445L, H445P, H445R, H445Q, S450Q, S450L, S450W, S450F, S450Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: ResFinder Database

747

Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.

PMID 29358649 · 2018

Mutation Information

rpoB: p.L731P

Protein Change: L731P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Source Database: ResFinder Database

748

Epidemiological and molecular aspects of rifampicin-resistant Staphylococcus aureus isolated from wounds, blood and respiratory samples.

PMID 21393177 · 2011

Mutation Information

rpoB: p.S463P rpoB: p.Q465K rpoB: p.N474K rpoB: p.H481N rpoB: p.H481Y rpoB: p.H481D rpoB: p.ins475G rpoB: c.ins1419GGA rpoB: c.ins1419GGC rpoB: c.ins1419GGG rpoB: c.ins1419GGT

Protein Change: S463P, Q465K, N474K, H481N, H481Y, H481D, ins475G
Nucleotide Change: ins1419GGA, ins1419GGC, ins1419GGG, ins1419GGT
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Effect on Function: Target modification
Source Database: ResFinder Database

749

Differential effect of rpoB mutations on antibacterial activities of rifampicin and KRM-1648 against Staphylococcus aureus.

PMID 11157898 · 2001

Mutation Information

Protein Change: S464P, Q465R, L466S, Q468K, Q468R, Q468L, D471Y, A473T, A477D, A477V, A477T, H481N, H481Y, H481D, R484H, S486L, I527F, I527M, I527L, S529L
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Effect on Function: Target modification
Source Database: ResFinder Database

750

Neurosurgical consideration of some features of the cerebral dural sinuses and their tributaries.

PMID 975676 · 1976

Mutation Information

rpoB: p.A477D rpoB: p.A477V

Protein Change: A477D, A477V
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Effect on Function: Target modification
Source Database: ResFinder Database

751

Posttraumatic headache and the postconcussion syndrome.

PMID 2020219 · 1991

Mutation Information

rpoB: p.A477T rpoB: p.I527M rpoB: p.I527L

Protein Change: A477T, I527M, I527L
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Effect on Function: Target modification
Source Database: ResFinder Database

752

The spectrum of spontaneous rifampin resistance mutations in the rpoB gene of Bacillus subtilis 168 spores differs from that of vegetative cells and resembles that of Mycobacterium tuberculosis.

PMID 12169622 · 2002

Bacillus subtilis rpoB mutants conferring resistance to rifampin; CARD accession: CARD:3007073

Mutation Information

rpoB: p.A478N rpoB: p.S487L

Protein Change: A478N, S487L
Organisms: Bacillus subtilis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

753

Mutations in the ss subunit of the Bacillus subtilis RNA polymerase that confer both rifampicin resistance and hypersensitivity to NusG.

PMID 11101662 · 2000

Bacillus subtilis rpoB mutants conferring resistance to rifampin; CARD accession: CARD:3007073

Mutation Information

rpoB: p.Q469K rpoB: p.Q469R rpoB: p.H482Y

Protein Change: Q469K, Q469R, H482Y
Organisms: Bacillus subtilis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

754

High-resolution melting analysis of the single nucleotide polymorphism hot-spot region in the rpoB gene as an indicator of reduced susceptibility to rifaximin in Clostridium difficile.

PMID 22361457 · 2012

Clostridioides difficile rpoB with mutation conferring resistance to rifampicin; CARD accession: CARD:3004563

rpoB

Mutation Information

rpoB: p.L487F rpoB: p.H502Y rpoB: p.H502L rpoB: p.S550Y rpoB: p.S550F rpoB: p.D492V rpoB: p.I548M rpoB: p.R505K rpoB: p.D492N

Protein Change: L487F, H502Y, H502L, S550Y, S550F, D492V, I548M, R505K, D492N
Organisms: Clostridium ljungdahlii, Clostridioides difficile
Confers Resistance To: rifampicinrifaximin
Effect on Function: multiple resistance variants; single resistance variant; DNA-directed RNA polymerase subunit beta RpoB
Source Database: Card DatabaseReference Gene Catalog

755

In vitro selection, via serial passage, of Clostridium difficile mutants with reduced susceptibility to fidaxomicin or vancomycin.

PMID 23887866 · 2014

Clostridioides difficile rpoB with mutation conferring resistance to rifampicin; CARD accession: CARD:3004563

rpoB

Mutation Information

rpoB: p.Q1073R rpoB: p.Q1074R

Protein Change: Q1073R, Q1074R
Organisms: Clostridium ljungdahlii, Clostridioides difficile
Confers Resistance To: rifampicinfidaxomicin
Effect on Function: single resistance variant; DNA-directed RNA polymerase subunit beta RpoB
Source Database: Card DatabaseReference Gene Catalog

756

Divergent rifamycin susceptibilities of Clostridium difficile strains in Canada and Italy and predictive accuracy of rifampin Etest for rifamycin resistance.

PMID 21998414 · 2011

Clostridioides difficile rpoB with mutation conferring resistance to rifampicin; CARD accession: CARD:3004563

rpoB

Mutation Information

rpoB: p.S498T rpoB: p.S488P

Protein Change: S498T, S488P
Organisms: Clostridium ljungdahlii, Clostridioides difficile
Confers Resistance To: rifampicinrifamycins
Effect on Function: single resistance variant; DNA-directed RNA polymerase subunit beta RpoB
Source Database: Card DatabaseReference Gene Catalog

757

Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene.

PMID 31992637 · 2020

Escherichia coli rpoB mutants conferring resistance to rifampicin; CARD accession: CARD:3003288

Mutation Information

rpoB: p.S531fs

Protein Change: S531fs
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Effect on Function: frameshift mutation
Source Database: Card Database

758

Mutations at four distinct regions of the rpoB gene can reduce the susceptibility of Helicobacter pylori to rifamycins.

PMID 10817737 · 2000

Helicobacter pylori rpoB mutation conferring resistance to rifampicin; CARD accession: CARD:3007051

Mutation Information

rpoB: p.V149E rpoB: p.R701H rpoB: p.V149W rpoB: p.V149D rpoB: p.V149K rpoB: p.V149Q rpoB: p.V149F rpoB: p.V148I

Protein Change: V149E, R701H, V149W, V149D, V149K, V149Q, V149F, V148I
Organisms: Helicobacter pylori
Confers Resistance To: rifampicin
Effect on Function: single resistance variant; multiple resistance variants
Source Database: Card Database

759

Characterization of rifampicin-resistant clinical Helicobacter pylori isolates from Germany.

PMID 17350989 · 2007

Helicobacter pylori rpoB mutation conferring resistance to rifampicin; CARD accession: CARD:3007051

Mutation Information

rpoB: p.D530Y rpoB: p.D530I rpoB: p.D530G rpoB: p.D530L rpoB: p.D530F rpoB: p.H540Y rpoB: p.H540N rpoB: p.L525I rpoB: p.D530N rpoB: p.D530E

Protein Change: D530Y, D530I, D530G, D530L, D530F, H540Y, H540N, L525I, D530N, D530E
Organisms: Helicobacter pylori
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

760

Rifampin and rifabutin resistance mechanism in Helicobacter pylori.

PMID 10348780 · 1999

Helicobacter pylori rpoB mutation conferring resistance to rifampicin; CARD accession: CARD:3007051

Mutation Information

rpoB: p.I586L rpoB: p.I586N rpoB: p.S545L rpoB: p.D530V rpoB: p.Q527R rpoB: p.Q527K rpoB: p.L525P

Protein Change: I586L, I586N, S545L, D530V, Q527R, Q527K, L525P
Organisms: Helicobacter pylori
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

761

Alternative eradication regimens for Helicobacter pylori infection in Indonesian regions with high metronidazole and levofloxacin resistance.

PMID 30774400 · 2019

Helicobacter pylori rpoB mutation conferring resistance to rifampicin; CARD accession: CARD:3007051

Mutation Information

rpoB: p.A2414V rpoB: p.A2414T rpoB: p.Q2079K rpoB: p.K2068R rpoB: p.I837V

Protein Change: A2414V, A2414T, Q2079K, K2068R, I837V
Organisms: Helicobacter pylori
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

762

Effective therapeutic regimens in two South Asian countries with high resistance to major Helicobacter pylori antibiotics.

PMID 30815255 · 2019

Helicobacter pylori rpoB mutation conferring resistance to rifampicin; CARD accession: CARD:3007051

Mutation Information

rpoB: p.F2538L rpoB: p.T2537A rpoB: p.V2592L rpoB: p.I2619V

Protein Change: F2538L, T2537A, V2592L, I2619V
Organisms: Helicobacter pylori
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

763

Mutations in genes related to drug resistance in Mycobacterium leprae isolates from leprosy patients in Korea.

