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Browse Mutations pmrAG53A

GenepmrA

polymyxin resistance

Protein ChangeG53A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: constitutive activation of PmrA or PmrB, subsequent overexpression of LPS modifying enzymes and thus colistin resistance
Resistance To: colistin
Organisms: Enterobacterales, Escherichia coli, Salmonella spp.
Papers: 1

Paper Information1

1

Global colistin use: a review of the emergence of resistant Enterobacterales and the impact on their genetic basis.

PMID 34612488 · 2022

Mutations in PmrA contribute to colistin resistance.

Mutation Information

Protein Change: G53A
Organisms: Enterobacterales, Escherichia coli, Salmonella spp.
Confers Resistance To: colistin
Effect on Function: constitutive activation of PmrA or PmrB, subsequent overexpression of LPS modifying enzymes and thus colistin resistance
Validation Method: experimental confirmation
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research