ResLit - Antimicrobial Resistance Gene & Mutation Database

GenerpoB

Protein ChangeD492V

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogReslit

Overview

Mechanism: single resistance variant, DNA-directed RNA polymerase subunit beta RpoB
Resistance To: rifampicin|rifaximin, rifampicin, rifaximin
Organisms: Clostridium difficile, Clostridium ljungdahlii, Clostridioides difficile
Papers: 2

Paper Information2

Coinfection and Emergence of Rifamycin Resistance during a Recurrent Clostridium difficile Infection.

PMID 27558181 · 2016

Mutation Information

rpoB: p.D492V

Protein Change: D492V
Organisms: Clostridium difficile
Confers Resistance To: rifampicin|rifaximin
Validation Method: sequencing
Source Database: Reslit

High-resolution melting analysis of the single nucleotide polymorphism hot-spot region in the rpoB gene as an indicator of reduced susceptibility to rifaximin in Clostridium difficile.

PMID 22361457 · 2012

Clostridioides difficile rpoB with mutation conferring resistance to rifampicin; CARD accession: CARD:3004563

rpoB

Mutation Information

rpoB: p.D492V

Protein Change: D492V
Organisms: Clostridium ljungdahlii, Clostridioides difficile
Confers Resistance To: rifampicinrifaximin
Effect on Function: single resistance variant; DNA-directed RNA polymerase subunit beta RpoB
Source Database: Card DatabaseReference Gene Catalog

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