PMID 15603834 · 2005

Mycobacterium leprae rpoB mutations conferring resistance to rifampicin; CARD accession: CARD:3003284

Mutation Information

rpoB: p.V472I rpoB: p.S456L

Protein Change: V472I, S456L
Organisms: Mycobacterium leprae
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

764

PMID 978-92-4-008241-0

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.A451G rpoB: p.D435H rpoB: p.D435L rpoB: p.D435V rpoB: p.D435E rpoB: p.Q436R rpoB: p.Q436P rpoB: p.N437H rpoB: p.N437D rpoB: p.N437S rpoB: p.N437I rpoB: p.N438H rpoB: p.P439S rpoB: p.P439L rpoB: p.P439A rpoB: p.S441A rpoB: p.S441L rpoB: p.S441V rpoB: p.S441Q rpoB: p.S441M rpoB: p.S441K rpoB: p.G442E rpoB: p.S441W rpoB: p.L443S rpoB: p.T444P rpoB: p.L443W rpoB: p.L443F rpoB: p.T444S rpoB: p.T444I rpoB: p.H445Y rpoB: p.H445S rpoB: p.K446Q rpoB: p.H445P rpoB: p.H445N rpoB: p.H445F rpoB: p.H445L rpoB: p.H445R rpoB: p.H445C rpoB: p.H445G rpoB: p.H445T rpoB: p.H445D rpoB: p.H445Q rpoB: p.K446R rpoB: p.K446E rpoB: p.K446T rpoB: p.R448L rpoB: p.R448K rpoB: p.R448Q rpoB: p.L449M rpoB: p.S450F rpoB: p.S450A rpoB: p.S450L rpoB: p.S450G rpoB: p.S450Q rpoB: p.S450V rpoB: p.S450M rpoB: p.S450C rpoB: p.S450Y rpoB: p.S450W rpoB: p.A451V rpoB: p.L452V rpoB: p.L452M rpoB: p.L452P rpoB: p.I491F rpoB: p.L452Var rpoB: p.A451Var rpoB: p.S428Var rpoB: p.Q429Var rpoB: p.L430Var rpoB: p.S431Var rpoB: p.Q432Var rpoB: p.F433Var rpoB: p.M434Var rpoB: p.D435Var rpoB: p.Q436Var rpoB: p.N437Var rpoB: p.N438Var rpoB: p.P439Var rpoB: p.L440Var rpoB: p.S441Var rpoB: p.G442Var rpoB: p.L443Var rpoB: p.S450Var rpoB: p.L449Var rpoB: p.R448Var rpoB: p.R447Var rpoB: p.V170F rpoB: p.G426S rpoB: p.T427P rpoB: p.T427S rpoB: p.T427A rpoB: p.T427G rpoB: p.T427N rpoB: p.T427I rpoB: p.S428G rpoB: p.S428R rpoB: p.S428T rpoB: p.S428I rpoB: p.Q429L rpoB: p.Q429P rpoB: p.Q429H rpoB: p.L430R rpoB: p.L430P rpoB: p.S431G rpoB: p.S431T rpoB: p.S431R rpoB: p.K446Var rpoB: p.S431N rpoB: p.Q432L rpoB: p.Q432E rpoB: p.Q432N rpoB: p.H445Var rpoB: p.Q432K rpoB: p.Q432P rpoB: p.Q432H rpoB: p.M434L rpoB: p.T444Var rpoB: p.M434R rpoB: p.M434V rpoB: p.M434T rpoB: p.D435G rpoB: p.D435Y rpoB: p.M434I rpoB: p.Q436N rpoB: p.N437Y rpoB: p.D435A rpoB: p.D435N rpoB: p.D435F

Protein Change: A451G, D435H, D435L, D435V, D435E, Q436R, Q436P, N437H, N437D, N437S, N437I, N438H, P439S, P439L, P439A, S441A, S441L, S441V, S441Q, S441M, S441K, G442E, S441W, L443S, T444P, L443W, L443F, T444S, T444I, H445Y, H445S, K446Q, H445P, H445N, H445F, H445L, H445R, H445C, H445G, H445T, H445D, H445Q, K446R, K446E, K446T, R448L, R448K, R448Q, L449M, S450F, S450A, S450L, S450G, S450Q, S450V, S450M, S450C, S450Y, S450W, A451V, L452V, L452M, L452P, I491F, L452Var, A451Var, S428Var, Q429Var, L430Var, S431Var, Q432Var, F433Var, M434Var, D435Var, Q436Var, N437Var, N438Var, P439Var, L440Var, S441Var, G442Var, L443Var, S450Var, L449Var, R448Var, R447Var, V170F, G426S, T427P, T427S, T427A, T427G, T427N, T427I, S428G, S428R, S428T, S428I, Q429L, Q429P, Q429H, L430R, L430P, S431G, S431T, S431R, K446Var, S431N, Q432L, Q432E, Q432N, H445Var, Q432K, Q432P, Q432H, M434L, T444Var, M434R, M434V, M434T, D435G, D435Y, M434I, Q436N, N437Y, D435A, D435N, D435F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

765

Universal pattern of RpoB gene mutations among multidrug-resistant isolates of Mycobacterium tuberculosis complex from Africa.

PMID 10423225 · 1999

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.Q432L rpoB: p.E423A rpoB: p.H445L rpoB: p.D435G rpoB: p.D435N rpoB: p.Q432K

Protein Change: Q432L, E423A, H445L, D435G, D435N, Q432K
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

766

Characterization of mutations causing rifampicin and isoniazid resistance of Mycobacterium tuberculosis in Syria.

PMID 22708343 · 2012

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.L430P rpoB: p.M434V rpoB: p.M434I rpoB: p.D435Y rpoB: p.D435T rpoB: p.K446Q rpoB: p.H445S rpoB: p.S450G rpoB: p.L452P

Protein Change: L430P, M434V, M434I, D435Y, D435T, K446Q, H445S, S450G, L452P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

767

Characterization of rpoB mutations in rifampin-resistant clinical isolates of Mycobacterium tuberculosis from Turkey by DNA sequencing and line probe assay.

PMID 12454132 · 2002

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.Q409H rpoB: p.Q432P rpoB: p.S441W

Protein Change: Q409H, Q432P, S441W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

768

Rifampicin resistance and mutation of the rpoB gene in Mycobacterium tuberculosis.

PMID 8870258 · 1996

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.L440P rpoB: p.A286V

Protein Change: L440P, A286V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

769

Mutations in the beginning of the rpoB gene can induce resistance to rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis.

PMID 10722516 · 2000

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.V170F

Protein Change: V170F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

770

rpoB mutations in multidrug-resistant strains of Mycobacterium tuberculosis isolated in Italy.

PMID 10074552 · 1999

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.H445D rpoB: p.S450L

Protein Change: H445D, S450L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: multiple resistance variants
Source Database: Card Database

771

High-level rifampin resistance correlates with multiple mutations in the rpoB gene of pulmonary tuberculosis isolates from the Afghanistan border of Iran.

PMID 19721079 · 2009

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.Q432Ter rpoB: p.S450F rpoB: p.H445Q rpoB: p.H445F rpoB: p.G442A rpoB: p.N438K rpoB: p.D435H rpoB: p.Q432E rpoB: p.Q432D rpoB: p.T427H rpoB: p.T427A rpoB: p.T427P rpoB: p.G426D rpoB: p.G426S

Protein Change: Q432Ter, S450F, H445Q, H445F, G442A, N438K, D435H, Q432E, Q432D, T427H, T427A, T427P, G426D, G426S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: nonsense mutation; single resistance variant
Source Database: Card Database

772

Distribution of rpoB mutations among multidrug-resistant Mycobacterium tuberculosis (MDRTB) strains from Thailand and development of a rapid method for mutation detection.

PMID 18294243 · 2008

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.S441L rpoB: p.D435E rpoB: p.D435Y rpoB: p.L430R rpoB: p.H445Y rpoB: p.E460G rpoB: p.H445S rpoB: p.P454H rpoB: p.M434V rpoB: p.S450L rpoB: p.S540A

Protein Change: S441L, D435E, D435Y, L430R, H445Y, E460G, H445S, P454H, M434V, S450L, S540A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant; multiple resistance variants
Source Database: Card Database

773

Analysis of rpoB and pncA mutations in the published literature: an insight into the role of oxidative stress in Mycobacterium tuberculosis evolution?

