ResLit - Antimicrobial Resistance Gene & Mutation Database

GenerpoB

Protein ChangeS442Y

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: The mutation causes a serine to tyrosine substitution at position 442, leading to a more hydrophobic environment in the rifampin binding pocket, which reduces the effectiveness of rifampin., DNA-directed RNA polymerase subunit beta RpoB
Resistance To: rifampicin, rifamycins
Organisms: Streptomyces albus, Corynebacterium diphtheriae
Papers: 2

Paper Information2

Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus.

PMID 14602594 · 2003

The rpoB mutations may affect antibiotic production by altering the initiation of secondary metabolism.

Mutation Information

rpoB: p.S442Y / c.C1325A

Protein Change: S442Y
Nucleotide Change: C1325A
Organisms: Streptomyces albus
Confers Resistance To: rifampicin
Validation Method: sequencing
Source Database: Reslit

Infection by a multidrug-resistant Corynebacterium diphtheriae strain: prediction of virulence factors, CRISPR-Cas system analysis, and structural implications of mutations conferring rifampin resistance.

PMID 39196424 · 2024

Mutation in rpoB gene causes rifampin resistance

Mutation Information

rpoB: p.S442Y

Protein Change: S442Y
Organisms: Corynebacterium diphtheriae
Confers Resistance To: rifampicin
Effect on Function: The mutation causes a serine to tyrosine substitution at position 442, leading to a more hydrophobic environment in the rifampin binding pocket, which reduces the effectiveness of rifampin.
Validation Method: genomic analysis and structural modeling
Source Database: Reslit

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