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Home Browse Genes Browse Mutations Download Collaborators About

Browse Mutations rpoBY421H

GenerpoB

Protein ChangeY421H

Nucleotide ChangeT1262C

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: rifampicin
Papers: 1

Paper Information1

1

Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic.

PMID 30862812 · 2019

Mutations in rpoB are commonly associated with rifampicin resistance.

Mutation Information

rpoB: p.Y421H / c.T1262C

Protein Change: Y421H
Nucleotide Change: T1262C
Confers Resistance To: rifampicin
Validation Method: whole-genome sequencing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research