PMID 15814606 · 2005

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.I491F rpoB: p.H445P rpoB: p.S441Ter rpoB: p.Q432R

Protein Change: I491F, H445P, S441Ter, Q432R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant; nonsense mutation
Source Database: Card Database

774

Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis.

PMID 21300839 · 2011

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.L457R rpoB: p.L452R

Protein Change: D435V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

775

Novel mutation detection IN rpoB OF rifampicin-resistant Mycobacterium tuberculosis using pyrosequencing.

PMID 25427352 · 2014

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

Protein Change: L457R, L452R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

776

Comparison of two commercial assays for the characterization of rpoB mutations in Mycobacterium tuberculosis and description of new mutations conferring weak resistance to rifampicin.

PMID 19520715 · 2009

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.E481G rpoB: p.P483L

Protein Change: E481G, P483L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: multiple resistance variants
Source Database: Card Database

777

Genotypic analysis of isoniazid and rifampin resistance in drug-resistant clinical Mycobacterium tuberculosis complex isolates in southern Turkey.

PMID 18653964 · 2008

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.L464M

Protein Change: L464M
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

778

A newly identified 191A/C mutation in the Rv2629 gene that was significantly associated with rifampin resistance in Mycobacterium tuberculosis.

PMID 17970586 · 2007

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.L457P

Protein Change: L457P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

779

Characterization of rifampin-resistance in pathogenic mycobacteria.

PMID 7840574 · 1994

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.H445P rpoB: p.K446Q

Protein Change: H445P, K446Q
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: multiple resistance variants
Source Database: Card Database

780

Disequilibrium in distribution of resistance mutations among Mycobacterium tuberculosis Beijing and non-Beijing strains isolated from patients in Germany.

PMID 15728936 · 2005

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.N437I

Protein Change: N437I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

781

Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis clinical isolates from India.

PMID 11474030 · 2001

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.N437H rpoB: p.D435K rpoB: p.L430M rpoB: p.T427S

Protein Change: N437H, D435K, L430M, T427S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

782

Identification of rifampin-resistant genotypes in Mycobacterium tuberculosis by PCR-reverse dot blot hybridization.

PMID 18600483 · 2009

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.Q436H

Protein Change: Q436H
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

783

Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis isolates from Brazil.

PMID 10921994 · 2000

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.L430P rpoB: p.M434I rpoB: p.L430R rpoB: p.D435V rpoB: p.S450L rpoB: p.H445C rpoB: p.F433V

Protein Change: L430P, M434I, L430R, D435V, S450L, H445C, F433V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: multiple resistance variants
Source Database: Card Database

784

Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update.

PMID 10645439 · 1998

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.H445G rpoB: p.L440M rpoB: p.S431R

Protein Change: H445G, L440M, S431R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

785

Characterization by automated DNA sequencing of mutations in the gene (rpoB) encoding the RNA polymerase beta subunit in rifampin-resistant Mycobacterium tuberculosis strains from New York City and Texas.

PMID 8027320 · 1994

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.H445E rpoB: p.S450C rpoB: p.S431T rpoB: p.L430R

Protein Change: H445E, S450C, S431T, L430R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

786

Molecular characterization of rifampin- and isoniazid-resistant Mycobacterium tuberculosis strains isolated in Poland.

PMID 15184414 · 2004

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.S431I rpoB: p.H445N rpoB: p.R448Q rpoB: p.H445T

Protein Change: S431I, H445N, R448Q, H445T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

787

Mutations in rpoB and katG genes in Mycobacterium isolates from the Southeast of Mexico.

PMID 19547874 · 2009

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

rpoB: p.R447P rpoB: p.L443S rpoB: p.Q436L rpoB: p.S428Q

Protein Change: R447P, L443S, Q436L, S428Q
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

788

Genetic changes that correlate with reduced susceptibility to daptomycin in Staphylococcus aureus.

PMID 16723576 · 2006

Staphylococcus aureus rpoB mutants conferring resistance to daptomycin; CARD accession: CARD:3003287

Mutation Information

rpoB: p.A1085V rpoB: p.I953S

Protein Change: A1085V, I953S
Organisms: Staphylococcus aureus
Confers Resistance To: daptomycin
Effect on Function: single resistance variant
Source Database: Card Database

789

Molecular characterization of rpoB mutations conferring cross-resistance to rifamycins on methicillin-resistant Staphylococcus aureus.

PMID 10543773 · 1999

Staphylococcus aureus rpoB mutants conferring resistance to rifampicin; CARD accession: CARD:3003285

Mutation Information

rpoB: p.Q465R rpoB: p.L466S rpoB: p.Q468K rpoB: p.H481N rpoB: p.A477T rpoB: p.A473T

Protein Change: Q465R, L466S, Q468K, H481N, A477T, A473T
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

790

Rifampicin-resistant RpoB S522L Vibrio vulnificus exhibits disturbed stress response and hypervirulence traits.

PMID 37877661 · 2023

Vibrio vulnificus rpoB mutants conferring resistance to rifampin; CARD accession: CARD:3007794

Mutation Information

rpoB: p.S522L

Protein Change: S522L
Organisms: Vibrio vulnificus
Confers Resistance To: rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

791

Genomic analysis of in vivo acquired resistance to colistin and rifampicin in Acinetobacter baumannii.

PMID 29127051 · 2018

rpoB

Mutation Information

rpoB: p.S583L

Protein Change: S583L
Organisms: Acinetobacter baumannii
Confers Resistance To: rifampicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

792

Rifamycin Resistance in Clostridium difficile Is Generally Associated with a Low Fitness Burden.

PMID 27381389 · 2016

rpoB

Mutation Information

rpoB: p.S488Y rpoB: p.Q489L rpoB: p.D492Y rpoB: p.H502R rpoB: p.R505L rpoB: p.S507L rpoB: p.G510R rpoB: p.L584F

Protein Change: S488Y, Q489L, D492Y, H502R, R505L, S507L, G510R, L584F
Organisms: Clostridioides difficile
Confers Resistance To: rifaximin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

793

Characterization of the impact of rpoB mutations on the in vitro and in vivo competitive fitness of Clostridium difficile and susceptibility to fidaxomicin.

PMID 29253242 · 2018

rpoB

Mutation Information

rpoB: p.Q1074K rpoB: p.V1143F

Protein Change: Q1074K, V1143F
Organisms: Clostridioides difficile
Confers Resistance To: fidaxomicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

794

Improved long-acting fertility regulating agents: what are the problems?

PMID 385987 · 1979

rpoB

Mutation Information

rpoB: p.Q1074K rpoB: p.Q1074R rpoB: p.V1143F

Protein Change: Q1074K, Q1074R, V1143F
Organisms: Clostridioides difficile
Confers Resistance To: fidaxomicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

795

Characterization of a clinical Clostridioides difficile isolate with markedly reduced fidaxomicin susceptibility and a V1143D mutation in rpoB.

PMID 30247587 · 2019

rpoB

Mutation Information

rpoB: p.V1143D

Protein Change: V1143D
Organisms: Clostridioides difficile
Confers Resistance To: fidaxomicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

796

In vivo emergence of a still uncommon resistance to fidaxomicin in the urgent antimicrobial resistance threat Clostridioides difficile.

PMID 37352110 · 2023

rpoB

Mutation Information

rpoB: p.V1143G

Protein Change: V1143G
Organisms: Clostridioides difficile
Confers Resistance To: fidaxomicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

797

Antimicrobial susceptibility and molecular characterisation using whole-genome sequencing of Clostridioides difficile collected in 82 hospitals in Japan between 2014 and 2016.

PMID 31527041 · 2019

rpoB

Mutation Information

rpoB: p.V1143L

Protein Change: V1143L
Organisms: Clostridioides difficile
Confers Resistance To: fidaxomicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

798

Genomic Diversity and Antimicrobial Resistance of Haemophilus Colonizing the Airways of Young Children with Cystic Fibrosis.

PMID 34463568 · 2021

rpoB

Mutation Information

rpoB: p.A1131T

Protein Change: A1131T
Organisms: Haemophilus influenzae
Confers Resistance To: rifampicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

799

Rifampicin Resistance Associated with rpoB Mutations in Neisseria gonorrhoeae Clinical Strains Isolated in Austria, 2016 to 2020.

