ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeP496S

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogReslit

Overview

Mechanism: single resistance variant, DNA-directed RNA polymerase subunit beta RpoB
Resistance To: rifampicin, rifamycins
Organisms: Clostridium difficile, Flavobacterium psychrophilum, Clostridium ljungdahlii, Clostridioides difficile
Papers: 2

Paper Information2

In vivo selection of rifamycin-resistant Clostridium difficile during rifaximin therapy.

The patient developed resistance to rifaximin, leading to the emergence of resistant C. difficile isolates.

Clostridioides difficile rpoB with mutation conferring resistance to rifampicin; CARD accession: CARD:3004563

rpoB

Protein Change: P496S
Organisms: Clostridium difficile, Clostridium ljungdahlii, Clostridioides difficile
Confers Resistance To: rifampicinrifamycins
Effect on Function: single resistance variant; DNA-directed RNA polymerase subunit beta RpoB
Validation Method: sequencing
Source Database: ReslitCard DatabaseReference Gene Catalog

Potential mechanisms of attenuation for rifampicin-passaged strains of Flavobacterium psychrophilum.

Mutations in rpoB are associated with rifampicin resistance and attenuation.

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