ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeD441A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: loss of interactions with drug except Gly438, Phe439 and Arg465
Resistance To: rifampicin
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

Correlation of drug resistance with single nucleotide variations through genome analysis and experimental validation in a multi-drug resistant clinical isolate of M. tuberculosis.

PMID 32711461 · 2020

Mutation Information

rpoB: p.D441A

Protein Change: D441A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Effect on Function: loss of interactions with drug except Gly438, Phe439 and Arg465
Validation Method: molecular docking analysis
Source Database: Reslit

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