PMID 35678576 · 2022

rpoB

mutations in rpoB are associated with rifampicin resistance

Mutation Information

rpoB: p.H553N rpoB: p.L560S

Protein Change: H553N, L560S
Organisms: Neisseria gonorrhoeae
Confers Resistance To: rifampicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Validation Method: whole-genome sequencing and Etest
Source Database: Reference Gene CatalogReslit

800

Description of new mutations in the rpoB gene in rifampicin-resistant Neisseria meningitidis selected in vitro in a stepwise manner.

PMID 14614066 · 2003

rpoB

Mutation Information

rpoB: p.S549F rpoB: p.H553N rpoB: p.H553Y

Protein Change: S549F, H553N, H553Y
Organisms: Neisseria meningitidis
Confers Resistance To: rifampicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

801

Effects of injury on [3H]putrescine uptake by types I and II cells in rat lung slices.

PMID 2060607 · 1991

rpoB

Mutation Information

rpoB: p.S549F

Protein Change: S549F
Organisms: Neisseria meningitidis
Confers Resistance To: rifampicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

802

Convergent Evolution Driven by Rifampin Exacerbates the Global Burden of Drug-Resistant Staphylococcus aureus.

PMID 29404415 · 2018

rpoB

All mutations were validated via reconstruction in an isogenic background and MIC testing.

Mutation Information

rpoB: p.L466S rpoB: p.S529L rpoB: p.D471G / c.A1414G rpoB: p.Q468K / c.C1404A rpoB: p.H481N / c.CAG->AAC rpoB: p.H481Y / c.CAG->TAC rpoB: p.A477D / c.GCC->GAT rpoB: p.S464P / c.T1392C

Protein Change: L466S, S529L, D471G, Q468K, H481N, H481Y, A477D, S464P
Nucleotide Change: A1414G, C1404A, CAG->AAC, CAG->TAC, GCC->GAT, T1392C
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicinrifampicin|vancomycin|daptomycin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Validation Method: reconstruction in USA300 NRS384 and MIC testing
Source Database: Reference Gene CatalogReslit

803

The oxygen radical disease in neonatology.

PMID 2632427 · 1989

rpoB

Mutation Information

rpoB: p.A477V

Protein Change: A477V
Organisms: Staphylococcus aureus
Confers Resistance To: beta lactams|rifampicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

804

Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression.

PMID 32706832 · 2020

rpoB

Mutation Information

rpoB: p.G639C rpoB: p.Q643P rpoB: p.H929Q rpoB: p.D949H rpoB: p.G1139D

Protein Change: G639C, Q643P, H929Q, D949H, G1139D
Organisms: Staphylococcus aureus
Confers Resistance To: beta lactams
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

805

Rifampicin resistance in Staphylococcus epidermidis: molecular characterisation and fitness cost of rpoB mutations.

PMID 29287710 · 2018

rpoB

Mutation Information

rpoB: p.Q468K rpoB: p.H481Y

Protein Change: Q468K, H481Y
Organisms: Staphylococcus epidermidis
Confers Resistance To: rifampicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

806

Effect of chronic metabolic acidosis on ammonia production from L-glutamine in microdissected rat nephron segments.

PMID 3991326 · 1985

rpoB

Mutation Information

rpoB: p.D471E rpoB: p.I527M

Protein Change: D471E, I527M
Organisms: Staphylococcus epidermidis
Confers Resistance To: rifampicin|teicoplanin|vancomycin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

807

Global Expansion of Linezolid-Resistant Coagulase-Negative Staphylococci.

PMID 34589061 · 2021

rpoB

Mutation Information

rpoB: p.H481N

Protein Change: H481N
Organisms: Staphylococcus epidermidis
Confers Resistance To: rifampicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

808

In Vitro Activity of Rifampin, Rifabutin, Rifapentine, and Rifaximin against Planktonic and Biofilm States of Staphylococci Isolated from Periprosthetic Joint Infection.

PMID 31451499 · 2019

rpoB

Mutation Information

rpoB: p.S486F rpoB: p.S486Y

Protein Change: S486F, S486Y
Organisms: Staphylococcus epidermidis
Confers Resistance To: rifampicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

809

Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.

PMID 18305127 · 2008

rpoB

Mutation Information

rpoB: p.A473AA rpoB: p.H481Y rpoB: p.S486L

Protein Change: A473AA, H481Y, S486L
Organisms: Staphylococcus pseudintermedius
Confers Resistance To: rifampicin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

810

Linking epidemiological and genomic data in cases of enteric fever in England to inform clinical management and public health action.

PMID 38873828 · 2024

Mutations in rpoB confer resistance to rifampicin.

Mutation Information

rpoB: p.H415R / c.A1244G

Protein Change: H415R
Nucleotide Change: A1244G
Confers Resistance To: rifampicin
Validation Method: genome-derived AMR profile
Source Database: Reslit

811

Drug resistance profiles and related gene mutations in slow-growing non-tuberculous mycobacteria isolated in regional tuberculosis reference laboratories of Iran: a three year cross-sectional study.

PMID 35261334 · 2023

Mutation Information

rpoB: c.A1249C rpoB: c.A1407G rpoB: c.C1479T rpoB: c.G1356C rpoB: c.G1533A rpoB: c.G1536C

Nucleotide Change: A1249C, A1407G, C1479T, G1356C, G1533A, G1536C
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

812

Efflux pumps positively contribute to rifampin resistance in rpoB mutant Mycobacterium tuberculosis.

PMID 40887591 · 2025

Mutations in rpoB gene were associated with increased rifampin resistance.

Mutation Information

rpoB: p.Q432P / c.A1297C rpoB: p.D435V / c.A1306T rpoB: p.K446Q / c.A1338C rpoB: p.I491F / c.A1473T rpoB: p.S450L / c.C1351T rpoB: p.H445R / c.CTG->AGG rpoB: p.H445D / c.CTG->GAT rpoB: p.H445Y / c.CTG->TAT rpoB: p.V170F / c.GTG->TTC rpoB: p.L430P / c.T1291C rpoB: p.S450F / c.TCG->TTC

Protein Change: Q432P, D435V, K446Q, I491F, S450L, H445R, H445D, H445Y, V170F, L430P, S450F
Nucleotide Change: A1297C, A1306T, A1338C, A1473T, C1351T, CTG->AGG, CTG->GAT, CTG->TAT, GTG->TTC, T1291C, TCG->TTC
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MIC determination
Source Database: Reslit

813

Evaluation of genotype MTBDRplus assay for rapid detection of isoniazid and rifampicin resistance in Mycobacterium tuberculosis clinical isolates from Pakistan.

PMID 28043516 · 2016

Mutation Information

rpoB: c.A1304T rpoB: c.C1333G rpoB: c.C1349T

Nucleotide Change: A1304T, C1333G, C1349T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType MTBDRplus assay
Source Database: Reslit

814

Compensatory mutations are associated with increased in vitro growth in resistant clinical samples of Mycobacterium tuberculosis.

PMID 38315172 · 2024

mutations associated with rifampicin resistance

Mutation Information

rpoB: p.D435V / c.A1304T rpoB: p.S450L / c.AGT->CTT rpoB: p.H445Y / c.C1333T

Protein Change: D435V, S450L, H445Y
Nucleotide Change: A1304T, AGT->CTT, C1333T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: statistical association testing
Source Database: Reslit

815

Diverse impacts of different rpoB mutations on the anti-tuberculosis efficacy of capreomycin.

PMID 40449326 · 2025

Mutations at codon 435 (D435G, D435V) conferred increased CAP tolerance, while mutations at codon 445 (H445Y, H445R) enhanced CAP bactericidal effect.

Mutation Information

rpoB: p.D435G / c.A1305G rpoB: p.D435V / c.A1305T rpoB: p.S441L / c.AGC->CTC rpoB: p.S441W / c.AGC->TGG rpoB: p.H445R / c.CAC->CGT rpoB: p.H445Y / c.CAC->TAT rpoB: p.S450L / c.TCA->CTA

Protein Change: D435G, D435V, S441L, S441W, H445R, H445Y, S450L
Nucleotide Change: A1305G, A1305T, AGC->CTC, AGC->TGG, CAC->CGT, CAC->TAT, TCA->CTA
Organisms: Mycobacterium tuberculosis, Mycobacterium smegmatis
Confers Resistance To: capreomycin
Validation Method: MIC testing and time-kill assay; time-kill assay; Time-kill assay; Not specified
Source Database: Reslit

816

Novel Chemical Scaffolds for Inhibition of Rifamycin-Resistant RNA Polymerase Discovered from High-Throughput Screening.

PMID 28027449 · 2017

Mutations in the rpoB gene were analyzed for their impact on rifampin resistance.

