ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeI953S

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogReslit

Overview

Mechanism: single resistance variant, DNA-directed RNA polymerase subunit beta RpoB
Resistance To: daptomycin
Organisms: Staphylococcus aureus
Papers: 2

Paper Information2

Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureus.

Protein Change: I953S
Organisms: Staphylococcus aureus
Confers Resistance To: daptomycin
Validation Method: experimental validation through MIC testing and gene expression analysis
Source Database: Reslit

Genetic changes that correlate with reduced susceptibility to daptomycin in Staphylococcus aureus.

Staphylococcus aureus rpoB mutants conferring resistance to daptomycin; CARD accession: CARD:3003287

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