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Browse Mutations mecAT116A

GenemecA

penicillin-binding protein 2'

Nucleotide ChangeT116A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reducing its affinity for beta-lactam antibiotics
Resistance To: oxacillin|cefoxitin|erythromycin
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

1

SNP Scanning in mecA Gene for Methicillin-Resistant Staphylococcus aureus.

PMID 33850938 · 2020

This mutation leads to a truncated PBP2a protein, reducing its affinity for beta-lactam antibiotics.

Mutation Information

Nucleotide Change: T116A
Organisms: Staphylococcus aureus
Confers Resistance To: oxacillin|cefoxitin|erythromycin
Effect on Function: reducing its affinity for beta-lactam antibiotics
Validation Method: sequencing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research