Mutation Information

rpoB: p.D435V / c.A1306T rpoB: p.H445Y / c.C1335T rpoB: p.V408G / c.T1225G rpoB: p.S450L / c.TCA -> CTG rpoB: p.S531L / c.TCT -> CTT

Protein Change: D435V, H445Y, V408G, S450L, S531L
Nucleotide Change: A1306T, C1335T, T1225G, TCA -> CTG, TCT -> CTT
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: high-throughput screening and subsequent confirmation
Source Database: Reslit

817

A comprehensive evaluation of a novel targeted-sequencing workflow for Mycobacterium species identification and anti-tuberculosis drug-resistance detection.

PMID 40552123 · 2025

missed by TB Pro assay

Mutation Information

rpoB: p.K446T / c.A1337T

Protein Change: K446T
Nucleotide Change: A1337T
Confers Resistance To: rifampicin
Validation Method: comparison with WGS
Source Database: Reslit

818

Genomic Analysis of Multidrug-Resistant Mycobacterium tuberculosis Strains From Patients in Kazakhstan.

PMID 34858467 · 2021

Mutation found in all eight MDR-TB isolates.

Mutation Information

rpoB: c.A1348T

Nucleotide Change: A1348T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

819

Signatures of Selection at Drug Resistance Loci in Mycobacterium tuberculosis.

PMID 29404424 · 2018

dominant RIF resistance mutation

Mutation Information

rpoB: p.D450V / c.A1349T

Protein Change: D450V
Nucleotide Change: A1349T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

820

Whole Genome Sequencing of Drug Resistant and Drug Susceptible Mycobacterium tuberculosis Isolates From Tigray Region, Ethiopia.

PMID 34938276 · 2021

major resistance mutation

Mutation Information

rpoB: p.S450L / c.A1351T

Protein Change: S450L
Nucleotide Change: A1351T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

821

Paradoxical Hypersusceptibility of Drug-resistant Mycobacteriumtuberculosis to β-lactam Antibiotics.

PMID 27333036 · 2016

Mutation in rpoB associated with rifampin resistance and MDR level drug-resistance.

Mutation Information

rpoB: c.A1356T

Nucleotide Change: A1356T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing and phenotypic testing
Source Database: Reslit

822

Dynamic PET-facilitated modeling and high-dose rifampin regimens for Staphylococcus aureus orthopedic implant-associated infections.

PMID 34851697 · 2021

missense mutation

Mutation Information

rpoB: c.A1390G

Nucleotide Change: A1390G
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing and rifampin MIC testing
Source Database: Reslit

823

Consensus numbering system for the rifampicin resistance-associated rpoB gene mutations in pathogenic mycobacteria.

PMID 27664776 · 2017

Mutations in the rpoB gene are associated with rifampicin resistance in Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium kansasii.

Mutation Information

rpoB: p.H472R / c.A1417G rpoB: p.I491F / c.A1473T rpoB: p.S450L / c.C1351T

Protein Change: H472R, I491F, S450L
Nucleotide Change: A1417G, A1473T, C1351T
Organisms: Mycobacterium tuberculosis, Mycobacterium leprae, Mycobacterium kansasii
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

824

Mycobacterium tuberculosis Drug Resistance and Transmission among Human Immunodeficiency Virus-Infected Patients in Ho Chi Minh City, Vietnam.

PMID 30382014 · 2018

Mutation Information

rpoB: p.I491F / c.A1472T rpoB: p.S450L / c.AGC->CTC

Protein Change: I491F, S450L
Nucleotide Change: A1472T, AGC->CTC
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

825

Prospective Comparative Evaluation of the Xpert MTB/RIF and Xpert MTB/RIF Ultra Assays for Detecting Mycobacterium tuberculosis and Rifampin Resistance in High-resource, Intermediate-burden Settings.

PMID 40947993 · 2025

Mutation Information

rpoB: p.I491F / c.A1473T rpoB: p.P439L / c.C1318T rpoB: p.H445D / c.C1335G rpoB: p.H445Y / c.C1335T rpoB: p.Q432K / c.CAG->AAA rpoB: p.Q432P / c.CAG->CCC rpoB: p.D435Y / c.G1305T rpoB: p.D545E / c.T1637A rpoB: p.S450L / c.TCA->CTA

Protein Change: I491F, P439L, H445D, H445Y, Q432K, Q432P, D435Y, D545E, S450L
Nucleotide Change: A1473T, C1318T, C1335G, C1335T, CAG->AAA, CAG->CCC, G1305T, T1637A, TCA->CTA
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: spiking experiment
Source Database: Reslit

826

Variable ability of rapid tests to detect Mycobacterium tuberculosis rpoB mutations conferring phenotypically occult rifampicin resistance.

PMID 31413308 · 2019

Disputed mutation

Mutation Information

rpoB: p.I491F / c.A1473T rpoB: p.L452P / c.CTG->CCC rpoB: p.D435Y / c.G1304T rpoB: p.L430P / c.T1290C rpoB: p.S450L / c.TCA->CTA

Protein Change: I491F, L452P, D435Y, L430P, S450L
Nucleotide Change: A1473T, CTG->CCC, G1304T, T1290C, TCA->CTA
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Sanger sequencing
Source Database: Reslit

827

Encapsulating bacteria in agarose microparticles using microfluidics for high-throughput cell analysis and isolation.

PMID 21142208 · 2011

Mutation Information

rpoB: p.Q513L / c.A1538T

Protein Change: Q513L
Nucleotide Change: A1538T
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: DNA sequencing
Source Database: Reslit

828

Pervasive genotype-by-environment interactions shape the fitness effects of antibiotic resistance mutations.

PMID 37583318 · 2023

All mutations are in the rpoB gene, which encodes the beta subunit of RNA polymerase.

Mutation Information

rpoB: p.Q513R / c.A1540G rpoB: p.Q513L / c.A1540T rpoB: p.R529H / c.AGA->CAT rpoB: p.S522F / c.C1567T rpoB: p.H526Y / c.C1578T rpoB: p.Q513P / c.CAA->CCC rpoB: p.V146F / c.GTT->TTC rpoB: p.S531F / c.TCA->TTC

Protein Change: Q513R, Q513L, R529H, S522F, H526Y, Q513P, V146F, S531F
Nucleotide Change: A1540G, A1540T, AGA->CAT, C1567T, C1578T, CAA->CCC, GTT->TTC, TCA->TTC
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: growth curves and MIC measurements
Source Database: Reslit

829

Environmental pleiotropy and demographic history direct adaptation under antibiotic selection.

PMID 30190561 · 2018

Mutation Information

rpoB: p.D516G / c.A1548G

Protein Change: D516G
Nucleotide Change: A1548G
Organisms: E. coli, Pseudomonas aeruginosa, Pseudomonas fluorescens
Confers Resistance To: rifampicin
Validation Method: Sanger sequencing of known resistance regions
Source Database: Reslit

830

Drug-resistant TB prevalence study in 5 health institutions in Haiti.

PMID 33735224 · 2021

Mutation Information

rpoB: p.D516V / c.A1548T rpoB: p.S531W / c.C1593G rpoB: p.S531L / c.TCA->CTA

Protein Change: D516V, S531W, S531L
Nucleotide Change: A1548T, C1593G, TCA->CTA
Confers Resistance To: rifampicin
Validation Method: genotypic and phenotypic testing
Source Database: Reslit

831

Mycobacterium tuberculosis resistance prediction and lineage classification from genome sequencing: comparison of automated analysis tools.

PMID 28425484 · 2017

Mutations in rpoB were identified in strains resistant to rifampicin.

Mutation Information

rpoB: p.D516V / c.A1548T rpoB: p.L452P / c.CTT->CCC rpoB: p.S450L / c.TCA->CTA

Protein Change: D516V, L452P, S450L
Nucleotide Change: A1548T, CTT->CCC, TCA->CTA
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Sanger sequencing and phenotypic DST
Source Database: Reslit

832

SAM-TB: a whole genome sequencing data analysis website for detection of Mycobacterium tuberculosis drug resistance and transmission.

PMID 35211720 · 2022

Mutation Information

rpoB: p.D516V / c.A1549T rpoB: p.S531L / c.TCA->CTA

Protein Change: D516V, S531L
Nucleotide Change: A1549T, TCA->CTA
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: comparison with phenotypic drug-susceptibility tests
Source Database: Reslit

833

Nanopore-based targeted next-generation sequencing (tNGS): A versatile technology specialized in detecting low bacterial load clinical specimens.

