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Browse Mutations rpoBH451G

GenerpoB

Protein ChangeH451G

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: rifampicin
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

1

The Structural Basis of Mycobacterium tuberculosis RpoB Drug-Resistant Clinical Mutations on Rifampicin Drug Binding.

PMID 35164151 · 2022

All mutations were identified in the RIF resistance-determining region (RRDR) of rpoB.

Mutation Information

Protein Change: H451G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: rifampicin
Validation Method: Molecular docking and molecular dynamics simulations
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research