PMID 40424288 · 2025

All mutations were identified in the rpoB gene, with 20 located in the rifampicin resistance-determining region (RRDR) and one outside the RRDR.

Mutation Information

rpoB: p.D516V / c.A1549T rpoB: p.H526L / c.A1578T rpoB: p.S531L / c.AGT->CTT rpoB: p.P454H / c.C1361A rpoB: p.H526Y / c.C1577T rpoB: p.Q531P / c.CAA->CCC rpoB: p.L524fs / c.CTG->TGA rpoB: p.L533P / c.T1600C rpoB: p.S512G / c.TCA->GGG

Protein Change: D516V, H526L, S531L, P454H, H526Y, Q531P, L524fs, L533P, S512G
Nucleotide Change: A1549T, A1578T, AGT->CTT, C1361A, C1577T, CAA->CCC, CTG->TGA, T1600C, TCA->GGG
Confers Resistance To: rifampicin
Validation Method: sequencing data
Source Database: Reslit

834

Diminishing Returns From Beneficial Mutations and Pervasive Epistasis Shape the Fitness Landscape for Rifampicin Resistance in Pseudomonas aeruginosa.

PMID 20876562 · 2010

Mutations in rpoB gene confer rifampicin resistance.

Mutation Information

Nucleotide Change: A1553G, A1553T, A1562G, A1592T, A455G, A455T, C1550G, C1550T, C1591G, C1591T, C1607T, C1610T, C1619T, C1736T, G1561A, G1622A, G1624T, G1716T, G1724C, T1529C, T1549G, T1655G, T1731C, T449C
Organisms: Pseudomonas aeruginosa
Confers Resistance To: rifampicin
Validation Method: sequencing and fitness assays
Source Database: Reslit

835

Testing the role of genetic background in parallel evolution using the comparative experimental evolution of antibiotic resistance.

PMID 25228081 · 2014

Mutations in rpoB were responsible for rifampicin resistance

Mutation Information

rpoB: p.H521R / c.A1562G

Protein Change: H521R
Nucleotide Change: A1562G
Organisms: Pseudomonas aeruginosa, P. fulva, P. stutzeri, P. mendocina, P. protegens, P. fluorescens, P. putida
Confers Resistance To: rifampicin
Validation Method: sequencing of rpoB in evolved clones
Source Database: Reslit

836

Environmental Dependence of Competitive Fitness in Rifampin-Resistant rpoB Mutants of Bacillus subtilis.

PMID 35258334 · 2022

Some mutations were found to have varying effects on fitness depending on the growth environment.

Mutation Information

rpoB: p.I528V / c.A1582G rpoB: p.H482N / c.C1445A rpoB: p.H482Y / c.C1445T rpoB: p.D472Y / c.G1414T rpoB: p.A478D / c.G1432A rpoB: p.S487L / c.T1459C

Protein Change: I528V, H482N, H482Y, D472Y, A478D, S487L
Nucleotide Change: A1582G, C1445A, C1445T, G1414T, G1432A, T1459C
Organisms: Bacillus subtilis
Confers Resistance To: rifampicin
Validation Method: competition assay and Sanger sequencing; growth rate measurement and competition assay
Source Database: Reslit

837

Molecular detection of Mycobacterium tuberculosis sensitivity to rifampicin and isoniazid in South Gondar Zone, northwest Ethiopia.

PMID 31023267 · 2019

RIF-resistance conferred by absence of rpoB WT7 without MUT3.

Mutation Information

rpoB: p.Y531C / c.A1594G

Protein Change: Y531C
Nucleotide Change: A1594G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType MTBDR plus assay
Source Database: Reslit

838

Antimicrobial Resistance in Rhodococcus equi.

PMID 29052538 · 2017

Mutation Information

rpoB: c.A2063G

Nucleotide Change: A2063G
Confers Resistance To: rifampicin
Validation Method: experimental confirmation
Source Database: Reslit

839

Whole genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates collected in the Czech Republic, 2005-2020.

PMID 35505072 · 2022

Mutation Information

rpoB: c.A435T

Nucleotide Change: A435T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing data
Source Database: Reslit

840

Light Forge: A Microfluidic DNA Melting-based Tuberculosis Test.

PMID 32445364 · 2020

Mutations in the rpoB gene were identified as responsible for rifampicin resistance in Mycobacterium tuberculosis.

Mutation Information

rpoB: p.L172R / c.A516G rpoB: p.L172F / c.A516T rpoB: p.S175F / c.C526T rpoB: p.P177S / c.C531T rpoB: p.Y178H / c.T533C

Protein Change: L172R, L172F, S175F, P177S, Y178H
Nucleotide Change: A516G, A516T, C526T, C531T, T533C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: High-resolution melting analysis
Source Database: Reslit

841

New mutations and horizontal transfer of rpoB among Rifampin-Resistant Streptococcus pneumoniae from four Spanish hospitals.

PMID 15917517 · 2005

Mutations in rpoB were identified as the cause of rifampin resistance in Streptococcus pneumoniae.

Mutation Information

Nucleotide Change: A547T, C150A, C486A, C486T, C499A, C499G, C499T, C501T, C535G, C537T, G489A, G489C, G489T, G638A, T481C, T482C, T485C, T495C, T498C, T506A, T506C
Organisms: Streptococcus pneumoniae
Confers Resistance To: rifampicin
Validation Method: genetic transformation
Source Database: Reslit

842

Successful Treatment of a Multidrug-Resistant Tuberculosis Patient with a Negative Xpert MTB/RIF Test for Rifampicin-Resistant Tuberculosis in Guizhou Province of China: A Case Report.

PMID 32440172 · 2020

Mutation outside the RIF resistance-determining region (RRDR) not detectable by Xpert MTB/RIF assay

Mutation Information

rpoB: c.A572T

Nucleotide Change: A572T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing of the rpoB gene
Source Database: Reslit

843

Modified methicillin-resistant Staphylococcus aureus detected in neonatal intensive care patients.

PMID 34368846 · 2021

An A574T substitution in RpoB was found in the resistant isolate from infant 2.

Mutation Information

rpoB: c.A574T

Nucleotide Change: A574T
Organisms: Staphylococcus aureus
Confers Resistance To: methicillin
Validation Method: whole-genome sequencing and phenotypic testing
Source Database: Reslit

844

The New Xpert MTB/RIF Ultra: Improving Detection of Mycobacterium tuberculosis and Resistance to Rifampin in an Assay Suitable for Point-of-Care Testing.

PMID 28851844 · 2017

Mutations in rpoB were analyzed for their effect on rifampin resistance.

Mutation Information

Protein Change: Q513K, Q513Q, H526N, H526R, H526L, H526D, H526Y, H526C, Q510V, R529K, L511P, L533P, L533R, D516V, D516Y, S531Q, S522L, S531L, S531W, F514F
Nucleotide Change: ACT->ACC, CAA->AAA, CAA->CAA, CAC->AAC, CAC->CGC, CAC->CTG, CAC->GAC, CAC->TAA, CAC->TAC, CAC->TGC, CAG->GTG, CGG->AAG, CTT->CCC, CTT->CCT, CTT->CGT, GAT->GTT, GAT->TAT, TCA->CAA, TCA->CTA, TCA->TGA, TTT->TTT
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: mutation panel challenge
Source Database: Reslit

845

Phenotypic and Genotypic Comparison of Antimicrobial-Resistant Variants of Escherichia coli and Salmonella Typhimurium Isolated from Evolution Assays with Antibiotics or Commercial Products Based on Essential Oils.

PMID 37895914 · 2023

Mutations in rpoB gene associated with rifampicin resistance

Mutation Information

rpoB: c.AGC -> CTC

Nucleotide Change: AGC -> CTC
Organisms: Escherichia coli, Salmonella enterica
Confers Resistance To: rifampicin
Validation Method: mutagenesis frequency assay
Source Database: Reslit

846

Potential contribution of HIV during first-line tuberculosis treatment to subsequent rifampicin-monoresistant tuberculosis and acquired tuberculosis drug resistance in South Africa: a retrospective molecular epidemiology study.

PMID 34766068 · 2021

The rpoB mutation Ser450Leu was identified as a rifampicin resistance-conferring mutation in the study.

Mutation Information

rpoB: p.S450L / c.AGC->CTC

Protein Change: S450L
Nucleotide Change: AGC->CTC
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

847

Redefining MTBDRplus test results: what do indeterminate results actually mean?

PMID 26792465 · 2016

mutations in rpoB confer resistance to rifampicin

Mutation Information

rpoB: p.S531L / c.AGC->CTC

Protein Change: S531L
Nucleotide Change: AGC->CTC
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: line probe assay and pyrosequencing
Source Database: Reslit

848

Fluoromycobacteriophages for rapid, specific, and sensitive antibiotic susceptibility testing of Mycobacterium tuberculosis.

PMID 19300517 · 2009

Mutation Information

rpoB: p.S456L / c.AGT->CTT

Protein Change: S456L
Nucleotide Change: AGT->CTT
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: recombineering with ssDNA substrates
Source Database: Reslit

849

Discordance in genotypic and phenotypic drug susceptibility results: time to reconsider critical concentration of rifampicin.

PMID 39902977 · 2025

Commonest mutation

Mutation Information

rpoB: p.I572F / c.ATC-TTC rpoB: p.H526N / c.CAC-AAC rpoB: p.H526L / c.CAC-CTC rpoB: p.P564R / c.CCT-CGT rpoB: p.L533P / c.CTG-CCG rpoB: p.D516Y / c.GAC-TAC rpoB: p.S531W / c.TCG-TGG

Protein Change: I572F, H526N, H526L, P564R, L533P, D516Y, S531W
Nucleotide Change: ATC-TTC, CAC-AAC, CAC-CTC, CCT-CGT, CTG-CCG, GAC-TAC, TCG-TGG
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: sequencing and MIC testing
Source Database: Reslit

850

A Macromolecule Reversing Antibiotic Resistance Phenotype and Repurposing Drugs as Potent Antibiotics.

PMID 32995131 · 2020

Mutation in rpoB gene was observed in all nine evolved colonies.

Mutation Information

rpoB: c.C102T

Nucleotide Change: C102T
Organisms: Acinetobacter baumannii
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

851

Antibacterial and antivirulence effect of 6-N-hydroxylaminopurine in Listeria monocytogenes.

PMID 28062853 · 2017

Mutations in rpoB were identified as a result of 6-N-HAP treatment, leading to rifampicin resistance.

Mutation Information

rpoB: p.P353L / c.C1057T

Protein Change: P353L
Nucleotide Change: C1057T
Organisms: Listeria monocytogenes
Confers Resistance To: rifampicin
Validation Method: sequencing of rpoB gene
Source Database: Reslit

852

Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana.

PMID 33667696 · 2021

Mutations detected in multiple cases.

Mutation Information

rpoB: p.Q432E / c.C1295G rpoB: p.L452P / c.C1355T rpoB: p.D435V / c.G1305T

Protein Change: Q432E, L452P, D435V
Nucleotide Change: C1295G, C1355T, G1305T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

853

Whole Genome Sequencing of Mycobacterium tuberculosis under routine conditions in a high-burden area of multidrug-resistant tuberculosis in Peru.

PMID 38861531 · 2024

Mutation Information

rpoB: p.Q432L / c.C1295T

Protein Change: Q432L
Nucleotide Change: C1295T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing
Source Database: Reslit

854

c-di-AMP signaling plays important role in determining antibiotic tolerance phenotypes of Mycobacterium smegmatis.

PMID 35907936 · 2022

Mutation in the rifampicin resistance-determining region (RRDR) of rpoB leads to rifampicin resistance.

Mutation Information

rpoB: p.H442Y / c.C1324T

Protein Change: H442Y
Nucleotide Change: C1324T
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

855

Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus.

PMID 14602594 · 2003

The rpoB mutations may affect antibiotic production by altering the initiation of secondary metabolism.

Mutation Information

rpoB: p.S442Y / c.C1325A rpoB: p.S442F / c.C1325T

Protein Change: S442Y, S442F
Nucleotide Change: C1325A, C1325T
Organisms: Streptomyces albus
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

856

Multidrug-resistant toxigenic Corynebacterium diphtheriae sublineage 453 with two novel resistance genomic islands.

PMID 36748453 · 2023

Mutation Information

rpoB: p.S444F / c.C1330T

Protein Change: S444F
Nucleotide Change: C1330T
Organisms: Corynebacterium diphtheriae
Confers Resistance To: rifampicin
Source Database: Reslit

857

Whole-genome sequencing reveals transmission pattern and drug resistance of Mycobacterium tuberculosis intra- or inter-hosts.

PMID 39906217 · 2024

Mutation Information

rpoB: p.H445R / c.C1333A rpoB: p.H445D / c.C1333G rpoB: p.H445Y / c.C1333T rpoB: p.D435G / c.G1303C rpoB: p.D435V / c.G1303T rpoB: p.D545E / c.G1633A rpoB: p.S450L / c.T1348C rpoB: p.L452P / c.T1354C

Protein Change: H445R, H445D, H445Y, D435G, D435V, D545E, S450L, L452P
Nucleotide Change: C1333A, C1333G, C1333T, G1303C, G1303T, G1633A, T1348C, T1354C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin|rifabutin
Validation Method: molecular drug susceptibility testing
Source Database: Reslit

858

Applying whole genome sequencing to predict phenotypic drug resistance in Mycobacterium tuberculosis: leveraging 20 years of nationwide data from Denmark.

PMID 38904390 · 2024

Mutation Information

rpoB: p.H445N / c.C1333A rpoB: p.H445D / c.C1333G rpoB: p.H445L / c.C1333T rpoB: p.D435Y / c.G1303T rpoB: p.L430P / c.T1288C rpoB: p.S431G / c.T1291C rpoB: p.S450L / c.T1348C

Protein Change: H445N, H445D, H445L, D435Y, L430P, S431G, S450L
Nucleotide Change: C1333A, C1333G, C1333T, G1303T, T1288C, T1291C, T1348C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic resistance prediction
Source Database: Reslit

859

Deciphering the population dynamics and drug-resistance characteristics of extrapulmonary tuberculosis: genomic and clinical insights from a Chinese hospital.

PMID 41459162 · 2025

Mutation Information

rpoB: p.S450L / c.C1349T

Protein Change: S450L
Nucleotide Change: C1349T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole_genome_sequencing
Source Database: Reslit

860

Transmission dynamics of drug-resistant tuberculosis in Ningbo, China: an epidemiological and genomic analysis.

PMID 38384306 · 2024

Mutation Information

rpoB: p.S450L / c.C1350T

Protein Change: S450L
Nucleotide Change: C1350T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole_genome_sequencing
Source Database: Reslit

861

First-line drug resistance profiling of Mycobacterium tuberculosis: a machine learning approach.

PMID 35309001 · 2021

Mutation Information

rpoB: p.S450L / c.C1351T

Protein Change: S450L
Nucleotide Change: C1351T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: variant calling
Source Database: Reslit

862

Drug resistant Mycobacterium tuberculosis strains have altered cell envelope hydrophobicity that influences infection outcomes in human macrophages.

PMID 39730579 · 2024

Mutations in rpoB are associated with rifampicin resistance in MDR and pre-XDR strains.

Mutation Information

rpoB: p.R456L / c.C1367T

Protein Change: R456L
Nucleotide Change: C1367T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: genotypic resistance profiling
Source Database: Reslit

863

In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: microbiology profiling studies with staphylococci and streptococci.

PMID 18443106 · 2008

Mutation in rpoB gene leads to rifampin resistance.

Mutation Information

rpoB: p.H481Y / c.C1441T

Protein Change: H481Y
Nucleotide Change: C1441T
Organisms: Staphylococcus aureus, Streptococcus pyogenes
Confers Resistance To: rifampicin
Validation Method: genetic analysis of mutant strains
Source Database: Reslit

864

In Vitro Activity of Dalbavancin against Refractory Multidrug-Resistant (MDR) Staphylococcus aureus Isolates.

PMID 33287376 · 2020

Mutations in rpoB were associated with rifampicin resistance and correlated with VISA/hVISA emergence.

Mutation Information

rpoB: p.N481Y / c.C1443T

Protein Change: N481Y
Nucleotide Change: C1443T
Organisms: Staphylococcus aureus
Confers Resistance To: rifampicin
Validation Method: molecular characterization
Source Database: Reslit

865

Genome-based assessment of antimicrobial resistance reveals the lineage specificity of resistance and resistance gene profiles in Riemerella anatipestifer from China.

PMID 38169285 · 2024

Mutation Information

rpoB: p.H491N / c.C1472T

Protein Change: H491N
Nucleotide Change: C1472T
Organisms: Riemerella anatipestifer
Confers Resistance To: rifampicin
Validation Method: identification of resistance mutations
Source Database: Reslit

866

Molecular epidemiology of Clostridioides difficile in companion animals: Genetic overlap with human strains and public health concerns.

PMID 36684930 · 2022

Detected in one isolate.

Mutation Information

rpoB: p.H502N / c.C1505A rpoB: p.R505K / c.C1514A

Protein Change: H502N, R505K
Nucleotide Change: C1505A, C1514A
Organisms: Clostridioides difficile
Confers Resistance To: rifampicin
Validation Method: PCR and/or Sanger sequencing
Source Database: Reslit

867

Genomic evolution and virulence association of Clostridioides difficile sequence type 37 (ribotype 017) in China.

PMID 34125660 · 2021

Mutations in rpoB associated with rifampicin resistance

Mutation Information

rpoB: p.H502N / c.C1505T rpoB: p.R505K / c.G1514A

Protein Change: H502N, R505K
Nucleotide Change: C1505T, G1514A
Organisms: Clostridioides difficile
Confers Resistance To: rifampicin
Validation Method: correlation with rifampicin resistance
Source Database: Reslit

868

Phenotypic drug susceptibility characterization and clinical outcomes of tuberculosis strains with A-probe mutation by GeneXpert MTB/RIF.

PMID 38012619 · 2023

Mutations in rpoB gene associated with rifampicin resistance

Mutation Information

rpoB: p.L511P / c.C1531T

Protein Change: L511P
Nucleotide Change: C1531T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: molecular-phenotypic discordance
Source Database: Reslit

869

Epistasis decreases with increasing antibiotic pressure but not temperature.

PMID 37004727 · 2023

Mutations in rpoB confer resistance to rifampicin by altering the binding site.

Mutation Information

rpoB: p.S512F / c.C1536T rpoB: p.H526Y / c.CTG->TAC rpoB: p.I572N / c.T1716A

Protein Change: S512F, H526Y, I572N
Nucleotide Change: C1536T, CTG->TAC, T1716A
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: competitive fitness assays
Source Database: Reslit

870

Lytic phages obscure the cost of antibiotic resistance in Escherichia coli.

PMID 25268496 · 2015

Mutation Information

rpoB: p.S512F / c.C1537T

Protein Change: S512F
Nucleotide Change: C1537T
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

871

Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs.

PMID 31234910 · 2019

Mutation Information

rpoB: c.C1538T

Nucleotide Change: C1538T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: whole genome sequencing and drug susceptibility testing
Source Database: Reslit

872

Efficacy and safety of low-dose rifabutin-based 7-day triple therapy as a third- or later-line Helicobacter pylori eradication regimen.

PMID 35644041 · 2022

Mutation Information

rpoB: p.L525I / c.C1573A rpoB: p.V538I / c.G1612A

Protein Change: L525I, V538I
Nucleotide Change: C1573A, G1612A
Organisms: Helicobacter pylori
Confers Resistance To: rifabutin
Validation Method: sequencing
Source Database: Reslit

873

Potential for adaptation overrides cost of resistance.

PMID 26343510 · 2015

Mutation Information

rpoB: p.H526D / c.C1576A

Protein Change: H526D
Nucleotide Change: C1576A
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

874

Molecular epidemiology of Mycobacterium tuberculosis complex in the Volta Region of Ghana.

PMID 33730036 · 2021

Mutation Information

rpoB: p.H526D / c.C1578T

Protein Change: H526D
Nucleotide Change: C1578T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: GenoType MTBDR plus version 2.0
Source Database: Reslit

875

Epidemiology of Staphylococcus haemolyticus nosocomial bacteraemia in neonatal intensive care units, France, 2019 to 2023: predominance of the ST29 (CC3) multidrug-resistant lineage.

PMID 40116031 · 2025

Mutation Information

rpoB: p.I527M / c.C1582G rpoB: p.D471E / c.G1415A rpoB: p.S532N / c.TCT->AAT

Protein Change: I527M, D471E, S532N
Nucleotide Change: C1582G, G1415A, TCT->AAT
Confers Resistance To: rifampicin
Source Database: Reslit

876

Genomic analysis of a multidrug-resistant Staphylococcus epidermidis isolate BPH0662 reveals insights into hospital adaptation and resistance mechanisms

PMID 28785416 · 2023

associated with rifampicin resistance

Mutation Information

rpoB: p.I527M / c.C1583G rpoB: p.D471E / c.G1415A

Protein Change: I527M, D471E
Nucleotide Change: C1583G, G1415A
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

877

Deletion of rifampicin-inactivating mono-ADP-ribosyl transferase gene of Mycobacterium smegmatis globally altered gene expression profile that favoured increase in ROS levels and thereby antibiotic resister generation.

PMID 35909599 · 2022

Mutations in the RRDR of rpoB conferred rifampicin resistance in arr-KO and WT strains.

Mutation Information

rpoB: c.C1595T

Nucleotide Change: C1595T
Confers Resistance To: rifampicin
Validation Method: sequencing of rifampicin resisters
Source Database: Reslit

878

Development of multiplex assay for rapid characterization of Mycobacterium tuberculosis.

PMID 18077627 · 2008

Mutation in rpoB codon 176 (C->T) leads to rifampin resistance.

Mutation Information

rpoB: c.C176T

Nucleotide Change: C176T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: MLPA and sequencing
Source Database: Reslit

879

Multidrug-resistant tuberculosis in Port-au-Prince, Haiti.

PMID 22569696 · 2012

Mutations in the rpoB gene were associated with rifampin resistance.

Mutation Information

rpoB: c.C510T

Nucleotide Change: C510T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: DNA sequencing and drug susceptibility testing
Source Database: Reslit

880

A molecular platform for the diagnosis of multidrug-resistant and pre-extensively drug-resistant tuberculosis based on single nucleotide polymorphism mutations present in Colombian isolates of Mycobacterium tuberculosis.

PMID 26841047 · 2016

Mutation Information

rpoB: c.C513A rpoB: c.C513C rpoB: c.C513G rpoB: c.C522T rpoB: c.C531T rpoB: c.G511C rpoB: c.T516A rpoB: c.T516G rpoB: c.T516T rpoB: c.T526A rpoB: c.T526C rpoB: c.T526G rpoB: c.T526T

Nucleotide Change: C513A, C513C, C513G, C522T, C531T, G511C, T516A, T516G, T516T, T526A, T526C, T526G, T526T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Reverse hybridisation and sequencing
Source Database: Reslit

881

Detection of Rifampin-Resistant Mycobacterium tuberculosis in Sputa by Nested PCR-Linked Single-Strand Conformation Polymorphism and DNA Sequencing.

PMID 11427578 · 2001

Mutations at codon 526 (His 526 -> Tyr) and 531 (Ser 531 -> Leu) were identified.

Mutation Information

rpoB: c.C526T

Nucleotide Change: C526T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: nested PCR-SSCP and DNA sequencing
Source Database: Reslit

882

Mycobacterium tuberculosis Beijing genotype resistance to transient rifampin exposure.

PMID 25340553 · 2014

Mutants were detected in the rpoB gene, which is associated with rifampin resistance.

Mutation Information

rpoB: c.C526T rpoB: c.G531A

Nucleotide Change: C526T, G531A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: molecular analysis
Source Database: Reslit

883

Spread of Drug-Resistant Mycobacterium tuberculosis Strains of the Beijing Genotype in the Archangel Oblast, Russia.

PMID 12037045 · 2002

The 531 TCG→TTG mutation was predominant among strains of the Beijing genotype.

Mutation Information

Nucleotide Change: C531T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Inno-LiPA Rif. TB test
Source Database: Reslit

884

Rifampin Resistance in Mycobacterium kansasii Is Associated with rpoB Mutations

PMID 11600355 · 2001

Mutations in codons 513, 526, and 531 have previously been described in rifampin-resistant M. tuberculosis isolates.

Mutation Information

Nucleotide Change: C531T
Organisms: Mycobacterium kansasii
Confers Resistance To: rifampicin|rifabutin
Validation Method: sequencing and E-test MIC determination
Source Database: Reslit

885

Unexpected Genomic and Phenotypic Diversity of Mycobacterium africanum Lineage 5 Affects Drug Resistance, Protein Secretion, and Immunogenicity.

PMID 30010947 · 2018

Mutation Information

Nucleotide Change: C531T
Organisms: Mycobacterium africanum
Confers Resistance To: rifampicin
Validation Method: DNA sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

886

Plasmid-based controls to detect rpoB mutations in Mycobacterium tuberculosis by quantitative polymerase chain reaction-high-resolution melting.

PMID 23440123 · 2013

C531T mutation in the rifampicin resistance-determining region of rpoB

Mutation Information